Cytokine combinations differentially influence the SDF-1α-dependent migratory activity of cultivated murine hematopoietic stem and progenitor cells

Biological Chemistry

Volumn 389, Issue 7, 2008, Pages 863-872

  Kassmer, Susannah H ^a   Niggemann, Bernd ^a   Punzel, Michael ^b   Mieck, Christine ^a   Zänker, Kurt S ^a   Dittmar, Thomas ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

Cell motility; Collagen matrix; CXCR4; Hematopoietic stem progenitor cells; Signal transduction; Stromal cell derived factor 1

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; COLLAGEN; CYTOKINE; INTERLEUKIN 11; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; STROMAL CELL DERIVED FACTOR 1ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CULTURE; CELL DIFFERENTIATION; CELL MIGRATION; CELL STIMULATION; CYTOKINE PRODUCTION; FEMALE; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TIME LAPSE VIDEO MICROSCOPY;

ANIMALS; CATTLE; CELL MOVEMENT; CHEMOKINE CXCL12; CULTURE MEDIA; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; HEMATOPOIESIS; HUMANS; INTRACELLULAR SPACE; MICE; MICE, INBRED C57BL; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; STEM CELLS;

MURINAE;

EID: 48749130865     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2008.099     Document Type: Article

References (30)

1. Albella, B., Segovia, J.C., Guenechea, G., Pragnell, I.B., and Bueren, J.A. (1999). Preserved long-term repopulation and differentiation properties of hematopoietic grafts subjected to ex vivo expansion with stem cell factor and interleukin 11. Transplantation 67, 1348-1357.
2. Audet, J., Miller, C.L., Eaves, C.J., and Piret, J.M. (2002). Common and distinct features of cytokine effects on hematopoietic stem and progenitor cells revealed by dose-response surface analysis. Biotechnol. Bioeng. 80, 393-404.
3. Breems, D.A., Blokland, E.A., Neben, S., and Ploemacher, R.E. (1994). Frequency analysis of human primitive haematopoietic stem cell subsets using a cobblestone area forming cell assay. Leukemia 8, 1095-1104.
4. Dittmar, T., Husemann, A., Schewe, Y., Nofer, J.R., Niggemann, B., Zanker, K.S., and Brandt, B.H. (2002). Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR. FASEB J. 16, 1823-1825.
5. Ema, H., Takano, H., Sudo, K., and Nakauchi, H. (2000). In vitro self-renewal division of hematopoietic stem cells. J. Exp. Med. 192, 1281-1288.
6. Fukuda, S., Broxmeyer, H.E., and Pelus, L.M. (2005). Flt3 ligand and the Flt3 receptor regulate hematopoietic cell migration by modulating the SDF-1a (CXCL12)/CXCR4 axis. Blood 105, 3117-3126.
7. Ganju, R.K., Brubaker, S.A., Meyer, J., Dutt, P., Yang, Y., Qin, S., Newman, W., and Groopman, J.E. (1998). The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J. Biol. Chem. 273, 23169-23175.
8. 2+ flux measurement on isolated human B cells that uses flow cytometry. Clin. Diagn. Lab. Immunol. 4, 70-74.
9. Giebel, B., Corbeil, D., Beckmann, J., Hoehn, J., Freund, D., Giesen, K., Fischer, J., Koegler, G., and Wernet, P. (2004). Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells. Blood 104, 2332-2338.
10. Heyder, C., Gloria-Maercker, E., Hatzmann, W., Niggemann, B., Zanker, K.S., and Dittmar, T. (2005). Role of the β1-integrin subunit in the adhesion, extravasation and migration of T24 human bladder carcinoma cells. Clin. Exp. Metastasis 22, 99-106.
11. Imai, K., Kobayashi, M., Wang, J., Shinobu, N., Yoshida, H., Hamada, J., Shindo, M., Higashino, F., Tanaka, J., Asaka, M., and Hosokawa, M. (1999). Selective secretion of chemoattractants for haemopoietic progenitor cells by bone marrow endothelial cells: a possible role in homing of haemopoietic progenitor cells to bone marrow. Br. J. Haematol. 106, 905-911.
12. Iscove, N.N. and Nawa, K. (1997). Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion. Curr. Biol. 7, 805-808.
13. + stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice. Blood 97, 3283-3291.
14. - sorted cells harbor intracellular CXCR4, which can be functionally expressed and provide NOD/SCID repopulation. Blood 100, 2778-2786.
15. Lapidot, T. and Kollet, O. (2002). The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice. Leukemia 16, 1992-2003.
16. - progenitors give rise to natural killer cells, B-lineage cells, dendritic cells, and myeloid cells. Blood 93, 96-106.
17. Moore, K.A., Ema, H., and Lemischka, I.R. (1997). In vitro maintenance of highly purified, transplantable hematopoietic stem cells. Blood 89, 4337-4347.
18. Morrison, S.J., Uchida, N., and Weissman, I.L. (1995). The biology of hematopoietic stem cells. Annu. Rev. Cell. Dev. Biol. 11, 35-71.
19. Peled, A., Petit, I., Kollet, O., Magid, M., Ponomaryov, T., Byk, T., Nagler, A., Ben-Hur, H., Many, A., Shultz, L., et al. (1999). Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283, 845-848.
20. + cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood 95, 3289-3296.
21. + progenitor cells. J. Clin. Invest. 115, 168-176.
22. + cord blood cells after ex vivo expansion: evidence for the amplification and self-renewal of repopulating stem cells. Blood 93, 3736-3749.
23. Punzel, M., Wissink, S.D., Miller, J.S., Moore, K.A., Lemischka, I.R., and Verfaillie, C.M. (1999). The myeloid-lymphoid initiating cell (ML-IC) assay assesses the fate of multipotent human progenitors in vitro. Blood 93, 3750-3756.
24. - bone marrow long-term culture-initiating cells (LTC-IC), extended LTC-IC, and murine in vivo long-term reconstituting stem cells. Blood 94, 4093-4102.
25. Rosu-Myles, M., Gallacher, L., Murdoch, B., Hess, D.A., Keeney, M., Kelvin, D., Dale, L., Ferguson, S.S., Wu, D., Fellows, F., and Bhatia, M. (2000). The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression. Proc. Natl. Acad. Sci. USA 97, 14626-14631.
26. Sanchez-Madrid, F. and del Pozo, M.A. (1999). Leukocyte polarization in cell migration and immune interactions. EMBO J. 18, 501-511.
27. Seidel, J., Niggemann, B., Punzel, M., Fischer, J., Zänker, K.S., and Dittmar, T. (2007a). The neurotransmitter γ-aminobutyric-acid (GABA) is a potent inhibitor of the stromal cell-derived factor-1. Stem Cells Dev. 16, 827-836.
28. Wang, J.F., Park, I.W., and Groopman, J.E. (2000). Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C. Blood 95, 2505-2513.
29. Weidt, C., Niggemann, B., Hatzmann, W., Zanker, K.S., and Dittmar, T. (2004). Differential effects of culture conditions on the migration pattern of stromal cell-derived factor-stimulated hematopoietic stem cells. Stem Cells 22, 890-896.
30. Weidt, C., Niggemann, B., Kasenda, B., Drell, T.L., Zänker, K.S., and Dittmar, T. (2007). Stem cell migration: a quintessential stepping stone to successful therapy. Curr. Stem Cell Res. Treat. 2, 89-103.