Decrease in intracellular glutathione level alters expressions of B-cell CLL/lymphoma 2 family members in the mouse retina

Journal of Health Science

Volumn 54, Issue 4, 2008, Pages 464-470

  Song, Hyoung Gon ^a   Moon, Cheil ^b   Park, Myoung Hee ^c   Moon, Jung Il ^c   Moon, Chanil ^d  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Kyungpook National University   (South Korea)

^c The Catholic University of Korea   (South Korea)

^d Gachon University   (South Korea)

Author keywords

B cell CLL lymphoma 2; Buthionine sulphoximine; Glutathione; Oxidative stress; Retina

Indexed keywords

BUTHIONINE SULFOXIMINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; RNA;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; GLAUCOMA; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RETINA DEGENERATION; RETINA MACULA AGE RELATED DEGENERATION; RETINOPATHY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA; MAMMALIA; MUS;

EID: 48749124646     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.54.464     Document Type: Article

References (42)

1. Janssen, Y. M., Van Houten, B., Borm, P. J. and Mossman, B. T. (1993) Cell and tissue responses to oxidative damage. Lab. Invest., 69, 261-274.
2. Halliwell, B. (1992) Reactive oxygen species and the central nervous system. J. Neurochem., 59, 1609-1623.
3. Dugan, L. L., Sensi, S. L., Canzoniero, L. M., Handran, S. D., Rothman, S. M., Lin, T. S., Goldberg, M. P. and Choi, D. W. (1995) Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J. Neurosci., 15, 6377-6388.
4. Mattson, M. P., Duan, W., Pedersen, W. A. and Culmsee, C. (2001) Neurodegenerative disorders and ischemic brain diseases. Apoptosis, 6, 69-81.
5. Knapp, L. T. and Klann, E. (2002) Role of reactive oxygen species in hippocampal long-term potentiation: contributory or inhibitory? J. Neurosci. Res., 70, 1-7.
6. Dringen, R. (2000a) Glutathione metabolism and oxidative stress in neurodegeneration. Eur. J. Biochem., 267, 4903.
7. Dringen, R. (2000b) Metabolism and functions of glutathione in brain. Prog. Neurobiol., 62, 649-671.
8. Hall, A. G. (1999) Review: The role of glutathione in the regulation of apoptosis. Eur. J. Clin. Invest., 29, 238-245.
9. Obrosova, I. G., Fathallah, L. and Greene, D. A. (2000) Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: effect of DL-alpha-lipoic acid. Eur. J. Pharmacol., 398, 139-146.
10. Moreno, M. C., Campanelli, J., Sande, P., Sanez, D. A., Keller Sarmiento, M. I. and Rosenstein, R. E. (2004) Retinal oxidative stress induced by high intraocular pressure. Free Radic. Biol. Med., 37, 803-812.
11. Tanito, M., Nishiyama, A., Tanaka, T., Masutani, H., Nakamura, H., Yodoi, J. and Ohira, A. (2002) Change of redox status and modulation by thiol replenishment in retinal photooxidative damage. Invest. Ophthalmol. Vis. Sci., 43, 2392-2400.
12. Kroemer, G., Dallaporta, B. and Resche-Rigon, M. (1998) The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol., 60, 619-642.
13. Cohen, G. M. (1997) Caspases: the executioners of apoptosis. Biochem. J., 326, 1-16.
14. Deveraux, Q. L. and Reed, J. C. (1999) IAP family proteins - suppressors of apoptosis. Genes Dev., 13, 239-252.
15. Hengartner, M. O. (2000) The biochemistry of apoptosis. Nature, 407, 770-776.
16. Mattson, M. P. (2000) Apoptosis in neurodegenerative disorders. Nat. Rev. Mol. Cell Biol., 1, 120-129.
17. Strasser, A., O'Connor, L. and Dixit, V. M. (2000) Apoptosis signaling. Annu. Rev. Biochem., 69, 217-245.
18. Liston, P., Fong, W. G. and Korneluk, R. G. (2003) The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene, 22, 8568-8580.
19. Thomadaki, H. and Scorilas, A. (2006) Bcl2 family of apoptosis-related genes: functions and clinical implications in cancer. Crit. Rev. Clin. Lab. Sci., 43, 1-67.
20. Shinoura, N., Yoshida, Y., Asai, A., Kirino, T. and Hamada, H. (1999) Relative level of expression of Bax and Bcl-XL determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax. Oncogene, 18, 5703-5713.
