Administration of purified human plasma cholinesterase protects against cocaine toxicity in mice

Journal of Toxicology - Clinical Toxicology

Volumn 34, Issue 3, 1996, Pages 259-266

  Hoffman, Robert S ^a,b   Morasco, Raymond ^b   Goldfrank, Lewis R ^a,b  

^a NEW YORK CITY POISON CONTROL CENTER   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINESTERASE; COCAINE; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLINESTERASE BLOOD LEVEL; CONTROLLED STUDY; DEATH; DOSE RESPONSE; DRUG EFFICACY; DRUG TOXICITY; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LETHALITY; MOUSE; NONHUMAN; SEIZURE;

ANIMALIA;

EID: 0030007690     PISSN: 07313810     EISSN: None     Source Type: Journal    
DOI: 10.3109/15563659609013786     Document Type: Article

References (34)

1. MacDonald DI. Cocaine leads emergency department drug visits. JAMA 1987;258:2029.
2. Stewart DJ, Inaba T, Lucassen M, Kalow W. Cocaine metabolism: cocaine and norcocaine hydrolysis by liver and serum esterases. Clin Pharmacol Ther 1979;25:464-468.
3. Jatlow P, Barash PG, Van Dyke C, Radding J, Byck R. Cocaine and succinylcholine sensitivity: a new caution. Anesth Analg 1979;58:235-238.
4. Lewin NA, Goldfrank LR, Hoffman RS. Cocaine. In: Goldfrank's Toxicologic Emergencies, 5th Ed. Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland MA, Hoffman RS, eds. Norwalk, CT: Appleton & Lange, 1994:847-862.
5. Cregler LL, Mark H. Medical complications of cocaine abuse. N Engl J Med 1986;315:1495-1500.
6. Anton AH. Unexpected cocaine-induced fatalities: a possible cause. Drug Intell Clin Pharm 1988;22:914.
7. Cregler LL. Protracted elimination of cocaine metabolites. Am J Med 1989;86:632-633.
8. Buchanan JF. Cocaine intoxication. Hosp Phys 1988;24:24-29.
9. Ellenhorn MJ, Barceloux DG. Cocaine. In: Medical Toxicology - Diagnosis and Treatment of Human Poisoning. Ellenhorn MJ, Barceloux DG, eds. New York: Elsevier Science Publishing Co., 1988:644-661.
10. Lange RA, Cigarroa RG, Flores ED, et al. Potentiation of cocaine-induced coronary vasoconstriction by beta-adrenergic blockade. Ann Intern Med 1990;112:897-903.
11. Hoffman RS, Henry GC, Rowland MA, Weisman RS, Weil L, Goldfrank LR. Association between life-threatening cocaine toxicity and plasma cholinesterase activity. Ann Emerg Med 1992;21:247-253.
12. Hoffman RS, Henry GC, Wax PM, Weisman RS, Rowland MA, Goldfrank LR. Decreased plasma cholinesterase activity enhances cocaine toxicity in mice. J Pharmacol Exp Ther 1992;263:698-702.
13. Woods JW. Behavioral effects of cocaine in animals. In: Cocaine 1977 Research Monograph #13. Peterson RC, Stillman RC, eds. Rockville, MD: National Institute on Drug Abuse, 1977:63-95.
14. Kalow W, Lindsay HA. A comparison of optical and manometric methods for the assay of human serum cholinesterase. Can J Biochem Physiol 1955;33:568-574.
15. Foster HL, Small JD, Fox JG. The Mouse in Biomedical Research, Volume 3. New York: Academic Press, 1983:313.
16. Inaba T, Stewart DJ, Kalow W. Metabolism of cocaine in man. Clin Pharmacol Ther 1978;23:547-552.
17. Leighty EG, Fentiman AF. Metabolism of cocaine to norcocaine and benzoylecgonine by an in vitro microsomal enzyme system. Res Comm Chem Pathol Pharmacol 1974;8:65-74.
18. Stewart DJ, Inaba T, Kalow W. N-demethylation of cocaine in the rat and in isolated rat hepatocytes: comparison with aminopyrine demethylation. J Pharmacol Exp Ther 1978;207:171-177.
19. Stewart DJ, Inaba T, Tang BK, Kalow W. Hydrolysis of cocaine in human plasma by cholinesterase. Life Sci 1977;20:1557-1563.
20. Dean RA, Christian CD, Sample RH, Bosron WF. Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine. FASEB J 1991;5:2735-2739.
21. Wilson MC, Bedford JA, Kibbe AH, Sam JA. Comparative pharmacology of norcocaine in M. mulatta and M. fascicularis. Pharmacol Biochem Behav 1978;9:141-145.
22. Borne RF, Bedford JA, Buelke JL, et al. Biological effects of cocaine derivatives. I: Improved synthesis and pharmacologic evaluation of norcocaine. J Pharm Sci 1977;66:119-120.
23. 3H]benzoylecgonine and pharmacological activity of some cocaine metabolites. J Pharm Pharmacol 1975;27:784-786.
24. Just WW, Hoyer J. The local anesthetic potency of norcocaine, a metabolite of cocaine. Experientia 1977;33:70-71.
25. Fish F, Wilson WD. Excretion of cocaine and its metabolites in man. J Pharm Pharmacol 1969;21: 1355-1385.
26. Ambre J, Fischman M, Ruo TI. Urinary excretion of ecgonine methyl ester, a major metabolite of cocaine in humans. J Anal Toxicol 1984;8:23-25.
27. Hamilton HE, Wallace JE, Shimek EL, Land P, Harris SC, Christenson JG. Cocaine and benzoylecgonine excretion in humans. J Forensic Sci 1977;22: 697-707.
28. Jeffcoat AR, Perez-Reyes M, Hill JM, Sadler BM, Cook CE. Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking. Drug Metab Dispos 1989;17:153-159.
29. Spealman RD, Madras BK, Bergman J. Effects of cocaine and related drugs in nonhuman primates. II. Stimulant effects on schedule-controlled behavior. J Pharmacol Exp Ther 1989;251:142-149.
30. Madden JA Powers RH. Effect of cocaine and cocaine metabolites on cerebral arteries in vitro. Life Sci 1990;47:1109-1114.
31. Herschman Z, Aaron C. Prolongation of cocaine effect. Anesthesiology 1991;74:631-632.
32. Kambam J, Mets B, Hickman RM, et al. The effects of inhibition of plasma cholinesterase and hepatic microsomal enzyme activity on cocaine, benzoylecgonine, ecgonine methyl ester, and norcocaine blood levels in pigs. J Lab Clin Med 1992;120:323-328.
33. Leibman D, Smolen A, Smolen TN. Strain, sex, and developmental profiles of cocaine metabolizing enzymes in mice. Pharmacol Biochem Behav 1990;37:161-165.
34. Thompson ML, Shuster L, Casey F, Kanel GC. Sex and strain differences in response to cocaine. Biochem Pharmacol 1984;33:1299-1307.