메뉴 건너뛰기




Volumn 106, Issue 5, 2008, Pages 2184-2193

Glutamate mobilizes [Zn2+]i through Ca 2+-dependent reactive oxygen species accumulation

Author keywords

Excitotoxicity; FluoZin 3; Intracellular calcium; Intracellular zinc; Mitochondria; Reactive oxygen species

Indexed keywords

CALCIUM CHANNEL; FURA 2; GLUTAMATE RECEPTOR; GLUTAMIC ACID; NITRIC OXIDE SYNTHASE; PHOSPHOLIPASE A2; REACTIVE OXYGEN METABOLITE; ZINC ION; CALCIUM; CHELATING AGENT; FLUORESCENT DYE; FLUOZIN 3; FLUOZIN-3; OXIDIZING AGENT; POLYCYCLIC HYDROCARBON; ZINC;

EID: 49549102218     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05536.x     Document Type: Article
Times cited : (40)

References (55)
  • 1
  • 3
    • 10744230660 scopus 로고    scopus 로고
    • Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels
    • Bossy-Wetzel E., Talantova M. V., Lee W. D. et al. (2004) Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron 41, 351 365.
    • (2004) Neuron , vol.41 , pp. 351-365
    • Bossy-Wetzel, E.1    Talantova, M.V.2    Lee, W.D.3
  • 4
    • 33745029895 scopus 로고    scopus 로고
    • Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor
    • Bozym R. A., Thompson R. B., Stoddard A. K. Fierke C. (2006) Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor. ACS Chem. Biol. 1, 103 111.
    • (2006) ACS Chem. Biol. , vol.1 , pp. 103-111
    • Bozym, R.A.1    Thompson, R.B.2    Stoddard, A.K.3    Fierke, C.4
  • 5
    • 0027452219 scopus 로고
    • Glutamate-induced increases in intracellular free Mg2+ in cultured cortical neurons
    • Brocard J. B., Rajdev S. Reynolds I. J. (1993) Glutamate-induced increases in intracellular free Mg2+ in cultured cortical neurons. Neuron 11, 751 757.
    • (1993) Neuron , vol.11 , pp. 751-757
    • Brocard, J.B.1    Rajdev, S.2    Reynolds, I.J.3
  • 6
    • 0035868972 scopus 로고    scopus 로고
    • Quantitative evaluation of mitochondrial calcium content in rat cortical neurones following a glutamate stimulus
    • Brocard J. B., Tassetto M. Reynolds I. J. (2001) Quantitative evaluation of mitochondrial calcium content in rat cortical neurones following a glutamate stimulus. J. Physiol. (Lond). 531, 793 805.
    • (2001) J. Physiol. (Lond). , vol.531 , pp. 793-805
    • Brocard, J.B.1    Tassetto, M.2    Reynolds, I.J.3
  • 7
    • 0030725602 scopus 로고    scopus 로고
    • Measurement of intracellular free zinc in living neurons
    • Canzoniero L. M., Sensi S. L. Choi D. W. (1997) Measurement of intracellular free zinc in living neurons. Neurobiol. Dis. 4, 275 279.
    • (1997) Neurobiol. Dis. , vol.4 , pp. 275-279
    • Canzoniero, L.M.1    Sensi, S.L.2    Choi, D.W.3
  • 8
    • 0033205843 scopus 로고    scopus 로고
    • Measurement of intracellular free zinc concentrations accompanying zinc-induced neuronal death
    • Canzoniero L. M. T., Turetsky D. M. Choi D. W. (1999) Measurement of intracellular free zinc concentrations accompanying zinc-induced neuronal death. J. Neurosci. 19, 1 6.
    • (1999) J. Neurosci. , vol.19 , pp. 1-6
    • Canzoniero, L.M.T.1    Turetsky, D.M.2    Choi, D.W.3
  • 9
    • 0031770844 scopus 로고    scopus 로고
    • Calcium-sensitive fluorescent dyes can report increases in intracellular free zinc concentration in cultured forebrain neurons
    • Cheng C. Reynolds I. J. (1998) Calcium-sensitive fluorescent dyes can report increases in intracellular free zinc concentration in cultured forebrain neurons. J. Neurochem. 71, 2401 2410.
    • (1998) J. Neurochem. , vol.71 , pp. 2401-2410
    • Cheng, C.1    Reynolds, I.J.2
  • 10
    • 12444334607 scopus 로고    scopus 로고
    • Simultaneous detection of intracellular free calcium and zinc using fura-2FF and FluoZin-3
    • Devinney II. M. J., Reynolds I. J. Dineley K. E. (2005) Simultaneous detection of intracellular free calcium and zinc using fura-2FF and FluoZin-3. Cell Calcium 37, 225 232.
