Effect of excipient composition on the biocompatibility of bupivacaine-containing microparticles at the sciatic nerve

Journal of Biomedical Materials Research - Part A

Volumn 68, Issue 4, 2004, Pages 651-659

  Colombo, Gaia ^a,b   Langer, Robert ^a   Kohane, Daniel S ^b,c  

^a UNIVERSITY OF PARMA   (Italy)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Controlled release; Epineurium; Inflammation; Myotoxicity; Prolonged duration local anesthesia

Indexed keywords

BIOCOMPATIBILITY; COMPOSITION; LIPIDS; PROTEINS; STATISTICAL METHODS; SUGARS; TOXICITY;

MICROPARTICLES; SENSORY NERVES;

BIOMATERIALS;

BUPIVACAINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; EXCIPIENT; ISOFLURANE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CHEMICAL COMPOSITION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; EXCIPIENT COMPATIBILITY; INFLAMMATION; MALE; MICROSCOPY; MUSCLE TOXICITY; NERVE BLOCK; NONHUMAN; PARTICLE SIZE; PARTICULATE MATTER; RAT; SCIATIC NERVE; SPRAY DRYING; STATISTICAL ANALYSIS; TISSUE REACTION;

EID: 1342323415     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.20074     Document Type: Article

References (22)

1. Masters DB, Berde CB, Dutta SK, Griggs CT, Hu D, Kupsky W, Langer R. Prolonged regional nerve blockade by controlled release of local anesthetic from a biodegradable polymer matrix. Anesthesiology 1993;79:001-007.
2. Curley J, Castillo J, Hotz J, Uezono M, Hernandez S, Lim J-O, Tigner J, Chasin M, Langer R, Berde C. Prolonged regional nerve blockade. Injectable biodegradable bupivacaine/polyester microspheres. Anesthesiology 1996;84:1401-1410.
3. Mowat JJ, Mok MJ, MacLeod BA, Madden TD. Liposomal bupivacaine. Extended duration nerve blockade using large unilamellar vesicles that exhibit a proton gradient. Anesthesiology 1996;85:635-643.
4. Le Corre P, Estebe JP, Clement R, Du Plessis L, Chevanne F, Ecoffey C, Le Verge R. Spray-dryed bupivacaine-loaded microspheres: In vitroa evaluation and biopharmaceutics of bupivacaine following brachial plexus administration in sheep. Int J Pharm 2002;238:191-203.
5. Anderson JM. In vivo biocompatibility of implantable delivery systems and biomaterials. Eur J Pharm Biopharmacol 1994;40:1-8.
6. Drager C, Benziger D, Gao F, Berde CB. Prolonged intercostal nerve blockade in sheep using controlled release bupivacaine and dexamethasone from polyester microspheres. Anesthesiology 1998;89:969-979.
7. Kohane DS, Lipp M, Kinney R, Anthony D, Lotan N, Langer R. Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium. J Biomed Mater Res 2002;59:450-459.
8. Kohane DS, Lipp M, Kinney R, Lotan N, Langer R. Sciatic nerve blockade with lipid-protein-sugar particles containing bupivacaine. Pharm Res 2000;17:1243-1249.
9. USP: United States pharmacopeia, 26th ed. Rockville, MD: United States Pharmacopeial Convention; 2003.
10. Thalhammer JG, Vladimirova M, Bershadsky B, Strichartz GR. Neurologic evaluation of the rat during sciatic nerve block with lidocaine. Anesthesiology 1995;82:1013-1025.
11. Kohane DS, Yieh J, Lu NT, Langer R, Strichartz G, Berde CB. A re-examination of tetrodotoxin for prolonged anesthesia. Anesthesiology 1998;89:119-131.
12. Benoit PW, Belt WD. Some effects of local anesthetic agents on skeletal muscle. Exp Neurol 1972;34:264-278.
13. Denson D, Coyle D, Thompson G, Myers J. Alpha 1-acid glycoprotein and albumin in human serum bupivacaine binding. Clin Pharmacol Ther 1984;35:409-415.
14. Kohane DS, Plesnila N, Thomas SS, Le D, Langer R, Moskowitz MA. Lipid-sugar particles for intracranial drug delivery: Safety and biocompatibility. Brain Res 2002;946:206-213.
15. Castillo J, Curley J, Hotz J, Uezono M, Tigner J, Chasin M, Wilder R, Langer R, Berde C. Glucocorticoids prolong rat sciatic nerve blockade in vivo from bupivacaine microspheres. Anesthesiology 1996;85:1157-1166.
16. Kohane DS, Smith SE, Louis DN, Colombo G, Ghoroghchian P, Hunfeld NGM, Berde CB, Langer RS. Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain 2003;104:415-421.
17. Edwards DA, Hanes J, Caponnetti G, Hrkach J, Ben-Jebria A, Eskew M-L, Mintzes J, Deaver D, Lotan N, Langer R. Large porous particles for pulmonary drug delivery. Science 1997;276:1868-1871.
18. Hedley ML, Curley J, Urban R. Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses. Nat Med 1998;4:365-368.
19. Agrawal AK, Gupta CM. Tuftsin-bearing liposomes in treatment of macrophage-based infections. Adv Drug Del Rev 2000;41:135-146.
20. Hogan Q, Dotson R, Erickson S, Kettler R, Hogan K. Local anesthetic myotoxicity: A case and review. Anesthesiology 1994;80:942-947.
21. Pere P, Watanabe H, Pitkanen M, Wahlstrom T, Rosenberg PH. Local myotoxicity of bupivacaine in rabbits after continuous supraclavicular brachial plexus blocks. Reg Anesth 1993;18:304-307.
22. Brazeau GA, Sciame M, al-Suwayeh SA, Fattal E. Evaluation of PLGA microsphere size effect on myotoxicity using the isolated rodent skeletal muscle model. Pharm Dev Technol 1996;1:279-283.