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Volumn 3, Issue 3, 2008, Pages 205-215

Update on targeted therapies for small cell carcinoma of the lung

Author keywords

Small cell lung cancer; Targeted therapy

Indexed keywords


EID: 49749096776     PISSN: 17762596     EISSN: 1776260X     Source Type: Journal    
DOI: 10.1007/s11523-008-0086-5     Document Type: Review
Times cited : (3)

References (79)
  • 1
    • 33947593200 scopus 로고    scopus 로고
    • American Cancer Society. American Cancer Society Atlanta, GA
    • American Cancer Society (2007) Cancer facts and figures 2007. American Cancer Society, Atlanta, GA
    • (2007) Cancer Facts and Figures 2007
  • 2
    • 0042590987 scopus 로고    scopus 로고
    • The changing epidemiology of lung cancer in Europe
    • 3
    • MLG Janssen-Heijnen J-WW Coebergh 2003 The changing epidemiology of lung cancer in Europe Lung Cancer 41 3 245 258
    • (2003) Lung Cancer , vol.41 , pp. 245-258
    • Janssen-Heijnen, M.L.G.1    J-Ww, C.2
  • 3
    • 37349053773 scopus 로고    scopus 로고
    • Occupational exposures, environmental tobacco smoke, and lung cancer
    • 6
    • F Veglia P Vineis K Overvad 2007 Occupational exposures, environmental tobacco smoke, and lung cancer Epidemiology 18 6 769 775
    • (2007) Epidemiology , vol.18 , pp. 769-775
    • Veglia, F.1    Vineis, P.2    Overvad, K.3
  • 4
    • 0033611522 scopus 로고    scopus 로고
    • Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide
    • 4
    • AT Turrisi K Kim R Blum 1999 Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide N Engl J Med 340 4 265 271
    • (1999) N Engl J Med , vol.340 , pp. 265-271
    • Turrisi, A.T.1    Kim, K.2    Blum, R.3
  • 5
    • 33750603100 scopus 로고    scopus 로고
    • Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database
    • 28
    • R Govindan N Page D Morgensztern 2006 Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database J Clin Oncol 24 28 4539 4544
    • (2006) J Clin Oncol , vol.24 , pp. 4539-4544
    • Govindan, R.1    Page, N.2    Morgensztern, D.3
  • 6
    • 33947582831 scopus 로고    scopus 로고
    • A review of first-line treatment for small-cell lung cancer
    • 3
    • N Murray AT Turrisi 3rd 2006 A review of first-line treatment for small-cell lung cancer J Thorac Oncol 1 3 270 278
    • (2006) J Thorac Oncol , vol.1 , pp. 270-278
    • Murray, N.1    Turrisi III, A.T.2
  • 7
    • 0033987746 scopus 로고    scopus 로고
    • Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
    • 1
    • BJ Druker NB Lydon 2000 Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia J Clin Invest 105 1 3 7
    • (2000) J Clin Invest , vol.105 , pp. 3-7
    • Druker, B.J.1    Lydon, N.B.2
  • 8
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • 7
    • GD Demetri M von Mehren CD Blanke 2002 Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors N Engl J Med 347 7 472 480
    • (2002) N Engl J Med , vol.347 , pp. 472-480
    • Demetri, G.D.1    Von Mehren, M.2    Blanke, C.D.3
  • 9
    • 0038514906 scopus 로고    scopus 로고
    • Expression and prognostic significance of kit, protein kinase B, and mitogen-activated protein kinase in patients with small cell lung cancer
    • 6
    • FH Blackhall M Pintilie M Michael 2003 Expression and prognostic significance of kit, protein kinase B, and mitogen-activated protein kinase in patients with small cell lung cancer Clin Cancer Res 9 6 2241 2247
    • (2003) Clin Cancer Res , vol.9 , pp. 2241-2247
    • Blackhall, F.H.1    Pintilie, M.2    Michael, M.3
  • 10
    • 18044381919 scopus 로고    scopus 로고
    • Imatinib mesylate lacks activity in small cell lung carcinoma expressing c-kit protein: A phase II clinical trial
    • 10
    • LM Krug JP Crapanzano CG Azzoli 2005 Imatinib mesylate lacks activity in small cell lung carcinoma expressing c-kit protein: a phase II clinical trial Cancer 103 10 2128 2131
    • (2005) Cancer , vol.103 , pp. 2128-2131
    • Krug, L.M.1    Crapanzano, J.P.2    Azzoli, C.G.3
  • 11
    • 0037674304 scopus 로고    scopus 로고
    • CD117 (c-KIT) overexpression in patients with extensive-stage small-cell lung carcinoma
