Leptin, soluble leptin receptor, lipid profiles, and LEPR gene polymorphisms in Thai children and adolescents

International Journal for Vitamin and Nutrition Research

Volumn 78, Issue 1, 2008, Pages 9-15

  Popruk, Supaluk ^a   Tungtrongchitr, Rungsunn ^a   Petmitr, Songsak ^a   Pongpaew, Praneet ^a   Harnroongroj, Talabporn ^a   Pooudong, Somchai ^a   Phonrat, Benjaluck ^a   Yamborisut, Uruwan ^a   Chongviriyaphan, Nalinee ^b   Tungtrongchitr, Anchalee ^c  

^a MAHIDOL UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Adolescents; Children; LEPR gene polymorphisms; Leptin; Lipid profiles; Soluble leptin receptor

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LEPTIN RECEPTOR; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ANTHROPOMETRY; ARTICLE; BODY MASS; CHILD; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DNA EXTRACTION; DNA POLYMORPHISM; FEMALE; GENE; GENOTYPE; HORMONE BLOOD LEVEL; HUMAN; HYPERLIPTENEMIA; LABORATORY TEST; LEPR GENE; LIPID ANALYSIS; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; NUTRITIONAL STATUS; OBESITY; RISK FACTOR; STATISTICAL SIGNIFICANCE; THAILAND; TRIACYLGLYCEROL BLOOD LEVEL; WAIST HIP RATIO;

ADOLESCENT; ADULT; BODY MASS INDEX; CHILD; CHILD, PRESCHOOL; CHOLESTEROL; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; HYPERLIPIDEMIAS; LEPTIN; LIPIDS; MALE; OBESITY; ODDS RATIO; OVERWEIGHT; POLYMORPHISM, GENETIC; RECEPTORS, LEPTIN; RISK FACTORS; SEX DISTRIBUTION; THAILAND;

EID: 48749130018     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831.78.1.9     Document Type: Article

References (18)

1. Ruangdaraganon, N., Kotchabhakdi, N., Udomsubpayakul, U., Kunanusont, C. and Suriyawongpaisal, P. (2002) The association between television viewing and childhood obesity: a national survey in Thailand. J. Med. Assoc. Thai. 85, S1075-S1080.
2. Maffeis, C. (2000) Aetiology of overweight and obesity in children and adolescents. Eur. J. Pediatr. 159, S35-S44.
3. Isse, N., Ogawa, Y., Tamura, N., Masuzaki, H., Mori, K., Okazaki, T. et al (1995) Structural organization and chromosomal assignment of the human obese gene. J. Biol. Chem. 270, 27728-27733.
4. Ahima, R. S. and Flier, J. S. (2000) Leptin. Annu. Rev. Physiol. 62, 413-437.
5. Bluher, S. and Mantzoros, C.S. (2004) The role of leptin in regulating neuroendocrine function in humans. J. Nutr. 134, S2469-S2474.
6. Chung, W. K., Power-Kehoe, L., Chua, M. and Leibel, R. L. (1996) Mapping of the OB receptor to lp in a region of non-conserved gene order from mouse and rat to human. Genome Res. 6, 431-438.
7. Bornstein, S. R., Abu-Asab, M., Glasow, A., Path, G., Hauner, H., Tsokos, M. et al (2000) Immunohistochemical and ultrastructural localization of leptin and leptin receptor in human white adipose tissue and differentiating human adipose cells in primary culture. Diabetes 49, 532-538.
8. Lammert, A., Kiess, W., Bottner, A., Glasow, A. and Kratzsch, J. (2001) Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem. Bio-phys. Res. Commun. 283, 982-988.
9. Kuczmarski, R. J., Ogden, C. L., Guo, S. S., Grummer-Strawn, L. M., Flegal, K. M., Mei, Z. et al (2002) CDC Growth Charts for the United States: methods and development. Vital Health Stat. 11. 246, 1-190.
10. Tungtrongchitr, R., Pongpaew, P., Phonrat, B., Tribunyatkul, S., Viroonudomphol, D., Supawan, V.etal (2001) Serum leptin and lipid profiles in Thai obese and overweight subjects. Int. J. Vitam. Nutr. Res. 71, 74-81.
11. Gotoda, T., Manning, B.S., Goldstone, A. P., Imrie, H., Evans, A. L., Strosberg, A. D. et al (1997) Leptin receptor gene variation and obesity: lack of association in a white British male population. Hum. Mol. Genet. 6, 869-876.
12. Ryan, T. A., Brian, L. B. and Ryan, B. F. (1985) Minitab student handbook. 2nd ed. PWS-Kent Publishing Company, Boston, MA.
13. Liuzzi, A., Savia, G., Tagliaferri, M., Lucantoni, R., Bersel-li, M. E., Petroni, M. L. et al (1999) Serum leptin concentration in moderate and severe obesity: relationship with clinical, anthropometric and metabolic factors. Int. J. Obes. Re-lat. Metab. Disord. 23, 1066-1073.
14. Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T .W., Nyce, M.R. et al. (1996) Serum im-munoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334, 292-295.
15. Ostlund, R. E, Jr., Yang, J. W., Klein, S. and Gingerich, R. (1996) Relation between plasma leptin concentration and body fat, gender, diet, age and metabolic covariates. J. Clin. Endocrinol. Metab. 81, 3909-3913.
16. Ogier, V., Ziegler, O., Mejean, L., Nicolas, J. P. and Strick-er-Krongrad, A. (2002) Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans. Int. J. Obes. Relat. Metab. Disord. 26, 496-503.
17. Caro, J. F., Kolaczynski, J. W., Nyce, M. R., Ohannesian, J. P., Opentanova, I., Goldman, W. H. et al (1996) Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348, 159-161.
18. Matsuoka, N., Ogawa, Y., Hosoda, K., Matsuda, J., Masuzaki, H., Miyawaki, T. et al (1997) Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity. Diabetologia 40, 1204-1210.