Schizophrenia-a parameters' game?

Journal of Theoretical Biology

Volumn 254, Issue 1, 2008, Pages 89-98

  Rǎdulescu, Anca ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Bifurcation; Brain; Dynamical system; Feedback loop; Pathway

Indexed keywords

BRAIN; MENTAL HEALTH;

AMYGDALOID NUCLEUS; ARTICLE; CLINICAL FEATURE; HIPPOCAMPUS; MATHEMATICAL MODEL; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA;

AMYGDALA; ANIMALS; EMOTIONS; EXTINCTION, PSYCHOLOGICAL; FEAR; HIPPOCAMPUS; HUMANS; MODELS, NEUROLOGICAL; NEURAL PATHWAYS; PREFRONTAL CORTEX; SCHIZOPHRENIC PSYCHOLOGY; STRESS, PSYCHOLOGICAL;

EID: 49049096879     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2008.05.009     Document Type: Article

References (120)

1. Amann J.F., and Constantinescu G.M. The anatomy of the visceral and autonomic nervous systems. Semin Vet. Med. Surg. (Small Anim.) 5 1 (1990) 4-11
2. American Psychiatric Association, 1994. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), fourth ed. Washington, DC.
3. Anand A. Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol. Psychiatry 57 10 (2005) 1079-1088
4. Anand A., and Shekhar A. Brain imaging studies in mood and anxiety disorders: special emphasis on the amygdala. Ann. NY Acad. Sci. 985 (2003) 370-388
5. Ananth H., Popescu I., Critchley H.D., Good C.D., Frackowiak R., and Dolan R.J. Cortical and subcortical gray matter abnormalities in schizophrenia determined through structural magnetic resonance imaging with optimized volumetric voxel-based morphometry. Am. J. Psychiatry 159 9 (2002) 1497-1505
6. Andreasen N., Nasrallah H.A., Dunn V., Olson S.C., Grove W.M., Ehrhardt J.C., Coffman J.A., and Crossett J.H. Structural abnormalities in the frontal system in schizophrenia. A magnetic resonance imaging study. Arch. Gen. Psychiatry 43 2 (1986) 136-144
7. Ashe P.C., Berry M.D., and Boulton A.A. Schizophrenia, a neurodegenerative disorder with neurodevelopmental antecedents. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 25 4 (2001) 691-707
8. Bachrach L.L. Chronicity in schizophrenia. Hosp. Community Psychiatry 38 11 (2000) 1226-1227
9. Baxter M.G., Parker A., Lindner C.C., Izquierdo A., and Murray E.A. Control of response selection by reinforcer value requires interaction of amygdala and orbital prefrontal cortex. J. Neurosci. 20 11 (2000) 4311-4319
10. Bearden C.E., van Erp T.G., Thompson P.M., Toga A.W., and Cannon T.D. Cortical mapping of genotype-phenotype relationships in schizophrenia. Hum. Brain Mapp. 28 6 (2007) 519-532
11. Berner P. Conceptualization of vulnerability models for schizophrenia: historical aspects. Am. J. Med. Genet. 114 8 (2002) 938-942
12. Berns G.S., McClure S.M., Pagnoni G., and Montague P.R. Predictability modulates human brain response to reward. J. Neurosci. 21 (2001) 2793-2798
13. Blackwood N.J., Howard R.J., and Murray R.M. Cognitive neuropsychiatric models of persecutory delusions. Am. J. Psychiatry 158 4 (2001) 527-539
14. Blair H.T., Sotres-Bayon F., Moita M.A., and LeDoux J.E. The lateral amygdala processes the value of conditioned and unconditioned aversive stimuli. Neuroscience 133 2 (2005) 561-569
15. Braff D.L., and Light G.A. Preattentional and attentional cognitive deficits as targets for treating schizophrenia. Psychopharmacology 174 1 (2004) 75-85
16. Brugger P., Regard M., Landis T., and Oelz O. Hallucinatory experiences in extreme-altitude climbers. Neuropsychiatry Neuropsychol. Behav. Neurol. 12 1 (1999) 67-71
17. Bush G., Luu P., and Posner M. Cognitive and emotional influences in anterior cingulate cortex. Trends Cognit. Sci. 4 (2000) 215-222
18. Caetano S., Hatch J., Brambilla P., Sassi R., Nicolettia M., Mallingerbe A., Frankbf E., Kupferbf D., Keshavanb M., and Soares J. Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression. Psychiatry Res. Neuroimaging 132 2 (2004) 141-147
19. Cerqueira J., Mailliet F., Almeida O., Jay T., and Sousa N. The prefrontal cortex as a key target of the maladaptive response to stress. J. Neurosci. 27 11 (2007) 2781-2787
20. Cerqueira, J., Taipa, R., Uylings, H., Almeida, O., Sousa, N., 2007b. Specific configuration of dendritic degeneration in pyramidal neurons of the medial prefrontal cortex induced by differing corticosteroid regimens. Cereb. Cortex 17 (9), 1998-2006.
