Pseudohyphal differentiation defect due to mutations in GPCR and ammonium signaling is suppressed by low glucose concentration: A possible integrated role for carbon and nitrogen limitation

Current Genetics

Volumn 54, Issue 2, 2008, Pages 71-81

  Iyer, Revathi S ^a   Das, Maitreyi ^b   Bhat, Paike Jayadeva ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Glucose; GPCR; MEP2; Pseudohyphae; Rapamycin; Yeast

Indexed keywords

AMMONIA; CARBON; G PROTEIN COUPLED RECEPTOR; GLUCORECEPTOR; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN; NITROGEN; PROTEIN GPA2; PROTEIN GPR1; PROTEIN MEP2; TREHALOSE;

CONCENTRATION RESPONSE; CONTROLLED STUDY; DIPLOIDY; FUNGAL METABOLISM; FUNGUS HYPHAE; FUNGUS MUTANT; FUNGUS PSEUDOHYPHAE; GENE MUTATION; NONHUMAN; NUTRIENT LIMITATION; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SPOROGENESIS; STRAIN DIFFERENCE; TISSUE DIFFERENTIATION; WILD TYPE;

CARBON; CELL DIFFERENTIATION; GLUCOSE; HYPHAE; MODELS, BIOLOGICAL; MUTATION; NITROGEN; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, G-PROTEIN-COUPLED; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 48749130372     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00294-008-0202-1     Document Type: Review

References (46)