21. Gross, A., Jockel, J., Wei, M. C. and Korsmeyer, S. J. (1998) Enforced dimerization of Bax results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J., 17, 3878-3885.
22. Wang, H. G., Rapp, U. R. and Reed, J. C. (1996) Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell, 87, 629-638.
23. Datta, S. R., Ranger, A. M., Lin, M. Z., Sturgill, J. F., Ma, Y. C., Cowan, C. W., Dikkes, P., Korsmeyer, S. J. and Greenberg, M. E. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell, 3, 631-643.
24. Finucane, D. M., Bossy-Wetzel, E., Waterhouse, N. J., Cotter, T. G. and Green, D. R. (1999) Bax-induced caspase activation and apoptosis via cytochrome c release from mitochodria is inhibitable by Bcl-xL. J. Biol. Chem., 274, 2225-2233.
25. Sun, Y. F., Yu, L. Y., Saarma, M., Timmusk, T. and Arumae, U. (2001) Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells. J. Biol. Chem., 276, 16240-16247.
26. Sun, Y. F., Yu, L. Y., Saarma, M. and Arumae, U. (2003) Mutational analysis of N-Bak reveals different structural requirements for antiapoptotic activity in neurons and proapoptotic activity in nonneuronal cells. Mol. Cell. Neurosci., 23, 134-143.
27. Ganea, E. and Harding, J. J. (2006) Glutathione-related enzymes and the eye. Curr. Eye Res., 31, 1-11.
28. Griffith, O. W. and Meister, A. (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J. Biol. Chem., 254, 7558-7560.
29. Chen, J., Tu, Y., Connolly, E. C. and Ronnett, G. V. (2005) Heme oxygenase-2 protects against glutathione depletion-induced neuronal apoptosis mediated by bilirubin and cyclic GMP. Curr. Neurovasc. Res., 2, 121-131.
30. Roh, Y. J., Moon, C., Kim, S. Y., Park, M. H., Bae, Y. C., Chun, M. H. and Moon, J. I. (2007) Glutathione depletion induces differential apoptosis in cells of mouse retina, in vivo. Neurosci. Lett., 417, 266-270.
31. Park, J. W., Moon, C. and Yun, S. (2007) Differential expression of heat shock protein mRNAs under in vivo glutathione depletion in the mouse retina. Neurosci. Lett., 413, 260-264.
32. Rozen, S. and Skaletsky, H. (2000) Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol., 132, 365-386.
33. Rossi, C., Strettoi, E. and Galli-Resta, L. (2003) The spatial order of horizontal cells is not affected by massive alterations in the organization of other retinal cells. J. Neurosci., 23, 9924-9928.
34. Tsang, S. H., Chen, J., Kjeldbye, H., Li, W. S., Simon, M. I., Gouras, P. and Goff, S. P. (1997) Retarding photoreceptor degeneration in Pdegtm1/Pdegtml mice by an apoptosis suppressor gene. Invest. Ophthalmol. Vis. Sci., 38, 943-950.
35. Chen, D. F., Schneider, G. E., Martinou, J. C. and Tonegawa, S. (1997) Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature, 385, 434-439.
36. Cenni, M. C., Bonfanti, L., Martinou, J. C., Ratto, G. M., Strettoi, E. and Maffei, L. (1996) Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice. Eur. J. Neurosci., 8, 1735-1745.
37. Bahr, M. (2000) Live or let die - retinal ganglion cell death and survival during development and in the lesioned adult CNS. Trends Neurosci., 23, 483-490.
38. Kane, D. J., Sarafian, T. A., Anton, R., Hahn, H., Gralla, E. B., Valentine, J. S., Ord, T. and Bredesen, D. E. (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science, 262, 1274-1277.
39. Minn, A. J., Velez, P., Schendel, S. L., Liang, H., Muchmore, S. W., Fesik, S. W., Fill, M. and Thompson, C. B. (1997) Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature, 385, 353-357.
40. Putcha, G. V., Harris, C. A., Moulder, K. L., Easton, R. M., Thompson, C. B. and Johnson, E. M., Jr. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J. Cell Biol., 157, 441-453.
41. Hahn, P., Lindsten, T., Ying, G. S., Bennett, J., Milam, A. H., Thompson, C. B. and Dunaief, J. L. (2003) Proapoptotic bcl-2 family members, Bax and Bak, are essential for developmental photoreceptor apoptosis. Invest. Ophthalmol. Vis. Sci., 44, 3598-3605.
42. Middleton, G., Nunez, G. and Davies, A. M. (1996) Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors. Development, 122, 695-701.