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Volumn 2, Issue 10, 2007, Pages 947-952

Targeting Lewis Y (Ley) in small cell lung cancer with a humanized monoclonal antibody, hu3S193: A pilot trial testing two dose levels

Author keywords

Hu3S193; Lewis Y; Monoclonal antibody; Small cell lung cancer

Indexed keywords

FLUORODEOXYGLUCOSE; INDIUM 111; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HU 3S193; UNCLASSIFIED DRUG;

EID: 34848863393     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3181560dcc     Document Type: Article
Times cited : (31)

References (23)
  • 2
    • 0026575769 scopus 로고
    • Phase I/II study of monoclonal antibody against Lewis Y hapten in relapsed small-cell lung cancer
    • Stahel RA, Lacroix H, Sculier JP, et al. Phase I/II study of monoclonal antibody against Lewis Y hapten in relapsed small-cell lung cancer. Ann Oncol 1992;3:319-320.
    • (1992) Ann Oncol , vol.3 , pp. 319-320
    • Stahel, R.A.1    Lacroix, H.2    Sculier, J.P.3
  • 3
    • 0026734888 scopus 로고
    • Correlation of expression of H/Le(y)/Le(b) antigens with survival in patients with carcinoma of the lung
    • Miyake M, Taki T, Hitomi S, Hakomori S. Correlation of expression of H/Le(y)/Le(b) antigens with survival in patients with carcinoma of the lung. N Engl J Med 1992;327:14-18.
    • (1992) N Engl J Med , vol.327 , pp. 14-18
    • Miyake, M.1    Taki, T.2    Hitomi, S.3    Hakomori, S.4
  • 4
    • 0030765682 scopus 로고    scopus 로고
    • Selection of tumor antigens as targets for immune attack using immunohistochemistry: II. Blood group-related antigens
    • Zhang S, Zhang HS, Cordon-Cardo C, et al. Selection of tumor antigens as targets for immune attack using immunohistochemistry: II. Blood group-related antigens. Int J Cancer 1997;73:50-56.
    • (1997) Int J Cancer , vol.73 , pp. 50-56
    • Zhang, S.1    Zhang, H.S.2    Cordon-Cardo, C.3
  • 5
    • 0028609075 scopus 로고
    • Specificity analysis of blood group Lewis-y (Le(y)) antibodies generated against synthetic and natural Le(y) determinants
    • Kitamura K, Stockert E, Garin-Chesa P, et al. Specificity analysis of blood group Lewis-y (Le(y)) antibodies generated against synthetic and natural Le(y) determinants. Proc Natl Acad Sci U S A 1994;91:12957-12961.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 12957-12961
    • Kitamura, K.1    Stockert, E.2    Garin-Chesa, P.3
  • 6
    • 0034045710 scopus 로고    scopus 로고
    • Construction, production, and characterization of humanized anti-Lewis Y monoclonal antibody 3S193 for targeted immunotherapy of solid tumors
    • Scott AM, Geleick D, Rubira M, et al. Construction, production, and characterization of humanized anti-Lewis Y monoclonal antibody 3S193 for targeted immunotherapy of solid tumors. Cancer Res 2000;60:3254-3261.
    • (2000) Cancer Res , vol.60 , pp. 3254-3261
    • Scott, A.M.1    Geleick, D.2    Rubira, M.3
  • 7
    • 0033818002 scopus 로고    scopus 로고
    • Therapeutic efficacy of anti-Lewis(y) humanized 3S193 radioimmunotherapy in a breast cancer model: Enhanced activity when combined with taxol chemotherapy
    • Clarke K, Lee FT, Brechbiel MW, Smyth FE, Old LJ, Scott AM. Therapeutic efficacy of anti-Lewis(y) humanized 3S193 radioimmunotherapy in a breast cancer model: enhanced activity when combined with taxol chemotherapy. Clin Cancer Res 2000;6:3621-3628.
    • (2000) Clin Cancer Res , vol.6 , pp. 3621-3628
    • Clarke, K.1    Lee, F.T.2    Brechbiel, M.W.3    Smyth, F.E.4    Old, L.J.5    Scott, A.M.6
  • 8
    • 33745113889 scopus 로고    scopus 로고
    • Enhanced efficacy of 90Y-radiolabeled anti-Lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combined-modality radioimmunotherapy in a breast cancer model
