Acute milk-based protein-CHO supplementation attenuates exercise-induced muscle damage

Applied Physiology, Nutrition and Metabolism

Volumn 33, Issue 4, 2008, Pages 775-783

  Cockburn, Emma ^a   Hayes, Philip R ^a   French, Duncan N ^b   Stevenson, Emma ^a   St Clair Gibson, Alan ^a  

^a NORTHUMBRIA UNIVERSITY   (United Kingdom)

^b ENGLISH INSTITUTE OF SPORT   (United Kingdom)

Author keywords

Creatine kinase; DOMS; Eccentric exercise; Isokinetic performance; Myoglobin; Sports drinks

Indexed keywords

CREATINE KINASE; MYOGLOBIN; WATER;

ADULT; ANIMAL; ARTICLE; BEVERAGE; BLOOD; CARBOHYDRATE DIET; CLINICAL TRIAL; DIET SUPPLEMENTATION; EXERCISE; HUMAN; INJURY; KINETICS; MALE; METABOLISM; MILK; PROTEIN INTAKE; REFERENCE VALUE; SINGLE BLIND PROCEDURE; SKELETAL MUSCLE; SPORT; SPORT INJURY; STATISTICS; TIME;

ANIMALS; ATHLETIC INJURIES; BEVERAGES; CREATINE KINASE; DIETARY CARBOHYDRATES; DIETARY PROTEINS; DIETARY SUPPLEMENTS; EXERCISE; HUMANS; KINETICS; MALE; MILK; MUSCLE, SKELETAL; MYOGLOBIN; REFERENCE VALUES; SINGLE-BLIND METHOD; SPORTS; TIME FACTORS; WATER; YOUNG ADULT;

EID: 48649092454     PISSN: 17155312     EISSN: None     Source Type: Journal    
DOI: 10.1139/H08-057     Document Type: Article

References (52)

