Intestinal fatty acid binding protein regulates mitochondrion β-oxidation and cholesterol uptake

Journal of Lipid Research

Volumn 49, Issue 5, 2008, Pages 961-972

  Montoudis, Alain ^a   Seidman, Ernest ^b,c   Boudreau, François ^c   Beaulieu, Jean François ^c   Menard, Daniel ^c   Elchebly, Mounib ^a   Mailhot, Geneviève ^a   Sane, Alain Theophile ^a   Lambert, Marie ^a   Delvin, Edgard ^a   Levy, Emile ^a,c  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MONTREAL GENERAL HOSPITAL   (Canada)

^c CANADIAN INSTITUTES OF HEALTH RESEARCH   (Canada)

Author keywords

Cholesterol metabolism; HIEC 6; I FABP

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; ABC TRANSPORTER A1; ACETYL COENZYME A CARBOXYLASE; CARBON DIOXIDE; CARNITINE PALMITOYLTRANSFERASE I; CELL NUCLEUS RECEPTOR; COMPLEMENTARY DNA; FATTY ACID BINDING PROTEIN; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIVER X RECEPTOR ALPHA; MESSENGER RNA; OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RADIOISOTOPE; ABC TRANSPORTER; CHOLESTEROL; PRIMER DNA;

CATALYSIS; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONFERENCE PAPER; DNA TRANSFECTION; ENZYME ACTIVITY; FATTY ACID OXIDATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIPOGENESIS; MITOCHONDRION; PEROXISOME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; ARTICLE; CELL LINE; GENETIC TRANSFECTION; GENETICS; HOMEOSTASIS; INTESTINE MUCOSA; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; CELL LINE; CHOLESTEROL; DNA PRIMERS; FATTY ACID-BINDING PROTEINS; HOMEOSTASIS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; INTESTINAL MUCOSA; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; OLEIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION;

EID: 50049083108     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M700363-JLR200     Document Type: Conference Paper

References (59)

