Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 10, 2006, Pages 3553-3562

  Huang, Xiaoqin ^a   Yan, Weili ^a   Gao, Daquan ^a   Tong, Min ^a   Tai, Hsin Hsiung ^a   Zhan, Chang Guo ^a  

^a University of Kentucky   (United States)

Author keywords

Binding affinity; Molecular modeling; mPGES 1; Mutagenesis; PGE2; Prostaglandin; Protein structure

Indexed keywords

AMINO ACID; CARBOXYL GROUP; FUNCTIONAL GROUP; GLUTATHIONE; HYDROGEN; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN H2; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CALCULATION; CATALYSIS; DRUG DESIGN; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; EXPERIMENTATION; HYDROGEN BOND; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NONHUMAN; PREDICTION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING;

ALGORITHMS; AMINO ACID SEQUENCE; COMPUTER SIMULATION; GLUTATHIONE; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MICROSOMES; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROSTAGLANDIN H2; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT;

EID: 33645881701     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.010     Document Type: Article

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