Chlorophyllin suppresses interleukin-1 beta expression in lipopolysaccharide-activated RAW 264.7 cells

International Immunopharmacology

Volumn 6, Issue 2, 2006, Pages 252-259

  Yun, Cheol Heui ^a   Jeon, Young Jin ^b   Yang, Young ^c   Ju, Hyang Ran ^d   Han, Seung Hyun ^a  

^a International Vaccine Institute   (South Korea)

^b Chosun University   (South Korea)

^c Sookmyung Women's University   (South Korea)

^d Korea Tourism College   (South Korea)

Author keywords

Chlorophyllin; Immunosuppression; Interleukin 1; Lipopolysaccharide; Macrophages

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BACTERIUM LIPOPOLYSACCHARIDE; CCAAT ENHANCER BINDING PROTEIN DELTA; CHLOROPHYLL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENETIC TRANSFECTION; IMMUNOBLOTTING; IN VITRO STUDY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; TRANSCRIPTION REGULATION;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CHLOROPHYLLIDES; DEPRESSION, CHEMICAL; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; INDICATORS AND REAGENTS; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 30144432343     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2005.08.012     Document Type: Article

References (34)

1. T. Kielian, E.D. Bearden, A.C. Baldwin, and N. Esen IL-1 and TNF-alpha play a pivotal role in the host immune response in a mouse model of Staphylococcus aureus-induced experimental brain abscess J Neuropathol Exp Neurol 63 2004 381 396
2. P.J. Morrissey, and K. Charrier Treatment of mice with IL-1 before infection increases resistance to a lethal challenge with Salmonella typhimurium. The effect correlates with the resistance allele at the Ity locus J Immunol 153 1994 212 219
3. L.A. O'Neill, and C. Greene Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants J Leukoc Biol 63 1998 650 657
4. B. Rossi IL-1 transduction signals Eur Cytokine Netw 4 1993 181 187
5. N. Maas-Szabowski, H.J. Stark, and N.E. Fusenig Keratinocyte growth regulation in defined organotypic cultures through IL-1-induced keratinocyte growth factor expression in resting fibroblasts J Invest Dermatol 114 2000 1075 1084
6. A. Werman, R. Werman-Venkert, R. White, J.K. Lee, B. Werman, and Y. Krelin The precursor form of IL-1 alpha is an intracrine proinflammatory activator of transcription Proc Natl Acad Sci U S A 101 2004 2434 2439
7. J.G. Gray, G. Chandra, W.C. Clay, S.W. Stinnett, S.A. Haneline, and J.J. Lorenz A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines Mol Cell Biol 13 1993 6678 6689
8. E. Serkkola, and M. Hurme Synergism between protein-kinase C and CAMP-dependent pathways in the expression of the interleukin-1 beta gene is mediated via the activator-protein-1 (AP-1) enhancer activity Eur J Biochem 213 1993 243 249
9. J.P. Cogswell, M.M. Godlevski, G.B. Wisely, W.C. Clay, L.M. Leesnitzer, and J.P. Ways NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site J Immunol 153 1994 712 723
10. S.A. Godambe, D.D. Chaplin, T. Takova, and C.J. Bellone Upstream NFIL-6-like site located within a DNase I hypersensitivity region mediates LPS-induced transcription of the murine interleukin-1 beta gene J Immunol 153 1994 143 152
11. E. Abraham NF-kappaB activation Crit Care Med 28 4 Suppl 2000 N100 N104
12. A.M. Mercado, N. Quan, D.A. Padgett, J.F. Sheridan, and P.T. Marucha Restraint stress alters the expression of interleukin-1 and keratinocyte growth factor at the wound site: an in situ hybridization study J Neuroimmunol 129 2002 74 83
13. S.S. Kumar, B. Shankar, and K.B. Sainis Effect of chlorophyllin against oxidative stress in splenic lymphocytes in vitro and in vivo Biochim Biophys Acta 1672 2004 100 111