    • 6
    • A Potti N Moazzam K Ramar 2003 CD117 (c-KIT) overexpression in patients with extensive-stage small-cell lung carcinoma Ann Oncol 14 6 894 897
    • (2003) Ann Oncol , vol.14 , pp. 894-897
    • Potti, A.1    Moazzam, N.2    Ramar, K.3
  • 12
    • 9144230676 scopus 로고    scopus 로고
    • Phase II study of imatinib in patients with small cell lung cancer
    • 16 Pt 1
    • BE Johnson T Fischer B Fischer 2003 Phase II study of imatinib in patients with small cell lung cancer Clin Cancer Res 9 16 Pt 1 5880 5887
    • (2003) Clin Cancer Res , vol.9 , pp. 5880-5887
    • Johnson, B.E.1    Fischer, T.2    Fischer, B.3
  • 13
    • 27744567206 scopus 로고    scopus 로고
    • A phase II trial of imatinib (ST1571) in patients with c-kit expressing relapsed small-cell lung cancer: A CALGB and NCCTG study
    • 11
    • GK Dy AA Miller SJ Mandrekar 2005 A phase II trial of imatinib (ST1571) in patients with c-kit expressing relapsed small-cell lung cancer: a CALGB and NCCTG study Ann Oncol 16 11 1811 1816
    • (2005) Ann Oncol , vol.16 , pp. 1811-1816
    • Dy, G.K.1    Miller, A.A.2    Mandrekar, S.J.3
  • 14
    • 34147154400 scopus 로고    scopus 로고
    • Phase II trial of imatinib maintenance therapy after irinotecan and cisplatin in patients with c-kit positive extensive-stage small cell lung cancer (ES SCLC)
    • 18S
    • B Schneider S Gadgeel N Ramnath 2006 Phase II trial of imatinib maintenance therapy after irinotecan and cisplatin in patients with c-kit positive extensive-stage small cell lung cancer (ES SCLC) J Clin Oncol 24 18S 17089
    • (2006) J Clin Oncol , vol.24 , pp. 17089
    • Schneider, B.1    Gadgeel, S.2    Ramnath, N.3
  • 15
    • 34548553041 scopus 로고    scopus 로고
    • Combination of SN-38 with gefitinib or imatinib overcomes SN-38-resistant small-cell lung cancer cells
    • 5
    • N Takigawa M Takeyama T Kozuki 2007 Combination of SN-38 with gefitinib or imatinib overcomes SN-38-resistant small-cell lung cancer cells Oncol Rep 17 5 983 987
    • (2007) Oncol Rep , vol.17 , pp. 983-987
    • Takigawa, N.1    Takeyama, M.2    Kozuki, T.3
  • 16
    • 30744452995 scopus 로고    scopus 로고
    • Phase I studies of imatinib mesylate combined with cisplatin and irinotecan in patients with small cell lung carcinoma
    • 2
    • FM Johnson LM Krug HT Tran 2006 Phase I studies of imatinib mesylate combined with cisplatin and irinotecan in patients with small cell lung carcinoma Cancer 106 2 366 374
    • (2006) Cancer , vol.106 , pp. 366-374
    • Johnson, F.M.1    Krug, L.M.2    Tran, H.T.3
  • 17
    • 34548407704 scopus 로고    scopus 로고
    • Irinotecan, carboplatin, and imatinib in untreated extensive-stage small-cell lung cancer: A phase II trial of the Minnie Pearl Cancer Research Network
    • 9
    • DR Spigel JD Hainsworth L Simons 2007 Irinotecan, carboplatin, and imatinib in untreated extensive-stage small-cell lung cancer: a phase II trial of the Minnie Pearl Cancer Research Network J Thorac Oncol 2 9 854 861
    • (2007) J Thorac Oncol , vol.2 , pp. 854-861
    • Spigel, D.R.1    Hainsworth, J.D.2    Simons, L.3
  • 18
    • 0033883653 scopus 로고    scopus 로고
    • The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth
    • 8
    • GW Krystal S Honsawek J Litz 2000 The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth Clin Cancer Res 6 8 3319 3326
    • (2000) Clin Cancer Res , vol.6 , pp. 3319-3326
    • Krystal, G.W.1    Honsawek, S.2    Litz, J.3
  • 19
    • 38949134552 scopus 로고    scopus 로고
    • Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate
    • 2
    • M Brave V Goodman E Kaminskas 2008 Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate Clin Cancer Res 14 2 352 359
    • (2008) Clin Cancer Res , vol.14 , pp. 352-359
    • Brave, M.1    Goodman, V.2    Kaminskas, E.3
  • 20
    • 40749147725 scopus 로고    scopus 로고
    • Essential role of Pyk2 and Src kinase activation in neuropeptide-induced proliferation of small cell lung cancer cells
    • 12
    • S Roelle R Grosse T Buech 2008 Essential role of Pyk2 and Src kinase activation in neuropeptide-induced proliferation of small cell lung cancer cells Oncogene 27 12 1737 1748
