Feasibility of employing model-based optimization of pulse amplitude and electrode distance for effective tumor electropermeabilization

IEEE Transactions on Biomedical Engineering

Volumn 54, Issue 5, 2007, Pages 773-781

  Šel, Davorka ^a   Lebar, Alenka Maček ^a   Miklavčič, Damijan ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Electro gene transfer; Electrochemotherapy; Electropermeabilization; Modeling; Optimization

Indexed keywords

CHEMOTHERAPY; COMPUTERIZED TOMOGRAPHY; ELECTRODES; FINITE ELEMENT METHOD; GENE TRANSFER; OPTIMIZATION; PULSE AMPLITUDE MODULATION; TUMORS;

ELECTRIC FIELD INTENSITIES; ELECTRO GENE TRANSFER; ELECTROCHEMOTHERAPY (ECT); TISSUE NECROSIS;

BIOMEDICAL ENGINEERING;

AMPLITUDE MODULATION; ARTICLE; BRAIN TISSUE; CELL PERMEABILIZATION; COMPUTER ASSISTED TOMOGRAPHY; ELECTRIC CURRENT; ELECTRIC POTENTIAL; ELECTROCHEMOTHERAPY; ELECTRODE; ELECTROPORATION; FEASIBILITY STUDY; FINITE ELEMENT ANALYSIS; GENE TRANSFER; GENERATOR; GEOMETRY; INTENSITY MODULATED RADIATION THERAPY; PULSED ELECTRIC FIELD; TISSUE NECROSIS; TUMOR;

BRAIN NEOPLASMS; CELL MEMBRANE PERMEABILITY; COMPUTER SIMULATION; ELECTRIC CONDUCTIVITY; ELECTRIC STIMULATION; ELECTROCHEMOTHERAPY; ELECTROMAGNETIC FIELDS; ELECTROPORATION; FEASIBILITY STUDIES; HUMANS; MICROELECTRODES; MODELS, BIOLOGICAL; TOMOGRAPHY, X-RAY COMPUTED; TUMOR BURDEN;

EID: 34247363645     PISSN: 00189294     EISSN: None     Source Type: Journal    
DOI: 10.1109/TBME.2006.889196     Document Type: Article

References (53)