    • (2005) Cell Calcium , vol.37 , pp. 225-232
    • Devinneyii., M.J.1    Reynolds, I.J.2    Dineley, K.E.3
  • 11
    • 0033830018 scopus 로고    scopus 로고
    • Astrocytes are more resistant than neurons to the cytotoxic effects of increased [Zn(2+)](i)
    • Dineley K. E., Scanlon J. M., Kress G. J., Stout A. K. Reynolds I. J. (2000) Astrocytes are more resistant than neurons to the cytotoxic effects of increased [Zn(2+)](i). Neurobiol. Dis. 7, 310 320.
    • (2000) Neurobiol. Dis. , vol.7 , pp. 310-320
    • Dineley, K.E.1    Scanlon, J.M.2    Kress, G.J.3    Stout, A.K.4    Reynolds, I.J.5
  • 12
    • 0036765589 scopus 로고    scopus 로고
    • A reevaluation of neuronal zinc measurements: Artifacts associated with high intracellular dye concentration
    • Dineley K. E., Malaiyandi L. M. Reynolds I. J. (2002) A reevaluation of neuronal zinc measurements: artifacts associated with high intracellular dye concentration. Mol. Pharmacol. 62, 618 627.
    • (2002) Mol. Pharmacol. , vol.62 , pp. 618-627
    • Dineley, K.E.1    Malaiyandi, L.M.2    Reynolds, I.J.3
  • 13
    • 49549120075 scopus 로고    scopus 로고
    • Simultaneous detection of intracellular free zinc and free calcium during glutamate stimulation of cultured forebrain neurons
    • Program No. 453.6. San Diego CA: Society for Neuroscience, 2004 Online.
    • Dineley K. E., Zeak J. A. Reynolds I. J. (2004) Simultaneous detection of intracellular free zinc and free calcium during glutamate stimulation of cultured forebrain neurons. Program No. 453.6. 2004 Neuroscience Meeting Planner. San Diego CA : Society for Neuroscience, 2004. Online.
    • (2004) 2004 Neuroscience Meeting Planner.
    • Dineley, K.E.1    Zeak, J.A.2    Reynolds, I.J.3
  • 14
    • 13344259905 scopus 로고    scopus 로고
    • Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria
    • Dineley K. E., Richards L. L., Votyakova T. V. Reynolds I. J. (2005) Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria. Mitochondrion 5, 55 65.
    • (2005) Mitochondrion , vol.5 , pp. 55-65
    • Dineley, K.E.1    Richards, L.L.2    Votyakova, T.V.3    Reynolds, I.J.4
  • 15
    • 0036759626 scopus 로고    scopus 로고
    • In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway
    • Du S., McLaughlin B., Pal S. Aizenman E. (2002) In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway. J. Neurosci. 22, 7408 7416.
    • (2002) J. Neurosci. , vol.22 , pp. 7408-7416
    • Du, S.1    McLaughlin, B.2    Pal, S.3    Aizenman, E.4
  • 16
    • 0004608219 scopus 로고    scopus 로고
    • Importance of zinc in the central nervous system: The zinc-containing neuron
    • Frederickson C. J., Suh S. W., Silva D. Thompson R. B. (2000) Importance of zinc in the central nervous system: the zinc-containing neuron. J. Nutr. 130, 1471S 1483S.
    • (2000) J. Nutr. , vol.130
    • Frederickson, C.J.1    Suh, S.W.2    Silva, D.3    Thompson, R.B.4
  • 17
    • 0036067137 scopus 로고    scopus 로고
    • Measuring zinc in living cells. a new generation of sensitive and selective fluorescent probes
    • Gee K. R., Zhou Z. L., Ton-That D., Sensi S. L. Weiss J. H. (2002) Measuring zinc in living cells. A new generation of sensitive and selective fluorescent probes. Cell Calcium 31, 245 251.
    • (2002) Cell Calcium , vol.31 , pp. 245-251
    • Gee, K.R.1    Zhou, Z.L.2    Ton-That, D.3    Sensi, S.L.4    Weiss, J.H.5
  • 18
    • 0021895138 scopus 로고
    • A new generation of Ca2+ indicators with greatly improved fluorescence properties
    • Grynkiewicz G., Poenie M. Tsien R. Y. (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440 3450.
    • (1985) J. Biol. Chem. , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 19
    • 0027525152 scopus 로고
    • Changes in intracellular pH associated with glutamate excitotoxicity
    • Hartley Z. Dubinsky J. M. (1993) Changes in intracellular pH associated with glutamate excitotoxicity. J. Neurosci. 13, 4690 4699.