    • (2008) Oncogene , vol.27 , pp. 1737-1748
    • Roelle, S.1    Grosse, R.2    Buech, T.3
  • 21
    • 0032532096 scopus 로고    scopus 로고
    • Lck associates with and is activated by Kit in a small cell lung cancer cell line: Inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1
    • 20
    • GW Krystal CS DeBerry D Linnekin 1998 Lck associates with and is activated by Kit in a small cell lung cancer cell line: inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1 Cancer Res 58 20 4660 4666
    • (1998) Cancer Res , vol.58 , pp. 4660-4666
    • Krystal, G.W.1    Deberry, C.S.2    Linnekin, D.3
  • 22
    • 33750491945 scopus 로고    scopus 로고
    • N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy] -5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor
    • 22
    • LF Hennequin J Allen J Breed 2006 N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2- (4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy) quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor J Med Chem 49 22 6465 6488
    • (2006) J Med Chem , vol.49 , pp. 6465-6488
    • Hennequin, L.F.1    Allen, J.2    Breed, J.3
  • 23
    • 26444574802 scopus 로고    scopus 로고
    • Development of farnesyl transferase inhibitors: A review
    • 8
    • NM Appels JH Beijnen JH Schellens 2005 Development of farnesyl transferase inhibitors: a review Oncologist 10 8 565 578
    • (2005) Oncologist , vol.10 , pp. 565-578
    • Appels, N.M.1    Beijnen, J.H.2    Schellens, J.H.3
  • 24
    • 4444236880 scopus 로고    scopus 로고
    • Phase II study of the farnesyl transferase inhibitor R115777 in patients with sensitive relapse small-cell lung cancer
    • 8
    • JV Heymach DH Johnson FR Khuri 2004 Phase II study of the farnesyl transferase inhibitor R115777 in patients with sensitive relapse small-cell lung cancer Ann Oncol 15 8 1187 1193
    • (2004) Ann Oncol , vol.15 , pp. 1187-1193
    • Heymach, J.V.1    Johnson, D.H.2    Khuri, F.R.3
  • 25
    • 33644770041 scopus 로고    scopus 로고
    • Gefitinib in patients with chemo-sensitive and chemo-refractory relapsed small cell cancers: A Hoosier Oncology Group phase II trial
    • 1
    • AM Moore LH Einhorn D Estes 2006 Gefitinib in patients with chemo-sensitive and chemo-refractory relapsed small cell cancers: a Hoosier Oncology Group phase II trial Lung Cancer 52 1 93 97
    • (2006) Lung Cancer , vol.52 , pp. 93-97
    • Moore, A.M.1    Einhorn, L.H.2    Estes, D.3
  • 26
    • 0035952679 scopus 로고    scopus 로고
    • Autocrine and paracrine signaling through neuropeptide receptors in human cancer
    • 13
    • LE Heasley 2001 Autocrine and paracrine signaling through neuropeptide receptors in human cancer Oncogene 20 13 1563 1569
    • (2001) Oncogene , vol.20 , pp. 1563-1569
    • Heasley, L.E.1
  • 27
    • 0025323953 scopus 로고
    • A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro
    • 13
    • PJ Woll E Rozengurt 1990 A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro Cancer Res 50 13 3968 3973
    • (1990) Cancer Res , vol.50 , pp. 3968-3973
    • Woll, P.J.1    Rozengurt, E.2
  • 28
    • 0035130471 scopus 로고    scopus 로고
    • SR48692 is a neurotensin receptor antagonist which inhibits the growth of small cell lung cancer cells
    • 1
    • TW Moody J Chiles M Casibang 2001 SR48692 is a neurotensin receptor antagonist which inhibits the growth of small cell lung cancer cells Peptides 22 1 109 115
    • (2001) Peptides , vol.22 , pp. 109-115
    • Moody, T.W.1    Chiles, J.2    Casibang, M.3
  • 29
    • 1542751639 scopus 로고    scopus 로고
    • The molecular target of rapamycin (mTOR) as a therapeutic target against cancer
    • 4 Suppl 1
    • MM Mita A Mita EK Rowinsky 2003 The molecular target of rapamycin (mTOR) as a therapeutic target against cancer Cancer Biol Ther 2 4 Suppl 1 S169 S177
    • (2003) Cancer Biol Ther , vol.2
    • Mita, M.M.1    Mita, A.2    Rowinsky, E.K.3
  • 30
    • 35848959875 scopus 로고    scopus 로고
    • A randomized, phase II trial of two dose levels of temsirolimus (CCI-779) in patients with extensive-stage small-cell lung cancer who have responding or stable disease after induction chemotherapy: A trial of the Eastern Cooperative Oncology Group (E1500)
