Linopirdine blocks α9α10-containing nicotinic cholinergic receptors of cochlear hair cells

JARO - Journal of the Association for Research in Otolaryngology

Volumn 5, Issue 3, 2004, Pages 261-269

  Gomez Casati, María E ^a   Katz, Eleonora ^a,b   Glowatzki, Elisabeth ^c   Lioudyno, María I ^c   Fuchs, Paul ^c   Elgoyhen, A Belén ^a  

^a INSTITUTO DE INVESTIGACIONES EN INGENIERÍA GENÉTICA Y BIOLOGÍA MOLECULAR   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetylcholine; Ion channels; K+ channels; Linopirdine; Nicotinic receptors

Indexed keywords

ACETYLCHOLINE; LINOPIRDINE; NICOTINIC RECEPTOR; POTASSIUM; POTASSIUM CHANNEL; ALPHA10 ACETYLCHOLINE RECEPTOR, RAT; CHRNA9 PROTEIN, RAT; INDOLE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN SUBUNIT; PYRIDINE DERIVATIVE; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COCHLEA; CONCENTRATION RESPONSE; HAIR CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; XENOPUS LAEVIS; ANIMAL; CELL MEMBRANE POTENTIAL; DRUG EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; OOCYTE; PATCH CLAMP; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACETYLCHOLINE; ANIMALS; GENE EXPRESSION; HAIR CELLS, OUTER; INDOLES; MEMBRANE POTENTIALS; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PROTEIN SUBUNITS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 4944231742     PISSN: 15253961     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10162-004-4025-6     Document Type: Article

References (39)