    • (1993) J. Neurosci. , vol.13 , pp. 4690-4699
    • Hartley, Z.1    Dubinsky, J.M.2
  • 20
    • 0026584089 scopus 로고
    • 2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase
    • 2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase. Biochem. J. 281, 627 630.
    • (1992) Biochem. J. , vol.281 , pp. 627-630
    • Heinzel, B.1    John, M.2    Klatt, P.3    Bohme, E.4    Mayer, B.5
  • 21
    • 0034055456 scopus 로고    scopus 로고
    • Ionic selectivity of low-affinity ratiometric calcium indicators: Mag-Fura-2, Fura-2FF and BTC
    • Hyrc K. L., Bownik J. M. Goldberg M. P. (2000) Ionic selectivity of low-affinity ratiometric calcium indicators: mag-Fura-2, Fura-2FF and BTC. Cell Calcium 27, 75 86.
    • (2000) Cell Calcium , vol.27 , pp. 75-86
    • Hyrc, K.L.1    Bownik, J.M.2    Goldberg, M.P.3
  • 22
    • 0042133328 scopus 로고    scopus 로고
    • Evidence for chelatable zinc in the extracellular space of the hippocampus, but little evidence for synaptic release of Zn.[erratum appears in J Neurosci. 2004 Jan 21;24(3):Table of Contents]
    • Kay A. R. (2003) Evidence for chelatable zinc in the extracellular space of the hippocampus, but little evidence for synaptic release of Zn.[erratum appears in J Neurosci. 2004 Jan 21;24(3):Table of Contents]. J. Neurosci. 23, 6847 6855.
    • (2003) J. Neurosci. , vol.23 , pp. 6847-6855
    • Kay, A.R.1
  • 23
    • 2942568135 scopus 로고    scopus 로고
    • Detecting and minimizing zinc contamination in physiological solutions
    • Kay A. R. (2004) Detecting and minimizing zinc contamination in physiological solutions. BMC Physiology 4, 4.
    • (2004) BMC Physiology , vol.4 , pp. 4
    • Kay, A.R.1
  • 25
    • 0034604723 scopus 로고    scopus 로고
    • Superoxide-induced stimulation of protein kinase C via thiol modification and modulation of zinc content
    • Knapp L. T. Klann E. (2000) Superoxide-induced stimulation of protein kinase C via thiol modification and modulation of zinc content. J. Biol. Chem. 275, 24136 24145.
    • (2000) J. Biol. Chem. , vol.275 , pp. 24136-24145
    • Knapp, L.T.1    Klann, E.2
  • 26
    • 0028343364 scopus 로고
    • Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-D-aspartate receptors
    • Koh J. Y. Choi D. W. (1994) Zinc toxicity on cultured cortical neurons: involvement of N-methyl-D-aspartate receptors. Neuroscience 60, 1049 1057.
    • (1994) Neuroscience , vol.60 , pp. 1049-1057
    • Koh, J.Y.1    Choi, D.W.2
  • 27
    • 0029777299 scopus 로고    scopus 로고
    • The role of zinc in selective neuronal death after transient global cerebral ischemia
    • Koh J. Y., Suh S. W., Gwag B. J., He Y. Y., Hsu C. Y. Choi D. W. (1996) The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272, 1013 1016.
    • (1996) Science , vol.272 , pp. 1013-1016
    • Koh, J.Y.1    Suh, S.W.2    Gwag, B.J.3    He, Y.Y.4    Hsu, C.Y.5    Choi, D.W.6
  • 28
    • 33751223540 scopus 로고    scopus 로고
    • Zinc-buffering capacity of a eukaryotic cell at physiological pZn
    • Krezel A. Maret W. (2006) Zinc-buffering capacity of a eukaryotic cell at physiological pZn. J. Biol. Inorg. Chem. 11, 1049 1062.
    • (2006) J. Biol. Inorg. Chem. , vol.11 , pp. 1049-1062
    • Krezel, A.1    Maret, W.2
  • 30
    • 0027221998 scopus 로고
    • NMDA-dependent superoxide production and neurotoxicity
    • Lafon-Cazal M., Pietri S., Culcasi M. Bockaert J. (1993) NMDA-dependent superoxide production and neurotoxicity. Nature 364, 535 537.
    • (1993) Nature , vol.364 , pp. 535-537
    • Lafon-Cazal, M.1    Pietri, S.2    Culcasi, M.3    Bockaert, J.4
  • 31
    • 0034202005 scopus 로고    scopus 로고
    • Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: Evidence against synaptic vesicle origin
    • Lee J. Y., Cole T. B., Palmiter R. D. Koh J. Y. (2000) Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin. J. Neurosci. (Online), 20, RC79.