    • 11
    • KJ Pandya S Dahlberg M Hidalgo 2007 A randomized, phase II trial of two dose levels of temsirolimus (CCI-779) in patients with extensive-stage small-cell lung cancer who have responding or stable disease after induction chemotherapy: a trial of the Eastern Cooperative Oncology Group (E1500) J Thorac Oncol 2 11 1036 1041
    • (2007) J Thorac Oncol , vol.2 , pp. 1036-1041
    • Pandya, K.J.1    Dahlberg, S.2    Hidalgo, M.3
  • 31
    • 33846933218 scopus 로고    scopus 로고
    • BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo
    • 4
    • M Steegmaier M Hoffmann A Baum 2007 BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo Curr Biol 17 4 316 322
    • (2007) Curr Biol , vol.17 , pp. 316-322
    • Steegmaier, M.1    Hoffmann, M.2    Baum, A.3
  • 33
    • 0036301281 scopus 로고    scopus 로고
    • Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms
    • 3
    • V Sandor S Bakke RW Robey 2002 Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms Clin Cancer Res 8 3 718 728
    • (2002) Clin Cancer Res , vol.8 , pp. 718-728
    • Sandor, V.1    Bakke, S.2    Robey, R.W.3
  • 34
    • 9444238027 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor FR901228 induces caspase-dependent apoptosis via the mitochondrial pathway in small cell lung cancer cells
    • 11
    • S Doi H Soda M Oka 2004 The histone deacetylase inhibitor FR901228 induces caspase-dependent apoptosis via the mitochondrial pathway in small cell lung cancer cells Mol Cancer Ther 3 11 1397 1402
    • (2004) Mol Cancer Ther , vol.3 , pp. 1397-1402
    • Doi, S.1    Soda, H.2    Oka, M.3
  • 35
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • 9
    • JM Adams S Cory 2007 The Bcl-2 apoptotic switch in cancer development and therapy Oncogene 26 9 1324 1337
    • (2007) Oncogene , vol.26 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 37
    • 0027279128 scopus 로고
    • Bcl-2 modulation of apoptosis induced by anticancer drugs: Resistance to thymidylate stress is independent of classical resistance pathways
    • 14
    • TC Fisher AE Milner CD Gregory 1993 bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways Cancer Res 53 14 3321 3326
    • (1993) Cancer Res , vol.53 , pp. 3321-3326
    • Fisher, T.C.1    Milner, A.E.2    Gregory, C.D.3
  • 38
    • 0036236808 scopus 로고    scopus 로고
    • A pilot trial of G3139, a bcl-2 antisense oligonucleotide, and paclitaxel in patients with chemorefractory small-cell lung cancer
    • 4
    • CM Rudin GA Otterson AM Mauer 2002 A pilot trial of G3139, a bcl-2 antisense oligonucleotide, and paclitaxel in patients with chemorefractory small-cell lung cancer Ann Oncol 13 4 539 545
    • (2002) Ann Oncol , vol.13 , pp. 539-545
    • Rudin, C.M.1    Otterson, G.A.2    Mauer, A.M.3
  • 39
    • 1842562213 scopus 로고    scopus 로고
    • Phase I study of G3139, a bcl-2 antisense oligonucleotide, combined with carboplatin and etoposide in patients with small-cell lung cancer
    • 6
    • CM Rudin M Kozloff PC Hoffman 2004 Phase I study of G3139, a bcl-2 antisense oligonucleotide, combined with carboplatin and etoposide in patients with small-cell lung cancer J Clin Oncol 22 6 1110 1117
    • (2004) J Clin Oncol , vol.22 , pp. 1110-1117
    • Rudin, C.M.1    Kozloff, M.2    Hoffman, P.C.3
  • 40
    • 39749166555 scopus 로고    scopus 로고
    • Randomized phase II Study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103
    • 6
    • CM Rudin R Salgia X Wang 2008 Randomized phase II Study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103 J Clin Oncol 26 6 870 876
    • (2008) J Clin Oncol , vol.26 , pp. 870-876
    • Rudin, C.M.1    Salgia, R.2    Wang, X.3
  • 41
    • 33845654040 scopus 로고    scopus 로고
    • Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl-2 as a chemosensitizer in cancer therapy
    • 1
    • R Kim M Emi K Matsuura 2007 Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl-2 as a chemosensitizer in cancer therapy Cancer Gene Ther 14 1 1 11
