Reduced activity without hyperphagia contributes to obesity in Tubby mutant mice

Physiology and Behavior

Volumn 95, Issue 1-2, 2008, Pages 168-175

  Coyle, Christopher A ^a   Strand, Sarah C ^a   Good, Deborah J ^a,b  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

Body fat; Body temperature; Food intake; Locomotor activity; Obesity; Wheel running

Indexed keywords

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY TEMPERATURE; BODY WEIGHT; C57BL 6 MOUSE; CONTROLLED STUDY; ENERGY EXPENDITURE; FOOD INTAKE; GENE; HYPERPHAGIA; MALE; MOUSE; NEWBORN; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SPONTANEOUS MUTATION; TUB GENE;

EID: 49349102758     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2008.05.014     Document Type: Article

References (43)

1. Coleman D.L., and Eicher E.M. Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. J Heredity 81 (1990) 424-427
2. Kleyn P.W., Fan W., Kovats S.G., Lee J.J., Pulido J.C., Wu Y., et al. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell 85 (1996) 281-290
3. Noben-Trauth K., Naggert J.K., North M.A., and Nishina P.M. A candidate gene for the mouse mutation tubby. Nature 380 (1996) 534-538
4. Ikeda A., Nishina P.M., and Naggert J.K. The tubby-like proteins, a family with roles in neuronal development and function. J Cell Sci 115 (2002) 9-14
5. Boggon T.J., Shan W.S., Santagata S., Myers S.C., and Shapiro L. Implication of tubby proteins as transcription factors by structure-based functional analysis. Science 286 (1999) 2119-2125
6. Santagata S., Boggon T.J., Baird C.L., Gomez C.A., Zhao J., Shan W.S., et al. G-protein signaling through tubby proteins. Science 292 (2001) 2041-2050
7. Koritschoner N.P., Alvarez-Dolado M., Kurz S.M., Heikenwalder M.F., Hacker C., Vogel F., et al. Thyroid hormone regulates the obesity gene tub. EMBO Rep 2 (2001) 499-504
8. Kapeller R., Moriarty A., Strauss A., Stubdal H., Theriault K., Siebert E., et al. Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin. J Biol Chem 274 (1999) 24980-24986
9. Guan X.M., Yu H., and Van der Ploeg L.H. Evidence of altered hypothalamic pro-opiomelanocortin/ neuropeptide Y mRNA expression in tubby mice. Brain Res Mol Brain Res 59 (1998) 273-279
10. Elmquist J.K., Coppari R., Balthasar N., Ichinose M., and Lowell B.B. Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol 493 (2005) 63-71
11. Snyder E.E., Walts B., Perusse L., Chagnon Y.C., Weisnagel S.J., Rankinen T., et al. The human obesity gene map: the 2003 update. Obes Res 12 (2004) 369-439
12. Shiri-Sverdlov R., Custers A., van Vliet-Ostaptchouk J.V., van Gorp P.J., Lindsey P.J., van Tilburg J.H., et al. Identification of TUB as a novel candidate gene influencing body weight in humans. Diabetes 55 (2006) 385-389
13. Ashrafi K., Chang F.Y., Watts J.L., Fraser A.G., Kamath R.S., Ahringer J., et al. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421 (2003) 268-272
14. Wang Y., Seburn K., Bechtel L., Lee B.Y., Szatkiewicz J.P., Nishina P.M., et al. Defective carbohydrate metabolism in mice homozygous for the tubby mutation. Physiol Genomics 27 (2006) 131-140
15. Good D.J., Porter F.D., Mahon K.A., Parlow A.F., Westphal H., and Kirsch I.R. Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Nat Genet 15 (1997) 397-401
16. Cox J.E., Laughton W.B., and Powley T.L. Precise estimation of carcass fat from total body water in rats and mice. Physiol Behav 35 (1985) 905-910
17. Coyle C.A., Jing E., Hosmer T., Powers J.B., Wade G., and Good D.J. Reduced voluntary activity precedes adult-onset obesity in Nhlh2 knockout mice. Physiol Behav 77 (2002) 387-402
18. Goodrick C.L. Effect of voluntary wheel exercise on food intake, water intake, and body weight for C57BL/6J mice and mutations which differ in maximal body weight. Physiol Behav 21 (1978) 345-351
19. Yen T.T., and Acton J.M. Locomotor activity of various types of genetically obese mice. Proc Soc Exp Biol Med 140 (1972) 647-650
