Antiinflammatory activities of flavonoids and a triterpene caffeate isolated from Bauhinia variegata

Phytotherapy Research

Volumn 22, Issue 7, 2008, Pages 957-962

  Rao, Yerra Koteswara ^a   Fang, Shih Hua ^b   Tzeng, Yew Min ^a  

^a CHAOYANG UNIVERSITY OF TECHNOLOGY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Bauhinia variegata; Flavonoids; IL 12; NO; TNF ; Triterpene caffeate

Indexed keywords

3 BETA (3,4 DIHYDROXYCINNAMOYLOXY)OLEAN 12 EN 28 OIC ACID; CAFFEIC ACID; CYTOKINE; FLAVONOID; GAMMA INTERFERON; HESPERIDIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; ISORHAMNETIN 3 O BETA DEXTRO GLUCOPYRANOSIDE; KAEMPFEROL; KAEMPFEROL 3 O BETA DEXTRO GLUCOPYRANOSIDE; KAEMPFEROL 7,4' DIMETHYLETHER 3 O BETA DEXTRO GLUCOPYRANOSIDE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; OMBUIN; TRITERPENE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BAUHINIA; BAUHINIA VARIEGATA; CONCENTRATION RESPONSE; DOSE RESPONSE; DRUG ISOLATION; FEMALE; IC 50; INFLAMMATION; MACROPHAGE FUNCTION; MEDICINAL PLANT; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BAUHINIA; CAFFEIC ACIDS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; INHIBITORY CONCENTRATION 50; INTERFERON TYPE II; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHYTOTHERAPY; PLANT EXTRACTS; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

BAUHINIA VARIEGATA;

EID: 48749084269     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2448     Document Type: Article

References (42)

