The effect of electroporation pulses on functioning of the heart

Medical and Biological Engineering and Computing

Volumn 46, Issue 8, 2008, Pages 745-757

  Mali, Barbara ^a   Jarm, Tomaz ^a   Corovic, Selma ^a   Paulin Kosir, Marija Snezna ^b   Cemazar, Maja ^b   Sersa, Gregor ^b   Miklavcic, Damijan ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b INSTITUTE OF ONCOLOGY   (Slovenia)

Author keywords

Electrocardiogram; Electrochemotherapy; QRS detection; Synchronization of electroporation pulse delivery with ECG

Indexed keywords

BOOLEAN FUNCTIONS; LEAD; METALLIZING; ONCOLOGY;

ANATOMICAL LOCATIONS; ANTI TUMORS; ELECTROCARDIOGRAM (ECG); ELECTROCHEMOTHERAPY (ECT); ELECTROPORATION; ELECTROPORATION DEVICES; HUMAN PATIENTS; LEVEL OF SAFETY (LOS); MORPHOLOGICAL CHANGES; R R INTERVAL; TUMOR ABLATION; VULNERABLE PERIOD (VP);

TUMORS;

BLEOMYCIN; CISPLATIN;

ADULT; AGED; ALGORITHM; ARTICLE; CLINICAL ARTICLE; ELECTRIC CONDUCTIVITY; ELECTROCARDIOGRAM; ELECTROCHEMOTHERAPY; ELECTROPORATION; FEMALE; HEART ELECTROPHYSIOLOGY; HEART FUNCTION; HUMAN; MALE; MATHEMATICAL MODEL; MELANOMA; PATIENT SAFETY; QRS COMPLEX; RR INTERVAL; SARCOMA;

AGED; AGED, 80 AND OVER; ALGORITHMS; ELECTROCARDIOGRAPHY; ELECTROCHEMOTHERAPY; FEMALE; HEART; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 48749096470     PISSN: 01400118     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11517-008-0346-7     Document Type: Article

References (57)

