A sequential tetra-n-propylammonium perruthenate (TPAP)-Wittig oxidation olefination protocol

Tetrahedron Letters

Volumn 44, Issue 42, 2003, Pages 7779-7781

  MacCoss, Rachel N ^a   Balskus, Emily P ^a   Ley, Steven V ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DERIVATIVE; AMMONIUM DERIVATIVE; OXIDIZING AGENT; PHOSPHONIUM DERIVATIVE; PHOSPHORANE DERIVATIVE; TETRAPROPYLAMMONIUM PERRUTHENATE; UNCLASSIFIED DRUG;

ALCOHOL OXIDATION; ARTICLE; EPIMERIZATION; HORNER REACTION; ISOMER; THIN LAYER CHROMATOGRAPHY;

EID: 0141459179     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.08.081     Document Type: Article

References (10)

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7. Ley S.V., Norman J., Griffith W.P., Marsden S.P. Synthesis. 1994;639-666.
8. 4, filtered, and concentrated in vacuo. The oil was then eluted through a Bond Elut cartridge (20 g, 60 ml) with hexanes (50 ml) and fractions collected and dried in vacuo to give the desired product.
9. nBuLi (3.6 equiv.) to keep its bright yellow colour.
10. 4, filtered, and concentrated in vacuo to give the crude product mixture. The alkene was purified by flash chromatography on silica gel (5% ethyl acetate/hexanes).