A continued study on the stealth liposomal topotecan plus amlodipine: In vitro and in vivo characterization in non-resistant solid tumors

Journal of Health Science

Volumn 54, Issue 4, 2008, Pages 450-463

  Zhang, Yu Teng ^a   Lu, Wei ^a,b   Li, Ting ^a   Liang, Gong Wen ^a   Sun, Jia Bei ^a   Guo, Jia ^a   Men, Ying ^a   Du, Ju ^a   Lu, Wan Liang ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Anti tumor activity; Human breast cancer cell line MCF 7; Murine sarcoma cell line S180; Solid tumors; Stealth liposomal topotecan plus amlodipine

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMLODIPINE; AMLODIPINE PLUS TOPOTECAN; ANTINEOPLASTIC AGENT; ARTELASTIN; CAMPTOTHECIN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DOXORUBICIN; ELACRIDAR; FLUOROURACIL; LIPOSOME; TOPOTECAN; TRIENTINE; VALSPODAR; VERAPAMIL; WOGONIN;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRAIN MCF 7; DRUG FORMULATION; DRUG POTENTIATION; ENCAPSULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INSTITUTE FOR CANCER RESEARCH MOUSE; LEUKEMIA CELL; MALE; MOUSE; MULTIDRUG RESISTANCE; NICK END LABELING; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; SARCOMA CELL; SOLID TUMOR; SUSTAINED DRUG RELEASE; TUMOR XENOGRAFT; ZETA POTENTIAL;

MURINAE; MUS;

EID: 48749095719     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.54.450     Document Type: Article

References (36)