1. ART J, FETTIPLACE R, FUCHS P. Synaptic hyperpolarization and inhibition of turtle cochlear hair cells. J. Physiol. (Lond.) 365:525-550, 1984.
2. BLANCHET C, EROSTEGUI C, SUGASAWA M, DULON D. Acetylcholine-induced potassium current of guinea pig outer hair cells: its dependence on a calcium influx through nicotinic-like receptors. J. Neurosci. 16:2574-2584, 1996.
3. BROWNELL W, BADER C, BERTRAND D, DE RIBAUPIERRE Y. Evoked mechanical responses of isolated cochlear hair cells. Science 227:194-196, 1985.
4. CHEN C, LEBLANC C, BOBBIN R. Differences in cholinergic responses from outer hair cells of rat and guinea pig. Hear. Res. 98:9-17, 1996.
5. COSTA A, BROWN B. Inhibition of M-current in cultured rat superior cervical ganglia by linopirdine: mechanism of action studies. Neuropharmacol. 36:1747-1753, 1997.
6. DALLOS P. The active cochlea. J. Neurosci. 12:4575-4585, 1992.
7. DALLOS P, EVANS BN. High-frequency motility of outer hair cells and the cochlear amplifier. Science 267:2006-2009, 1995.
8. DULON D, LENOIR M. Cholinergic responses in developing outer hair cells of the rat cochlea. Eur. J. Neurosci. 8:1945-1952, 1996.
9. ELGOYHEN AB, JOHNSON DS, BOULTER J, VETTER DE, HEINEMANN S. α9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79:705-715, 1994.
10. ELGOYHEN AB, VETTER D, KATZ E, ROTHLIN C, HEINEMANN S, BOULTER J. Alpha 10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechano-sensory hair cells. Proc. Natl. Acad. Sci. USA 98:3501-3506, 2001.
11. EROSTEGUI C, NORRIS CH, BOBBIN RP. In vitro characterization of a cholinergic receptor on outer hair cells. Hear. Res. 74:135-147, 1994.
12. EVANS M. Acetylcholine activates two currents in guinea-pig outer hair cells. J. Physiol. (Lond.). 491:563-578, 1996.
13. EYBALIN M. Neurotransmitters and neuromodulators of the mammalian cochlea. Physiol. Rev. 73:309-373, 1993.
14. FUCHS P. Synaptic transmission at vertebrate hair cells. Curr. Opin. Neurobiol. 6:514-519, 1996.
15. FUCHS PA, MURROW BW. A novel cholinergic receptor mediates inhibition of chick cochlear hair cells. Proc. R. Soc. Lond. B Biol. Sci. 248:35-40, 1992.
16. GLOWATZKI E, FUCHS P. Cholinergic synaptic inhibition of inner hair cells in the neonatal mammalian cochlea. Science 288:2366-2368, 2000.
17. GUINAN JJ. Physiology of olivocochlear efferents. In: DALLOS P, POPPER AN, FAY RR (eds) The Cochlea. Springer-Verlag, New York, pp 435-502, 1996.
18. HIEL H, LUEBKE AE, FUCHS PA. Cloning and expression of the 9 nicotinic acetylcholine receptor subunit in cochlear hair cells of the chick. Brain Res. 858:215-225, 2000.
19. HOUSLEY GD, ASHMORE JF. Direct measurement of the action of acetylcholine on isolated outer hair cells of the guinea pig cochlea. Proc. R. Soc. Lond. B Biol. Sci. 244:161-167, 1991.
20. HOUSLEY GD, ASHMORE JF. Ionic currents of outer hair cells isolated from the guinea-pig cochlea. J. Physiol (Lond.). 448:73-98, 1992.
21. KAKEHATA S, NAKAGAWA T, TAKASAKA T, AKAIKE N. Cellular mechanism of acetylcholine-induced response in dissociated outer hair cells of guinea-pig cochlea. J. Physiol. (Lond.). 463:227-244, 1993.
22. KROS CJ, RUPPERSBERG JP, RUSCH A. Expression of a potassium current in inner hair cells during development of hearing in mice. Nature 394:281-284, 1998.
23. KUBISCH C, SCHROEDER BC, FRIEDRICH T, LUTJOHANN B, EL-AMRAOUI A, MARLIN S, PETIT C, JENTSCH TJ. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 96:437-446, 1999.
24. LAMAS JA, SELYANKO AA, BROWN DA. Effects of a cognition-enhancer, linopirdine (DuP 996), on M-type potassium currents (IK(M)) and some other voltage- and ligand-gated membrane currents in rat sympathetic neurons. Eur. J. Neurosci. 9:605-616, 1997.
25. + channel determined by construction of multimeric cDNAs. Neuron. 9:861-871, 1992.
26. LUSTIG LR, PENG H, HIEL H, YAMAMOTO T, FUCHS P. Molecular cloning and mapping of the human nicotinic acetylcholine receptor α10 (CHRNA10). Genomics 73:272-283, 2001.
27. MARCOTTI W, KROS CJ. Developmental expression of the potassium current IK, n contributes to maturation of mouse outer hair cells. J. Physiol. (Lond.). 520 (Pt 3):653-660, 1999.
28. MARCOTTI W, JOHNSON SL, HOLLEY MC, KROS CJ. Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells. J. Physiol. (Lond.). 548:383-400, 2003.
29. MCNIVEN AI, YUHAS WA, FUCHS PA. Ionic dependence and agonist preference of an acetylcholine receptor in hair cells. Audit Neurosci 2:63-77, 1996.
30. MORLEY BJ, SIMMONS DD. Developmental mRNA expression of the alpha10 nicotinic acetylcholine receptor subunit in the rat cochlea. Brain Res. Dev. Brain Res. 139:87-96, 2002.
31. MORLEY B, LI H, HEIL H, DRESCHER D, ELGOYHEN AB. Identification of the subunits of the nicotinic cholinergic receptors in the rat cochlea using RT-PCR and in situ hybridization. Mol. Brain Res. 53:78-87, 1998.
32. NICKOLSON V, TAM S, MYERS M, COOK L. Dup 996 (3,3-bis(pyrindinylmethyl)- 1-phenyl-2-one) enhances the stimulus-induced release of acetylcholine from rat brain in vitro and in vivo. Drug Dev. Res. 19:285-300, 1990.
33. + channels controls fast inhibitory synaptic transmission at auditory outer hair cells. Neuron 26:595-601, 1998.
34. OLIVER D, LUDWIG J, REISINGER E, ZOELLNER W, RUPPERSBERG JP, FAKLER B. Memantine inhibits efferent cholinergic transmission in the cochlea by blocking nicotinic acetylcholine receptors of outer hair cells. Mol. Pharmacol. 60:183-189, 2001.
35. OLIVER D, KNIPPER M, DERST C, FAKLER B. Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea set by KCNQ-type potassium channels. J. Neurosci. 23:2141-2149, 2003.
36. TSAI M, SU J, CHEN M, FAN S, CHENG C. The effect of 3,3-dipyridyl-methyl- 1-phenyl-2-indolinone on the neuromuscular transmission in the rodent skeletal muscles. Neuropharmacology 31:89-94, 1992.
37. VICKROY T. Presynaptic cholinergic actions by the putative cognitive enhancing agent DuP 996. J. Pharmacol. Exp. Ther. 264:910-917, 1993.
38. WANG HS, PAN Z, SHI W, BROWN BS, WYMORE RS, COHEN IS, DIXON JE, MCKINNON D. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 282:1890-1893, 1998.
39. WEISSTAUB N, VETTER D, ELGOYHEN A, KATZ E. The alpha9/alpha10 nicotinic acetylcholine receptor is permeable to and is modulated by divalent cations. Hear. Res. 167:122-135, 2002.