1. Adams BG (1972) Induction of galactokinase in Saccharomyces cerevisiae: kinetics of induction and glucose effects. J Bacteriol 111:308-315
2. Adams A, Gottschling DE, Kaiser CA, Stearns T (1997) Methods in yeast genetics. Cold Spring Harbor Laboratory, New York, pp 1-157
3. Beck T, Hall MN (1999) The TOR signaling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402:689-692
4. Betram PG, Choi JH, Carvalho J, Chan T, Ai W, Steven Zheng XF (2002) Convergence of TOR-nitrogen and Snf1-glucose signaling pathways onto Gln3. Mol Cell Biol 22:1246-1252
5. Boeckstaens M, Andre B, Marini AM (2007) The yeast ammonium transport protein Mep2 and its positive regulator, the Npr1 kinase, play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium. Mol Microbiol 64:534-546
6. Carlson M (1999) Glucose repression in yeast. Curr Opin Microbiol 2:202-207
7. Carlson M, Osmond BC, Neigeborn L, Botstein D (1984) A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis yeast. Genetics 107:19-32
8. Chen XJ, Clark-Walker GD (1999) The petite mutation in yeasts: 50 years on. Int Rev Cytol 194:197-237
9. Crespo JL, Hall MN (2002) Elucidating TOR signaling and rapamycin action: Lessons from Saccharomyces cerevisiae. Microbiol Mol Bio Rev 66:579-591
10. Cutler NS, Pan X, Heitman J, Cardenas M (2001) The TOR signal transduction cascade controls cellular differentiation in response to nutrients. Mol Biol Cell 12:4103-4113
11. Donzeau M, Bandlow W (1999) The yeast trimeric guanine nucleotide-binding protein α subunit, Gpa2p, controls the meiosis-specific kinase Ime2p activity in response to nutrients. Mol Cell Biol 19:6110-6119
12. Engebrecht J (2003) Cell signaling in yeast sporulation. BBRC 306:325-328
13. Erdman S, Snyder M (2001) A filamentous growth response mediated by the yeast mating pathway. Genetics 159:919-928
14. Gancedo JM (2001) Control of pseudohyphae formation in Saccharomyces cerevisiae. FEMS Microbiol Rev 25:107-123
15. Gasch AP (2003) The environmental stress response: A common yeast response to diverse environmental stress. In: Hohmann S, Mager WH (eds) Yeast stress response. Springer-Verlag, Berlin, pp 11-57
16. Gimeno CJ, Ljungdahl PO, Styles CA, Fink GR (1992) Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68:1077-1090
17. Gray JV, Petsko GA, Johnston GC, Ringe D, Singer RA, Werner-Wahsburne M (2004) "Sleeping beauty": Quiescence in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 68:187-206
18. Harashima T, Heitman J (2002) The Gα protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gβ subunits. Mol Cell 10:163-173
19. Hedbacker K, Townley R, Carlson M (2004) Cyclic AMP-dependent protein kinase regulates the subcellular localization of Snf1-Sip1 protien kinase. Mol Cell Biol 24:1836-1843
20. Holstege FC, Jennings EG, Wyrick JJ, Lee TI, Hengartner CJ, Green MR, Golub TR, Lander ES, Young RA (1998) Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95:717-728
21. Honigberg SM, Purnapatre K (2003) Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast. J Cell Sci 116:2137-2147
22. Kienle I, Burgert M, Holzer H (1993) Assay of trehalose with acid trehalase purified from Saccharomyces cerevisiae. Yeast 9:607-611
23. Kubler E, Mosch H, Rupp S, Lisanti MP (1997) Gpa2p, a G-protein α-subunit, regulates growth and pseudohyphal development in Saccharomyces cerevsiae via a cAMP-dependent mechanism. J Biol Chem 272:20321-20323
24. Kuchin S, Vyas VK, Carlson M (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth and diploid pseudohyphal growth. Mol Cell Biol 22:3994-4000
25. Lengeler KB, Davidson RC, D'Souza C, Harashima T, Shen W, Wang P, Pan X, Waugh M, Heitman J (2000) Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev 64:746-785
26. Lo W, Dranginis AM (1998) The cell surface flocculin Flo11 is required for pseudohyphae formation and invasion by Saccharomyces cerevisiae. Mol Biol Cell 9:161-171
27. Lorenz MC, Heitman J (1997) Yeast pseudohyphal growth is regulated by GPA2, a G protein α homolog. EMBO J 16:7008-7018
28. Lorenz MC, Heitman J (1998) The MEP2 ammonium permease regulates pseudohyphal differentiation Saccharomyces cerevisiae. EMBO J 17:1236-1247
29. Lorenz MC, Pan X, Harashima T, Cardenas ME, Xue Y, Hirsch JP, Heitman J (2000) The G protein-coupled receptor Gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Genetics 154:609-622
30. Lu A, Hirsch JP (2005) Cyclic AMP-independent regulation of protein kinase: A substrate phosphorylation by Kelch repeat homologues. Eukaryot Cell 4:1794-1800
31. Marini A, Soussi-Boudekou S, Vissers S, Andre B (1997) A family of ammonium transporters in Saccharomyces cerevisiae. Mol Cell Biol 17:4282-4283
32. Mosch H, Roberts RL, Fink G (1996) Ras2 signals via the Cdc42/Ste20/ mitogen-activated protein kinase module to induce filamenatous growth in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 93:5352-5356
33. Orlova M, Kanter E, Krakovich D, Kuchin S (2006) Nitrogen availability and TOR regulate the Snf1 protein kinase in Saccharomyces cerevisiae. Eukaryot Cell 5:1831-1837
34. Palecek SP, Parikh AS, Kron SJ (2002) Sensing, signaling and integrating physical processes during Saccharomyces cerevisiae invasive and filamentous growth. Microbiol 148:893-907
35. Pan X, Heitman J (2002) Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation. Mol Cell Biol 22:3981-3993
36. Peeters T, Louwet W, Gelade R, Nauwelaers D, Thevelein JM, Versele M (2006) Kelch-repeat proteins interacting with the G{alpha} protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci USA 103:13034-13039
37. Piskur J, Rozpedowska E, Polakava S, Merico A, Compagno A (2006) How did Saccharomyces cerevisiae become a good brewer? Trends Genet 22:183-187
38. Roberts RL, Fink GR (1994) Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: Mating and invasive growth. Genes Dev 8:2974-2985
39. Rupp S, Summers E, Lo HJ, Madhani H, Fink G (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J 18:1257-1269
40. Thevelein JM, Gelade R, Holsbeeks I, Legatie O, Popova Y, Rolland F, Stolz F, Van de Velde S, Van Dijck P et al (2005) Nutrient sensing systems for rapid activation of the protein kinase A pathway in yeast. Biochem Soc Trans 33:253-256
41. Thomas G, Hall MN (1997) TOR signaling and control of cell growth. Curr Opin Cell Biol 9:782-787
42. Van de Velde S, Thevelein JM (2008) cAMP-PKA and Snf1 signaling mechanisms underlie the superior potency of sucrose for induction of filamentation in yeast. Eukaryot Cell 7:286-293
43. van Nuland A, Vandormael P, Donaton M, Alenquer M, Lourenco A, Quintino E, Versele M, Thevelein JM (2006) Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase: A pathway in yeast. Mol Microbiol 59:1485-1505
44. Xie MW, Jin F, Hwang H, Hwang S, Anand V, Duncan MC, Huang J (2005) Insights into TOR function and rapamycin response: Chemical genomic profiling by using a high-density cell array method. Proc Natl Acad Sci USA 102:7215-7220
45. Xue Y, Batlle M, Hirsch JP (1998) GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2 Gα subunit and functions in a Ras-independent pathway. EMBO J 17:1996-2007
46. Zurita-Martinez SA, Cardenas ME (2005) Tor and cyclic AMP-Protein kinase A: Two parallel pathways regulating expression of genes required for cell growth. Eukaryot Cell 4:63-71