21. Chua S.E., and McKenna P.J. Schizophrenia-a brain desease? A critical review of structural and functional cerebral abnormality in the disorder. Br. J. Psychiatry 166 5 (1995) 563-582
22. Collins D.R., Pelletier J.G., and Pare D. Slow and fast (gamma) neuronal oscillations in the perirhinal cortex and lateral amygdala. J. Neurophysiol. 85 4 (2001) 1661-1672
23. Corcoran C., Mujica-Parodi L., Yale S., Leitman D., and Malaspina D. Could stress cause psychosis in individuals vulnerable to schizophrenia?. CNS Spectrum 7 1 (2002) 33-38 41-42
24. Corcoran K., and Maren S. Hippocampal inactivation disruots contextual retrieval of fear memory after extinction. J. Neurosci. 21 (2001) 1720-1726
25. Damasio A.R. Synchronous activation in multiple cortical regions: a mechanism for recall. Semin. Neurosci. 2 (1990) 287-296
26. Davidson R. Anxiety and affective style: role of prefrontal cortex and amygdala. Biol. Psychiatry 51 (2002) 68-80
27. Davis M., and Whalen P.J. The amygdala: vigilance and emotion. Mol. Psychiatry 6 1 (2001) 13-34
28. Dawson M.E., Nuechterlein K.H., and Schell A.M. Electrodermal anomalies in recent-onset schizophrenia: relationships to symptoms and prognosis. Schizophr. Bull. 18 2 (1992) 295-311
29. Dawson M.E., Nuechterlein K.H., Schell A.M., and Mintz J. Concurrent and predictive electrodermal correlates of symptomatology in recent-onset schizophrenic patients. J. Abnorm. Psychol. 101 1 (1992) 153-164
30. Dawson M.E., Nuechterlein K.H., Schell A.M., Gitlin M., and Ventura J. Autonomic abnormalities in schizophrenia. State or trait indicators?. Arch. Gen. Psychiatry 51 10 (1994) 813-824
31. de Haan L., and Bakker J.M. Overview of neuropathological theories of schizophrenia: from degeneration to progressive developmental disorder. Psychopathology 37 1 (2004) 1-7
32. DeLisi L.E. Defining the course of brain structural change and plasticity in schizophrenia. Psychiatry Res. 92 1 (1999) 1-9
33. Depue B., Curran T., and Banich M. Prefrontal regions orchestrate suppression of emotional memories via a two-phase process. Science 317 (2007) 215
34. Dickey C., McCarley R., Xu M., Seidman L., Voglmaier M., Niznikiewicz M., Connor E., and Shenton M. MRI abnormalities of the hippocampus and cavum septi pellucidi in females with schizotypal personality disorder. Schizophr. Res. 89 (2007) 49-58
35. Dirkin G.R. Cognitive tunneling: use of visual information under stress. Percept. Mot. Skills 56 1 (1983) 191-198
36. Elliott G.R., and Eisdorfer C. Stress and Human Health (1982), Springer Publishing Company, New York
37. Ferrer J.M., Sabater R., and Saez J.A. Neurotensin participates in self-stimulation of the medial prefrontal cortex in the rat. Eur. J. Pharmacol. 231 1 (1993) 39-45
38. Finlay J.M., and Zigmond M.J. The effects of stress on central dopaminergic neurons: possible clinical implications. Neurochem. Res. 22 11 (1997) 1387-1394
39. Friedman J.I., Ocampo R., Elbaz Z., Parrella M., White L., Bowler S., Davis K.L., and Harvey P.D. The effect of citalopram adjunctive treatment added to atypical antipsychotic medications for cognitive performance in patients with schizophrenia. J. Clin. Psychopharmacol 25 3 (2005) 237-242