1. Chan SH, Perussia B, Gupta JW et al. 1991. Induction of interferon-γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med 173: 869-879.
2. Chi DS, Qui M, Krishnaswamy G, Li C, Stone W. 2003. Regulation of NO production from macrophages by LPS and catecholamines. Nitric Oxide 8: 127-132.
3. Clancy RM, Abramson SB. 1995. Nitric oxide: a novel mediator of inflammation. Proc Soc Exp Biol Med 210: 93-101.
4. n. J Agric Food Chem 52: 4039-4046.
5. Feldmann M, Brennan FM, Maini R. 1998. Cytokines in autoimmune disorders. Int Rev Immunol 17: 217-228.
6. Gamble JS. 1956. Flora of the Presidency of Madras. Botanical Survey of India: Calcutta.
7. Gerard C, Rollins BJ. 2001. Chemokines and diseases. Nat Immunol 2: 108-115.
8. Giner RM, Villalba ML, Recio MC, Manez S, Cerda NM, Rios JL. 2000. Anti-inflammatory glycoterpenoids from Scrophularia auriculata. Eur J Pharmacol 389: 243-252.
9. Giner-Larza EM, Manez S, Recio MC et al. 2001. Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity. Eur J Pharmacol 428: 137-143.
10. Gu JQ, Park EJ, Luyengi L et al. 2001. Constituents of Eugenia sandwichensis with potential cancer chemopreventive activity. Phytochemistry 58: 121-127.
11. Gupta AK, Chauhan JS. 1984. Constituents from the stem of Bauhinia variegata. Nat Acad Sci Lett 7: 15-16.
12. Gupta AK, Vidyapati TJ, Chauhan JS. 1979. 5,7-Dihydroxy-flavanone- 4′-O-α-L-rhamnopyranosyl-β-D- glucopyranoside from Bauhinia variegata. Indian J Chem 18B: 85-86.
13. Gupta AK, Vidyapati TJ, Chauhan JS. 1980. Chemical examination of the stem of Bauhinia variegata. Planta Med 38: 174-176.
14. Hamburger M, Riese U, Graf H et al. 2002. Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities. J Agric Food Chem 50: 5533-5538.
15. Huguet Al, Recio MC, Manez S, Giner RM, Rios JL. 2000. Effect of triterpenoids on the inflammation induced by protein kinase C activators, neuronally-acting irritants and other agents. Eur J Pharmacol 410: 69-81.
16. Kim HK, Cheon BS, Kim YH, Kim SY, Kim HP. 1999. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol 58: 759-765.
17. Kirtikar KR, Basu BD. 1993. Indian Medicinal Plants, vol. 2. International Book Publisher: Dehradun.
18. Koo TH, Lee JH, Park YJ et al. 2001. A sesquiterpene lactone, costunolide from Magnolia grandiflora, inhibits NF-kB by targeting lKB phosphorylation. Planta Med 67: 103-107.
19. Latte KP, Kolodziej H. 2004. Antioxidant properties of phenolic compounds from Pelargonium reniforme. J Agric Food Chem 52: 4899-4902.
20. Li X, Xiao H, Liang X, Shi D, Liu J. 2004. LC-MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii. J Pharm Biomed Anal 34: 159-166.
21. Lin HY, Juan SH, Shen SC, Hsu FL, Chen YC. 2003. Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW 264.7 macrophages involves heme oxygenase-1. Biochem Pharmacol 66: 1821-1832.
22. Macmicking JD, Xie QW, Nathan C. 1997. Nitric oxide and macrophage function. Annu Rev Immunol 15: 323-350.
23. Matsuda H, Morikawa T, Ando S, Toguchida I, Yoshikawa M. 2003. Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action. Bioorg Med Chem 11: 1995-2000.
24. Middleton EJ, Kandaswami C, Theoharides TC. 2000. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev 52: 673-751.
25. Moreland LW. 1999. Inhibition of tumor necrosis factor for rheumatoid arthritis. J Rheumatol 26: 7-15.
26. Namgoong SY, Son KH, Chang HW, Kang SS, Kim HP. 1994. Effects of naturally occurring flavonoids on mitogen-induced lymphocyte proliferation and mixed lymphocyte culture. Life Sci 54: 313-320.
27. Pan H, Lundgren LN, Andersson R. 1994. Triterpene caffeates from bark of Betula pubescens. Phytochemistry 37: 795-799.
28. Rajkapoor B, Jayakar B, Murugesh N. 2003. Antitumour activity of Bauhinia variegata on dalton's ascetic lymphoma. J Ethnopharmacol 89: 107-109.
29. Rao YK, Fang SH, Tzeng YM. 2005a. Anti-inflammatory activities of flavonoids isolated from Caesalpinia pulcherrima. J Ethnopharmacol 100: 249-253.
30. Rao YK, Fang SH, Tzeng YM. 2005b. Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-α and IL-12 in activated macrophages. Biol Pharm Bull 28: 912-915.
31. Reddy MVB, Reddy MK, Gunasekar D, Caux C, Bodo B. 2003. A flavanone and a dihydrodibenzoxepin from Bauhinia variegata. Phytochemistry 64: 879-882.
32. Rhaman W, Begum SJ. 1966. Flavonoids from the white flowers of Bauhinia variegata. Naturwissenschaften 53: 384.
33. Roland K, Hamburger M. 2004. Quantitative analysis of antiinflammatory and radical scavenging triterpenoid esters in evening primrose oil. J Agric Food Chem 52: 3319-3324.
34. Sakata K, Hirose Y, Quiao Z, Tanaka T, Mori H. 2003. Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line. Cancer Lett 199: 139-145.
35. Sultana N, Armstrong JA, Waterman PG. 1999. Benzopyran derivatives from the aerial parts of Eriostemon rhomboideus. Phytochemistry 52: 895-900.
36. Takada Y, Aggarwal BB. 2004. Flavopiridol inhibits NF-kB activation induced by various carcinogens and inflammatory agents through inhibition of IkBk kinase and p65 phosphorylation. J Biol Chem 279: 4750-4759.
37. Thiemermann C. 1997. Nitric oxide and septic shock. Gen Pharmacol 29: 159-166.
38. Wahab SMAE, Wassel GM, Ammar NM, Hanna T. 1987. Flavonoid constituents in the different organs of selected Bauhinia species and their effect on blood glucose. Herba Hung 26: 27-39.
39. Wang J, Mazza G. 2002. Inhibitory effects of anthocyanins and other phenolic compounds on NO production in LPS/IFN-γ-activated RAW 264.7 macrophages. J Agric Food Chem 501: 850-857.
40. Xiong Q, Shi D, Mizuno M. 1995. Flavonol glucosides in pericarps of Zanthoxylum bungeanum. Phytochemistry 39: 723-725.
41. Yadava RN, Reddy VM. 2001. A new flavone glycoside 5-hydroxy-7,3′, 4′,5′-tetramethoxyflavone 5-β-D- xylopyranosyl(1→2)-α-L-rhamnopyranoside from Bauhinia variegata. J Asian Nat Prod Res 3: 341-346.
42. Yadava RN, Reddy VM. 2003. Anti-inflammatory activity of a novel flavonol glycoside from the Bauhinia variegata. Nat Prod Res 17: 165-169.