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Volumn 79, Issue 3, 2008, Pages 416-426

Enhancement of ventricular gap-junction coupling by rotigaptide

Author keywords

Antiarrhythmic agents; Cell communication; Connexins; Gap junctions; Rotigaptide

Indexed keywords

ROTIGAPTIDE;

EID: 48749096457     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn100     Document Type: Article
Times cited : (33)

References (43)
  • 1
    • 1942533420 scopus 로고    scopus 로고
    • Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall
    • H2001-H2009
    • Poelzing S, Akar FG, Baron E, Rosenbaum DS. Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall. Am J Physiol Heart Circ Physiol 2004;286:H2001-H2009.
    • (2004) Am J Physiol Heart Circ Physiol , vol.286
    • Poelzing, S.1    Akar, F.G.2    Baron, E.3    Rosenbaum, D.S.4
  • 2
    • 0035806899 scopus 로고    scopus 로고
    • Heterologous expression of gap junction channels in the heart leads to conduction defects and ventricular dysfunction
    • Gutstein DE, Morley GE, Vaidya D, Liu F, Chen FL, Stuhlmann H et al. Heterologous expression of gap junction channels in the heart leads to conduction defects and ventricular dysfunction. Circulation 2001;104:1194-1199.
    • (2001) Circulation , vol.104 , pp. 1194-1199
    • Gutstein, D.E.1    Morley, G.E.2    Vaidya, D.3    Liu, F.4    Chen, F.L.5    Stuhlmann, H.6
  • 4
    • 0038662776 scopus 로고    scopus 로고
    • ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs
    • Xing D, Kjølbye AL, Nielsen MS, Petersen JS, Harlow KW, Holstein-Rathlou NH et al. ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs. J Cardiovasc Electrophysiol 2003;14:510-520.
    • (2003) J Cardiovasc Electrophysiol , vol.14 , pp. 510-520
    • Xing, D.1    Kjølbye, A.L.2    Nielsen, M.S.3    Petersen, J.S.4    Harlow, K.W.5    Holstein-Rathlou, N.H.6
  • 5
    • 33744473829 scopus 로고    scopus 로고
    • Pharmacology of cardiovascular gap junctions
    • Herve JC, Dhein S. Pharmacology of cardiovascular gap junctions. Adv Cardiol 2006;42:107-131.
    • (2006) Adv Cardiol , vol.42 , pp. 107-131
    • Herve, J.C.1    Dhein, S.2
  • 6
    • 33751527644 scopus 로고    scopus 로고
    • Innovative approaches to anti-arrhythmic drug therapy
    • Nattel S, Carlsson L. Innovative approaches to anti-arrhythmic drug therapy. Nat Rev Drug Disc 2006;5:1034-1049.
    • (2006) Nat Rev Drug Disc , vol.5 , pp. 1034-1049
    • Nattel, S.1    Carlsson, L.2
  • 7
    • 33644823558 scopus 로고    scopus 로고
    • The antiarrhythmic pewptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin43
    • Clark TC, Thomas D, Petersen JS, Evans WH, Martin PEM. The antiarrhythmic pewptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin43. Brit J Pharmacol 2006;147:486-495.
    • (2006) Brit J Pharmacol , vol.147 , pp. 486-495
    • Clark, T.C.1    Thomas, D.2    Petersen, J.S.3    Evans, W.H.4    Martin, P.E.M.5
  • 9
    • 33746463210 scopus 로고    scopus 로고
    • Treatment with the gap junction modifier rotigaptide (ZP123) reduces infarct size in rats with chronic myocardial infarction
    • Haugan K, Marcussen N, Kjølbye AL, Nielsen MS, Hennan JK, Petersen JS. Treatment with the gap junction modifier rotigaptide (ZP123) reduces infarct size in rats with chronic myocardial infarction. J Cardiovasc Pharmacol 2006;47:236-242.