40. Friston K.J., Harrison L., and Penny W. Dynamic causal modeling. NeuroImage 19 (2003) 1273-1302
41. Ghisolfi E.S., Schuch A., Strimitzer Jr. I.M., Luersen G., Martins F.F., Ramos F., Becker J., and Lara D.R. Caffeine modulates P50 auditory sensory gating in healthy subjects. Eur. Neuropsychopharmacol. 16 3 (2006) 204-210
42. Goto Y., and Grace A. Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization. Neuron 47 (2005) 255-266
43. Guilding C., and Piggins H.D. Challenging the omnipotence of the suprachiasmatic timekeeper: are circadian oscillators present throughout the mammalian brain?. Eur. J. Neurosci. 25 11 (2007) 3195-3216
44. Harding C.M., Zubin J., and Strauss J.S. Chronicity in schizophrenia: revisited. Br. J. Psychiatry Suppl. 18 (1992) 27-37
45. Harrison P. Review: the neuropathological effects of antipsychotic drugs. Schizophr. Res. 40 (1999) 87-99
46. Hazlett H., Dawson M.E., Schell A.M., and Nuechterlin K.H. Electrodermal activity as a prodromal sign in schizophrenia. Biol. Psychiatry 41 1 (1997) 111-113
47. Hirsch S., and Weinberger D. Schizophrenia. first ed. (1995), Blackwell Science
48. Ishikawa A., and Namura S. Convergence and interaction of hippocampal and amygdalar projections within the prefrontal cortex in the rat. J. Neurosci. 23 (2003) 9987-9995
49. Izquierdo A., and Murray E.A. Opposing effects of amygdala and orbital prefrontal cortex lesions on the extinction of instrumental responding in macaque monkeys. Eur. J. Neurosci. 22 9 (2005) 2341-2346
50. Izquierdo A., Suda R.K., and Murray E.A. Comparison of the effects of bilateral orbital prefrontal cortex lesions and amygdala lesions on emotional responses in rhesus monkeys. J. Neurosci. 25 37 (2005) 8534-8542
51. Jackson M.E., and Moghaddam B. Stimulus-specific plasticity of prefrontal cortex dopamine neurotransmission. J. Neurochem. 88 6 (2004) 1327-1334
52. Jarvis G.E. The social causes of psychosis in North American psychiatry: a review of a disappearing literature. Can. J. Psychiatry 52 5 (2007) 287-294
53. Javitt D.C., Doneshka P., Grochowski S., and Ritter W. Impaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia. Arch. Gen. Psychiatry 52 7 (1995) 550-558
54. Jay T.M., and Witter M.P. Distribution of hippocampus CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris leucoagglutinine. J. Comp. Neurol. 313 (1991) 574-586
55. Jones C.J., Harris G., Leung N., Blissett J., and Meyer C. The effect of induced stress on the relationship between perfectionism and unhealthy eating attitudes. Eat Weight Disord. 12 2 (2007) 39-43
56. Joyce J.N., and Milan M.J. Dopamine D3 receptor agonists and therapeutic agents. Drug Discov. Today 10 13 (2005) 917-925
57. Kapur S., and Mamo D. Half a century of antipsychotics and still a central role for dopamine D2 receptors. Prog. Neuropsychopharmacol. Biol. Psychiatry 27 7 (2003) 1081-1090
58. Kemp, A., Manahan-Vaughan, D., 2008. The hippocampal CA1 region and dentate gyrus differentiate between environmental and spatial feature encoding through long-term depression. Cereb. Cortex 18 (4), 968-977.