    • Kelly MP, Lee FT, Smyth FE, Brechbiel MW, Scott AM. Enhanced efficacy of 90Y-radiolabeled anti-Lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combined-modality radioimmunotherapy in a breast cancer model. J Nucl Med 2006;47:716-725.
    • (2006) J Nucl Med , vol.47 , pp. 716-725
    • Kelly, M.P.1    Lee, F.T.2    Smyth, F.E.3    Brechbiel, M.W.4    Scott, A.M.5
  • 9
    • 3042770596 scopus 로고    scopus 로고
    • Antibody-targeted chemotherapy with the calicheamicin conjugate hu3S193-N-acetyl gamma calicheamicin dimethyl hydrazide targets Lewisy and eliminates Lewis y-positive human carcinoma cells and xenografts
    • Boghaert ER, Sridharan L, Armellino DC, et al. Antibody-targeted chemotherapy with the calicheamicin conjugate hu3S193-N-acetyl gamma calicheamicin dimethyl hydrazide targets Lewisy and eliminates Lewis y-positive human carcinoma cells and xenografts. Clin Cancer Res 2004;10:4538-4549.
    • (2004) Clin Cancer Res , vol.10 , pp. 4538-4549
    • Boghaert, E.R.1    Sridharan, L.2    Armellino, D.C.3
  • 10
    • 34250634799 scopus 로고    scopus 로고
    • A phase 1 biodistribution and pharmacokinetic trial of humanized monoclonal antibody Hu3S193 in patients with advanced epithelial cancers that express the Lewis-Y antigen
    • Scott AM, Tebbutt N, Lee FT, et al. A phase 1 biodistribution and pharmacokinetic trial of humanized monoclonal antibody Hu3S193 in patients with advanced epithelial cancers that express the Lewis-Y antigen. Clin Cancer Res. 2007;13:3286-3292.
    • (2007) Clin Cancer Res , vol.13 , pp. 3286-3292
    • Scott, A.M.1    Tebbutt, N.2    Lee, F.T.3
  • 11
    • 0031956319 scopus 로고    scopus 로고
    • Evaluation of the in vivo biodistribution of yttrium-labeled isomers of CHX-DTPA-conjugated monoclonal antibodies
    • Kobayashi H, Wu C, Yoo TM, et al. Evaluation of the in vivo biodistribution of yttrium-labeled isomers of CHX-DTPA-conjugated monoclonal antibodies. J Nucl Med 1998;39:829-836.
    • (1998) J Nucl Med , vol.39 , pp. 829-836
    • Kobayashi, H.1    Wu, C.2    Yoo, T.M.3
  • 12
    • 0034665171 scopus 로고    scopus 로고
    • In vitro characterization of radiolabeled monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
    • Smith-Jones PM, Vallabahajosula S, Goldsmith SJ, et al. In vitro characterization of radiolabeled monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen. Cancer Res 2000;60:5237-5243.
    • (2000) Cancer Res , vol.60 , pp. 5237-5243
    • Smith-Jones, P.M.1    Vallabahajosula, S.2    Goldsmith, S.J.3
  • 13
    • 0022556055 scopus 로고
    • Determination of the true immunoreactive fraction of monoclonal antibodies after radiolabeling
    • Lindmo T, Bunn PA Jr. Determination of the true immunoreactive fraction of monoclonal antibodies after radiolabeling. Methods Enzymol 1986;121:678-691.
    • (1986) Methods Enzymol , vol.121 , pp. 678-691
    • Lindmo, T.1    Bunn Jr., P.A.2
  • 14
    • 0035884115 scopus 로고    scopus 로고
    • Serological analysis of human anti-human antibody responses in colon cancer patients treated with repeated doses of humanized monoclonal antibody A33
    • Ritter G, Cohen LS, Williams C Jr, Richards EC, Old LJ, Welt S. Serological analysis of human anti-human antibody responses in colon cancer patients treated with repeated doses of humanized monoclonal antibody A33. Cancer Res 2001;61:6851-6859.
    • (2001) Cancer Res , vol.61 , pp. 6851-6859
    • Ritter, G.1    Cohen, L.S.2    Williams Jr, C.3    Richards, E.C.4    Old, L.J.5    Welt, S.6
  • 15
    • 0025847147 scopus 로고
    • Tumor cell lysis and tumor growth inhibition by the isotype variants of MAb BR55-2 directed against Y oligosaccharide
    • Steplewski Z, Lubeck MD, Scholz D, Loibner H, McDonald Smith J, Koprowski H. Tumor cell lysis and tumor growth inhibition by the isotype variants of MAb BR55-2 directed against Y oligosaccharide. In Vivo 1991;5:79-83.
