Structural plasticity in G-protein coupled receptors as demonstrated by the allosteric actions of homocysteine and computer-assisted analysis of disordered domains

Brain Research Reviews

Volumn 58, Issue 2, 2008, Pages 459-474

  Agnati, L F ^a,d   Leo, G ^a   Genedani, S ^a   Andreoli, N ^a   Marcellino, D ^b   Woods, A ^c   Piron, L ^d   Guidolin, D ^e   Fuxe, K ^b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^d SAN CAMILLO FORLANINI HOSPITAL   (Italy)

^e UNIVERSITY OF PADOVA   (Italy)

Author keywords

D2 receptors; Homocysteine; Intrinsically disordered proteins; Parkinson's disease; Receptor mosaics

Indexed keywords

ADENOSINE A2 RECEPTOR ANTAGONIST; DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; HOMOCYSTEINE; LIGAND;

ALLOSTERISM; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CIRCLING BEHAVIOR; COMPUTER ANALYSIS; CONFORMATION; DOPAMINERGIC TRANSMISSION; DRUG INHIBITION; DRUG POTENTIATION; HUMAN; INFORMATION PROCESSING; NONHUMAN; PARKINSON DISEASE; PLASTICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SCHIZOPHRENIA; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; HOMOCYSTEINE; HUMANS; MODELS, BIOLOGICAL; NEURONAL PLASTICITY; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 49449090028     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2007.10.003     Document Type: Review

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