    • (2007) Cancer Gene Ther , vol.14 , pp. 1-11
    • Kim, R.1    Emi, M.2    Matsuura, K.3
  • 42
    • 42349109916 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program
    • R Lock H Carol PJ Houghton 2007 Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program Pediatr Blood Cancer 50 1198 1206
    • (2007) Pediatr Blood Cancer , vol.50 , pp. 1198-1206
    • Lock, R.1    Carol, H.2    Houghton, P.J.3
  • 43
    • 37649023004 scopus 로고    scopus 로고
    • Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
    • 49
    • M Nguyen RC Marcellus A Roulston 2007 Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis Proc Natl Acad Sci USA 104 49 19512 19517
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19512-19517
    • Nguyen, M.1    Marcellus, R.C.2    Roulston, A.3
  • 44
    • 49749150107 scopus 로고    scopus 로고
    • Extended phase I trial of the oral pan-Bcl-2 inhibitor AT-101 by multiple dosing schedules in patients with advanced cancers
    • 18S
    • H Pitot M Saleh J Holmlund J Maleski A Forero 2007 Extended phase I trial of the oral pan-Bcl-2 inhibitor AT-101 by multiple dosing schedules in patients with advanced cancers Proc Am Soc Clin Oncol 25 18S 3583
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 3583
    • Pitot, H.1    Saleh, M.2    Holmlund, J.3    Maleski, J.4    Forero, A.5
  • 45
    • 33644663463 scopus 로고    scopus 로고
    • Proteasome inhibition in small-cell lung cancer: Preclinical rationale and clinical applications
    • Suppl 2
    • PN Lara Jr. RJ Bold PC Mack 2005 Proteasome inhibition in small-cell lung cancer: preclinical rationale and clinical applications Clin Lung Cancer 7 Suppl 2 S67 S71
    • (2005) Clin Lung Cancer , vol.7
    • Lara Jr., P.N.1    Bold, R.J.2    MacK, P.C.3
  • 46
    • 34247855046 scopus 로고    scopus 로고
    • Bortezomib (PS-341) in relapsed or refractory extensive stage small cell lung cancer: A Southwest Oncology Group phase II trial (S0327)
    • 9
    • PN Lara Jr. K Chansky AM Davies 2006 Bortezomib (PS-341) in relapsed or refractory extensive stage small cell lung cancer: a Southwest Oncology Group phase II trial (S0327) J Thorac Oncol 1 9 996 1001
    • (2006) J Thorac Oncol , vol.1 , pp. 996-1001
    • Lara Jr., P.N.1    Chansky, K.2    Davies, A.M.3
  • 47
    • 0031942430 scopus 로고    scopus 로고
    • High pre-treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer
    • 2
    • P Salven T Ruotsalainen K Mattson 1998 High pre-treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer Int J Cancer 79 2 144 146
    • (1998) Int J Cancer , vol.79 , pp. 144-146
    • Salven, P.1    Ruotsalainen, T.2    Mattson, K.3
  • 49
    • 49749118333 scopus 로고    scopus 로고
    • Available at:
    • Barron H (2007) MedWatch safety alert. Available at: http://www.fda.gov/ medwatch/safety/2007/Avastin_DHCP_TEF_Final_April2007.pdf
    • (2007) MedWatch Safety Alert
    • Barron, H.1
  • 50
    • 49749131985 scopus 로고    scopus 로고
    • CALGB 30306: A phase II study of cisplatin (C), irinotecan (I) and bevacizumab (B) for untreated extensive stage small cell lung cancer (ES-SCLC)
    • 18S
    • N Ready AZ Dudek XF Wang 2007 CALGB 30306: A phase II study of cisplatin (C), irinotecan (I) and bevacizumab (B) for untreated extensive stage small cell lung cancer (ES-SCLC) Proc Am Soc Clin Oncol 25 18S 7563
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 7563
    • Ready, N.1    Dudek, A.Z.2    Wang, X.F.3
  • 51
    • 37749048789 scopus 로고    scopus 로고
    • A phase II study of cisplatin (P) plus etoposide (E) plus bevacizumab (B) for previously untreated extensive stage small cell lung cancer (SCLC) (E3501): A trial of the Eastern Cooperative Oncology Group
    • 18S
    • A Sandler S Szwaric A Dowlati 2007 A phase II study of cisplatin (P) plus etoposide (E) plus bevacizumab (B) for previously untreated extensive stage small cell lung cancer (SCLC) (E3501): a trial of the Eastern Cooperative Oncology Group Proc Am Soc Clin Oncol 25 18S 7564
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 7564
    • Sandler, A.1    Szwaric, S.2    Dowlati, A.3
  • 53
    • 34948844052 scopus 로고    scopus 로고