59. Kessler R.C., Amminger G., Aguilar-Gaxiola S., Alonso J., Lee S., and Ustn T. Age of onset of mental disorders: a review of recent literature. Curr. Opin. Psychiatry 20 4 (2007) 359-364
60. Kim, H.G., Kim, K.L., 2007. Decreased hippocampal cholinergic neurostimulating peptide precursor protein associated with stress exposure in rat brain by proteomic analysis. J. Neurosci. Res., Epub.
61. Larsen R.J. The stability of mood variability: a spectral analytic approach to daily mood assessments. J. Pers. Soc. Psychol. 52 6 (1987) 1195-1204
62. Lawrie S.M., Whalley H.C., Job D.E., and Johnstone E.C. Structural and functional abnormalities of the amygdala in schizophrenia. Ann. NY Acad. Sci. 985 (2003) 445-460
63. LeDoux J. The emotional brain, fear, and the amygdala. Cell Mol. Neurobiol. 23 4-5 (2003) 727-738
64. LeDoux J. The Amygdala. Curr. Biol. 17 20 (2007) R868-R874
65. Lipska B., Aultman J., Verma A., Weinberger D., and Moghaddam B. Neonatal damage of the ventral hippocampus impairs working memory in the rat. Neuropsychopharmachology 27 (2002) 47-54
66. Lowry C.A., and Moore F.L. Regulation of behavioral responses by corticotropin-releasing factor. Gen. Comp. Endocrinol. 146 1 (2006) 19-27
67. Manuck S.B., Cohen S., Rabin B.S., Muldoon M.F., and Bachen E.A. Individual differences in cellular immune response to stress. Psychol. Sci. 2 (1991) 111-114
68. Mason J., Iqauta W.J.H., Brody J.V., Robinson J.A., and Sachar E.J. The role of limbic system structures in the regulation of ACTH secretion. J. Neural Transm. 23 1-2 (1961) 4-14
69. Mathalon D.H., Heinks T., and Ford J.M. Selective attention in schizophrenia: sparing and loss of executive control. Am. J. Psychiatry 161 5 (2004) 872-881
70. McEwen B.S. Plasticity of the hippocampus: adaptation to chronic stress and allostatic load. Ann. NY Acad. Sci. 933 (2001) 265-277
71. McEwen B.S. Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann. NY Acad. Sci. 1032 (2004) 1-7
72. McGlashan T.H. Early detection and intervention of schizophrenia: rationale and research. Br. J. Psychiatry 172 Suppl. 33 (1998) 3-6
73. McGlashan T.H., Zipursky R.B., Perkins D., Addington J., Miller T.J., Woods S.W., Hawkins K.A., Hoffman R., David S., Tohen M., and Breier A. The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis. I. Study rationale and design. Schizophr. Res. 61 1 (2003) 7-18
74. Medoff D.R., Holcomb H.H., Lahti A.C., and Tamminga C.A. Probing the human hippocampus using rCBF: contrasts in schizophrenia. Hippocampus 11 5 (2001) 543-550
75. Miller E.K., and Cohen J.D. An integrative theory of prefrontal cortex function. Ann. Rev. Neurosci. 24 (2001) 167-202
76. Moghaddam B., and Jackson M. Effect of stress on prefrontal cortex function. Neurotox. Res. 6 1 (2004) 73-78
77. Mora F., and Myres R.D. Brain self-stimulation: direct evidence for the involvment of dopamine in the prefrontal cortex. Science 197 (1977) 1387-1389
78. Morgan M.A., Romanski L.M., and LeDoux J.E. Extinction of emotional learning: contribution of medial prefrontal cortex. Neurosci. Lett. 163 (1993) 109-113
79. Mujica-Parodi L.R. Are cognitive symptoms of schizophrenia mediated by abnormalities in emotional arousal?. CNS Spectrums 7 1 (2002) 58-60 65-69
80. Mujica-Parodi L.R., Yeregani V., and Malaspina D. Nonlinear complexity and spectral analyses of heart rate variability in medicated and unmedicated patients with schizophrenia. Neuropsychobiology 51 1 (2005) 10-15
81. Mujica-Parodi, L.R., Korgaonkar, M., Greenberg, T., Dardo, T., Wagshul, M., Ardekani, B., Guilfoyle, D., Zong, Y., Chon, K., Malaspina, D., 2007. Lymbic dysregulation is associated with lowered heart rate variability and increased trait anxiety in healthy adults. Hum. Brain Mapp.
