In vitro and in vivo pharmacological analysis of imidazole-free histamine H3 receptor antagonists: Promising results for a brain-penetrating H3 blocker with weak anticholinesterase activity

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 378, Issue 3, 2008, Pages 335-343

  Bertoni, Simona ^a   Ballabeni, Vigilio ^a   Flammini, Lisa ^a   Saccani, Francesca ^a   Domenichini, Giuseppe ^a   Morini, Giovanni ^a   Comini, Mara ^a   Rivara, Mirko ^a   Barocelli, Elisabetta ^a  

^a UNIVERSITY OF PARMA   (Italy)

Author keywords

Binding study; Brain access; Histamine H3 receptor; Non imidazole H3 antagonist; Passive avoidance

Indexed keywords

ALPHA METHYLHISTAMINE; CHOLINESTERASE; DONEPEZIL; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST; IMIDAZOLE; SCOPOLAMINE; THIOPERAMIDE; TRITIUM;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN HOMOGENATE; CELL CULTURE; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; CHOLINESTERASE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; EX VIVO STUDY; GUINEA PIG; HUMAN; HUMAN CELL; ILEUM; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PASSIVE AVOIDANCE; RAT; RECEPTOR AFFINITY;

ANIMALS; AVOIDANCE LEARNING; BRAIN; CELL SURVIVAL; CELLS, CULTURED; CHOLINESTERASE INHIBITORS; DATA INTERPRETATION, STATISTICAL; ELECTRIC STIMULATION; GUINEA PIGS; HEART; HISTAMINE H3 ANTAGONISTS; HUMANS; ILEUM; IMIDAZOLES; MEMORY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE;

EID: 49749088907     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-008-0299-2     Document Type: Article

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