1. Acharya UR, Joseph KP, Kannathal N, Lim CM, Suri JS (2006) Heart rate variability: A review. Med Biol Eng Comput 44:1031-1051
2. Al-Khadra A, Nikolski V, Efimov IR (2000) The role of electroporation in the fibrillation. Circ Res 87:797-804
3. Al-Sakere B, Bernat C, André F, Connault E, Opolon P, Davalos RV, Mir LM (2007) A study of the immunological response to tumor ablation with irreversible electroporation. Technol Cancer Res Treat 6:301-305
4. Anderson ME (2006) QT interval prolongation and arrhythmia: An unbreakable connection? J Intern Med 259:81-90
5. Ayers GM, Alferness CA, Ilina M, Wagner DO, Sirokman WA, Adams JM, Griffin JC (1994) Ventricular proarrhythmic effects of ventricular cycle length and shock strength in a sheep model of transvenous atrial defibrillation. Circulation 89:413-422
6. Benitez DS, Gaydecki PA, Zaidi A, Fitzpatrick AP, Laguna P (2000) A new QRS detection algorithm based on the Hilbert transform. IEEE Comput Cardiol 27:379-382
7. Bruner JMR, Leonard PF (1989) Electricity, safety, and the patient. Year Book Medical Publishers, Inc., Chicago
8. Bureau MF, Gehl J, Deleuze V, Mir LM, Scherman D (2000) Importance of association between permeabilization and electrophoretic forces for intramuscular DNA electrotransfer. Biochim Biophys Acta 1474:353-359
9. Camacho MA, Lehr JL, Eisenberg SR (1995) A three-dimensional finite element model of human transthoracic defibrillation: Paddle placement and size. IEEE Trans Biomed Eng 42:572-578
10. Chen C, Smye SW, Robinson MP, Evans JA (2006) Membrane electroporation theories: A review. Med Biol Eng Comput 44:5-14
11. Clayton RH, Holden AV (2000) Re-entry in computational models of heterogenous and abnormal myocardium. Int J Bioelectromagn, available online: http://www.rgi.tut.fi/ijbem/volume2/number2/clayton/ paper_ijbem.htm
12. Cuesta-Frau D, Biagetti MO, Quinteiro RA, Micó-Tormos P, Aboy M (2007) Unsupervised classification of ventricular extrasystoles using bounded clustering algorithms and morphology matching. Med Biol Eng Comput 45:229-239
13. Cukjati D, Batiuskaite D, André F, Miklavcic D, Mir LM (2007) Real time electroporation control for accurate and safe in vivo non-viral gene therapy. Bioelectrochemistry 70:501-507
14. Davalos RV, Mir LM, Rubinsky B (2005) Tissue ablation with irreversible electroporation. Ann Biomed Eng 33:223-231
15. Fish RM, Geddes LA, Babbs CF (2003) Medical and bioengineering aspects of electrical injuries. Lawyers and Judges Publishing Company, Arizona
16. Friedman BH, Thayer JF (1998) Autonomic balance revisited: Panic anxiety and heart rate variability. J Psychosom Res 44:133-151
17. Galvão KM, Mateus EF, Gomes PAP (2001) Electric stimulation of isolated hearts: Age dependance of the threshold electric field. Memorias II Congreso Latinoamericano de Ingeniería Biomédica 950-7132-57-5 (c)
18. Heller R, Jaroszeski M, Atkin A, Moradpour D, Gilbert R, Wands J, Nicolau C (1996) In vivo gene electroinjection and expression in rat liver. FEBS Lett 389:225-228
19. Heller R, Jaroszeski MJ, Reintgen DS, Puleo CA, DeConti RC, Gilbert RA, Glass LF (1998) Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin. Cancer 83:148-157
20. Heller LC, Heller R (2006) In vivo electroporation for gene therapy: review. Hum Gene Ther 17:890-897
21. Hofmann GA (2000) Instrumentation and electrodes for in vivo electroporation. In: Jaroszeski MJ, Heller R, Gilbert R (eds) Electrochemotherapy, electrogenetherapy, and transdermal drug delivery: electrically mediated delivery of molecules to cells. Humana, Totowa
22. Houghton AR, Gray D (1997) Making sense of the ECG: A hands-on guide. Arnold, London
23. Jager F, Taddei A, Moody GB, Emdin M, Antolic G, Dorn R, Smrdel A, Marchesi C, Mark RG (2003) Long-term ST database: A reference for the development and evaluation of automated ischaemia detectors and for the study of the dynamics of myocardial ischaemia. Med Biol Eng Comput 41:172-182
24. Johnsen BH, Thayer JF, Laberg JC, Wormnes B, Raadal M, Skaret E, Kvale G, Berg E (2003) Attentional and physiological characteristics of patients with dental anxiety. J Anxiety Disord 17:75-87
25. Jones M, Geddes LA (1977) Strength-duration curves for cardiac pacemaking and ventricular fibrillation. Cardiovasc Res Cent Bull 15:101-112
26. Karlon WJ, Lehr JL, Eisenberg SR (1994) Finite element models of thoracic conductive anatomy: Sensitivity to changes in inhomogeneity and anisotropy. IEEE Trans Biomed Eng 41:1010-1017
27. Kirchhof PF, Fabritz CL, Zabel M, Franz MR (1996) The vulnerable period for low and high energy T-wave shocks: Role of dispersion of repolarization and effect of d -sotalol. Cardiovasc Res 31:953-962
28. Lavee J, Onik G, Mikus P, Rubinsky B (2007) A novel nonthermal energy source for surgical epicardial atrial ablation: Irreversible electroporation. Heart Surg Forum 10:96-101
29. Lin CH (2006) Classification enhancible grey relational analysis for cardiac arrhythmias discrimination. Med Biol Eng Comput 44:311-320