    • (2006) J Cardiovasc Pharmacol , vol.47 , pp. 236-242
    • Haugan, K.1    Marcussen, N.2    Kjølbye, A.L.3    Nielsen, M.S.4    Hennan, J.K.5    Petersen, J.S.6
  • 10
    • 33645128256 scopus 로고    scopus 로고
    • Rotigaptide (ZP123) prevents spontaneous ventricular arrhythmias reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs
    • Hennan JK, Swillo RE, Morgan GA, Keith JC Jr, Schaub RG, Smith RP et al. Rotigaptide (ZP123) prevents spontaneous ventricular arrhythmias reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. J Pharmacol Exp Ther 2006;317:236-243.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 236-243
    • Hennan, J.K.1    Swillo, R.E.2    Morgan, G.A.3    Keith Jr, J.C.4    Schaub, R.G.5    Smith, R.P.6
  • 11
    • 36649038408 scopus 로고    scopus 로고
    • Pharmacological modulation of gap junction function with the novel compound Rotigaptide: A promising new principle for prevention of arrhythmias
    • Kjølbye AL, Haugan L, Hennan JK, Petersen JS. Pharmacological modulation of gap junction function with the novel compound Rotigaptide: a promising new principle for prevention of arrhythmias. Basic Clin Pharmacol Toxicol 2007;101:215-230.
    • (2007) Basic Clin Pharmacol Toxicol , vol.101 , pp. 215-230
    • Kjølbye, A.L.1    Haugan, L.2    Hennan, J.K.3    Petersen, J.S.4
  • 12
    • 13944261228 scopus 로고    scopus 로고
    • Dynamic model for ventricular junctional conductance during the cardiac action potential
    • Lin X, Gemel J, Beyer EC, Veenstra RD. Dynamic model for ventricular junctional conductance during the cardiac action potential. Am J Physiol Heart Circ Physiol 2005;288:H1113-H1123.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Lin, X.1    Gemel, J.2    Beyer, E.C.3    Veenstra, R.D.4
  • 13
    • 0023939687 scopus 로고
    • Action potential transfer in cell pairs isolate from adult rat and guinea pig ventricles
    • Weingart R, Maurer P. Action potential transfer in cell pairs isolate from adult rat and guinea pig ventricles. Circ Res 1988;63:72-80.
    • (1988) Circ Res , vol.63 , pp. 72-80
    • Weingart, R.1    Maurer, P.2
  • 14
    • 18844479760 scopus 로고    scopus 로고
    • Basic mechanisms of cardiac impulse propagation and associated arrhythmias
    • Kléber AG, Rudy Y. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev 2004;84:431-488.
    • (2004) Physiol Rev , vol.84 , pp. 431-488
    • Kléber, A.G.1    Rudy, Y.2
  • 15
    • 34248595219 scopus 로고    scopus 로고
    • Arrhythmogenic ion-channel remodeling in the heart: Heart failure, myocardial infarction, and atrial fibrillation
    • Nattel S, Maguy A, Le Bouter S, Yeh T-S. Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev 2007;87:425-456.
    • (2007) Physiol Rev , vol.87 , pp. 425-456
    • Nattel, S.1    Maguy, A.2    Le Bouter, S.3    Yeh, T.-S.4
  • 16
    • 0035038838 scopus 로고    scopus 로고
    • Voltage clamp limitations of dual whole-cell gap junction current and voltage recordings. I. Conductance measurements
    • Veenstra RD. Voltage clamp limitations of dual whole-cell gap junction current and voltage recordings. I. Conductance measurements. Biophys J 2001;80:2231-2247.
    • (2001) Biophys J , vol.80 , pp. 2231-2247
    • Veenstra, R.D.1
  • 17
    • 0028233422 scopus 로고
    • A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes
    • Luo C-H, Rudy Y. A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ Res 1994;74:1071-1096.
    • (1994) Circ Res , vol.74 , pp. 1071-1096
    • Luo, C.-H.1    Rudy, Y.2
  • 18
    • 49249098962 scopus 로고    scopus 로고
    • Mathematical model of the neonatal mouse action potential
    • Epub ahead of print 11 April
    • Wang LJ, Sobie EA. Mathematical model of the neonatal mouse action potential. Am J Physiol Heart Circ Physiol 2008; Epub ahead of print 11 April 2008.