    • (2000) J. Neurosci. (Online) , vol.20
    • Lee, J.Y.1    Cole, T.B.2    Palmiter, R.D.3    Koh, J.Y.4
  • 32
    • 26844509261 scopus 로고    scopus 로고
    • Zn2+ inhibits mitochondrial movement in neurons by phosphatidylinositol 3-kinase activation
    • Malaiyandi L. M., Honick A. S., Rintoul G. L., Wang Q. J. Reynolds I. J. (2005a) Zn2+ inhibits mitochondrial movement in neurons by phosphatidylinositol 3-kinase activation. J. Neurosci. 25, 9507 9514.
    • (2005) J. Neurosci. , vol.25 , pp. 9507-9514
    • Malaiyandi, L.M.1    Honick, A.S.2    Rintoul, G.L.3    Wang, Q.J.4    Reynolds, I.J.5
  • 33
    • 20144370934 scopus 로고    scopus 로고
    • Direct visualization of mitochondrial zinc accumulation reveals uniporter-dependent and -independent transport mechanisms
    • Malaiyandi L. M., Vergun O., Dineley K. E. Reynolds I. J. (2005b) Direct visualization of mitochondrial zinc accumulation reveals uniporter-dependent and -independent transport mechanisms. J. Neurochem. 93, 1242 1250.
    • (2005) J. Neurochem. , vol.93 , pp. 1242-1250
    • Malaiyandi, L.M.1    Vergun, O.2    Dineley, K.E.3    Reynolds, I.J.4
  • 34
    • 0032584166 scopus 로고    scopus 로고
    • Thiolate ligands in metallothionein confer redox activity on zinc clusters
    • Maret W. Vallee B. L. (1998) Thiolate ligands in metallothionein confer redox activity on zinc clusters. Proc. Natl Acad. Sci. USA, 95, 3478 3482.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 3478-3482
    • Maret, W.1    Vallee, B.L.2
  • 35
    • 0035873497 scopus 로고    scopus 로고
    • P38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis
    • McLaughlin B., Pal S., Tran M. P., Parsons A. A., Barone F. C., Erhardt J. A. Aizenman E. (2001) p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis. J. Neurosci. 21, 3303 3311.
    • (2001) J. Neurosci. , vol.21 , pp. 3303-3311
    • McLaughlin, B.1    Pal, S.2    Tran, M.P.3    Parsons, A.A.4    Barone, F.C.5    Erhardt, J.A.6    Aizenman, E.7
  • 36
    • 0033971898 scopus 로고    scopus 로고
    • Mitochondria and neuronal survival
    • Nicholls D. G. Budd S. L. (2000) Mitochondria and neuronal survival. Physiol. Rev. 80, 315 360.
    • (2000) Physiol. Rev. , vol.80 , pp. 315-360
    • Nicholls, D.G.1    Budd, S.L.2
  • 37
    • 0034573392 scopus 로고    scopus 로고
    • Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes
    • Noh K. M. Koh J. Y. (2000) Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes. J. Neurosci. 20, RC111.
    • (2000) J. Neurosci. , vol.20
    • Noh, K.M.1    Koh, J.Y.2
  • 39
    • 0014668762 scopus 로고
    • Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate
    • Olney J. W. (1969) Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 164, 719 721.
    • (1969) Science , vol.164 , pp. 719-721
    • Olney, J.W.1
  • 40
    • 3042595335 scopus 로고    scopus 로고
    • Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons
    • Pivovarova N. B., Nguyen H. V., Winters C. A., Brantner C. A., Smith C. L. Andrews S. B. (2004) Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons. J. Neurosci. 24, 5611 5622.
    • (2004) J. Neurosci. , vol.24 , pp. 5611-5622
    • Pivovarova, N.B.1    Nguyen, H.V.2    Winters, C.A.3    Brantner, C.A.4    Smith, C.L.5    Andrews, S.B.6
  • 42
    • 0029064518 scopus 로고
    • Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation
    • Reynolds I. J. Hastings T. G. (1995) Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci. 15, 3318 3327.
    • (1995) J. Neurosci. , vol.15 , pp. 3318-3327
    • Reynolds, I.J.1    Hastings, T.G.2
  • 43
    • 0033232908 scopus 로고    scopus 로고
    • Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress
    • Sah R. Schwartz-Bloom R. D. (1999) Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. J. Neurosci. 19, 9209 9217.