82. Muller N.G., Machado L., and Knight R.T. Contributions of subregions of the prefrontal cortex to working memory: evidence from brain lesions in humans. J. Cogn. Neurosci. 14 (2002) 673-686
83. Murray G., Allen N., and Trinder J. Longitudinal investigation of mood variability and the ffm: neuroticism predicts variability in extended states of positive and negative affect. Pers. Individ. Differences 33 (2002) 1217-1228
84. Myin-Germeys I., Delespaul P., and van Os J. Behavioural sensitization to daily life stress in psychosis. Psychol. Med. 35 5 (2005) 733-741
85. Nuechterlein K.H., Dawson M.E., Gitlin M., Ventura J., Goldstein M.J., Snyder K.S., Yee C.M., and Mintz J. Developmental processes in schizophrenic disorders: longitudinal studies of vulnerability and stress. Schizophr. Bull. 18 3 (1992) 387-425
86. Pavlides C., Nivon L., and McEwen B. Effects of chronic stress on hippocampal long-term potentiation. Hippocampus 12 2 (2002) 245-257
87. Pelletier J.G., and Pare D. Role of amygdala oscillations in the consolidation of emotional memories. Biol. Psychiatry 55 6 (2004) 559-562
88. Perko L. Differential Equations and Dynamical Systems (1993), Springer, New York
89. Phelps E.A., Delgado M., Nearing K., and LeDoux J. Extinction learning in humans: role of the amygdala and vmPFC. Neuron 43 6 (2004) 897-905
90. Pitkanen A., Pikkarainen M., Nurminen N., and Ylinen A. Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review. Ann. NY Acad. Sci. 911 (2000) 369-391
91. Preston A.R. Hippocampal function, declarative memory, and schizophrenia: anatomic and functional neuroimaging considerations. Curr. Neurol. Neurosci. Rep. 5 4 (2005) 249-256
92. Quirk G., and Gehlert D. Inhibition of the amygdala: key to pathological states?. Ann. NY Acad. Sci. 985 (2003) 263-272
93. Radley J., Rocher A., Janssen W., Hof P., McEwen B., and Morrison J. Reversibility of atypical dendritic retraction in the rat medial prefrontal cortex following repeated stress. Exp. Neurol. 196 (2005) 199-203
94. Rǎdulescu, A., Mujica-Parodi, L.R., 2007. A systems approach to schizophrenia and limbic dysregulation. Schizophr. Res., unpublished work.
