메뉴 건너뛰기




Volumn 1226, Issue , 2008, Pages 61-69

Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: An immunohistochemical study

Author keywords

Astrocyte; Astrocyte neuron lactate shuttle; Energy metabolism; Lactate; Neuron; Postsynaptic density

Indexed keywords

KETONE BODY; LACTIC ACID; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 2; PYRUVIC ACID;

EID: 49049086050     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.06.025     Document Type: Article
Times cited : (27)

References (38)
  • 2
    • 28044442099 scopus 로고    scopus 로고
    • Brain lactate kinetics: modeling evidence for neuronal lactate uptake upon activation
    • Aubert A., Costalat R., Magistretti P.J., and Pellerin L. Brain lactate kinetics: modeling evidence for neuronal lactate uptake upon activation. Proc. Natl. Acad. Sci. U S A 102 (2005) 16448-16453
    • (2005) Proc. Natl. Acad. Sci. U S A , vol.102 , pp. 16448-16453
    • Aubert, A.1    Costalat, R.2    Magistretti, P.J.3    Pellerin, L.4
  • 3
    • 34247185200 scopus 로고    scopus 로고
    • A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism
    • Aubert A., Pellerin L., Magistretti P.J., and Costalat R. A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism. Proc. Natl. Acad. Sci. USA 104 (2007) 4188-4193
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 4188-4193
    • Aubert, A.1    Pellerin, L.2    Magistretti, P.J.3    Costalat, R.4
  • 4
    • 0035114149 scopus 로고    scopus 로고
    • A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is co-localized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses
    • Bergersen L., Waerhaug O., Helm J., Thomas M., Laake P., Davies A.J., Wilson M.C., Halestrap A.P., and Ottersen O.P. A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is co-localized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses. Exp. Brain Res. 136 (2001) 523-534
    • (2001) Exp. Brain Res. , vol.136 , pp. 523-534
    • Bergersen, L.1    Waerhaug, O.2    Helm, J.3    Thomas, M.4    Laake, P.5    Davies, A.J.6    Wilson, M.C.7    Halestrap, A.P.8    Ottersen, O.P.9
  • 5
    • 0036130456 scopus 로고    scopus 로고
    • Immunogold cytochemistry identifies specialized membrane domains for monocarboxylate transport in the central nervous system
    • Bergersen L., Rafiki A., and Ottersen O.P. Immunogold cytochemistry identifies specialized membrane domains for monocarboxylate transport in the central nervous system. Neurochem. Res. 27 (2002) 89-96
    • (2002) Neurochem. Res. , vol.27 , pp. 89-96
    • Bergersen, L.1    Rafiki, A.2    Ottersen, O.P.3
  • 6
    • 15244358180 scopus 로고    scopus 로고
    • Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking
    • Bergersen L.H., Magistretti P.J., and Pellerin L. Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking. Cereb. Cortex 15 (2005) 361-370
    • (2005) Cereb. Cortex , vol.15 , pp. 361-370
    • Bergersen, L.H.1    Magistretti, P.J.2    Pellerin, L.3
  • 7
    • 0030774069 scopus 로고    scopus 로고
    • Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons
    • Bröer S., Rahman B., Pellegri G., Pellerin L., Martin J.L., Verleysdonk S., Hamprecht B., and Magistretti P.J. Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons. J. Biol. Chem. 272 (1997) 30096-30102
    • (1997) J. Biol. Chem. , vol.272 , pp. 30096-30102
    • Bröer, S.1    Rahman, B.2    Pellegri, G.3    Pellerin, L.4    Martin, J.L.5    Verleysdonk, S.6    Hamprecht, B.7    Magistretti, P.J.8
  • 8
    • 0039351371 scopus 로고    scopus 로고
    • Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes
    • Bröer S., Bröer A., Schneider H.P., Stegen C., Halestrap A.P., and Deitmer J.W. Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem. J. 31 (1999) 529-535
    • (1999) Biochem. J. , vol.31 , pp. 529-535
    • Bröer, S.1    Bröer, A.2    Schneider, H.P.3    Stegen, C.4    Halestrap, A.P.5    Deitmer, J.W.6
  • 9
    • 34347242128 scopus 로고    scopus 로고
    • Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway
    • Chenal J., and Pellerin L. Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway. J. Neurochem. 102 (2007) 389-397
    • (2007) J. Neurochem. , vol.102 , pp. 389-397
    • Chenal, J.1    Pellerin, L.2
  • 10
    • 37749021939 scopus 로고    scopus 로고
    • Insulin and IGF-1 enhance the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin pathway
    • Chenal J., Pierre K., and Pellerin L. Insulin and IGF-1 enhance the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin pathway. Eur. J. Neurosci. 27 (2008) 53-65