    • (1999) J. Neurosci. , vol.19 , pp. 9209-9217
    • Sah, R.1    Schwartz-Bloom, R.D.2
  • 45
    • 0033514513 scopus 로고    scopus 로고
    • Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production
    • Sensi S. L., Yin H. Z., Carriedo S. G., Rao S. S. Weiss J. H. (1999a) Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production. Proc. Natl Acad. Sci. USA, 96, 2414 2419.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 2414-2419
    • Sensi, S.L.1    Yin, H.Z.2    Carriedo, S.G.3    Rao, S.S.4    Weiss, J.H.5
  • 46
    • 0033519569 scopus 로고    scopus 로고
    • Glutamate triggers preferential Zn2+ flux through Ca2+ permeable AMPA channels and consequent ROS production
    • Sensi S. L., Yin H. Z. Weiss J. H. (1999b) Glutamate triggers preferential Zn2+ flux through Ca2+ permeable AMPA channels and consequent ROS production. Neuroreport 10, 1723 1727.
    • (1999) Neuroreport , vol.10 , pp. 1723-1727
    • Sensi, S.L.1    Yin, H.Z.2    Weiss, J.H.3
  • 47
    • 0036075891 scopus 로고    scopus 로고
    • Mitochondrial sequestration and Ca(2+)-dependent release of cytosolic Zn(2+) loads in cortical neurons
    • Sensi S. L., Ton-That D. Weiss J. H. (2002) Mitochondrial sequestration and Ca(2+)-dependent release of cytosolic Zn(2+) loads in cortical neurons. Neurobiol. Dis. 10, 100 108.
    • (2002) Neurobiol. Dis. , vol.10 , pp. 100-108
    • Sensi, S.L.1    Ton-That, D.2    Weiss, J.H.3
  • 49
    • 33749831752 scopus 로고    scopus 로고
    • Intracellular zinc elevation measured with a "calcium-specific" indicator during ischemia and reperfusion in rat hippocampus: A question on calcium overload
    • Stork C. J. Li Y. V. (2006) Intracellular zinc elevation measured with a "calcium-specific" indicator during ischemia and reperfusion in rat hippocampus: a question on calcium overload. J. Neurosci. 26, 10430 10437.
    • (2006) J. Neurosci. , vol.26 , pp. 10430-10437
    • Stork, C.J.1    Li, Y.V.2
  • 51
    • 0028091628 scopus 로고
    • Hypochlorous acid and chloramines increase endothelial permeability: Possible involvement of cellular zinc
    • Tatsumi T. Fliss H. (1994) Hypochlorous acid and chloramines increase endothelial permeability: possible involvement of cellular zinc. Am. J. Physiol. 267, H1597 H1607.
    • (1994) Am. J. Physiol. , vol.267
    • Tatsumi, T.1    Fliss, H.2
  • 52
    • 0037113963 scopus 로고    scopus 로고
    • Potassium-evoked glutamate release liberates arachidonic acid from cortical neurons
    • Taylor A. L. Hewett S. J. (2002) Potassium-evoked glutamate release liberates arachidonic acid from cortical neurons. J. Biol. Chem. 277, 43881 43887.
    • (2002) J. Biol. Chem. , vol.277 , pp. 43881-43887
    • Taylor, A.L.1    Hewett, S.J.2
  • 53
    • 0035865259 scopus 로고    scopus 로고
    • Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture
    • Vergun O., Sobolevsky A. I., Yelshansky M. V., Keelan J., Khodorov B. I. Duchen M. R. (2001) Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture. J. Physiol. (Lond). 531, 147 163.
    • (2001) J. Physiol. (Lond). , vol.531 , pp. 147-163
    • Vergun, O.1    Sobolevsky, A.I.2    Yelshansky, M.V.3    Keelan, J.4    Khodorov, B.I.5    Duchen, M.R.6
  • 54
    • 3342941452 scopus 로고    scopus 로고
    • Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate
    • Vesce S., Kirk L. Nicholls D. G. (2004) Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate. J. Neurochem. 90, 683 693.
    • (2004) J. Neurochem. , vol.90 , pp. 683-693
    • Vesce, S.1    Kirk, L.2    Nicholls, D.G.3
  • 55
    • 18144427184 scopus 로고    scopus 로고
    • Ca2+-induced permeabilization promotes free radical release from rat brain mitochondria with partially inhibited complex I
    • Votyakova T. V. Reynolds I. J. (2005) Ca2+-induced permeabilization promotes free radical release from rat brain mitochondria with partially inhibited complex I. J. Neurochem. 93, 526 537.
    • (2005) J. Neurochem. , vol.93 , pp. 526-537
    • Votyakova, T.V.1    Reynolds, I.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.