1. Baty, J.J., Hwang, H., Ding, Z., Bernard, J.R., Wang, B., Kwon, B., and Ivy, J.L. 2007. The effect of a carbohydrate and protein supplement on resistance exercise performance, hormonal response, and muscle damage. J. Strength Cond. Res. 21: 321-329. doi:10.1519/R-21706.1. PMID:17530986.
2. Biolo, G., Tipton, K.D., Klein, S., and Wolfe, R.R. 1997. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am. J. Physiol. 273: E122-E129. PMID:9252488.
3. Bird, S.P., Tarpenning, K.M., and Marino, F.E. 2006. Liquid carbohydrate / essential amino acid ingestion during a short term bout of resistance exercise suppresses myofibrillar protein degradation. Metabolism, 55: 570-577. doi:10.1016/j.metabol.2005.11.011. PMID:16631431.
4. Bloomer, R.J., and Goldfarb, A.H. 2003. Can nutritional supplements reduce exercise-induced skeletal muscle damage? Strength Cond. 25: 30-37.
5. Borsheim, E., Cree, M.G., Tipton, K.D., Elliott, T.A., Aarsland, A., and Wolfe, R.R. 2004. Effect of carbohydrate intake on net muscle protein synthesis during recovery from resistance exercise. J. Appl. Physiol. 96: 674-678. doi:10.1152/japplphysiol.00333.2003. PMID:14594866.
6. Bowers, E.J., Morgan, D.L., and Proske, U. 2004. Damage to the human quadriceps muscle from eccentric exercise and the training effect. J. Sports Sci. 22: 1005-1014. PMID:15801494.
7. Byrne, C., and Eston, R. 2002a. The effect of exercise-induced muscle damage on isometric and dynamic knee extensor strength and vertical jump performance. J. Sports Sci. 20: 417-425. doi:10.1080/026404102317366672. PMID:12043831.
8. Byrne, C., and Eston, R. 2002b. Maximal-intensity isometric and dynamic exercise performance after eccentric muscle actions. J. Sports Sci. 20: 951-959. doi:10.1080/026404102321011706. PMID:12477004.
9. Cade, J.R., Reese, R.H., Privette, R.M., Hommen, N.M., Rogers, J.L., and Fregly, M.J. 1991. Dietary intervention and training in swimmers. Eur. J. Appl. Physiol. 63: 210-215. doi:10.1007/BF00233850.
10. Clarkson, P.M., Byrnes, W.C., McCormick, K.M., Turcotte, L.P., and White, J.S. 1986. Muscle soreness and serum creatine kinase activity following isometric, eccentric, and concentric exercise. Int. J. Sports Med. 7: 152-155. PMID:3733311.
11. Cleak, M.J., and Eston, R.G. 1992. Muscle soreness, swelling, stiffness and strength loss after intense eccentric exercise. Br. J. Sports Med. 26: 267-272. PMID:1490222.
12. Close, G.L., Ashton, T., Cable, T., Doran, D., and MacLaren, D.P.M. 2004. Eccentric exercise, isokinetic muscle torque and delayed onset muscle soreness: the role of reactive oxygen species. Eur. J. Appl. Physiol. 91: 615-621. doi:10.1007/s00421-003-1012-2. PMID:14685863.
13. Dalton, R.A., Walberg-Ranking, J., Sebolt, D., and Gwazdauskas, F.C. 1999. Acute carbohydrate consumption does not influence resistance exercise performance during energy restriction. Int. J. Sport Nutr. 9: 319-332. PMID:10660864.
14. Elliot, T.A., Cree, M.G., Sanford, A.P., Wolfe, R.R., and Tipton, K.D. 2006. Milk ingestion stimulates net muscle protein synthesis following resistance exercise. Med. Sci. Sports Exerc. 38: 667-674. PMID:16679981.
15. Field, A. 2005. Discovering statistics using SPSS. Sage, London, UK.
16. Fielding, R.A., Meredith, C.N., O'Reilly, K.P., Frontera, W.R., Cannon, J.G., and Evans, W.J. 1991. Enhanced protein breakdown after eccentric exercise in young and older men. J. Appl. Physiol. 71: 674-679. PMID:1938741.
17. Friden, J., and Lieber, R.L. 2001. Eccentric exercise-induced injuries to contractile and cytoskeletal muscle fibre components. Acta Physiol. Scand. 171: 321-326. doi:10.1046/j.1365-201x.2001.00834.x. PMID:11412144.
18. Friden, J., Sjostrom, M., and Ekblom, B. 1983. Myofibrillar damage following intense eccentric exercise in man. Int. J. Sports Med. 4: 170-176. PMID:6629599.
19. Harrison, A.J., and Gaffney, S.D. 2004. Effects of muscle damage on stretch-shortening cycle function and muscle stiffness control. J. Strength Cond. Res. 18: 771-776. doi:10.1519/14343.1. PMID:15574081.
20. Howell, J.N., Chleboun, G., and Conatser, R. 1993. Muscle stiffness, strength loss, swelling and soreness following exerciseinduced injury in humans. J. Physiol. 464: 183-196. PMID:8229798.
21. Ivy, J.L. 2004. Regulation of muscle glycogen repletion, muscle protein synthesis and repair following exercise. J. Sports Sci. Med. 3: 131-138.
22. Karp, J.R., Johnston, J.D., Tecklenburg, S., Mickleborough, T.D., Fly, A.D., and Stager, J.M. 2006. Chocolate milk as a post-exercise recovery aid. Int. J. Sport Nutr. 16: 78-91.
