Extracorporeal photopheresis normalizes some lymphocyte subsets (including T regulatory cells) in chronic graft-versus-host-disease

Therapeutic Apheresis and Dialysis

Volumn 12, Issue 4, 2008, Pages 311-318

  Bladon, John ^a   Taylor, Peter ^a  

^a ROTHERHAM GENERAL HOSPITAL   (United Kingdom)

Author keywords

Extracorporeal photopheresis; Flow cytometry; Graft versus host disease; Lymphocyte; T regulatory cell

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHRONIC GRAFT VERSUS HOST DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; EXTRACORPOREAL PHOTHOPHERESIS; FEMALE; HEMODIALYSIS; HOMEOSTASIS; HUMAN; IMMUNOPHENOTYPING; IMMUNOREGULATION; LYMPHOCYTE COUNT; MALE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

ADULT; ANIMALS; CASE-CONTROL STUDIES; CHRONIC DISEASE; FEMALE; GRAFT VS HOST DISEASE; HOMEOSTASIS; HUMANS; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; MICE; MIDDLE AGED; PHOTOPHERESIS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 49249104107     PISSN: 17449979     EISSN: 17449987     Source Type: Journal    
DOI: 10.1111/j.1744-9987.2008.00593.x     Document Type: Article

References (45)

1. Lee SJ, Klein JP, Barrett AJ et al. Severity of chronic graft-versus-host-disease: association with treatment-related mortality and relapse. Blood 2002 100: 406 14.
2. Horwitz ME, Sullivan KM. Chronic graft-versus-host disease. Blood Rev 2006 20: 15 27.
3. Rouquette-Gally AM, Boyeldieu D, Gluckman E, Abauf N, Combrisson A. Autoimmunity in 28 patients after allogeneic bone marrow transplantation: comparison with Sjögren's syndrome and scleroderma. Br J Haematol 1987 66: 45 7.
4. + cytotoxic T cells in chronic graft-versus-host disease. Bone Marrow Transplant 1994 14: 525 33.
5. Parkman R. Is chronic graft-versus-host disease an autoimmune disease? Curr Opin Immunol 1993 5: 800 3.
6. Tivol E, Komorowski R, Drobyski R. Emergent autoimmunity in graft-versus-host disease. Blood 2005 105: 4885 91.
7. Vogelsang GB. How I treat chronic graft versus host disease. Blood 2001 97: 1196 201.
8. Lee SJ. New approaches for preventing and treating chronic graft-versus-host disease. Blood 2005 105: 4200 6.
9. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol 1998 160: 1212 18.
10. + immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002 99: 3493 9.
11. reg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT. Blood 2006 108: 1291 7.
12. + regulatory T cells in patients with chronic graft-versus-host-disease. Blood 2005 106: 2903 11.
13. high regulatory T cells. Blood 2004 103: 2410 16.
14. Child FJ, Ratnavel R, Watkins P et al. Extracorporeal photopheresis (ECP) in the treatment of chronic graft-versus-host disease (GVHD). Bone Marrow Transplant 1999 23: 881 7.
15. Edelson R, Berger C, Gasparro F et al. Treatment of cutaneous T cell lymphoma by Extracorporeal photochemotherapy: preliminary results. N Engl J Med 1987 316: 297 303.
16. Maeda A, Schwarz A, Kernebeck K et al. Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen-specific regulatory T cells. J Immunol 2005 174: 5968 76.
17. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995 155: 1151 64.
18. Beissert S, Schwarz A, Schwarz T. Regulatory T cells. J Invest Dermatol 2006 126: 15 24.
19. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000 192: 303 10.
20. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003 299: 1057 61.
21. Peritt D. Potential mechanism of photopheresis in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006 12: 7 12.
22. Sakaguchi S, Sakaguchi N, Shimizu J et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells; their common role in controlling autoimmunity, tumor immunity and transplantation tolerance. Immunol Rev 2001 182: 18 32.
23. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998 188: 287 96.
24. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J Exp Med 2001 194: 629 44.
25. Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999 190: 995 1004.
26. + regulatory T cells is antigen-specific and requires IL-10 and TGFβ. J Immunol 2005 175: 4283 91.
27. Korholz D, Kunst D, Hempel L et al. Decreased interleukin 10 and increased interferon-gamma production in patients with chronic graft-versus-host disease after allogeneic bone marrow transplantation. Bone Marrow Transplant 1997 19: 691 5.
28. Lin MT, Storer B, Martin PJ et al. Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. N Engl J Med 2003 349: 2201 10.
29. Wang P, Wu P, Siegel MI, Egan RW, Ballah MM. IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells. J Immunol 1994 153: 811 16.
30. de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes. An autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991 174: 1209 20.
31. Taams LS, van Amelsfort JMR, Tiemessen MM et al. Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells. Hum Immunol 2005 66: 222 30.
32. Bladon J, Taylor PC. Lymphocytes treated by extracorporeal photopheresis can down-regulate cytokine production in untreated monocytes. Photodermatol Photoimmunol Photomed 2005 21: 293 302.
33. Craciun LI, Stordeur P, Schandene L et al. Increased production of interleukin-10 and interleukin-1 receptor antagonist after extracorporeal photochemotherapy in chronic graft-versus-host disease. Transplantation 2002 74: 995 1000.
34. Di Renzo M, Rubegni P, Pasqui AL et al. Extracorporeal photopheresis affects interleukin (IL) -10 and IL12 production by monocytes in patients with chronic graft-versus-host disease. Br J Dermatol 2005 153: 59 65.
35. + T lymphocytes. J Immunol 2005 174: 155 63.
36. Giver CR, Montes RO, Mittlesta S et al. Ex-vivo fludarabine exposure inhibits graft-versus-host activity of allogeneic T cells while preserving graft-versus-leukemia effects. Biol Blood Marrow Transplant 2003 9: 616 32.
37. Willenbacher W, Basara N, Blau IW, Fausser AA, Kiehl MG. Treatment of steroid refractory acute and chronic graft-versus-host-disease with daclizumab. Br J Haematol 2001 112: 820 3.
38. Chiang KY, Abhyankar S, Bridges K, Godder K, Henslee-Downey JP. Recombinant human tumor necrosis factor receptor fusion protein as complimentary treatment for chronic graft-versus-host disease. Transplantation 2002 73: 665 7.
39. Chung EY, Kim SJ, Ma XJ. Regulation of cytokine production during phagocytosis of apoptotic cells. Cell Res 2006 16: 154 61.
40. Crispin JC, Martinez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 2003 21: 273 6.
41. Miyara M, Amoura Z, Parizot C et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005 175: 8392 400.
42. Bladon J, Taylor PC. Extracorporeal photopheresis in cutaneous T-cell lymphoma and graft-versus-host disease induces both immediate and progressive apoptotic processes. Br J Dermatol 2002 146: 59 68.
43. Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR, Girkontaite I. Immunosuppressive effects of apoptotic cells. Nature 1997 390: 350 1.
44. Biedermann BC, Sahner S, Gregor M et al. Endothelial injury mediated by cytotoxic T lymphocytes and loss of microvessels in chronic graft versus host disease. Lancet 2002 359: 2078 83.
45. + T cell activation. Eur J Immunol 2003 33: 3473 83.