1. 2+ by amlodipine thus leading to an enhanced anti-tumor activity in leukemia. J. Control. Release, 112, 186-198.
2. Ozben, T. (2006) Mechanisms and strategies to overcome multiple drug resistance in cancer. FEBS Lett., 580, 2903-2909.
3. Wong, H. L., Bendayan, R., Rauth, A. M., Li, Y. and Wu, X. Y. (2007) Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv. Drug Deliv. Rev., 59, 491-504.
4. Limtrakul, P., Siwanon, S., Yodkeeree, S. and Duangrat, C. (2007) Effect of Stemona curtisii root extract on P-glycoprotein and MRP-1 function in multidrug-resistant cancer cells. Phytomedicine, 14, 381-389.
5. Wang, Y., Yu, L., Han, L., Sha, X. and Fang, X. (2007) Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines. Int. J. Pharm., 337, 63-73.
6. Simoni, D., Rizzi, M., Rondanin, R., Baruchello, R., Marchetti, P., Invidiata, F. P., Labbozzetta, M., Poma, P., Carina, V., Notarbartolo, M., Alaimo, A. and D'Alessandro, N. (2008) Anti-tumor effects of curcumin and structurally beta-diketone modified analogs on multidrug resistant cancer cells. Bioorg. Med. Chem. Lett., 18, 845-849.
7. Andresen, T. L., Jensen, S. S. and Jorgensen, K. (2005) Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specific drug release. Prog. Lipid Res., 44, 68-97.
8. Gabizon, A., Goren, D., Horowitz, A. T., Tzemach, D., Lossos, A. and Siegal, T. (1997) Long-circulating liposomes for drug delivery in cancer therapy: a review of biodistribution studies in tumor-bearing animals. Adv. Drug Deliv. Rev., 24, 337-344.
9. Lukyanov, A. N., Elbayoumi, T. A., Chakilam, A. R. and Torchilin, V. P. (2004) Tumor-targeted liposomes: doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody. J. Control. Release, 100, 135-144.
10. Plassat, V., Martina, M. S., Barratt, G., Ménager, C. and Lesieur, S. (2007) Sterically stabilized super-paramagnetic liposomes for MR imaging and cancer therapy: Pharmacokinetics and biodistribution. Int. J. Pharm., 344, 118-127.
11. Xiong, X. B., Huang, Y., Lu, W. L., Zhang, X., Zhang, H., Nagai, T. and Zhang, Q. (2005) Enhanced intracellular delivery and improved antitumor efficacy of doxorubicin by sterically stabilized liposomes modified with a synthetic RGD mimetic. J. Control. Release, 107, 262-275.
12. Tardi, P., Choice, E., Masin, D., Redelmeier, T., Bally, M. and Madden, T. D. (2000) Liposomal encapsulation of topotecan enhances anticancer efficacy in murine and human xenograft models. Cancer Res., 60, 3389-3393.
13. Dadashzadeh, S., Vali, A. M. and Rezaie, M. (2008) The effect of PEG coating on in-vitro cytotoxicity and in-vivo disposition of topotecan loaded liposomes in rats. Int. J. Pharm., 353, 251-259.
14. Akbas, S. H., Timur, M. and Ozben, T. (2005) The effect of quercetin on topotecan cytotoxicity in MCF-7 and MDA-MB 231 human breast cancer cells. J. Surg. Res., 125, 49-55.
15. Emerson, D. L. (2000) Liposomal delivery of camptothecins. Pharm. Sci. Technol. Today, 3, 205-209.
16. Abraham, S. A., Edwards, K., Karlsson, G., Hudon, N., Mayer, L. D. and Bally, M. B. (2004) An evaluation of transmembrane ion gradient-mediated encapsulation of topotecan within liposomes. J. Control. Release, 96, 449-461.
17. Wong, H. L., Bendayan, R., Rauth, A. M. and Wu, X. Y. (2006) Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new polymer-lipid hybrid nanoparticles (PLN) for enhanced treatment of multidrug-resistant breast cancer. J. Control. Release, 116, 275-284.
18. Leitner, H. M., Kachadourian, R. and Day, B. J. (2007) Harnessing drug resistance: using ABC transporter proteins to target cancer cells. Biochem. Pharmacol., 74, 1677-1685.
19. Kim, H. S., Min, Y. D. and Choi, C. H. (2001) Double-edged sword of chemosensitizer: increase of multidrug resistance protein (MRP) in leukemic cells by an MRP inhibitor probenecid. Biochem. Biophys. Res. Commun., 283, 64-71.
20. 2+ channel blocker, in human epidermoid carcinoma A431 cells. Biochem. Pharmacol., 73, 943-953.
21. Yoshida, J., Ishibashi, T. and Nishio, M. (2004) Anti-tumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur. J. Pharmacol., 492, 103-112.
22. Li, X., Lu, W. L., Liang, G. W., Ruan, G. R., Hong, H. Y., Long, C., Zhang, Y. T., Liu, Y., Wang, J. C., Zhang, X. and Zhang, Q. (2006) Effect of stealthy liposomal topotecan plus amlodipine on the multidrug-resistant leukaemia cells in vitro and xenograft in mice. Eur. J. Clin. Invest., 36, 409-418.
23. Yu, F., Yu, F., McGuire, P. M., Li, R. and Wang, R. (2007) Effects of Hydrocotyle sibthorpioides extract on transplanted tumors and immune function in mice. Phytomedicine, 14, 166-171.
24. Qi, X. R., Maitani, Y., Nagai, T. and Wei, S. L. (1997) Comparative pharmacokinetics and anti-tumor efficacy of doxorubicin encapsulated in soybean-derived sterols and poly(ethylene glycol) liposomes in mice. Int. J. Pharm., 146, 31-39.
25. Hu, Y., Yang, Y., You, Q. D., Liu, W., Gu, H. Y., Zhao, L., Zhang, K., Wang, W., Wang, X. T. and Guo, Q. L. (2006) Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its anti-tumor activity. Biochem. Biophys. Res. Commun., 351, 521-527.
26. Djuric, Z., Heilbrun, L. K., Lababidi, S., Everett-Bauer, C. K. and Fariss, M. W. (1997) Growth inhibition of MCF-7 and MCF-10A human breast cells by alpha-tocopheryl hemisuccinate, cholesteryl hemisuccinate and their ether analogs. Cancer Lett., 111, 133-139.
27. Chhipa, R. R., Singh, S., Surve, S. V., Vijayakumar, M. V. and Bhat, M. K. (2005) Doxycycline potentiates anti-tumor effect of cyclophosphamide in mice. Toxicol. Appl. Pharmacol., 202, 268-277.
28. Pedro, M., Ferreira, M. M., Cidade, H., Kijjoa, A., Bronze-da-Rocha, E. and Nascimento, M. S. (2005) Artelastin is a cytotoxic prenylated flavone that disturbs microtubules and interferes with DNA replication in MCF-7 human breast cancer cells. Life Sci., 77, 293-311.
29. Liu, J., Guo, L., Yin, F., Zheng, X., Chen, G. and Wang, Y. (2007) Characterization and anti-tumor activity of triethylene tetramine, a novel telomerase inhibitor. Biomed. Pharmacother., In Press.
30. Liu, J., Gong, T., Wang, C., Zhong, Z. and Zhang, Z. (2007) Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: preparation and characterization. Int. J. Pharm., 340, 153-162.
31. Cui, F., Shi, K., Zhang, L., Tao, A. and Kawashima, Y. (2006) Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation. J. Control. Release, 114, 242-250.
32. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63.
33. Soto-Cerrato, V., Llagostera, E., Montaner, B., Scheffer, G. L. and Perez-Tomas, R. (2004) Mitochondria-mediated apoptosis operating irrespective of multidrug resistance in breast cancer cells by the anticancer agent prodigiosin. Biochem. Pharmacol., 68, 1345-1352.
34. Haran, G., Cohen, R., Bar, L. K. and Barenholz, Y. (1993) Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases. Biochim. Biophys. Acta, 1151, 201-215.
35. Ragno, G., Cione, E., Garofalo, A., Genchi, G., Ioele, G., Risoli, A. and Spagnoletta, A. (2003) Design and monitoring of photostability systems for amlodipine dosage forms. Int. J. Pharm., 265, 125-132.
36. Nagayasu, A., Uchiyama, K. and Kiwada, H. (1999) The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal anti-tumor drugs. Adv. Drug Deliv. Rev., 40, 75-87.