Role of motoneurons in the generation of muscle spasms after spinal cord injury

Brain

Volumn 127, Issue 10, 2004, Pages 2247-2258

  Gorassini, Monica A ^a   Knash, Michael E ^a   Harvey, Philip J ^a   Bennett, Dave J ^a   Yang, Jaynie F ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Human; Motoneurons; Muscle spasms; Plateau potentials; Spinal cord injury

Indexed keywords

ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRIC CURRENT; FEMALE; HUMAN; MALE; MOTONEURON; MOTOR UNIT; MUSCLE CONTRACTION; MUSCLE SPASM; PRIORITY JOURNAL; SPIKE; SPINAL CORD INJURY; SYNAPSE; CHRONIC DISEASE; ELECTROMYOGRAPHY; METHODOLOGY; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PHYSIOLOGY; SKELETAL MUSCLE; STIMULATION;

CHRONIC DISEASE; ELECTROMYOGRAPHY; FEMALE; HUMANS; MALE; MOTOR ACTIVITY; MOTOR NEURONS; MUSCLE CONTRACTION; MUSCLE, SKELETAL; PHYSICAL STIMULATION; SPASM; SPINAL CORD INJURIES; SYNAPSES;

EID: 4944254979     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/awh243     Document Type: Article

References (47)

1. Baldissera F, Hultborn H, Illert M. Integration in spinal neuronal systems. In: Brookhart JM, Mountcastle VB, editors. Handbook of physiology, Sect. 1, Vol. 2, Pt.1. Bethesda (MA): American Physiological Society; 1981:509-95.
2. Bennett DJ, Hultborn H, Fedirchuk B, Gorassini M. Synaptic activation of plateaus in hindlimb motoneurons of decerebrate cats. J Neurophysiol 1998; 80: 2023-37.
3. Bennett DJ, Li Y, Harvey PJ, Gorassini M. Evidence for plateau potentials in tail motoneurons of awake chronic spinal rats with spasticity. J Neurophysiol 2001a; 86: 1972-82.
4. Bennett DJ, Li Y, Siu M. Plateau potentials in sacrocaudal motoneurons of chronic spinal rats, recorded in vitro. J Neurophysiol 2001b; 86: 1955-71.
5. Binder MD. Integration of synaptic and intrinsic dendritic currents in cat spinal motoneurons. Brain Res Brain Res Rev 2002; 40: 1-8.
6. Boorman GI, Lee RG, Becker WJ, Windhorst UR. Impaired 'natural recipfrocal inhibition' in patients with spasticity due to incomplete spinal cord injury. Electroencephalogr Clin Neurophysiol 1996; 101: 84-92.
7. 2+-dependent spiking and plateau potentials under pharmacological treatment. J Neurophysiol 1997; 78: 3371-85.
8. Conway BA, Hultborn H, Kiehn O, Mintz I. Plateau potentials in alpha-motoneurones induced by intravenous injection of L-dopa and clonidine in the spinal cat. J Physiol 1988; 405: 369-84.
9. Crone C, Johnsen LL, Biering-Sorensen F, Nielsen JB. Appearance of reciprocal facilitation of ankle extensors from ankle flexors in patients with stroke or spinal cord injury. Brain 2003; 126: 495-507.
10. Davey NJ, Ellaway PH, Friedland CL, Short DJ. Motor unit discharge characteristics and short term synchrony in paraplegic humans. J Neurol Neurosurg Psychiatry 1990; 53: 764-9.
11. De Luca CJ, Erim Z. Common drive of motor units in regulation of muscle force. Trends Neurosci 1994; 17: 299-305.
12. Eken T, Kiehn O. Bistable firing properties of soleus motor units in unrestrained rats. Acta Physiol Scand 1989; 136: 383-94.
13. Eken T, Hultborn H, Kiehn O. Possible functions of transmitter-controlled plateau potentials in alpha motoneurones. Prog Brain Res 1989; 80: 257-67; discussion 239-42.
14. Faist M, Mazevet D, Dietz V, Pierrot-Deseilligny E. A quantitative assessment of presynaptic inhibition of Ia afferents in spastics. Differences in hemiplegics and paraplegics. Brain 1994; 117: 1449-55.
15. Freund HJ. Motor unit and muscle activity in voluntary motor control. Physiol Rev 1983; 63: 387-436.
16. Gorassini MA, Bennett DJ, Yang JF. Self-sustained firing of human motor units. Neurosci Lett 1998; 247: 13-6.
17. Gorassini M, Yang JF, Siu M, Bennett DJ. Intrinsic activation of human motoneurons: possible contribution to motor unit excitation. J Neurophysiol 2002a; 87: 1850-8.
18. Gorassini M, Yang JF, Siu M, Bennett DJ. Intrinsic activation of human motoneurons: reduction of motor unit recruitment thresholds by repeated contractions. J Neurophysiol 2002b; 87: 1859-66.
19. Heckman CJ, Lee RH, Brownstone RM. Hyperexcitable dendrites in motoneurons and their neuromodulatory control during motor behavior. Trends Neurosci 2003; 26: 688-95.
20. Hiersemenzel LP, Curt A, Dietz V. From spinal shock to spasticity: neuronal adaptations to a spinal cord injury. Neurology 2000; 54: 1574-82.