    • Phase II study of vandetanib or placebo in small-cell lung cancer patients after complete or partial response to induction chemotherapy with or without radiation therapy: National Cancer Institute of Canada Clinical Trials Group Study BR.20
    • 27
    • AM Arnold L Seymour M Smylie 2007 Phase II study of vandetanib or placebo in small-cell lung cancer patients after complete or partial response to induction chemotherapy with or without radiation therapy: National Cancer Institute of Canada Clinical Trials Group Study BR.20 J Clin Oncol 25 27 4278 4284
    • (2007) J Clin Oncol , vol.25 , pp. 4278-4284
    • Arnold, A.M.1    Seymour, L.2    Smylie, M.3
  • 54
    • 34547681379 scopus 로고    scopus 로고
    • Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors
    • 21
    • J Drevs P Siegert M Medinger 2007 Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors J Clin Oncol 25 21 3045 3054
    • (2007) J Clin Oncol , vol.25 , pp. 3045-3054
    • Drevs, J.1    Siegert, P.2    Medinger, M.3
  • 55
    • 49749108603 scopus 로고    scopus 로고
    • Cediranib (AZD2171) for the treatment of recurrent small cell lung cancer (SCLC): A California Consortium phase II study (NCI # 7097)
    • SS Ramalingam PC Mack EE Vokes 2008 Cediranib (AZD2171) for the treatment of recurrent small cell lung cancer (SCLC): A California Consortium phase II study (NCI # 7097) Proc Am Soc Clin Oncol 26 8078
    • (2008) Proc Am Soc Clin Oncol , vol.26 , pp. 8078
    • Ramalingam, S.S.1    MacK, P.C.2    Vokes, E.E.3
  • 56
    • 49749137912 scopus 로고    scopus 로고
    • Sorafenib in patients with platinum (plat) treated extensive stage small cell lung cancer (E-SCLC): A SWOG (S0435) phase II trial
    • BJ Gitlitz BS Glisson J Moon 2008 Sorafenib in patients with platinum (plat) treated extensive stage small cell lung cancer (E-SCLC): a SWOG (S0435) phase II trial Proc Am Soc Clin Oncol 26 8039
    • (2008) Proc Am Soc Clin Oncol , vol.26 , pp. 8039
    • Gitlitz, B.J.1    Glisson, B.S.2    Moon, J.3
  • 57
    • 33750046673 scopus 로고    scopus 로고
    • A prospective randomized phase III, double-blind, placebo-controlled study of thalidomide in extended-disease (ED) SCLC patients after response to chemotherapy (CT): An intergroup study FNCLCC Cleo04-IFCT 00-01
    • 18S
    • JL Pujol JL Breton R Gervais 2006 A prospective randomized phase III, double-blind, placebo-controlled study of thalidomide in extended-disease (ED) SCLC patients after response to chemotherapy (CT): An intergroup study FNCLCC Cleo04-IFCT 00-01 Proc Am Soc Clin Oncol 24 18S 17089
    • (2006) Proc Am Soc Clin Oncol , vol.24 , pp. 17089
    • Pujol, J.L.1    Breton, J.L.2    Gervais, R.3
  • 58
    • 34548538283 scopus 로고    scopus 로고
    • Phase III double-blind, placebo-controlled study of thalidomide in extensive-disease small-cell lung cancer after response to chemotherapy: An intergroup study FNCLCC cleo04 IFCT 00-01
    • 25
    • JL Pujol JL Breton R Gervais 2007 Phase III double-blind, placebo-controlled study of thalidomide in extensive-disease small-cell lung cancer after response to chemotherapy: an intergroup study FNCLCC cleo04 IFCT 00-01 J Clin Oncol 25 25 3945 3951
    • (2007) J Clin Oncol , vol.25 , pp. 3945-3951
    • Pujol, J.L.1    Breton, J.L.2    Gervais, R.3
  • 59
    • 37349086947 scopus 로고    scopus 로고
    • A phase III randomised, double blind, placebo controlled trial of etoposide/carboplatin with or without thalidomide in advanced small cell lung cancer (SCLC)
    • Suppl 4
    • SW Lee PJ Woll LE James M Hatton K Ali SG Spiro SR Ali A Hackshaw 2007 A phase III randomised, double blind, placebo controlled trial of etoposide/carboplatin with or without thalidomide in advanced small cell lung cancer (SCLC) J Thor Oncol 2 Suppl 4 S306
    • (2007) J Thor Oncol , vol.2 , pp. 306
    • Lee, S.W.1    Woll, P.J.2    James, L.E.3    Hatton, M.4    Ali, K.5    Spiro, S.G.6    Ali, S.R.7    Hackshaw, A.8
  • 60
    • 0027970573 scopus 로고
    • Phase III trial of recombinant interferon gamma in complete responders with small-cell lung cancer
    • 11