    • (2008) Am J Physiol Heart Circ Physiol 2008
    • Wang, L.J.1    Sobie, E.A.2
  • 19
    • 1942470638 scopus 로고    scopus 로고
    • Pharmacology of gap junctions in the cardiovascular system
    • Dhein S. Pharmacology of gap junctions in the cardiovascular system. Cardiovasc Res 2004;62:287-298.
    • (2004) Cardiovasc Res , vol.62 , pp. 287-298
    • Dhein, S.1
  • 20
    • 0034026881 scopus 로고    scopus 로고
    • Action potential and contractility changes in. Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: A simulation study
    • Faber GM, Rudy Y. Action potential and contractility changes in. Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophys J 2000;78:2392-2404.
    • (2000) Biophys J , vol.78 , pp. 2392-2404
    • Faber, G.M.1    Rudy, Y.2
  • 21
    • 0030665763 scopus 로고    scopus 로고
    • Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling
    • Shaw RM, Rudy Y. Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res 1997;81:727-741.
    • (1997) Circ Res , vol.81 , pp. 727-741
    • Shaw, R.M.1    Rudy, Y.2
  • 22
    • 0025905587 scopus 로고
    • Remodeling of ventricular conduction pathways in healed canine infarct border zones
    • Luke RA, Saffitz JE. Remodeling of ventricular conduction pathways in healed canine infarct border zones. J Clin Invest 1991;87:11594- 11602.
    • (1991) J Clin Invest , vol.87 , pp. 11594-11602
    • Luke, R.A.1    Saffitz, J.E.2
  • 23
    • 33749433382 scopus 로고    scopus 로고
    • Heterogeneous gap junction remodeling in reentrant circuits in the epicardial border zone of the healing canine infarct
    • Cabo C, Yao J, Boyden PA, Chen S, Hussain W, Duffy HS et al. Heterogeneous gap junction remodeling in reentrant circuits in the epicardial border zone of the healing canine infarct. Cardiovasc Res 2006;72:241-249.
    • (2006) Cardiovasc Res , vol.72 , pp. 241-249
    • Cabo, C.1    Yao, J.2    Boyden, P.A.3    Chen, S.4    Hussain, W.5    Duffy, H.S.6
  • 24
    • 0023278269 scopus 로고
    • Electrical uncoupling and increase of extracellular resistance after induction of ischemia in isolated, arterially perfused rabbit papillary muscle
    • Kléber AG, Riegger CB, Janse MJ. Electrical uncoupling and increase of extracellular resistance after induction of ischemia in isolated, arterially perfused rabbit papillary muscle. Circ Res 1987;61:271-279.
    • (1987) Circ Res , vol.61 , pp. 271-279
    • Kléber, A.G.1    Riegger, C.B.2    Janse, M.J.3
  • 26
    • 0016825329 scopus 로고
    • Effect of intracellular injection of calcium and strontium on cell communication in the heart
    • De Mello WC. Effect of intracellular injection of calcium and strontium on cell communication in the heart. J Physiol 1975;250:231-245.
    • (1975) J Physiol , vol.250 , pp. 231-245
    • De Mello, W.C.1
  • 27
    • 0016689599 scopus 로고
    • Uncoupling of heart cells produced by intracellular sodium injection
    • De Mello WC. Uncoupling of heart cells produced by intracellular sodium injection. Experentia 1975;31:460-461.
    • (1975) Experentia , vol.31 , pp. 460-461
    • De Mello, W.C.1
  • 28
    • 0017364846 scopus 로고
    • The actions of ouabain on intercellular coupling and conduction velocity in mammalian ventricular muscle
    • Weingart R. The actions of ouabain on intercellular coupling and conduction velocity in mammalian ventricular muscle. J Physiol 1977;264:341-365.