30. Mali B, Jarm T, Jager F, Miklavcic D (2005) An algorithm for synchronization of in vivo electroporation with ECG. J Med Eng Technol 29:288-296
31. Marty M, Sersa G, Garbay JR, Gehl J, Collins CG, Snoj M, Billard V, Geertsen PF, Larkin JO, Miklavcic D, Pavlovic I, Paulin-Kosir SM, Cemazar M, Morsli N, Soden DM, Rudolf Z, Robert C, O'Sullivan GC, Mir LM (2006) Electrochemotherapy - an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. Eur J Cancer Suppl 4:3-13
32. McCraty R, Atkinson M, Tomasino D, Stuppy WP (2001) Analysis of twenty-four hour heart rate variability in patients with panic disorder. Biol Psychol 56:131-150
33. Miklavcic D, Corovic S, Pucihar G, Pavselj N (2006) Importance of tumour coverage by sufficiently high local electric field for effective electrochemotherapy. Eur J Cancer Suppl 4:45-51
34. Miklavcic D, Pavselj N, Hart FX (2006) Electric properties of tissues. In: Wiley encyclopedia of biomedical engineering. Wiley, New York
35. Miller L, Leor J, Rubinsky B (2005) Cancer cells ablation with irreversible electroporation. Technol Cancer Res Treat 4:1-7
36. Mir LM, Glass LF, Sersa G, Teissie J, Domenge C, Miklavcic D, Jaroszeski MJ, Orlowski S, Reintgen DS, Rudolf Z, Belehradek M, Gilbert R, Rols MP, Belehradek J Jr, Bachaud JM, DeConti R, Stabuc B, Cemazar M, Coninx P, Heller R (1998) Effective treatment of cutaneous and subcutaneous malignant tumors by electrochemotherapy. Br J Cancer 77:2336-2342
37. Mir LM, Orlowski S (1999) Mechanisms of electrochemotherapy. Adv Drug Deliv Rev 35:107-118
38. Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH (1982) Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J 1:841-845
39. Neumann E, Sowers AE, Jordan CA (1989) Electroporation and electrofusion in cell biology. Plenum Press, New York
40. Niu G, Heller R, Catlett-Falcone R, Coppola D, Jaroszeski M, Dalton W, Jove R, Yu H (1999) Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo. Cancer Res 59:5059-5063
41. Onik G, Mikus P, Rubinsky B (2007) Irreversible electroporation: implications for prostate ablation. Technol Cancer Res Treat 6:295-300
42. Pavlin M, Kanduser M, Rebersek M, Pucihar G, Hart FX, Magjarevic R, Miklavcic D (2005) Effect of cell electroporation on the conductivity of a cell suspension. Biophys J 88:4378-4390
43. Pavselj N, Bregar Z, Cukjati D, Batiuskaite D, Mir LM, Miklavcic D (2005) The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumour in small animals. IEEE Trans Biomed Eng 52:1373-1381
44. Prausnitz MR (1996) The effects of electric current applied to skin: A review for transdermal drug delivery. Adv Drug Deliv Rev 18:395-425
45. Rebersek M, Faurie C, Kanduser M, Corovic S, Teissié J, Rols MP, Miklavcic D (2007) Electroporator with automatic change of electric field direction improves gene electrotransfer in vitro. Biomed Eng Online 6:25
46. Reilly JP (1998) Applied bioelectricity: From electrical stimulation to electropathology. Springer, New York
47. Ruha A, Sallinen S, Nissilä S (1997) A real-time microprocessor QRS detector system with a 1-ms timing accuracy for the measurement of ambulatory HRV. IEEE Trans Biomed Eng 44:159-167
48. Satkauskas S, Bureau MF, Puc M, Mahfoudi A, Scherman D, Miklavcic D, Mir LM (2002) Mechanisms of in vivo DNA electrotransfer: Respective contributions of cell electropermeabilization and DNA electrophoresis. Mol Ther 5:133-140
49. Sel D, Macek Lebar A, Miklavcic D (2007) Feasibility of employing model-based optimization of pulse amplitude and electrode distance for effective tumor electropermeabilization. IEEE Trans Biomed Eng 54:773-781
50. Sel D, Cukjati D, Batiuskaite D, Slivnik T, Mir LM, Miklavcic D (2005) Sequential finite element model of tissue electropermeabilization. IEEE Trans Biomed Eng 52:816-827
51. Sersa G, Cufer T, Cemazar M, Miklavcic D, Rebersek M, Rudolf Z (2000) Electrochemotherapy with bleomycin in the treatment of hypernephroma metastasis: Case report and literature review. Tumori 86:163-165
52. Sersa G (2006) The state-of-the-art of electrochemotherapy before the ESOPE study; advantages and clinical uses. Eur J Cancer Suppl 4:52-59
53. Task Force of the European Society of Cardiology, the North American Society of Pacing and Electrophysiology (1996) Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Eur Heart J 17:354-381
54. The visible human project. National Library of Medicine, United States, online: http://www.nlm.nih.gov/research/visible/visible_human.html
55. Wiggers CJ, Wégria R (1940) Ventricular fibrillation due to single, localized induction and condenser shocks applied during the vulnerable phase of ventricular systole. Am J Physiol 128:500-505
56. Yeragani VK, Balon R, Pohl R, Ramesh C, Glitz D, Weinberg P, Merlos B (1990) Decreased R-R variance in panic disorder patients. Acta Psychiatr Scand 81:554-559
57. Zupanic A, Ribaric S, Miklavcic D (2007) Increasing the repetition frequency of electric pulse delivery reduces unpleasant sensations that occur in electrochemotherapy. Neoplasma 54:246-250