1. T. Y. Tsong, "Electroporation of cell membranes," Biophysical J., vol. 60, pp. 297-306, 1991.
2. J. C. Weaver and Y. A. Chizmadzhev, "Theory of electroporation: A review," Bioelectrochem. Bioenerg., vol. 41, pp. 135-160, 1996.
3. E. Neumann and S. Kakorin, "Digression on membrane electroporation and electroporative delivery of drugs and genes," Radiol. Oncol., vol. 32, no. 1, pp. 7-17, 1998.
4. M. R. Jaroszeski, R. Gilbert, and R. Heller, "Electrochemotherapy: An emerging drug delivery method for the treatment of cancer," Adv. Drug Delivery Rev., vol. 26, pp. 185-197, 1997.
5. R. Heller, R. Gilbert, and M. J. Jaroszeski, "Clinical applications of electrochemotherapy," Adv. Drug Delivery Rev., vol. 35, no. 1, pp. 119-129, 1999.
6. L. M. Mir, "Therapeutical perspectives of in vivo cell electropermeabilization," Bioelectrochemistry, vol. 53, pp. 1-10, 2000.
7. M. P. Rols, J. M. Bachaud, P. Giraud, C. Chevreau, H. Roche, and J. Teissie, "Electrochemotherapy of cutaneous metastases in malignant melanoma," Melanoma Res., vol. 10, no. 5, pp. 468-474, 2000.
8. M. ReberŠek, T. Čufer, M. Čemažar, S. Kranjc, and G. Serša, "Electrochemotherapy with cisplatin of cutaneous tumor lesions in breast cancer," Anti-Cancer Drugs, vol. 15, pp. 593-597, 2004.
9. J. P. Allegretti and W. R. Panje, "Electroporation therapy for head and neck cancer including carotid artery involvement," Laryngoscope, vol. 111, no. 1, pp. 52-56, 2001.
10. S. Rodriguez-Cuevas, S. Barroso-Bravo, J. Almanza-Estrada, L. Cristobal-Martinez, and E. Gonzalez-Rodriguez, "Electrochemotherapy in primary and metastatic skin tumors: Phase II trial using intralesional bleomycin," Arch. Med. Res., vol. 32, no. 4, pp. 273-276, 2001.
11. Gothelf, L. M. Mir, and J. Gehl, "Electrochemotherapy: Results of cancer treatment using enhanced delivery of bleomycin by electroporation," Cancer Treatment Rev., vol. 29, no. 5, pp. 371-387, 2003.
12. G. Serša, M. Čemažar, and Z. Rudolf, "Electrochemotherapy: Advantages and drawbacks in treatment of cancer patients," Cancer Therapy, vol. 1, pp. 133-142, 2003.
13. L. M. Mir, S. Orlowski, J. Belehradek, and C. Paoletti, "Elecrochemotherapy potentiation of antitumor effect of bleomycin by local electric pulses," Eur. J. Cancer, vol. 27, no. 1, pp. 68-72, 1991.
14. M. J. Jaroszeski, R. Gilbert, C. Nicolau, and R. Heller, "In vivo gene delivery by electroporation," Adv. Drug Delivery Rev., vol. 35, pp. 131-137, 1999.
15. M. P. Rols, C. Delteil, M. Golzio, P. Dumond, S. Cros, and J. Teissie, "In vivo electrically mediated protein and gene transfer in murine melanoma," Nature Biotechnol., vol. 16, pp. 168-171, 1998.
16. H. Aihara and J. Miyazaki, "Gene transfer into muscle by electroporation in vivo," Nature Biotechnol., vol. 16, pp. 867-870, 1998.
17. L. M. Mir, M. F. Bureau, J. Gehl, Rangara, D. Rouy, J. M. Caillaud, P. Delaere, D. Branellec, B. Schwartz, and D. Scherman, "High-efficieny gene transfer into skeletal muscle mediated by electric pulses," Proc. Nat. Acad. Sci., vol. 96, pp. 4262-4267, 1999.
18. J. Glasspool-Malone, S. Somiari, J. J. Drabick, and R. W. Malone, "Efficient nonviral cutaneous transfection," Molec. Therapy, vol. 2, no. 2, pp. 140-146, 2000.
19. S. Satkauskas, M. Breau, M. Puc, A. Mahfoudi, D. Scherman, D. Miklavčič, and L. M. Mir, "Mechanisms of in vitro DNA electrotransfer: Respective contributions of cell electropermeabilization and DNA electrophoresis," Molec. Therapy, vol. 5, no. 2, pp. 1-8, 2002.
20. M. L. Lucas and R. Heller, "IL-12 gene therapy using an electrically mediated nonviral approach reduces metastatic growth of melanoma," DNA Cell Biol., vol. 22, no. 12, pp. 755-763, 2003.
21. N. Pavšelj and V. Preat, "DNA electrotransfer into the skin using a combination of one high- and one low-voltage pulse," J. Controlled Release, vol. 106, no. 3, pp. 407-415, 2005.
22. L. Heller, K. Merkler, and J. Westover, "Evaluation of toxicity following electrically mediated interleukin-12 gene delivery in a B16 mouse melanoma model," Clin. Cancer Res., vol. 12, no. 10, pp. 3177-3183, 2006.
23. T. Kawano, M. Yamagata, H. Takahashi, Y. Niidome, S. Yamada, Y. Katayama, and T. Niidome, "Stabilizing of plasmid DNA in vivo by PEG-modified cationic gold nanoparticles and the gene expression assisted with electrical pulses," J. Controlled Release, vol. 111, no. 3, pp. 382-389, 2006.
24. B. M. Medi and J. Sigh, "Skin targeted DNA vaccine delivery using electroporation in rabbits II. Safety," Int. J. Pharmaceutics, vol. 308, no. 1-2, pp. 61-68, 2006.
25. A. K. Roos, S. Moreno, C. Leder, M. Pavlenko, A. King, and P. Pisa, "Enhancement of cellular immune response to a prostate cancer DNA vaccine by intradermal electroporation," Molec. Therapy, vol. 13, no. 2, pp. 20-327, 2006.
26. D. Ferber, "Gene therapy: Safer and virus-free?," Science, vol. 294, pp. 1638-1642, 2001.