1. Agellon, L. B., M.J. Toth, and A. B. Thomson. 2002. Intracellular lipid binding proteins of the small intestine. Mol. Cell. Biochem. 239: 79-82.
2. Gordon, J. I., N. Elshourbagy, J. B. Lowe, W. S. Liao, D. H. Alpers, and J. M. Taylor. 1985. Tissue specific expression and developmental regulation of two genes coding for rat fatty acid binding proteins. J. Biol. Chem. 260: 1995-1998.
3. Bass, N. M.,J. A. Manning, R. K Ockner,J. I. Gordon, S. Seetharam, and D. H. Alpers. 1985. Regulation of the biosynthesis of two distinct fatty acid-binding proteins in rat liver and intestine. Influences of sex difference and of clofibrate. J. Biol. Chem. 260: 1432-1436.
4. Vassileva, G., L. Huwyler, K. Poirier, L. B. Agellon, and M.J. Toth. 2000. The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice. FASEB J. 14: 2040-2046.
5. Montoudis, A., E. Delvin, D. Menard, J. F. Beaulieu, D. Jean, E. Tremblay, M. Bendayan, and E. Levy. 2006. Intestinal-fatty acid binding protein and lipid transport in human intestinal epithelial cells. Biochem. Biophys. Res. Commun. 339: 248-254.
6. Darimont, C., N. Gradoux, E. Persohn, F. Cumin, and A. De Pover. 2000. Effects ofintestinal fatty acid-binding protein overexpression on fatty acid metabolism in Caco-2 cells. J. Lipid Res. 41: 84-92.
7. Baier, L. J., J. C. Sacchettini, W. C. Knowler, J. Eads, G. Paolisso, P. A. Tataranni, H. Mochizuki, P. H. Bennett, C. Bogardus, and M. Prochazka. 1995. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J. Clin. Invest. 95: 1281-1287.
8. Agren, J. J., R. Valve, H. Vidgren, M. Laakso, and M. Uusitupa. 1998. Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene. Arterioscler. Thromb. Vasc. Biol. 18: 1606-1610.
9. Stan, S., M. Lambert, E. Delvin, G. Paradis, J. O'Loughlin, J. A. Hanley, and E. Levy. 2005. Intestinal fatty acid binding protein and microsomal triglyceride transfer protein polymorphisms in French-Canadian youth. J. Lipid Res. 46: 320-327.
10. Perreault, N., and B. Jean-Francois. 1996. Use of the dissociating enzyme thermolysin to generate viable human normal intestinal epithelial cell cultures. Exp. Cell Res. 224: 354-364.
11. Sane, A. T., D. Sinnett, E. Delvin, M. Bendayan, V. Marcil, D. Menard, J. F. Beaulieu, and E. Levy. 2006. Localization and role of NPC1L1 in cholesterol absorption in human intestine. J. Lipid Res. 47: 2112-2120.
12. Ferre, P., P. Satabin, J. F. Decaux, F. Escriva, and J. Girard. 1983. Development and regulation of ketogenesis in hepatocytes isolated from newborn rats. Biochem. J. 214: 937-942.
13. Coleman, R. A. 1992. Diacylglycerol acyltransferase and mono-acylglycerol acyltransferase from liver and intestine. Methods Enzymol. 209: 98-104.
14. Schlossman, D. M., and R. M. Bell. 1976. Triacylglycerol synthesis in isolated fat cells. Evidence that the sn-glycerol-3-phosphate and dihydroxyacetone phosphate acyltransferase activities are dual catalytic functions of a single microsomal enzyme. J. Biol. Chem. 251: 5738-5744.
15. Courtois, F., I. Suc, C. Garofalo, M. Ledoux, E. Seidman, and E. Levy. 2000. Iron-ascorbate alters the efficiency of Caco-2 cells to assemble and secrete lipoproteins. Am. J. Physiol. Gastrointest. Liver Physiol. 279: G12-G19.
16. Levy, E., N. Loirdighi, L. Thibault, T. D. Nguyen, D. Labuda, E. Delvin, and D. Menard. 1996. Lipid processing and lipoprotein synthesis by the developing human fetal colon. Am. J. Physiol. 270:G813-G820.
17. McGarry, J. D., and N. F. Brown. 1997. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 244: 1-14.
18. Noyes, B. E., and R. A. Bradshaw. 1973. L-3-Hydroxyacyl coenzyme A dehydrogenase from pig heart muscle. I. Purification and properties. J. Biol. Chem. 248: 3052-3059.
19. bu-Elheiga, L., W. R. Brinkley, L. Zhong, S. S. Chirala, G. Woldegiorgis, and S. J. Wakil. 2000. The subcellular localization of acetyl-CoA carboxylase 2. Proc. Natl. Acad. Sci. USA. 97: 1444-1449.
20. Werder, M., C. H. Han, E. Wehrli, D. Bimmler, G. Schulthess, and H. Hauser. 2001. Role of scavenger receptors SR-BI and CD36 in selective sterol uptake in the small intestine. Biochemistry. 40:11643-11650.
21. Lehner, R., and A. Kuksis. 1996. Biosynthesis of triacylglycerols. Prog. Lipid Res. 35: 169-201.
22. Johnston, J. M. 1977. Lipid Metabolism in Mammals. Plenum Press, New York. 23. Coleman, R. A., and D. P. Lee. 2004. Enzymes of triacylglycerol synthesis and their regulation. Prog. Lipid Res. 43: 134-176.
23. bu-Elheiga, L., D. B. Marza-Ortega, A. Baldini, and S.J. Wakil. 1997. Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms. J. Biol. Chem. 272: 10669-10677.
24. bu-Elheiga, L., M. M. Matzuk, K. A. bo-Hashema, and S. J. Wakil. 2001. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 291: 2613-2616.
25. 14C]fatty acid oxidation. Biochem. Med. Metab. Biol. 35: 248-259.
26. Zammit, V. A. 1999. Carnitine acyltransferases: functional significance of subcellular distribution and membrane topology. Prog. Lipid Res. 38: 199-224.
27. Linden, D., K. Lindberg, J. Oscarsson, C. Claesson, L. Asp, L. Li, M. Gustafsson, J. Boren, and S. O. Olofsson. 2002. Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (apo) B-100 and apoB-48. J. Biol. Chem. 277: 23044-23053.
28. Martin, G. G., H. Danneberg, L. S. Kumar, B. P. Atshaves, E. Erol, M. Bader, F. Schroeder, and B. Binas. 2003. Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid-binding protein gene. J. Biol. Chem. 278:21429-21438.