    • (1991) In Vivo , vol.5 , pp. 79-83
    • Steplewski, Z.1    Lubeck, M.D.2    Scholz, D.3    Loibner, H.4    McDonald Smith, J.5    Koprowski, H.6
  • 16
    • 0000799375 scopus 로고
    • Anti-Lewis Y (LeY) monoclonal antibody (mAb) BR55-2 (IgG2a) in patients with advanced breast cancer
    • Theodoulou M, Gilewski T, Welt S, et al. Anti-Lewis Y (LeY) monoclonal antibody (mAb) BR55-2 (IgG2a) in patients with advanced breast cancer. Proc Am Soc Clin Oncol 1994;13:A974.
    • (1994) Proc Am Soc Clin Oncol , vol.13
    • Theodoulou, M.1    Gilewski, T.2    Welt, S.3
  • 17
    • 0029925934 scopus 로고    scopus 로고
    • Pai LH, WR, Setser A, et al. Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to Pseudomonas exotoxin. Nat Med 1996;2:350-353.
    • Pai LH, WR, Setser A, et al. Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to Pseudomonas exotoxin. Nat Med 1996;2:350-353.
  • 18
    • 17444453362 scopus 로고    scopus 로고
    • Imaging and phase I study of 111In- and 90Y-labeled anti-LewisY monoclonal antibody B3
    • Pai-Scherf LH, Carrasquillo JA, Paik C, et al. Imaging and phase I study of 111In- and 90Y-labeled anti-LewisY monoclonal antibody B3. Clin Cancer Res 2000;6:1720-1730.
    • (2000) Clin Cancer Res , vol.6 , pp. 1720-1730
    • Pai-Scherf, L.H.1    Carrasquillo, J.A.2    Paik, C.3
  • 19
    • 29444436033 scopus 로고    scopus 로고
    • Results from a phase I clinical trial with IGN311, a fully humanized IgG1 antibody against Lewis Y in patients with solid tumors expressing Lewis Y antigen
    • Oruzio DV, Aulmann C, Eller N, et al. Results from a phase I clinical trial with IGN311, a fully humanized IgG1 antibody against Lewis Y in patients with solid tumors expressing Lewis Y antigen. Proc Am Sci Clin Oncol 2004:A2624.
    • (2004) Proc Am Sci Clin Oncol
    • Oruzio, D.V.1    Aulmann, C.2    Eller, N.3
  • 20
    • 0027218284 scopus 로고
    • Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates
    • Trail PA, Willner D, Lasch SJ, et al. Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates. Science 1993;261:212-215.
    • (1993) Science , vol.261 , pp. 212-215
    • Trail, P.A.1    Willner, D.2    Lasch, S.J.3
  • 21
    • 0034077405 scopus 로고    scopus 로고
    • Phase I trial of the anti-Lewis Y drug immunoconjugate BR96-doxorubicin in patients with Lewis Y-expressing epithelial tumors
    • Saleh MN, Sugarman S, Murray J, et al. Phase I trial of the anti-Lewis Y drug immunoconjugate BR96-doxorubicin in patients with Lewis Y-expressing epithelial tumors. J Clin Oncol 2000;18:2282-2292.
    • (2000) J Clin Oncol , vol.18 , pp. 2282-2292
    • Saleh, M.N.1    Sugarman, S.2    Murray, J.3
  • 22
    • 0032975042 scopus 로고    scopus 로고
    • Randomized phase II study of BR96-doxorubicin conjugate in patients with metastatic breast cancer
    • Tolcher AW, Sugarman S, Gelmon KA, et al. Randomized phase II study of BR96-doxorubicin conjugate in patients with metastatic breast cancer. J Clin Oncol 1999;17:478-484.
    • (1999) J Clin Oncol , vol.17 , pp. 478-484
    • Tolcher, A.W.1    Sugarman, S.2    Gelmon, K.A.3
  • 23
    • 34249285842 scopus 로고    scopus 로고
    • A randomized, multicenter study to determine the safety and efficacy of the immunoconjugate SGN-15 plus docetaxel for the treatment of non-small cell lung carcinoma
    • Ross HJ, Hart LL, Swanson PM, et al. A randomized, multicenter study to determine the safety and efficacy of the immunoconjugate SGN-15 plus docetaxel for the treatment of non-small cell lung carcinoma. Lung Cancer 2006;54:69-77.
    • (2006) Lung Cancer , vol.54 , pp. 69-77
    • Ross, H.J.1    Hart, L.L.2    Swanson, P.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.