27. D. Miklavčič, K. Beravs, D. Šemrov, M. Čemazar, F. Demšar, and G. Serša, "The importance of electric field distribution for effective in vivo electroporation of tissues," Biophysical J., vol. 74, pp. 2152-2158, 1998.
28. J. Gehl, T. H. Sorensen, K. Nielsen, P. Raskmark, S. L. Nielsen, T. Skovsgaard, and L. M. Mir, "In vivo electroporation of skeletal muscle: Threshold, efficacy and relation to electric field distribution," Biochimica et Biophysica Acta, vol. 1428, pp. 233-240, 1999.
29. K. Brandisnky and I. Daskalov, "Electric field and current distributions in electrochemotherapy," Biochem. Bioenerg., vol. 48, pp. 201-208, 1999.
30. G. A. Hofmann, S. B. Dev, S. Dimmer, and G. S. Nanda, "Electroporation therapy: A new approach for the treatment of head and neck cancer," IEEE Trans. Biomed. Eng, vol. 46, no. 6, pp. 752-759, Jun. 1999.
31. D. Miklavčič, D. Šemrov, H. Mekid, and L. M. Mir, "A validated model of in vivo electric field distribution in tissue for electrochemotherapy and for DNA electrotransfer for gene therapy," Biochim. Biophys. Acta, vol. 1523, pp. 73-83, 2000.
32. M. P. Rols and J. Teissie, "Electropermeabilization of mammalian cells: Quantitative analysis of the phenomenon," Biophysical J., vol. 58, pp. 1089-1098, 1990.
33. J. Gehl and L. M. Mir, "Determination of optimal parameters for in vivo gene transfer by electroporation, using a rapid in vivo test for cell permeabilisation," Biochem. Biophysical Res. Commun., vol. 261, pp. 377-380, 1999.
34. S. B. Dev, D. Dhar, and W. Krassowska, "Electric field of a six-needle array electrode used in drug and gene delivery in vivo: Analytical versus numerical solution," IEEE Trans. Biomed. Eng., vol. 50, no. 11, pp. 1296-1300, Nov. 2003.
35. N. Pavšelj, Z. Bregar, D. Cukjati, D. Batiuskaite, L. M. Mir, and D. Miklavčič, "The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals," IEEE Trans. Biomed. Eng., vol. 52, no. 8, pp. 1373-1381, Aug. 2005.
36. D. Šel, D. Cukjati, D. Batiuskaite, T. Slivnik, L. M. Mir, and D. Miklavčič, "Sequential finite element model of tissue electropermeabilization," IEEE Trans. Biomed. Eng., vol. 52, no. 5, pp. 816-827, May 2005.
37. S. Satkauskas, D. Batiuskaite, S. Salomskaite-Davalgiene, and M. S. Venslauskas, "Effectiveness pf tumour electrochemotherapy as a function of electric pulse strength and duration," Bioelectrochemistry, vol. 65, pp. 105-111, 2005.
38. M. Puc, T. Kotnik, L. M. Mir, and D. Miklavčič, "Quantitative model of small molecules uptake after in vitro cell electropermeabilisation," Bioelectrochemistry, vol. 60, pp. 1-10, 2003.
39. "FEMLAB User Guide and Introduction," ver. 2.2, Comsol AB, Stockholm, Sweden, 2001.
40. D. J. Murray-Smith, "Advances in simulation model validation: theory, software and applications," in Proc. EUROSIM'95, 1995, pp. 75-84.
41. L. A. Geddes and L. E. Baker, "The specific resistance of biological material - A compendium of data for the biomedical engineer and physiologist," Med. Biol. Eng., vol. 5, pp. 271-293, 1967.
42. D. C. Barber and B. H. Brown, "Applied potential tomography," J. Phys. E.: Sci. Intsrum., vol. 17, pp. 723-733, 1984.
43. H. P. Schwan, "Electric characteristics of tissue," Biophysik, vol. 1, pp. 198-208, 1963.
44. A. J. Surowiec, S. Stuchly, J. R. Barr, and A. Swarp, "Dielectric properties of breast carcinoma and the surrounding tissues," IEEE Trans. Biomed. Eng., vol. 35, no. 4, pp. 257-263, Apr. 1988.
45. T. J. William, Y. Zhang, C. Li, and R. L. Jirtle, "The measured properties of normal and malignant human tissues from 50 to 900 MHz," Med. Phys, vol. 21, pp. 4-7, 1994.
46. S. R. Smith, K. R. Foster, and G. L. Wolf, "Dielectric properties of VX-2 carcinoma versus normal liver tissue," IEEE Trans. Biomed. Eng., vol. BME-33, no. 5, pp. 522-524, May 1986.
47. M. Pavlin, M. Kandu?ser, M. Reberšek, G. Pucihar, F. X. Hart, R. Magjarević, and D. Miklavčič, "Effect of cell electroporation on the conductivity of a cell suspension," Biophys. J., vol. 88, pp. 4378-4390, 2005.
48. R. Fletcher and S. Leyffer, "Solving mixed integer nonlinear programs by outer approximation," Math. Programming, vol. 66, pp. 327-349, 1994.
49. R. J. Dakin, "A tree-search algorithm for mixed integer programming problems," Comput. J., vol. 8, pp. 250-255, 1965.
50. R. A. Gilbert, M. J. Jaroszeski, and R. Heller, "Novel electrode designs for electrochemotherapy," Biochimica et Biophysica Acta., vol. 1334, no. 1, pp. 9-14, 1997.
51. M. Pavlin and D. Miklavčič, "Conductivity of a suspension of permeabilised cells - A theoretical analysis," Biophys. J., vol. 85, 2003.
52. R. Davalos, B. Rubinsky, and D. M. Otten, "A feasibility study for electrical impedance tomography as a means to monitor tissue electroporation for molecular medicine," IEEE Trans. Biomed. Eng., vol. 49, no. 4, pp. 400-403, Apr. 2002.
53. R. V. Davalos, L. M. Mir, and B. Rubinsky, "Tissue ablation with irreversible electroporation," Ann. Biomed. Eng., vol. 33, pp. 223-231, 2005.