Development and evaluation of an in silico model for hERG binding

Journal of Chemical Information and Modeling

Volumn 46, Issue 1, 2006, Pages 392-400

  Song, Minghu ^a   Clark, Matthew ^a  

^a Locus Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DATA REDUCTION; DRUG PRODUCTS; ETHERS; FUNCTION EVALUATION; MATHEMATICAL MODELS; REGRESSION ANALYSIS; VECTORS;

DESCRIPTORS; ETHER-A-GO-GO-RELATED GENE (HERG); IN SILICO MODEL; QT PROLONGATION;

GENES;

KCNH2 PROTEIN, HUMAN; POTASSIUM CHANNEL HERG;

ARTICLE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; CLUSTER ANALYSIS; COMPUTER SIMULATION; DRUG ANTAGONISM; HUMAN; IC 50; METABOLISM; PROTEIN BINDING; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

CELL LINE; CLUSTER ANALYSIS; COMPUTER SIMULATION; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33244474244     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci050308f     Document Type: Conference Paper

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