21. Hounsgaard J, Kiehn O. Calcium spikes and calcium plateaux evoked by differential polarization in dendrites of turtle motoneurones in vitro. J Physiol 1993; 468: 245-59.
22. Hounsgaard J, Hultborn H, Jespersen B, Kiehn O. Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J Physiol 1988; 405: 345-67.
23. Hultborn H, Denton ME, Wienecke J, Nielsen JB. Variable amplification of synaptic input to cat spinal motoneurones by dendritic persistent inward current. J Physiol 2003; 552: 945-52.
24. Jones KE. The physiology and simulation of alpha motoneurons in the human spinal cord [PhD thesis]. Vancouver (BC): Simon Fraser University; 1995.
25. Kawamura J, Ise M, Tagami M. The clinical features of spasms in patients with a cervical cord injury. Paraplegia 1989; 27: 222-6.
26. Kiehn O, Eken T. Prolonged firing in motor units: evidence of plateau potentials in human motoneurons? J Neurophysiol 1997; 78: 3061-8.
27. Lee RH, Heckman CJ. Influence of voltage-sensitive dendritic conductances on bistable firing and effective synaptic current in cat spinal motoneurons in vivo. J Neurophysiol 1996; 76: 2107-10.
28. Lee RH, Heckman CJ. Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha 1 agonist methoxamine. J Neurophysiol 1999; 81: 2164-74.
29. Lee RH, Heckman CJ. Adjustable amplification of synaptic input in the dendrites of spinal motoneurons in vivo. J Neurosci 2000; 20: 6734-40.
30. Lee RH, Kuo JJ, Jiang MC, Heckman CJ. Influence of active dendritic currents on input-output processing in spinal motoneurons in vivo. J Neurophysiol 2003; 89: 27-39.
31. Li Y, Bennett DJ. Persistent sodium and calcium currents cause plateau potentials in motoneurons of chronic spinal rats. J Neurophysiol 2003; 90: 857-69.
32. Li Y, Gorassini MA, Bennett DJ. Role of persistent sodium and calcium currents in motoneuron firing and spasticity in chronic spinal rats. J Neurophysiol 2004; 91: 767-83.
33. Mailis A, Ashby P. Alterations in group Ia projections to motoneurons following spinal lesions in humans. J Neurophysiol 1990; 64: 637-47.
34. Matthews PB. Relationship of firing intervals of human motor units to the trajectory of post-spike after-hyperpolarization and synaptic noise. J Physiol 1996; 492: 597-628.
35. Mazzocchio R, Rossi A. Involvement of spinal recurrent inhibition in spasticity. Further insight into the regulation of Renshaw cell activity. Brain 1997; 120: 991-1003.
36. Person RS, Kudina LP. Discharge frequency and discharge pattern of human motor units during voluntary contraction of muscle. Electroencephalogr Clin Neurophysiol 1972; 32: 471-83.
37. Powers RK, Binder MD. Effective synaptic current and motoneuron firing rate modulation. J Neurophysiol 1995; 74: 793-801.
38. Powers RK, Binder MD. Relationship between the time course of the afterhyperpolarization and discharge variability in cat spinal motoneurones. J Physiol 2000; 528: 131-50.
39. Powers RK, Binder MD. Input-output functions of mammalian motoneurons. Rev Physiol Biochem Pharmacol 2001; 143: 137-263.
40. Prather JF, Powers RK, Cope TC. Amplification and linear summation of synaptic effects on motoneuron firing rate. J Neurophysiol 2001; 85: 43-53.
41. Remy-Neris O, Barbeau H, Daniel O, Boiteau F, Bussel B. Effects of intrathecal clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects. Exp Brain Res 1999; 129: 433-40.
42. Roby-Brami A, Bussel B. Long-latency spinal reflex in man after flexor reflex afferent stimulation. Brain 1987; 110: 707-25.
43. Schmit BD, Benz EN, Rymer WZ. Reflex mechanisms for motor impairment in spinal cord injury. Adv Exp Med Biol 2002; 508: 315-23.
44. Sivak M, Ochoa J, Fernandez JM. Positive manifestations of nerve fibre dysfunction: clinical, electrophysiological and pathological correlates. In: Brown WF and Bolton CF, editors. Clinical electromyography. 2nd ed. Boston (MA): Butterworth-Heinemann; 1993. p. 117-47.
45. Tanaka R. Reciprocal Ia inhibitory pathway in normal man and in patients with motor disorders. Adv Neurol 1983; 39: 433-41.
46. Young RR. Spasticity: a review. Neurology 1994; 44 (11 Suppl 9): S12-S20.
47. Zijdewind I, Thomas CK. Spontaneous motor unit behaviour in human thenar muscles after spinal cord injury. Muscle Nerve 2001; 24: 952-62.