Immunotoxin therapy of small-cell lung cancer: A phase I study of N901- blocked ricin

Journal of Clinical Oncology

Volumn 15, Issue 2, 1997, Pages 723-734

  Lynch Jr , T J ^a   Lambert, J M ^a   Coral, F ^a   Shefner, J ^a   Wen, P ^a   Blattler, W A ^a   Collinson, A R ^a   Ariniello, P D ^a   Braman, G ^a   Cook, S ^a   Esseltine, D ^a   Elias, A ^a   Skarin, A ^a   Ritz, J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOTOXIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY N 901; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOTHERAPY; CARDIOTOXICITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; FEMALE; HUMAN; HUMAN TISSUE; LUNG SMALL CELL CANCER; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0342940801     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1997.15.2.723     Document Type: Article

References (29)

1. Souhami RL, Law K: Longevity in small cell lung cancer: A report to the Lung Cancer Subcommittee of the United Kingdom Coordinating Committee tor Cancer Research. Br J Cancer 61:584-589, 1990
2. Leonard RCF: Small cell lung cancer. Br J Cancer 59:487-490, 1989
3. Doria MI, Montag AG, Franklin WA: Immunophenotype of small cell lung carcinoma: Expression of NKH-1 and transferrin receptor and absence of most myeloid antigens. Cancer 62:1939-1945, 1988
4. Stahel R, Gilks W, Schenker T: Antigens of lung cancer: Results of the Third International Workshop on Lung Tumor and Differentiation Antigens. J Natl Cancer Inst 86:669-672, 1994
5. Lambert JM, McIntyre G, Gauthier MN, et al.: The galactose-binding sites of the cytotoxic lectin ricin can be chemically blocked in high yield with reactive ligands prepared by chemical modification of glycopeptides containing triantennay N-linked oligosaccharides. Biochemistry 30:3224-3247, 1991
6. Lambert JM, Goldmacher VS, Collinson AR, et al.: An immunotoxin prepared with blocked ricin: A natural plant toxin adapted for therapeutic use. Cancer Res 51:6236-6242, 1991
7. Rutishauser U, Acheson A, Hall A, et al.: The neural cell adhesion molecule (NCAM) as a regulator of cell-cell interactions. Science 240:53-57, 1988
8. Roy DC, Ouellet S, Le Houiller C, et al.: Elimination of neuroblastoma and small cell lung cancer cells with an anti-NCAM immunotoxin. J Natl Cancer Inst 88:1136-1145, 1996
9. Griffin J, Hercend T, Beveridge R, et al.: Characterization of an antigen expressed by human natural killer cells. J Immunol 130:2947-2951, 1983
10. Collinson AR, Lambert JM, Liu Y, et al.: Anti-CD6-blocked ricin: An anti-pan T-cell immunotoxin. Int J Immunopharmacol 16:37-49, 1994
11. Smith A, Waibel R, Westera G, et al.: Immunolocalization and imaging of small cell cancer xenografts by the IgG2a monoclonal antibody SWA 11. Br J Cancer 59:174-178, 1989
12. Scott CF Jr, Goldmacher VS, Lambert JM, et al.: The antileukemic efficacy of an immunotoxin composed of a monoclonal antiThy-1 antibody disulfide linked to the ribosome inactivating protein gelonin. Cancer Immunol Immunother 25:31-40, 1987
13. Rice GE, Munro JM, Corless C, et al.: Vascular and nonvascular expression of INCAM-10. Am J Pathol 138:385-393, 1991
14. Sellers JR, Cook S, Goldmacher VS: A cytotoxicity assay utilizing a fluorescent dye that determines accurate surviving fractions of cells. J Immunol Methods 172:255-264, 1994
15. Cordell JL, Falini B, Erber W, et al.: Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase complexes. J Histochem Cytochem 32:2129-2139, 1984
16. Wawrynczak EJ: Systemic immunotoxin therapy of cancer: advances and prospects. Br J Cancer 64:624-630, 1991
17. Dillman RO: Antibodies as cytotoxic therapy. J Clin Oncol 12:1497-1515, 1994
18. Kibbelaar RE, Moolenaar K, Michalides R, et al.: Neural cell adhesion molecule expression, neuroendocrine differentiation and prognosis in lung carcinoma. Eur J Cancer 27:431-435, 1991
19. Rygaard K, Moller C, Bock E, et al.: Expression of cadherin and NCAM in human small cell lung cancer cell lines and xenografts. Br J Cancer 65:573-577, 1992
20. Gould B, Borowitz M, Groves E, et al.: Phase I study of anti-breast cancer immunotoxin by continuous infusion: Report of a targeted toxic effect not predicted by animal studies. J Natl Cancer Inst 81:775-781, 1989
21. Mechtersheimer G, Staudter M, Moller P: Expression of the natural killer cell associated antigens CD56 and CD57 in human neural and striated muscle cells and in their tumors. Cancer Res 51:1300-1307, 1991
22. Gordon L, Wharton J, Moore S, et al.: Myocardial localization and isoforms of neural cell adhesion molecule (N-CAM) in the developing and transplanted human heart. J Clin Invest 86:1293-1300, 1990
23. Grossbard ML, Lambert JM, Goldmacher VS, et al.: Anti-B4-blocked ricin: A phase I trial of 7-day continuous infusion in patients with B-cell neoplasms. J Clin Oncol 11:726-737, 1993
24. Grossbard ML, Gribben JG, Freedman AS, et al.: Adjuvant immunotoxin therapy with anti-B4-blocked ricin after autologous bone marrow transplantation for patients with B-cell non-Hodgkin's lymphoma. Blood 81:2263-2271, 1993
25. Esseltine D, Braman G, Park Y, et al.: Use of anti-B4-blocked ricin as an immunosuppressant. Blood 82:240a, 1993 (suppl 1, abstr)
26. Pai LH, FitzGerald DJ, Tepper M, et al.: Inhibition of antibody response to Pseudomonas exotoxin and an immunotoxin containing Pseudomonas exotoxin by 15-deoxyspergualin in mice. Cancer Res 50:7750-7753, 1990
27. Epstein C, Lynch T, Shefner J, et al.: Use of the immunotoxin N901-blocked ricin in patients with small-cell lung cancer. Int J Cancer 8:57-59, 1994 (suppl)
28. Jain RK, Baxter LT: Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: Significance of elevated interstitial pressure. Cancer Res 48:7022-7032, 1988
29. Houghton AN, Mintzer D, Cordon-Cardo C, et al.: Mouse monoclonal IgG3 antibody detecting CD3 ganglioside: A phase I trial in patients with malignant melanoma. Proc Natl Acad Sci USA 82:1242-1246, 1985