Drug permeability across a phospholipid vesicle-based barrier. 4. The effect of tensides, co-solvents and pH changes on barrier integrity and on drug permeability

European Journal of Pharmaceutical Sciences

Volumn 34, Issue 2-3, 2008, Pages 173-180

  Flaten, Gøril Eide ^a   Luthman, Kristina ^b   Vasskog, Terje ^a   Brandl, Martin ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Artificial membrane; Bilayer; Co solvents; Drug permeability; Flux; Liposomes; pH; Phospholipid; Phospholipid dissolution; Solubility enhancing agents; Surfactants; Tensides

Indexed keywords

ALCOHOL; CALCEIN; CREMOPHOR; DIMETHYL SULFOXIDE; LIPOSOME; MACROGOL 400; METOPROLOL TARTRATE; NAPROXEN; POLYSORBATE 80; SOLVENT; SURFACTANT; TESTOSTERONE;

ARTICLE; ARTIFICIAL MEMBRANE; DRUG PENETRATION; DRUG SOLUBILITY; ELECTRIC RESISTANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PH; PHOSPHOLIPID VESICLE; PRIORITY JOURNAL; SOLVENT EFFECT; STATISTICAL ANALYSIS; TANDEM MASS SPECTROMETRY;

CACO-2 CELLS; CHEMISTRY, PHYSICAL; ELECTRIC IMPEDANCE; FLUORESCEINS; HUMANS; HYDROGEN-ION CONCENTRATION; MEMBRANES, ARTIFICIAL; METOPROLOL; NAPROXEN; PERMEABILITY; PHOSPHOLIPIDS; SOLVENTS; SURFACE-ACTIVE AGENTS; TESTOSTERONE;

EID: 49949152609     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.04.001     Document Type: Article

References (25)

1. Aungst B.J. Intestinal permeation enhancers. J. Pharm. Sci. 89 (2000) 429-442
2. Avdeef A. Absorption and Drug Development: Solubility Permeability and Charge State (2003), Wiley-Interscience, New Jersey pp. 116-246
3. Avdeef A., Box K.J., Comer J.E.A., Hibbert C., and Tam K.Y. pH-metric log P 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs. Pharm. Res. 15 (1998) 209-215
4. Bendels S., Tsinman O., Wagner B., Lipp D., Parrilla I., Kansy M., and Avdeef A. PAMPA-excipient classification gradient map. Pharm. Res. 23 (2006) 2525-2535
5. Dressman J.B., Berardi R.R., Dermentzoglou L.C., Russell T.L., Schmaltz S.P., Barnett J.L., and Jarvenpaa K.M. Upper gastrointestinal (Gi) Ph in young, healthy-men and women. Pharm. Res. 7 (1990) 756-761
6. Flaten G.E., Bunjes H., Luthman K., and Brandl M. Drug permeability across a phospholipid vesicle based barrier. 2. Characterization of barrier structure, storage stability and stability towards pH changes. Eur. J. Pharm. Sci. 28 (2006) 336-343
7. Flaten G.E., Dhanikula A.B., Luthman K., and Brandl M. Drug permeability across a phospholipid vesicle based barrier: a novel approach for studying passive diffusion. Eur. J. Pharm. Sci. 27 (2006) 80-90
8. Flaten G.E., Skar M.L., Luthman K., and Brandl M. Drug permeability across a phospholipid vesicle-based barrier. 3. Characterization of drug-membrane interactions and the effect of agitation on the barrier integrity and on the permeability. Eur. J. Pharm. Sci. 30 (2007) 324-332
9. Grohganz H., Ziroli V., Massing U., and Brandl M. Quantification of various phosphatidylcholines in liposomes by enzymatic assay. AAPS PharmSciTech 4 (2003) E63
10. Hait S.K., and Moulik S.P. Determination of critical micelle concentration (CMC) of nonionic surfactants by donor-acceptor interaction with iodine and correlation of CMC with hydrophile-lipophile balance and other parameters of the surfactants. J. Surfact. Detergents 4 (2001) 303-309
11. Kansy M., Senner F., and Gubernator K. Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. J. Med. Chem. 41 (1998) 1007-1010
12. Katneni K., Charman S.A., and Porter C.J.H. Permeability assessment of poorly water-soluble compounds under solubilizing conditions: the reciprocal permeability approach. J. Pharm. Sci. 95 (2006) 2170-2185
13. Lin S.Y.D., and Krochta J.M. Whey protein coating efficiency on surfactant-modified hydrophobic surfaces. J. Agricult. Food Chem. 53 (2005) 5018-5023
14. Liu H.L., Sabus C., Carter G.T., Du C., Avdeef A., and Tischler M. In vitro permeability of poorly aqueous soluble compounds using different solubilizers in the PAMPA assay with liquid chromatography/mass spectrometry detection. Pharm. Res. 20 (2003) 1820-1826
15. Nerurkar M.M., Ho N.F.H., Burton P.S., Vidmar T.J., and Borchardt R.T. Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cells. J. Pharm. Sci. 86 (1997) 813-821
16. Neuhoff S., Ungell A., Zamora I., and Artursson P. pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions. Pharm. Res. 20 (2003) 1141-1148
17. Notman R., den Otter W.K., Noro M.G., Briels W.J., and Anwar J. The permeability enhancing mechanism of DMSO in ceramide bilayers simulated by molecular dynamics. Biophys. J. 93 (2007) 2056-2068
18. Palm K., Luthman K., Ros J., Grasjo J., and Artursson P. Effect of molecular charge on intestinal epithelial drug transport: pH-dependent transport of cationic drugs. J. Pharmacol. Exp. Ther. 291 (1999) 435-443
19. Riad L.E., and Sawchuk R.J. Effect of polyethylene glycol-400 on the intestinal permeability of carbamazepine in the rabbit. Pharm. Res. 8 (1991) 491-497
20. Saha P., and Kou J.H. Effect of solubilizing excipients on permeation of poorly water-soluble compounds across Caco-2 cell monolayers. Eur. J. Pharm. Biopharm. 50 (2000) 403-411
21. Schubert R., Beyer K., Wolburg H., and Schmidt K.H. Structural-changes in membranes of large unilamellar vesicles after binding of sodium cholate. Biochemistry 25 (1986) 5263-5269
22. Shore P.A., Brodie B.B., and Hogben C.A.M. The gastric secretion of drugs: a pH partition hypothesis. J. Pharmacol. Exp. Ther. 119 (1957) 361-369
23. Takahashi Y., Kondo H., Yasuda T., Watanabe T., Kobavashi S.I., and Yokohama S. Common solubilizers to estimate the Caco-2 transport of poorly water-soluble drugs. Int. J. Pharm. 246 (2002) 85-94
24. Thomae A.V., Wunderli-Allenspach H., and Kramer S.D. Permeation of aromatic carboxylic acids across lipid bilayers: the pH-partition hypothesis revisited. Biophys. J. 89 (2005) 1802-1811
25. Yamashita S., Furubayashi T., Kataoka M., Sakane T., Sezaki H., and Tokuda H. Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells. Eur. J. Pharm. Sci. 10 (2000) 195-204