Failure to restore the Vγ2-Jγ1.2 repertoire in HIV-infected men receiving highly active antiretroviral therapy (HAART)

Clinical Immunology

Volumn 128, Issue 3, 2008, Pages 349-357

  Hebbeler, Andrew M ^a   Propp, Nadia ^a   Cairo, Cristiana ^a   Li, Haishan ^a,b   Cummings, Jean Saville ^a,c   Jacobson, Lisa P ^d   Margolick, Joseph B ^d   Pauza, C David ^a,c  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^c UNIVERSITY OF MARYLAND   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Antiretroviral therapy; Gamma delta; HIV AIDS; Immune reconstitution; Repertoire; T cell receptor

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; GAMMADELTA T LYMPHOCYTE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN VARIANT; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TREATMENT DURATION; CD4 LYMPHOCYTE COUNT; CLINICAL TRIAL; COHORT ANALYSIS; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOLOGY; LYMPHOCYTE COUNT; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; VIROLOGY;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; COHORT STUDIES; HIV; HIV INFECTIONS; HUMANS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS;

EID: 49149114866     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2008.04.008     Document Type: Article

References (33)

1. Fauci A.S., Pantaleo G., Stanley S., and Weissman D. Immunopathogenic mechanisms of HIV infection. Ann. Intern. Med. 124 (1996) 654-663
2. Hel Z., McGhee J.R., and Mestecky J. HIV infection: first battle decides the war. Trends Immunol. 27 (2006) 274-281
3. Benito J.M., Lopez M., and Soriano V. The role of CD8+ T-cell response in HIV infection. AIDS Rev. 6 (2004) 79-88
4. Moir S., Malaspina A., Ogwaro K.M., et al. HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 10362-10367
5. Moir S., Malaspina A., Pickeral O.K., et al. Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily. J. Exp. Med. 200 (2004) 587-599
6. Moir S., Ogwaro K.M., Malaspina A., et al. Perturbations in B cell responsiveness to CD4+ T cell help in HIV-infected individuals. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 6057-6062
7. Fauci A.S., Mavilio D., and Kottilil S. NK cells in HIV infection: paradigm for protection or targets for ambush. Nat. Rev. Immunol. 5 (2005) 835-843
8. Enders P.J., Yin C., Martini F., et al. HIV-Mediated gammadelta T cell depletion is specific for Vgamma2(+) cells expressing the Jgamma1.2 segment. AIDS Res. Hum. Retrovir. 19 (2003) 21-29
9. Hebbeler A.M., Cairo C., Cummings J.S., and Pauza C.D. Individual Vgamma2-Jgamma1.2+ T cells respond to both isopentenyl pyrophosphate and Daudi cell stimulation: generating tumor effectors with low molecular weight phosphoantigens. Immunother. 56 (2007) 819-829
10. Viey E., Laplace C., and Escudier B. Peripheral gammadelta T-lymphocytes as an innovative tool in immunotherapy for metastatic renal cell carcinoma. Expert Rev. Anticancer Ther. 5 (2005) 973-986
11. Lamb Jr. L.S., and Lopez R.D. gammadelta T cells: a new frontier for immunotherapy?. Biol. Blood Marrow Transplant. 11 (2005) 161-168
12. Fisch P., Malkovsky M., Braakman E., et al. Gamma/delta T cell clones and natural killer cell clones mediate distinct patterns of non-major histocompatibility complex-restricted cytolysis. J. Exp. Med. 171 (1990) 1567-1579
13. Sicard H., Al Saati T., Delsol G., and Fournie J.J. Synthetic phosphoantigens enhance human Vgamma9Vdelta2 T lymphocytes killing of non-Hodgkin's B lymphoma. Mol. Med. 7 (2001) 711-722
14. Tanaka Y., Brenner M.B., Bloom B.R., and Morita C.T. Recognition of nonpeptide antigens by T cells. J. Mol. Med. 74 (1996) 223-231