    • JR Jett AW Maksymiuk JQ Su 1994 Phase III trial of recombinant interferon gamma in complete responders with small-cell lung cancer J Clin Oncol 12 11 2321 2326
    • (1994) J Clin Oncol , vol.12 , pp. 2321-2326
    • Jett, J.R.1    Maksymiuk, A.W.2    Su, J.Q.3
  • 61
    • 0028792251 scopus 로고
    • Role of recombinant interferon alfa-2a maintenance in patients with limited-stage small-cell lung cancer responding to concurrent chemoradiation: A Southwest Oncology Group study
    • 12
    • K Kelly JJ Crowley PA Bunn Jr. 1995 Role of recombinant interferon alfa-2a maintenance in patients with limited-stage small-cell lung cancer responding to concurrent chemoradiation: a Southwest Oncology Group study J Clin Oncol 13 12 2924 2930
    • (1995) J Clin Oncol , vol.13 , pp. 2924-2930
    • Kelly, K.1    Crowley, J.J.2    Bunn Jr., P.A.3
  • 62
    • 0008958704 scopus 로고    scopus 로고
    • Alpha interferon as maintenance therapy for small cell lung cancer (SCLC)
    • B Lebeau PDL Salmoniere G Ozenne 1999 Alpha interferon as maintenance therapy for small cell lung cancer (SCLC) Proc Am Soc Clin Oncol 18 475a
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Lebeau, B.1    Salmoniere, P.D.L.2    Ozenne, G.3
  • 63
    • 0025744654 scopus 로고
    • Recombinant interferon gamma treatment in non-small cell lung cancer. Antitumour effect and cardiotoxicity
    • 5
    • K Mattson A Niiranen S Pyrhonen 1991 Recombinant interferon gamma treatment in non-small cell lung cancer. Antitumour effect and cardiotoxicity Acta Oncol 30 5 607 610
    • (1991) Acta Oncol , vol.30 , pp. 607-610
    • Mattson, K.1    Niiranen, A.2    Pyrhonen, S.3
  • 64
    • 27244446896 scopus 로고    scopus 로고
    • Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guerin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study)
    • 28
    • G Giaccone C Debruyne E Felip 2005 Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guerin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study) J Clin Oncol 23 28 6854 6864
    • (2005) J Clin Oncol , vol.23 , pp. 6854-6864
    • Giaccone, G.1    Debruyne, C.2    Felip, E.3
  • 65
    • 32944468708 scopus 로고    scopus 로고
    • Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer
    • 3 Pt 1
    • SJ Antonia N Mirza I Fricke 2006 Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer Clin Cancer Res 12 3 Pt 1 878 887
    • (2006) Clin Cancer Res , vol.12 , pp. 878-887
    • Antonia, S.J.1    Mirza, N.2    Fricke, I.3
  • 66
    • 0342940801 scopus 로고    scopus 로고
    • Immunotoxin therapy of small-cell lung cancer: A phase I study of N901-blocked ricin
    • 2
    • TJ Lynch Jr. JM Lambert F Coral 1997 Immunotoxin therapy of small-cell lung cancer: a phase I study of N901-blocked ricin J Clin Oncol 15 2 723 734
    • (1997) J Clin Oncol , vol.15 , pp. 723-734
    • Lynch Jr., T.J.1    Lambert, J.M.2    Coral, F.3
  • 67
    • 34848863393 scopus 로고    scopus 로고
    • Targeting Lewis Y (Le(y)) in small cell lung cancer with a humanized monoclonal antibody, hu3S193: A pilot trial testing two dose levels
    • 10
    • LM Krug DT Milton AA Jungbluth 2007 Targeting Lewis Y (Le(y)) in small cell lung cancer with a humanized monoclonal antibody, hu3S193: a pilot trial testing two dose levels J Thorac Oncol 2 10 947 952
    • (2007) J Thorac Oncol , vol.2 , pp. 947-952
    • Krug, L.M.1    Milton, D.T.2    Jungbluth, A.A.3
  • 68
    • 0035876039 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the novel MDR1 and MRP1 inhibitor biricodar administered alone and in combination with doxorubicin
    • 12
    • RA Peck J Hewett MW Harding 2001 Phase I and pharmacokinetic study of the novel MDR1 and MRP1 inhibitor biricodar administered alone and in combination with doxorubicin J Clin Oncol 19 12 3130 3141
    • (2001) J Clin Oncol , vol.19 , pp. 3130-3141
    • Peck, R.A.1    Hewett, J.2    Harding, M.W.3
  • 69
    • 33748745549 scopus 로고    scopus 로고
    • Phase I study of Aplidine in a dailyx5 one-hour infusion every 3 weeks in patients with solid tumors refractory to standard therapy. a National Cancer Institute of Canada Clinical Trials Group study: NCIC CTG IND 115
