Synthesis and evaluation of 5′-modified 2′-deoxyadenosine analogues as anti-hepatitis C virus agents

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4638-4641

  Ikejiri, Masahiro ^a,b   Ohshima, Takayuki ^a   Fukushima, Akemi ^a   Shimotohno, Kunitada ^c   Maruyama, Tokumi ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b OSAKA OHTANI UNIVERSITY   (Japan)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antiviral agent; HCV; Hepatitis C virus; Nucleoside

Indexed keywords

DEOXYADENOSINE DERIVATIVE;

ACYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG SYNTHESIS; HEPATITIS C; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

ANTIVIRAL AGENTS; CHEMISTRY, PHARMACEUTICAL; DEOXYADENOSINES; DNA, VIRAL; DRUG DESIGN; HEPACIVIRUS; HEPATITIS C; HUMANS; MODELS, CHEMICAL; NUCLEOSIDES; PHOSPHORYLATION; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 48849117297     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.015     Document Type: Article

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