15. Bukowski J.F., Morita C.T., and Brenner M.B. Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity. Immunity 11 (1999) 57-65
16. Kunzman V., Feurle J., Weissinger F., Tony H., and Wilhelm M. Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma. Blood 96 (2000) 384-392
17. Li H., Deetz C.O., Zapata J.C., et al. Vaccinia virus inhibits T cell receptor-dependent responses by human gammadelta T cells. J. Infect. Dis. 195 (2007) 37-45
18. Evans P.S., Enders P.J., Yin C., Ruckwardt T.J., Malkovsky M., and Pauza C.D. In vitro stimulation with a non-peptidic alkylphosphate expands cells expressing Vgamma2-Jgamma1.2/Vdelta2 T-cell receptors. Immunology 104 (2001) 19-27
19. Parker C.M., Groh V., Band H., et al. Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire. J. Exp. Med. 171 (1990) 1597-1612
20. De Rosa S.C., Andrus J.P., Perfetto S.P., et al. Ontogeny of gamma delta T cells in humans. J. Immunol. 172 (2004) 1637-1645
21. Poccia F., Boullier S., Lecoeur H., et al. Peripheral Vgamma9/Vdelta2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons. J. Immunol. 157 (1996) 449-461
22. Hinz T., Wesch D., Friese K., Reckziegel A., Arden B., and Kabelitz D. T cell receptor gamma delta repertoire in HIV-1-infected individuals. Eur. J. Immunol. 24 (1994) 3044-3049
23. Li B., Bassiri H., Rossman M.D., et al. Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human gamma delta T cells: a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosis. J. Immunol. 161 (1998) 1558-1567
24. Gan Y.H., Wallace M., and Malkovsky M. Fas-dependent, activation-induced cell death of gammadelta cells. J. Biol. Regul. Homeost. Agents 15 (2001) 277-285
25. Bordon J., Evans P., Propp N., Davis C., Redfield R., and Pauza C.D. Association between longer duration of HIV-suppressive therapy and partial recovery of the Vgamma2 T cell receptor repertoire. J. Infect. Dis. 189 (2004) 1482-1486
26. Autran B., Carcelain G., Li T.S., et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 277 (1997) 112-116
27. Caccamo N., Dieli F., Wesch D., Jomaa H., and Eberl M. Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells. J. Leukoc. Biol. 79 (2006) 663-666
28. Kaslow R.A., Ostrow D.G., Detels R., Phair J.P., Polk B.F., and Rinaldo Jr. C.R. The multicenter AIDS cohort study: rationale, organization, and selected characteristics of the participants. Am. J. Epidemiol. 126 (1987) 310-318
29. Davodeau F., Peyrat M.A., Hallet M.M., et al. Close correlation between Daudi and mycobacterial antigen recognition by human gamma delta T cells and expression of V9JPC1 gamma/V2DJC delta-encoded T cell receptors. J. Immunol. 151 (1993) 1214-1223
30. Bukowski J.F., Morita C.T., Band H., and Brenner M.B. Crucial role of TCR gamma chain junctional region in prenyl pyrophosphate antigen recognition by gamma delta T cells. J. Immunol. 161 (1998) 286-293
31. Sandberg J.K., Fast N.M., Palacios E.H., et al. Selective loss of innate CD4(+) V alpha 24 natural killer T cells in human immunodeficiency virus infection. J. Virol. 76 (2002) 7528-7534
32. Giovannetti A., Pierdominici M., Marziali M., et al. Persistently biased T-cell receptor repertoires in HIV-1-infected combination antiretroviral therapy-treated patients despite sustained suppression of viral replication. J. Acquir. Immune Defic. Syndr. 34 (2003) 140-154
33. Gea-Banacloche J.C., Martino L., Mican J.M., et al. Longitudinal changes in CD4+ T cell antigen receptor diversity and naive/memory cell phenotype during 9 to 26 months of antiretroviral therapy of HIV-infected patients. AIDS Res. Hum. Retrovir. 16 (2000) 1877-1886