    • 9
    • JA Maroun K Belanger L Seymour 2006 Phase I study of Aplidine in a dailyx5 one-hour infusion every 3 weeks in patients with solid tumors refractory to standard therapy. A National Cancer Institute of Canada Clinical Trials Group study: NCIC CTG IND 115 Ann Oncol 17 9 1371 1378
    • (2006) Ann Oncol , vol.17 , pp. 1371-1378
    • Maroun, J.A.1    Belanger, K.2    Seymour, L.3
  • 70
    • 0037112183 scopus 로고    scopus 로고
    • Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: A trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer
    • 22
    • FA Shepherd G Giaccone L Seymour 2002 Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: a trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer J Clin Oncol 20 22 4434 4439
    • (2002) J Clin Oncol , vol.20 , pp. 4434-4439
    • Shepherd, F.A.1    Giaccone, G.2    Seymour, L.3
  • 71
    • 0035071939 scopus 로고    scopus 로고
    • Phase I study of the matrix metalloproteinase inhibitor, BAY 12-9566
    • 3
    • C Erlichman AA Adjei SR Alberts 2001 Phase I study of the matrix metalloproteinase inhibitor, BAY 12-9566 Ann Oncol 12 3 389 395
    • (2001) Ann Oncol , vol.12 , pp. 389-395
    • Erlichman, C.1    Adjei, A.A.2    Alberts, S.R.3
  • 72
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • 24
    • A Sandler R Gray MC Perry 2006 Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer N Engl J Med 355 24 2542 2550
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 73
    • 42649138944 scopus 로고    scopus 로고
    • Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses
    • 7
    • R Harrop N Drury W Shingler 2008 Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses Cancer Immunol Immunother 57 7 977 986
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 977-986
    • Harrop, R.1    Drury, N.2    Shingler, W.3
  • 74
    • 0036188465 scopus 로고    scopus 로고
    • Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer
    • 2
    • G Maulik T Kijima PC Ma 2002 Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer Clin Cancer Res 8 2 620 627
    • (2002) Clin Cancer Res , vol.8 , pp. 620-627
    • Maulik, G.1    Kijima, T.2    Ma, P.C.3
  • 75
    • 0032818149 scopus 로고    scopus 로고
    • Is small cell lung cancer the perfect target for anti-telomerase treatment?
    • 8
    • J Sarvesvaran JJ Going R Milroy 1999 Is small cell lung cancer the perfect target for anti-telomerase treatment? Carcinogenesis 20 8 1649 1652
    • (1999) Carcinogenesis , vol.20 , pp. 1649-1652
    • Sarvesvaran, J.1    Going, J.J.2    Milroy, R.3
  • 76
    • 0142219315 scopus 로고    scopus 로고
    • Bombesin/gastrin-releasing peptide receptor: A potential target for antibody-mediated therapy of small cell lung cancer
    • 13
    • J Zhou J Chen M Mokotoff 2003 Bombesin/gastrin-releasing peptide receptor: a potential target for antibody-mediated therapy of small cell lung cancer Clin Cancer Res 9 13 4953 4960
    • (2003) Clin Cancer Res , vol.9 , pp. 4953-4960
    • Zhou, J.1    Chen, J.2    Mokotoff, M.3
  • 77
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    • 6929
    • DN Watkins DM Berman SG Burkholder 2003 Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer Nature 422 6929 313 317
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1    Berman, D.M.2    Burkholder, S.G.3
  • 78
    • 24744453982 scopus 로고    scopus 로고
    • Somatic mutations of the protein kinase gene family in human lung cancer
    • 17
    • H Davies C Hunter R Smith 2005 Somatic mutations of the protein kinase gene family in human lung cancer Cancer Res 65 17 7591 7595
    • (2005) Cancer Res , vol.65 , pp. 7591-7595
    • Davies, H.1    Hunter, C.2    Smith, R.3
  • 79
    • 43049111423 scopus 로고    scopus 로고
    • Optimisation of circulating biomarkers of cell death for routine clinical use
    • 5
    • A Greystoke J Cummings T Ward 2008 Optimisation of circulating biomarkers of cell death for routine clinical use Ann Oncol 19 5 990 995
    • (2008) Ann Oncol , vol.19 , pp. 990-995
    • Greystoke, A.1    Cummings, J.2    Ward, T.3


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