5′-O-Masked 2′-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 22, 2007, Pages 6882-6892

  Ikejiri, Masahiro ^a   Ohshima, Takayuki ^a   Kato, Keizo ^a   Toyama, Masaaki ^a   Murata, Takayuki ^b   Shimotohno, Kunitada ^b   Maruyama, Tokumi ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Antiviral agent; HCV; Hepatitis C virus; Nucleoside

Indexed keywords

5' O BENZOYL 2' DEOXY 6 METHYL 6 THIOINOSINE; 6 CHLORO 9 (5 O 4 METHOXYBENZOYL BETA DEXTRO 2 DEOXYRIBOFURANOSYL)PURINE; 6 CHLORO 9 (5 O PIVALOYL BETA DEXTRO 2 DEOXYRIBOFURANOSYL)PURINE; 9 (5 O BENZENESULFONYL BETA DEXTRO 2 DEOXYRIBOFURANOSYL) 6 CHLOROPURINE; 9 (5 O BENZOYL BETA DEXTRO 2 DEOXYRIBOFURANOSYL) 6 CHLOROPURINE; 9 (5 O BENZOYL BETA DEXTRO 3 DEOXYRIBOFURANOSYL) 6 CHLOROPURINE; 9 (5 O BENZYL BETA DEXTRO 2 DEOXYRIBOFURANOSYL) 6 CHLOROPURINE; 9 (5 O BUTYRYL BETA DEXTRO 2 DEOXYRIBOFURANOSYL) 6 CHLOROPURINE; ANTIVIRUS AGENT; HYDROXYL GROUP; NUCLEOSIDE DERIVATIVE; RIBAVIRIN; UNCLASSIFIED DRUG; 2'-DEOXYADENOSINE; DEOXYADENOSINE; DEOXYADENOSINE DERIVATIVE; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; REPLICON; SARS CORONAVIRUS; CELL LINE; CELL PROLIFERATION; CHEMISTRY; CONFORMATION; DRUG EFFECT; MICROBIOLOGICAL EXAMINATION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VIRUS REPLICATION;

HEPATITIS C VIRUS; SARS CORONAVIRUS;

ANTIVIRAL AGENTS; CELL LINE; CELL PROLIFERATION; DEOXYADENOSINES; HEPACIVIRUS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; RNA, VIRAL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 34748890056     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.025     Document Type: Article

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