Cytochrome P450 2C11 5′-flanking region and promoter mediate in vivo suppression by 3-methylcholanthrene

Drug Metabolism and Disposition

Volumn 36, Issue 9, 2008, Pages 1803-1811

  Sawaya, Rana M ^a   Riddick, David S ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; AROMATIC HYDROCARBON; AROMATIC HYDROCARBON RECEPTOR; CIS ACTING ELEMENT; CYTOCHROME P450 1A1; CYTOCHROME P450 2C11; GROWTH HORMONE; LUCIFERASE; MESSENGER RNA; PLASMID DNA;

ADOLESCENT; ANIMAL EXPERIMENT; ARTICLE; DNA FLANKING REGION; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HYDRODYNAMICS; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INDUCTION; RAT; RECEPTOR UPREGULATION; REGULATORY SEQUENCE; REPORTER GENE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; MALE; METHYLCHOLANTHRENE; PROMOTER REGIONS (GENETICS); RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEROID 16-ALPHA-HYDROXYLASE;

RATTUS;

EID: 50049111397     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.020966     Document Type: Article

References (40)

1. Ahmed TA, Buzzelli MD, Lang CH, Capen JB, Shumate ML, Navaratnarajah M, Nagarajan M, and Cooney RN (2007) Interleukin-6 inhibits growth hormone-mediated gene expression in hepatocytes. Am J Physiol Gastrointest Liver Physiol 292:G1793-G1803.
2. Bhathena A, Lee C, and Riddick DS (2002) Suppression of cytochrome P450 2C11 by aromatic hydrocarbons: mechanistic insights from studies of the 5′-flanking region of the CYP2C11 gene. Drug Metab Dispos 30:1385-1392.
3. Boutros PC, Moffat ID, Franc MA, Tijet N, Tuomisto J, Pohjanvirta R, and Okey AB (2004) Dioxin-responsive AHRE-II gene battery: identification by phylogenetic footprinting. Biochem Biophys Res Commun 321:707-715.
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. Budker VG, Subbotin VM, Budker T, Sebestyén MG, Zhang G, and Wolff JA (2006) Mechanism of plasmid delivery by hydrodynamic tail vein injection. II. Morphological studies. J Gene Med 8:874-888.
6. Caron E, Rioux N, Nicolas O, Lebel-Talbot H, and Hamelin BA (2005) Quantification of the expression and inducibility of 12 rat cytochrome P450 isoforms by quantitative RT-PCR. J Biochem Mol Toxicol 19:368-378.
7. Cheng PY, Wang M, and Morgan ET (2003) Rapid transcriptional suppression of rat cytochrome P450 genes by endotoxin treatment and its inhibition by curcumin. J Pharmacol Exp Ther 307:1205-1212.
8. Dhir RN, Dworakowski W, Thangavel C, and Shapiro BH (2006) Sexually dimorphic regulation of hepatic isoforms of human cytochrome P450 by growth hormone. J Pharmacol Exp Ther 316:87-94.
9. Franc MA, Pohjanvirta R, Tuomisto J, and Okey AB (2001) In vivo up-regulation of aryl hydrocarbon receptor expression by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) in a dioxin-resistant rat model. Biochem Pharmacol 62:1565-1578.
10. Garrison PM, Tullis K, Aarts JMMJG, Brouwer A, Giesy JP, and Denison MS (1996) Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam Appl Toxicol 30:194-203.
11. Holloway MG, Laz EV, and Waxman DJ (2006) Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor-4. Mol Endocrinol 20:647-660.
12. Iber H, Chen Q, Cheng PY, and Morgan ET (2000) Suppression of CYP2C11 gene transcription by interleukin-1 mediated by NF-κB binding at the transcription start site. Arch Biochem Biophys 377:187-194.
13. Jones EJ and Riddick DS (1996) Regulation of constitutive rat hepatic cytochromes P450 by 3-methylcholanthrene. Xenobiotica 26:995-1012.
14. Kurose K, Tohkin M, Ushio F, and Fukuhara M (1998) Cloning and characterization of Syrian hamster testosterone 7 -hydroxylase, CYP2A9. Arch Biochem Biophys 351:60-65.
15. Lee BM and Shim GA (2007) Dietary exposure estimation of benzo[a]pyrene and cancer risk assessment. J Toxicol Environ Health A 70:1391-1394.
16. Lee C, Hutson JR, Tzau VK-F, and Riddick DS (2006) Regulation of constitutive mouse hepatic cytochromes P450 and growth hormone signaling components by 3-methylcholanthrene. Drug Metab Dispos 34:1530-1538.
17. Lee C and Riddick DS (2000) Transcriptional suppression of cytochrome P4502C11 gene expression by 3-methylcholanthrene. Biochem Pharmacol 59:1417-1423.
18. Liu F, Song Y, and Liu D (1999) Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 6:1258-1266.