    • (1977) J Physiol , vol.264 , pp. 341-365
    • Weingart, R.1
  • 29
    • 0019940746 scopus 로고
    • Active modulation of electrical coupling between cardiac cells of the dog. A mechanism for transient and steady state variations in conduction velocity
    • Spach MS, Kootsey JM, Sloan JD. Active modulation of electrical coupling between cardiac cells of the dog. A mechanism for transient and steady state variations in conduction velocity. Circ Res 1982;51:347-362.
    • (1982) Circ Res , vol.51 , pp. 347-362
    • Spach, M.S.1    Kootsey, J.M.2    Sloan, J.D.3
  • 30
    • 0025696503 scopus 로고
    • Consequences of acute ischemia for the electrical and mecjhanical function of the ventricular myocardium. A brief review
    • Kléber AG. Consequences of acute ischemia for the electrical and mecjhanical function of the ventricular myocardium. A brief review. Experentia 1990;46:1162-1167.
    • (1990) Experentia , vol.46 , pp. 1162-1167
    • Kléber, A.G.1
  • 31
    • 38149068097 scopus 로고    scopus 로고
    • Mantenance of intercellular couopling by the antiarrhythmic peptide rotigaptide suppresses arrhythmogenic discordant alternans
    • Kjølbye AL, Dikshteyn M, Eloff BC, Deschênes I, Rosenbaum DS. Mantenance of intercellular couopling by the antiarrhythmic peptide rotigaptide suppresses arrhythmogenic discordant alternans. Am J Physiol Heart Circ Physiol 2008;294:H41-H49.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Kjølbye, A.L.1    Dikshteyn, M.2    Eloff, B.C.3    Deschênes, I.4    Rosenbaum, D.S.5
  • 32
    • 33745389980 scopus 로고    scopus 로고
    • Identification of a novel peptide that interferes with the chemical regulation of connexin43
    • Shibayama J, Lewandowski R, Kieken F, Coombs W, Shah S, Sorgen PL et al. Identification of a novel peptide that interferes with the chemical regulation of connexin43. Circ Res 2006;98:1365-1372.
    • (2006) Circ Res , vol.98 , pp. 1365-1372
    • Shibayama, J.1    Lewandowski, R.2    Kieken, F.3    Coombs, W.4    Shah, S.5    Sorgen, P.L.6
  • 33
    • 0347418930 scopus 로고    scopus 로고
    • Pharmacological modulation of cardiac gap junctions to enhance cardiac conduction: Evidence supporting a novel target for antiarrhythmic therapy
    • Eloff BC, Gilat E, Wan X, Rosenbaum DS. Pharmacological modulation of cardiac gap junctions to enhance cardiac conduction: evidence supporting a novel target for antiarrhythmic therapy. Circulation 2003;108:3157- 3163.
    • (2003) Circulation , vol.108 , pp. 3157-3163
    • Eloff, B.C.1    Gilat, E.2    Wan, X.3    Rosenbaum, D.S.4
  • 34
    • 33846471716 scopus 로고    scopus 로고
    • Model-dependent effects of the gap junction conduction-enhancing antiarrhytmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs
    • Shiroshita-Takeshita A, Sakabe M, Haugan K, Hennan JK, Nattel S. Model-dependent effects of the gap junction conduction-enhancing antiarrhytmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs. Circulation 2007;115:310-318.
    • (2007) Circulation , vol.115 , pp. 310-318
    • Shiroshita-Takeshita, A.1    Sakabe, M.2    Haugan, K.3    Hennan, J.K.4    Nattel, S.5
  • 35
    • 33747031207 scopus 로고    scopus 로고
    • Effects of the gap junction modifier rotigaptide (ZP123) on atrial conduction and vulnerability to atrial fibrillation
    • Guerra JM, Everett TH, Lee KW, Wilson E, Olgin JE. Effects of the gap junction modifier rotigaptide (ZP123) on atrial conduction and vulnerability to atrial fibrillation. Circulation 2006;114:110-118.
