Synthesis of a C-glucosylated cyclopropylamide and evaluation as a glycogen phosphorylase inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 17, 2008, Pages 4774-4778

  Bertus, Philippe ^a,b   Szymoniak, Jan ^b   Jeanneau, Erwann ^c   Docsa, Tibor ^d   Gergely, Pál ^d   Praly, Jean Pierre ^c,e,f   Vidal, Sébastien ^c,e,f  

^a UNIVERSITÉ DU MAINE   (France)

^b UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^c UNIVERSITÉ LYON 1   (France)

^d UNIVERSITY OF DEBRECEN   (Hungary)

^e CNRS   (France)

^f UNIVERSITÉ DE LYON   (France)

Author keywords

Acyl migration; C Glycoside; Cyclopropane; Glycogen phosphorylase; Nitrile; Titanium

Indexed keywords

CYCLOPROPYLAMIDE; ENZYME INHIBITOR; GLYCOGEN PHOSPHORYLASE INHIBITOR; TITANIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DEPROTECTION REACTION; DIMERIZATION; DRUG INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; IC 50; MOLECULAR INTERACTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN GLYCOSYLATION; RABBIT; X RAY CRYSTALLOGRAPHY;

ANIMALS; BENZAMIDES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DRUG EVALUATION, PRECLINICAL; GLUCOSIDES; GLYCOGEN; GLYCOGEN PHOSPHORYLASE, LIVER FORM; GLYCOGEN PHOSPHORYLASE, MUSCLE FORM; GLYCOSYLATION; RABBITS;

EID: 50049117181     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.098     Document Type: Article

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