95. Ritsner M., Maayan R., Gibel A., Strous R.D., Modai I., and Weizman A. Elevation of the cortisol/dehydroepiandrosterone ratio in schizophrenia patients. Eur. Neuropsychopharmacol. 14 4 (2004) 267-273
96. Robbins T.W. Dissociating executive functions of the prefrontal cortex. Philos. Trans. R. Soc. Lond. B Biol. Sci. 351 (1996) 1463-1470
97. Rocher C., Spedding M., Munoz C., and Jay T. Acute stress-induced changes in hippocampal-prefrontal circuits in rats: effects of antidepressants. Cereb. Cortex 14 (2004) 224-229
98. Rosenkranz J.A., Moore H., and Grace A.A. The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli. J. Neurosci. 23 35 (2003) 11054-11064
99. Sapolski R. Why Zebras Don't Get Ulcers. third ed. (2004), Henry Holt and Co
100. Sapolsky R.M., and Plotsky P.M. Hypercortisolism and its possible neural bases. Biol. Psychiatry 27 9 (1990) 937-952
101. Seamans J.K., Floresco S.B., and Phillips A.G. Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex. Behav. Neurosci. 109 (1995) 1063-1073
102. Siegle G., Konecky R., Thase M., and Carter C. Relationships between amygdala volume and activity during emotional information processing tasks in depressed and never-depressed individuals: an fMRI investigation. Ann. NY Acad. Sci. 985 (2003) 481-484
103. Silva J.A., Leong G.B., Harry B.E., Ronan J., and Weinstock R. Dangerous misidentification of people due to flashback phenomena in posttraumatic stress disorder. J. Forensic Sci. 43 6 (1998) 1107-1111
104. Sotres-Bayon F., Bush D., and LeDoux J.E. Emotional perseveration: an update on prefrontal-amygdala interactions in fear extinction. Learn. Memory. 11 (2004) 525-535
105. Sousa N., Lukoyanov N.V., Madeira M.D., Almeida O.F., and Paula-Barbosa M.M. Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement. Neuroscience 97 (2000) 253-266
106. Squire L.R., and Zola-Morgan S. The medial temporal lobe memory system. Science 253 (1991) 1380-1386
107. Staal W.G., Hulshoff Pol H.E., Schnack H.G., van Haren N.E.M., Seifert N., and Kahn R.S. Structural brain abnormalities in chronic schizophrenia at the extremes of the outcome spectrum. Am. J. Psychiatry 158 7 (2001) 1140-1142
108. Stamm R., and Buhler K.E. Concepts of vulnerability of psychiatric diseases. Fortschr. Neurol. Psychiatry 69 7 (2001) 300-309
109. Tamminga C.A. The neurobiology of cognition in schizophrenia. J. Clin. Psychiatry 67 Suppl 9 (2006) 9-13 discussion 36-42
110. Tandon R., Mazzara C., DeQuardo J., Craig K.A., Meador-Woodruff J.H., and Goldman R. Dexamethasone suppression test in schizophrenia: relationship to symptomatology, ventricular enlargement, and outcome. Biol. Psychiatry 29 10 (1991) 953-964
111. Ventura J., Nuechterlein K.H., Lukoff D., and Hardesty J.P. A prospective study of stressful life events and schizophrenic relapse. J. Abnorm. Psychol. 98 4 (1989) 407-411
112. Ventura J., Nuechterlein K.H., Hardesty J.P., and Gitlin M. Life events and schizophrenic relapse after withdrawal of medication. Br. J. Psychiatry 161 (1992) 615-620
113. Vidal-Gonzales I., Vidal-Gonzales B., Rauch S., and Quirk G. Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear. Learn. Mem. 13 (2007) 728-733
114. Weinberger D., and McClure R. Neurotoxicity, neuroplasticity and magnetic resonance imaging morphometry. Arch. Gen. Psychiatry 59 (2002) 553-558
115. Wik G., Wiesel F.A., Eneroth P., Sedvall G., and Astrom G. Dexamethasone suppression test in schizophrenic patients before and during neuroleptic treatment. Acta Psychiatr. Scand. 74 2 (1986) 161-167
116. Williams L.M., Harris A.W.F., Liddell B.B., Olivieri G., Phillips M.L., Peduto A., and Gordon E. Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. Am. J. Psychiatry 161 3 (2004) 480-489
117. Williams H.J., Owen M.J., and O'Donovan M.C. Is COMT a susceptibility gene for schizophrenia?. Schizophr. Bull. 33 3 (2007) 635-641
118. Yamamoto K., and Hornykiewich O. Proposal for a noradrenaline hypothesis of schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 28 5 (2004) 913-922
119. Yuii K., Suzuki M., and Kurachi M. Stress sensitization in schizophrenia. Ann. NY Acad. Sci. 1113 (2007) 276-290
120. Zahn T.P. Autonomic nervous system markers of psychopathology in childhood-onset schizophrenia. Arch. Gen. Psychiatry 54 10 (1997) 904-912