An increase in Aβ42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw mice

Current Alzheimer Research

Volumn 5, Issue 4, 2008, Pages 385-391

  Zhuo, Jia Min ^a,e   Prakasam, Annamalai ^b   Murray, Melissa E ^a   Zhang, Hai Yan ^a,f   Baxter, Mark G ^c   Sambamurti, Kumar ^b   Nicolle, Michelle M ^a,d  

^a MAYO CLINIC   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Amyloid precursor protein; Executive function; Learning errors; Perseverative errors

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENOTYPE; HIPPOCAMPUS; LEARNING DISORDER; MOUSE; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; TRANSGENIC MOUSE; AGE; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; DISCRIMINATION LEARNING; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; HUMAN; LEARNING; METABOLISM; METHODOLOGY; ODOR; PATHOLOGY; PHYSIOLOGY; STATISTICAL MODEL;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; DISCRIMINATION LEARNING; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LEARNING DISORDERS; LINEAR MODELS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; ODORS; PEPTIDE FRAGMENTS; PREFRONTAL CORTEX; REVERSAL LEARNING;

EID: 48749104822     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720508785132280     Document Type: Article

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