19. Maruyama H, Higuchi N, Nishikawa Y, Kameda S, Iino N, Kazama JJ, Takahashi N, Sugawa M, Hanawa H, Tada N, et al. (2002) High-level expression of naked DNA delivered to rat liver via tail vein injection. J Gene Med 4:333-341.
20. McCluskey SA, Racz WJ, and Marks GS (1986) Properties of 17- to 19-day old chick embryo liver microsomes: induction of cytochrome P-450, effect of storage at low temperature, and resistance to lipid peroxidation. J Pharmacol Methods 16:111-123.
21. Morgan ET, Goralski KB, Piquette-Miller M, Renton KW, Robertson GR, Chaluvadi MR, Charles KA, Clarke SJ, Kacevska M, Liddle C, et al. (2008) Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer. Drug Metab Dispos 36:205-216.
22. Morgan ET, MacGeoch C, and Gustafsson J-A (1985) Sexual differentiation of cytochrome P450 in rat liver: evidence for a constitutive isozyme as the male-specific 16α-hydroxylase. Mol Pharmacol 27:471-479.
23. Ning B, Dial S, Sun Y, Wang J, Yang J, and Guo L (2008) Systematic and simultaneous gene profiling of 84 drug-metabolizing genes in primary human hepatocytes. J Biomol Screen 13:194-201.
24. Nukaya M, Takahashi Y, Gonzalez FJ, and Kamataki T (2004) Aryl hydrocarbon receptor-mediated suppression of GH receptor and Janus kinase 2 expression in mice. FEBS Lett 558:96-100.
25. Okey AB, Riddick DS, and Harper PA (1994) The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Toxicol Lett 70:1-22.
26. Ovando BJ, Vezina CM, McGarrigle BP, and Olson JR (2006) Hepatic gene down-regulation following acute and subchronic exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin. Toxicol Sci 94:428-438.
27. Park SH and Waxman DJ (2001) Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3β: impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression. J Biol Chem 276:43031-43039.
28. Riddick DS, Lee C, Bhathena A, and Timsit YE (2003) The 2001 Veylien Henderson Award of the Society of Toxicology of Canada: positive and negative transcriptional regulation of cytochromes P450 by polycyclic aromatic hydrocarbons. Can J Physiol Pharmacol 81:59-77.
29. Riddick DS, Lee C, Bhathena A, Timsit YE, Cheng PY, Morgan ET, Prough RA, Ripp SL, Michael Miller KK, Jahan A, et al. (2004) Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals. Drug Metab Dispos 32:367-375.
30. Sasaki Y, Takahashi Y, Nakayama K, and Kamataki T (1999) Cooperative regulation of CYP2C12 gene expression by STAT5 and liver-specific factors in female rats. J Biol Chem 274:37117-37124.
31. Sawaya RM and Riddick DS (2008) Cytochrome P450 2C11 5′-flanking region and promoter: regulation by aromatic hydrocarbons in vitro. Toxicology 248:104-112.
32. Serron SC, Zhang S, Bergeron RM, and Backes WL (2001) Effect of hypophysectomy and growth hormone replacement on the modulation of P450 expression after treatment with the aromatic hydrocarbon ethylbenzene. Toxicol Appl Pharmacol 172:163-171.
33. Shaban Z, Soliman M, El-Shazly S, El-Bohi K, Abdelazeez A, Kehelo K, Kim HS, Muzandu K, Ishizuka M, Kazusaka A, et al. (2005) AhR and PPAR: antagonistic effects on CYP2B and CYP3A, and additive inhibitory effects on CYP2C11. Xenobiotica 35:51-68.
34. Simon P (2003) Q-Gene: processing quantitative real-time RT-PCR data. Bioinformatics 19:1439-1440.
35. Sogawa K, Numayama-Tsuruta K, Takahashi T, Matsushita N, Miura C, Nikawa J, Gotoh O, Kikuchi Y, and Fujii-Kuriyama Y (2004) A novel induction mechanism of the rat CYP1A2 gene mediated by Ah receptor·Arnt heterodimer. Biochem Biophys Res Commun 318:746-755.
36. Tijet N, Boutros PC, Moffat ID, Okey AB, Tuomisto J, and Pohjanvirta R (2006) Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries. Mol Pharmacol 69:140-153.
37. Timsit YE and Riddick DS (2000) Interference with growth hormone stimulation of hepatic cytochrome P450 2C11 expression in hypophysectomized male rats by 3-methylcholanthrene. Toxicol Appl Pharmacol 163:105-114.
38. Timsit YE and Riddick DS (2002) Stimulation of hepatic signal transducer and activator of transcription 5b by GH is not altered by 3-methylcholanthrene. Endocrinology 143:3284-3294.
39. Waxman DJ and O'Connor C (2006) Growth hormone regulation of sex-dependent liver gene expression. Mol Endocrinol 20:2613-2629.
40. Weng MW, Hsiao YM, Chen CJ, Wang JP, Chen WC, and Ko JL (2004) Benzo[a]pyrene diol epoxide up-regulates COX-2 expression through NF-κB in rat astrocytes. Toxicol Lett 151:345-355.