Structure - Antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents

Journal of Medicinal Chemistry

Volumn 51, Issue 15, 2008, Pages 4404-4411

  Sakami, Satoshi ^a   Maeda, Masayuki ^a   Kawai, Koji ^a   Aoki, Takumi ^a   Kawamura, Kuniaki ^a   Fujii, Hideaki ^a,c   Hasebe, Ko ^a   Nakajima, Mayumi ^a   Endo, Takashi ^a   Ueno, Shinya ^a   Ito, Tsuyoshi ^a   Kamei, Junzo ^b   Nagase, Hiroshi ^a,c  

^a TORAY INDUSTRIES INC   (Japan)

^b HOSHI UNIVERSITY   (Japan)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4,4A,5,12,12AALPHA OCTAHYDRO 4AALPHA (3 HYDROXYPHENYL) 2 METHYLQUINOLINO[2,3 G]ISOQUINOLINE; 17 CYCLOPROPYLMETHYL 6,7 DIDEHYDRO 4,5 EPOXY 5',6' DIHYDRO 3 METHOXY 4'H PYRROLO[3,2,1 IJ]QUINOLINO[2',1':6,7]RNORPHINAN 14 OL METHANESULFONATE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; ALKYL GROUP; CAPSAICIN; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; NALTRINDOLE; TRK 850; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTITUSSIVE ACTIVITY; ARTICLE; BRAIN HOMOGENATE; CHO CELL; COUGHING; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; GUINEA PIG; HYDROPHOBICITY; MALE; MOUSE; NONHUMAN; SPRAGUE DAWLEY RAT; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE;

ALKYLATION; ANIMALS; ANTITUSSIVE AGENTS; CAPSAICIN; CHO CELLS; COUGH; CRICETINAE; CRICETULUS; MALE; MICE; MOLECULAR STRUCTURE; NALTREXONE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 49449116031     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701440h     Document Type: Article

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