    • (2006) Circulation , vol.114 , pp. 110-118
    • Guerra, J.M.1    Everett, T.H.2    Lee, K.W.3    Wilson, E.4    Olgin, J.E.5
  • 37
    • 12344258568 scopus 로고    scopus 로고
    • Pharmacological stimulation of cardiac gap junction coupling does not affect ischemia-induced focal ventricular tachycardia or triggered activity in dogs
    • Xing D, Kjølbye AL, Petersen JS, Martins JB. Pharmacological stimulation of cardiac gap junction coupling does not affect ischemia-induced focal ventricular tachycardia or triggered activity in dogs. Am J Physiol Heart Circ Physiol 2005;288:H511-H516.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Xing, D.1    Kjølbye, A.L.2    Petersen, J.S.3    Martins, J.B.4
  • 38
    • 0141608941 scopus 로고    scopus 로고
    • Regulation of connexin43 gap junctional conductance by ventricular action potentials
    • Lin X, Crye M, Veenstra RD. Regulation of connexin43 gap junctional conductance by ventricular action potentials. Circ Res 2003;93:e63-e73.
    • (2003) Circ Res , vol.93
    • Lin, X.1    Crye, M.2    Veenstra, R.D.3
  • 39
    • 0036634865 scopus 로고    scopus 로고
    • Pharmacological modification of gap junction coupling by an antiarrhythmic peptide via protein kinase C activation
    • Weng S, Lauven M, Schaefer T, Polontchouk L, Grover R, Dhein S. Pharmacological modification of gap junction coupling by an antiarrhythmic peptide via protein kinase C activation. FASEB J 2002;16:1114- 1116.
    • (2002) FASEB J , vol.16 , pp. 1114-1116
    • Weng, S.1    Lauven, M.2    Schaefer, T.3    Polontchouk, L.4    Grover, R.5    Dhein, S.6
  • 40
    • 33744521144 scopus 로고    scopus 로고
    • Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123)
    • Axelsen LN, Stahlhut M, Mohammed S, Larsen BD, Nielsen MS, Holstein-Rathlou N-H et al. Identification of ischemia-regulated phosphorylation sites in connexin43: a possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123). J Molec Cell Cardiol 2006;40:790-798.
    • (2006) J Molec Cell Cardiol , vol.40 , pp. 790-798
    • Axelsen, L.N.1    Stahlhut, M.2    Mohammed, S.3    Larsen, B.D.4    Nielsen, M.S.5    Holstein-Rathlou, N.-H.6
  • 41
    • 0025017732 scopus 로고
    • Unidirectional block and reentry of cardiac excitation: A model study
    • Quan W, Rudy Y. Unidirectional block and reentry of cardiac excitation: a model study. Circ Res 1990;66:367-382.
    • (1990) Circ Res , vol.66 , pp. 367-382
    • Quan, W.1    Rudy, Y.2
  • 42
    • 0025889071 scopus 로고
    • Unidirectional block between isolated rabbit ventricular cells coupled by a variable resistor
    • Joyner RW, Sugiura H, Tan RC. Unidirectional block between isolated rabbit ventricular cells coupled by a variable resistor. Biophys J 1991;60:1038-1045.
    • (1991) Biophys J , vol.60 , pp. 1038-1045
    • Joyner, R.W.1    Sugiura, H.2    Tan, R.C.3
  • 43
    • 0034804291 scopus 로고    scopus 로고
    • Influence of dynamic gap junction resistance on impulse propagation in ventricular myocardium: A computer simulation study
    • Henriquez AP, Vogel R, Muller-Borer BJ, Henriquez CS, Weingart R, Cascio WE. Influence of dynamic gap junction resistance on impulse propagation in ventricular myocardium: a computer simulation study. Biophys J 2001;81:2112-2121.
    • (2001) Biophys J , vol.81 , pp. 2112-2121
    • Henriquez, A.P.1    Vogel, R.2    Muller-Borer, B.J.3    Henriquez, C.S.4    Weingart, R.5    Cascio, W.E.6


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