    • (2008) Eur. J. Neurosci. , vol.27 , pp. 53-65
    • Chenal, J.1    Pierre, K.2    Pellerin, L.3
  • 12
    • 0842322960 scopus 로고    scopus 로고
    • A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain
    • Dalsgaard M.K., Quistorff B., Danielsen E.R., Selmer C., Vogelsang T., and Secher N.H. A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain. J. Physiol. 15 (2004) 571-578
    • (2004) J. Physiol. , vol.15 , pp. 571-578
    • Dalsgaard, M.K.1    Quistorff, B.2    Danielsen, E.R.3    Selmer, C.4    Vogelsang, T.5    Secher, N.H.6
  • 13
    • 33745726895 scopus 로고    scopus 로고
    • Fuelling cerebral activity in exercising man
    • Dalsgaard M.K. Fuelling cerebral activity in exercising man. J. Cereb. Blood Flow Metab. 26 (2006) 731-750
    • (2006) J. Cereb. Blood Flow Metab. , vol.26 , pp. 731-750
    • Dalsgaard, M.K.1
  • 14
    • 0037963512 scopus 로고    scopus 로고
    • Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures
    • Debernardi R., Pierre K., Lengacher S., Magistretti P.J., and Pellerin L. Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures. J. Neurosci. Res. 73 (2003) 141-155
    • (2003) J. Neurosci. Res. , vol.73 , pp. 141-155
    • Debernardi, R.1    Pierre, K.2    Lengacher, S.3    Magistretti, P.J.4    Pellerin, L.5
  • 15
    • 0742324436 scopus 로고    scopus 로고
    • Immunocytochemical expression of monocarboxylate transporters in the human visual cortex at midgestation
    • Fayol L., Baud O., Monier A., Pellerin L., Magistretti P.J., Evrard P., and Verney C. Immunocytochemical expression of monocarboxylate transporters in the human visual cortex at midgestation. Dev. Brain Res. 148 (2004) 69-76
    • (2004) Dev. Brain Res. , vol.148 , pp. 69-76
    • Fayol, L.1    Baud, O.2    Monier, A.3    Pellerin, L.4    Magistretti, P.J.5    Evrard, P.6    Verney, C.7
  • 16
    • 0036301412 scopus 로고    scopus 로고
    • Relative distribution of three major lactate transporters in frozen human tissues and their localization in unfixed skeletal muscle
    • Fishbein W.N., Merezhinskaya N., and Foellmer J.W. Relative distribution of three major lactate transporters in frozen human tissues and their localization in unfixed skeletal muscle. Muscle Nerve 26 (2002) 101-112
    • (2002) Muscle Nerve , vol.26 , pp. 101-112
    • Fishbein, W.N.1    Merezhinskaya, N.2    Foellmer, J.W.3
  • 18
    • 0030837750 scopus 로고    scopus 로고
    • Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats
    • Gerhart D.Z., Enerson B.E., Zhdankina O.Y., Leino R.L., and Drewes L.R. Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats. Am. J. Physiol. 273 (1997) E207-E213
    • (1997) Am. J. Physiol. , vol.273
    • Gerhart, D.Z.1    Enerson, B.E.2    Zhdankina, O.Y.3    Leino, R.L.4    Drewes, L.R.5
  • 19
    • 1242340302 scopus 로고    scopus 로고
    • The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
    • Halestrap A.P., and Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 447 (2004) 619-628
    • (2004) Pflugers Arch. , vol.447 , pp. 619-628
    • Halestrap, A.P.1    Meredith, D.2
  • 20
    • 0034041755 scopus 로고    scopus 로고
    • Monocarboxylic acid transporters, MCT1 and MCT2, in cortical astrocytes in vitro and in vivo
    • Hanu R., McKenna M., O'Neill A., Resneck W.G., and Bloch R.J. Monocarboxylic acid transporters, MCT1 and MCT2, in cortical astrocytes in vitro and in vivo. Am. J. Physiol. 278 (2000) C921-C930
    • (2000) Am. J. Physiol. , vol.278
    • Hanu, R.1    McKenna, M.2    O'Neill, A.3    Resneck, W.G.4    Bloch, R.J.5
  • 21
    • 0030909127 scopus 로고    scopus 로고
    • Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation
    • Jackson V.N., Price N.T., Carpenter L., and Halestrap A.P. Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation. Biochem. J. 324 (1997) 447-453
    • (1997) Biochem. J. , vol.324 , pp. 447-453
    • Jackson, V.N.1    Price, N.T.2    Carpenter, L.3    Halestrap, A.P.4
  • 23
    • 0032582702 scopus 로고    scopus 로고
    • Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter
    • Lin R.Y., Vera J.C., Chaganti R.S., and Golde D.W. Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J. Biol. Chem. 273 (1998) 28959-28965
    • (1998) J. Biol. Chem. , vol.273 , pp. 28959-28965
    • Lin, R.Y.1    Vera, J.C.2    Chaganti, R.S.3    Golde, D.W.4
  • 25
    • 0032584084 scopus 로고    scopus 로고
    • Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain
    • Pellerin L., Pellegri G., Martin J.L., and Magistretti P.J. Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 3990-3995
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 3990-3995
    • Pellerin, L.1    Pellegri, G.2    Martin, J.L.3    Magistretti, P.J.4
  • 26
    • 12244262261 scopus 로고    scopus 로고
    • Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain
    • Pellerin L., Bergersen L.H., Halestrap A.P., and Pierre K. Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain. J. Neurosci. Res. 79 (2005) 55-64
    • (2005) J. Neurosci. Res. , vol.79 , pp. 55-64
    • Pellerin, L.1    Bergersen, L.H.2    Halestrap, A.P.3    Pierre, K.4
  • 28
    • 0034721575 scopus 로고    scopus 로고
    • Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy
    • Pierre K., Pellerin L., Debernardi R., Riederer B.M., and Magistretti P.J. Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy. Neuroscience 100 (2000) 617-627
    • (2000) Neuroscience , vol.100 , pp. 617-627
    • Pierre, K.1    Pellerin, L.2    Debernardi, R.3    Riederer, B.M.4    Magistretti, P.J.5
  • 29
    • 0036254152 scopus 로고    scopus 로고
    • MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain
    • Pierre K., Magistretti P.J., and Pellerin L. MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain. J. Cereb. Blood Flow Metab. 22 (2002) 586-595
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 586-595
    • Pierre, K.1    Magistretti, P.J.2    Pellerin, L.3
  • 30
    • 0141655180 scopus 로고    scopus 로고
    • Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulation
    • Pierre K., Debernardi R., Magistretti P.J., and Pellerin L. Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulation. J. Neurochem. 86 (2003) 1468-1476
    • (2003) J. Neurochem. , vol.86 , pp. 1468-1476
    • Pierre, K.1    Debernardi, R.2    Magistretti, P.J.3    Pellerin, L.4
  • 31
    • 21344444566 scopus 로고    scopus 로고
    • Monocarboxylate transporters in the central nervous system: distribution, regulation and function
    • Pierre K., and Pellerin L. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J. Neurochem. 94 (2005) 1-14
    • (2005) J. Neurochem. , vol.94 , pp. 1-14
    • Pierre, K.1    Pellerin, L.2
  • 32
    • 0032518981 scopus 로고    scopus 로고
    • Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past
    • Price N.T., Jackson V.N., and Halestrap A.P. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem. J. 329 (1998) 321-328
    • (1998) Biochem. J. , vol.329 , pp. 321-328
    • Price, N.T.1    Jackson, V.N.2    Halestrap, A.P.3
  • 34
    • 0242485280 scopus 로고    scopus 로고
    • Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain
    • Rafiki A., Bouland J.L., Halestrap A.P., Ottersen O.P., and Bergersen L. Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain. Neuroscience 122 (2003) 677-688
    • (2003) Neuroscience , vol.122 , pp. 677-688
    • Rafiki, A.1    Bouland, J.L.2    Halestrap, A.P.3    Ottersen, O.P.4    Bergersen, L.5
  • 35
    • 0031279854 scopus 로고    scopus 로고
    • Cytochrome oxidase, acetylcholinesterase, and NADPH-diaphorase staining in human supratemporal and insular cortex: evidence for multiple auditory areas
    • Rivier F., and Clarke S. Cytochrome oxidase, acetylcholinesterase, and NADPH-diaphorase staining in human supratemporal and insular cortex: evidence for multiple auditory areas. Neuroimage 6 (1997) 288-304
    • (1997) Neuroimage , vol.6 , pp. 288-304
    • Rivier, F.1    Clarke, S.2
  • 37
    • 27244442141 scopus 로고    scopus 로고
    • Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity
    • Tekkök S.B., Brown A.M., Westenbroek R., Pellerin L., and Ransom B.R. Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity. J. Neurosci. Res. 81 (2005) 644-652
    • (2005) J. Neurosci. Res. , vol.81 , pp. 644-652
    • Tekkök, S.B.1    Brown, A.M.2    Westenbroek, R.3    Pellerin, L.4    Ransom, B.R.5
  • 38
    • 37449028557 scopus 로고    scopus 로고
    • Alternative promoter usage and alternative splicing contribute to mRNA heterogeneity of mouse monocarboxylate transporter 2
    • Zhang S.X.L., Searcy T.R., Wu Y., Gozal D., and Wang Y. Alternative promoter usage and alternative splicing contribute to mRNA heterogeneity of mouse monocarboxylate transporter 2. Physiol. Genomics 32 (2007) 95-104
    • (2007) Physiol. Genomics , vol.32 , pp. 95-104
    • Zhang, S.X.L.1    Searcy, T.R.2    Wu, Y.3    Gozal, D.4    Wang, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.