14. R.H. Dashwood The importance of using pure chemicals in (anti) mutagenicity studies: chlorophyllin as a case in point Mutat Res 381 1997 283 286
15. S. Arimoto, S. Fukuoka, C. Itome, H. Nakano, H. Rai, and H. Hayatsu Binding of polycyclic planar mutagens to chlorophyllin resulting in inhibition of the mutagenic activity Mutat Res 287 1993 293 305
16. C.H. Yun, H.G. Jeong, J.W. Jhoun, and F.P. Guengerich Non-specific inhibition of cytochrome P450 activities by chlorophyllin in human and rat liver microsomes Carcinogenesis 16 1995 1437 1440
17. T. Negishi, S. Arimoto, C. Nishizaki, and H. Hayatsu Inhibitory effect of chlorophyll on the genotoxicity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) Carcinogenesis 10 1989 145 149
18. S. Arimoto, T. Negishi, and H. Hayatsu Inhibitory effect of hemin on the mutagenic activities of carcinogens Cancer Lett 11 1980 29 33
19. Y. Katoh, N. Nemoto, M. Tanaka, and S. Takayama Inhibition of benzo[a]pyrene-induced mutagenesis in Chinese hamster V79 cells by hemin and related compounds Mutat Res 121 1983 153 157
20. T.W. Kensler, P.A. Egner, J.B. Wang, Y.R. Zhu, B.C. Zhang, and P.X. Lu Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas Gastroenterology 127 5 Suppl 1 2004 S310 S318
21. R.H. Dashwood, V. Breinholt, and G.S. Bailey Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay Carcinogenesis 12 1991 939 942
22. K.J. Cho, S.H. Han, B.Y. Kim, S.G. Hwang, K.K. Park, and K.H. Yang Chlorophyllin suppression of lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells Toxicol Appl Pharmacol 166 2000 120 127
23. Y.J. Jeon, S.H. Han, Y.W. Lee, M. Lee, K.H. Yang, and H.M. Kim Dexamethasone inhibits IL-1 beta gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activation Immunopharmacology 48 2000 173 183
24. S.H. Han, S.S. Yea, Y.J. Jeon, K.H. Yang, and N.E. Kaminski Transforming growth factor-beta 1 (TGF-beta1) promotes IL-2 mRNA expression through the up-regulation of NF-kappaB, AP-1 and NF-AT in EL4 cells J Pharmacol Exp Ther 287 1998 1105 1112
25. C.M. Gorman, L.F. Moffat, and B.H. Howard Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells Mol Cell Biol 2 1982 1044 1051
26. S.H. Han, Y.J. Jeon, S.S. Yea, and K.H. Yang Suppression of the interleukin-2 gene expression by aflatoxin B1 is mediated through the down-regulation of the NF-AT and AP-1 transcription factors Toxicol Lett 108 1999 1 10
27. C.C. Chen, and J.K. Wang p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages Mol Pharmacol 55 1999 481 488
28. S.W. Lee, A.P. Tsou, H. Chan, J. Thomas, K. Petrie, and E.M. Eugui Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA Proc Natl Acad Sci U S A 85 1988 1204 1208
29. J.A. Kern, R.J. Lamb, J.C. Reed, R.P. Daniele, and P.C. Nowell Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms J Clin Invest 81 1988 237 244
30. B. Schmeck, J. Zahlten, K. Moog, V. van Laak, S. Huber, and A.C. Hocke Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor J Biol Chem 279 2004 53241 53247
31. R. Korhonen, R. Korpela, and E. Moilanen Signalling mechanisms involved in the induction of inducible nitric oxide synthase by Lactobacillus rhamnosus GG, endotoxin, and lipoteichoic acid Inflammation 26 2002 207 214
32. A.R. Nebreda, and A. Porras p38 MAP kinases: beyond the stress response Trends Biochem Sci 25 2000 257 260
33. T. Zarubin, and J. Han Activation and signaling of the p38 MAP kinase pathway Cell Res 15 2005 11 18
34. J. Macdonald, H.F. Galley, and N.R. Webster Oxidative stress and gene expression in sepsis Br J Anaesth 90 2003 221 232