29. Newberry, E. P., Y. Xie, S. Kennedy, X. Han, K K. Buhman, J. Luo, R. W. Gross, and N. O. Davidson. 2003. Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. J. Biol. Chem. 278: 51664-51672.
30. Wanders, R. J. 2004. Peroxisomes, lipid metabolism, and peroxisomal disorders. Mol. Genet. Metab. 83: 16-27.
31. Rinaldo, P., D. Matern, and M. J. Bennett. 2002. Fatty acid oxidation disorders. Annu. Rev. Physiol. 64: 477-502.
32. Kunau, W. H., V. Dommes, and H. Schulz. 1995. Beta-oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: a century of continued progress. Prog. Lipid Res. 34: 267-342.
33. Reddy, J. K., and T. Hashimoto. 2001. Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system. Annu. Rev. Nutr. 21: 193-230.
34. Levy, E., S. Spahis, D. Sinnett, N. Peretti, F. Maupas-Schwalm, E. Delvin, M. Lambert, and M. A. Lavoie. 2007. Intestinal cholesterol transport proteins: an update and beyond. Curr. Opin. Lipidol. 18: 310-318.
35. Mulligan, J. D., M. T. Flowers, A. Tebon, J. J. Bitgood, C. Wellington, M. R. Hayden, and A. D. Attie. 2003. ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens. J. Biol. Chem. 278: 13356-13366.
36. Murthy, S., E. Born, S. N. Mathur, and F.J. Field. 2002. LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. J. Lipid Res. 43: 1054-1064.
37. Repa, J. J., S. D. Turley, J. A. Lobaccaro, J. Medina, L. Li, K. Lustig, B. Shan, R. A. Heyman, J. M. Dietschy, and D. J. Mangelsdorf. 2000. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 289: 1524-1529.
38. Yu, L., J. Li-Hawkins, R. E. Hammer, K. E. Berge, J. D. Horton, J. C. Cohen, and H. H. Hobbs. 2002. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J. Clin. Invest. 110: 671-680.
39. Altmann, S. W., H. R. Davis, Jr., L. J. Zhu, X. Yao, L. M. Hoos, G. Tetzloff, S. P. Iyer, M. Maguire, A. Golovko, M. Zeng, et al. 2004. Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science. 303: 1201-1204.
40. Garcia-Calvo, M., J. Lisnock, H. G. Bull, B. E. Hawes, D. A. Burnett, M. P. Braun, J. H. Crona, H. R. Davis, Jr., D. C. Dean, P. A. Detmers, et al. 2005. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proc. Natl. Acad. Sci. USA. 102: 8132-8137.
41. Bietrix, F., D. Yan, M. Nauze, C. Rolland, J. Bertrand-Michel, C. Comera, S. Schaak, R. Barbaras, A. K. Groen, B. Perret, et al. 2006. Accelerated lipid absorption in mice overexpressing intestinal SR-BI. J. Biol. Chem. 281: 7214-7219.
42. Levy, E., D. Menard, I. Suc, E. Delvin, V. Marcil, L. Brissette, L. Thibault, and M. Bendayan. 2004. Ontogeny, immunolocalisa- tion, distribution and function of SR-BI in the human intestine. J. Cell Sci. 117: 327-337.
43. Tontonoz, P., E. Hu, R. A. Graves, A. I. Budavari, and B. M. Spiegelman. 1994. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8: 1224-1234.
44. Poirier, H., I. Niot, M.C. Monnot, O. Braissant, C. Meunier-Durmort, P.Costet, T. Pineau, W. Wahli, T.M. Willson, and P.Besnard. 2001. Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. Biochem. J. 355: 481-488.
45. Desvergne, B., and W. Wahli. 1999. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 20: 649-688.
46. Berger, J., and D. E. Moller. 2002. The mechanisms of action of PPARs. Annu. Rev. Med. 53: 409-435.
47. Knouff, C., and J. Auwerx. 2004. Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology. Endocr. Rev. 25: 899-918.
48. Mayerson, A. B., R. S. Hundal, S. Dufour, V. Lebon, D. Befroy, G. W. Cline, S. Enocksson, S. E. Inzucchi, G. I. Shulman, and K. F. Petersen. 2002. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes. 51: 797-802.
49. Mandard, S., M. Muller, and S.Kersten. 2004. Peroxisome proliferator-activated receptor alpha target genes. Cell. Mol. Life Sci. 61: 393-416.
50. Savage, D. B., G. D. Tan, C. L. Acerini, S. A. Jebb, M. Agostini, M. Gurnell, R. L. Williams, A. M. Umpleby, E. L. Thomas, J. D. Bell, et al. 2003. Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. Diabetes. 52: 910-917.
51. Kubota, N., Y. Terauchi, H. Miki, H. Tamemoto, T. Yamauchi, K. Komeda, S. Satoh, R. Nakano, C. Ishii, T. Sugiyama, et al. 1999. PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell. 4: 597-609.
52. Lu, T. T., J. J. Repa, and D. J. Mangelsdorf. 2001. Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J. Biol. Chem. 276: 37735-37738.
53. Marx, N., H. Duez, J. C. Fruchart, and B. Staels. 2004. Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells. Circ. Res. 94: 1168-1178.
54. Staels, B., J. Dallongeville, J. Auwerx, K. Schoonjans, E. Leitersdorf, and J. C. Fruchart. 1998. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation. 98: 2088-2093.
55. Li, A. C., and C. K. Glass. 2004. PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis. J. Lipid Res. 45: 2161-2173.
56. Millatt, L. J., V. Bocher, J. C. Fruchart, and B. Staels. 2003. Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis. Biochim. Biophys. Acta. 1631: 107-118.
57. Repa, J. J., K. E. Berge, C. Pomajzl, J. A. Richardson, H. Hobbs, and D. J. Mangelsdorf. 2002. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J. Biol. Chem. 277: 18793-18800.
58. Graf, G. A., W. P. Li, R. D. Gerard, I. Gelissen, A. White, J. C. Cohen, and H. H. Hobbs. 2002. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J. Clin. Invest. 110: 659-669.
59. Duval, C., V. Touche, A. Tailleux, J. C. Fruchart, C. Fievet, V. Clavey, B. Staels, and S. Lestavel. 2006. Niemann-Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine. Biochem. Biophys. Res. Commun. 340: 1259-1263.