20. Yen T.T., and Acton J.M. Stimulation of locomotor activity of genetically obese mice by amphetamine. Experientia 29 (1973) 1297-1298
21. R.V. Lenth. Java Applets for Power and Sample Size [Computer software]. 2006 [cited 2007 June 26]; Available from: http://www.stat.uiowa.edu/~rlenth/Power.
22. Lenth R.V. Statistical power calculations. J Anim Sci 85 (2007) E24-29
23. de Visser L., van den Bos R., Stoker A.K., Kas M.J., and Spruijt B.M. Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice. Behav Brain Res 177 2 (2006) 290-297
24. Lett B.T., Grant V.L., Byrne M.J., and Koh M.T. Pairings of a distinctive chamber with the aftereffect of wheel running produce conditioned place preference. Appetite 34 (2000) 87-94
25. Sherwin C.M. Voluntary wheel running: a review and novel interpretation. Anim Behav 56 (1998) 11-27
26. Chang B., Hawes N.L., Hurd R.E., Davisson M.T., Nusinowitz S., and Heckenlively J.R. Retinal degeneration mutants in the mouse. Vision Res 42 (2002) 517-525
27. Kong L., Li F., Soleman C.E., Li S., Elias R.V., Zhou X., et al. Bright cyclic light accelerates photoreceptor cell degeneration in tubby mice. Neurobiol Dis 21 (2006) 468-477
28. Ohlemiller K.K., Hughes R.M., Lett J.M., Ogilvie J.M., Speck J.D., Wright J.S., et al. Progression of cochlear and retinal degeneration in the tubby (rd5) mouse. Audiol Neurootol 2 (1997) 175-185
29. Ohlemiller K.K., Hughes R.M., Mosinger-Ogilvie J., Speck J.D., Grosof D.H., and Silverman M.S. Cochlear and retinal degeneration in the tubby mouse. Neuroreport 6 (1995) 845-849
30. Zeng Q., Kwan A., and Oakley B. Gustatory innervation and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells. J Comp Neurol 424 (2000) 640-650
31. Backberg M., Madjid N., Ogren S.O., and Meister B. Down-regulated expression of agouti-related protein (AGRP) mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice. Brain Res Mol Brain Res 125 (2004) 129-139
32. Figlewicz D.P., Naleid A.M., and Sipols A.J. Modulation of food reward by adiposity signals. Physiol Behav 91 5 (2006) 473-478
33. Lowell B.B., and Bachman E.S. Beta-adrenergic receptors, diet-induced thermogenesis, and obesity. J Biol Chem 278 (2003) 29385-29388
34. Tou J.C., and Wade C.E. Determinants affecting physical activity levels in animal models. Exp Biol Med (Maywood) 227 (2002) 587-600
35. McFadyen M.P., Kusek G., Bolivar V.J., and Flaherty L. Differences among eight inbred strains of mice in motor ability and motor learning on a rotorod. Genes Brain Behav 2 (2003) 214-219
36. Heldermon C.D., Hennig A.K., Ohlemiller K.K., Ogilvie J.M., Herzog E.D., Breidenbach A., et al. Development of sensory, motor and behavioral deficits in the murine model of Sanfilippo syndrome type B. PLoS ONE 2 (2007) e772
37. Gleason S.D., and Shannon H.E. Meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-HT1 as well as 5-HT2C receptors in mice. Eur J Pharmacol 341 (1998) 135-138
38. Heisler L.K., and Tecott L.H. A paradoxical locomotor response in serotonin 5-HT(2C) receptor mutant mice. J Neurosci 20 (2000) RC71
39. Nonogaki K., Abdallah L., Goulding E.H., Bonasera S.J., and Tecott L.H. Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice. Diabetes 52 (2003) 315-320
40. Wise R.A. The parsing of food reward. Am J Physiol Regul Integr Comp Physiol 291 (2006) R1234-1235
41. Wise R.A. Role of brain dopamine in food reward and reinforcement. Philos Trans R Soc Lond B Biol Sci 361 (2006) 1149-1158
42. Must A., and Tybor D.J. Physical activity and sedentary behavior: a review of longitudinal studies of weight and adiposity in youth. Int J Obes (Lond) 29 Suppl 2 (2005) S84-96
43. Loos R.J., Rankinen T., Tremblay A., Perusse L., Chagnon Y., and Bouchard C. Melanocortin-4 receptor gene and physical activity in the Quebec Family Study. Int J Obes Relat Metab Disord 29 4 (2004) 420-428