23. Koller, A. 2005. Creatine phosphokinase and muscle damage. Med. Sci. Sports Exerc. 37: 166. doi:10.1249/01.MSS.0000149772.78950.BD. PMID:15632687.
24. Kreider, R.B., Earnest, C.P., Lundberg, J., Rasmussen, C., Greenwood, M., Cowan, P., and Almada, A.L. 2007. Effects of ingesting protein with various forms of carbohydrate following resistance-exercise on substrate availability and markers of anabolism, catabolism, and immunity. J. Intl. Soc. Sports Nutr. 4: 18-28. doi:10.1186/1550-2783-4-18. PMID:17997840.
25. Lieber, R.L., Schmitz, M.C., Mishra, D.K., and Friden, J. 1994. Contractile and cellular remodelling in rabbit skeletal muscle after cyclic eccentric contractions. J. Appl. Physiol. 77: 1926-1934. PMID:7836220.
26. Lowe, D.A., Warren, G.L., Ingalls, C.P., Boorstein, D.B., and Armstrong, R.B. 1995. Muscle function and protein metabolism after initiation of eccentric contraction-induced injury. J. Appl. Physiol. 79: 1260-1270. PMID:8567571.
27. Luden, N.D., Saunders, M.J., and Todd, M.K. 2007. Postexercise carbohydrate-protein-antioxidant ingestion decreases plasma creatine kinase and muscle soreness. Int. J. Sport Nutr. 17: 109-123.
28. MacIntyre, D.L., Sorichter, S., Mair, J., Berg, A., and McKenzie, D.C. 2001. Markers of inflammation and myofibrillar proteins following eccentric exercise in humans. Eur. J. Appl. Physiol. 84: 180-186. doi:10.1007/s004210170002. PMID:11320633.
29. Millard-Stafford, M., Warren, G.L., Thomas, L.M., Doyle, J.A., Snow, T., and Hitchcock, K. 2005. Recovery from run training: efficacy of a carbohydrate-protein beverage? Int. J. Sport Nutr. 15: 610-624.
30. Miller, S.L., Tipton, K.D., Chinkes, D.L., Wolf, S.E., and Wolfe, R.R. 2003. Independent and combined effects of amino acids and glucose after resistance exercise. Med. Sci. Sports Exerc. 35: 449-455. doi:10.1249/01.MSS.0000053910.63105.45. PMID:12618575.
31. Moore, D.R., Phillips, S.M., Babraj, J.A., Smith, K., and Rennie, M.J. 2005. Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions. Am. J. Physiol. 288: E1153-E1159.
32. Newham, D.J., McPhail, G., Mills, K.R., and Edwards, R.H.T. 1983. Ultrastructural changes after concentric and eccentric contractions of human muscle. J. Neurol. Sci. 61: 109-122. doi:10.1016/0022-510X(83)90058-8. PMID:6631446.
33. Nosaka, K., Newton, M., and Sacco, P. 2002. Delayed-onset muscle soreness does not reflect the magnitude of eccentric exercise-induced muscle damage. Scand. J. Med. Sci. Sports, 12: 337-346. doi:10.1034/j.1600-0838.2002. 10178.x. PMID:12453160.
34. Rasmussen, B.B., Tipton, K.D., Miller, S.L., Wolf, S.E., and Wolfe, R.R. 2000. An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise. J. Appl. Physiol. 88: 386-392. PMID:10658002.
35. Ratamess, N.A., Kraemer, W.J., Volek, J.S., Rubin, M.R., Gomez, A.L., French, D.N., et al. 2003. The effects of amino acid supplementation on muscular performance during resistance training overreaching. J. Strength Cond. Res. 17: 250-258. doi:10.1519/1533-4287(2003)017〈0250:TEOAAS〉2.0. CO;2. PMID:12741860.
36. Ready, S.L., Seifert, J.G., and Burke, E. 1999. The effect of two sport drink formulations on muscle stress and performance. Med. Sci. Sports Exerc. 31(Suppl.): S119. PMID:8365997.
37. Rodenburg, J.B., Bar, P.R., and De Boer, R.W. 1993. Relations between muscle soreness and biochemical and functional outcomes of eccentric exercise. J. Appl. Physiol. 74: 2976-2983. PMID:8365997.
38. Roy, B.D., Fowles, J.R., Hill, R., and Tarnapolsky, M.A. 2000. Macronutrient intake and whole body protein metabolism following resistance exercise. Med. Sci. Sports Exerc. 32: 1412-1418. PMID:10949007.
39. Saunders, M.J., Kane, M.D., and Todd, M.K. 2004. Effects of a carbohydrate-protein beverage on cycling endurance and muscle damage. Med. Sci. Sports Exerc. 36: 1233-1238. doi:10.1249/01.MSS.0000132377.66177.9F. PMID:15235331.
40. Sayers, S.P., and Clarkson, P.M. 2001. Force recovery after eccentric exercise in males and females. Eur. J. Appl. Physiol. 84: 122-126. doi:10.1007/s004210000346. PMID:11394240.
41. Sayers, S.P., Clarkson, P.M., and Lee, J. 2000. Activity and immobilization after eccentric exercise: I. Recovery of muscle function. Med. Sci. Sports Exerc. 32: 1587-1592. PMID:10994909.
42. Seifert, J.G., Kipp, R.W., Amann, M., and Gazal, O. 2005. Muscle damage, fluid ingestion, and energy supplementation during recreational alpine skiing. Int. J. Sport Nutr. 15: 528-536.
43. Semark, A., Noakes, T.D., St. Clair Gibson, A., and Lambert, M.I. 1999. The effect of a prophylactic dose of flurbiprofen on muscle soreness and sprinting performance in trained subjects. J. Sports Sci. 17: 197-203. doi:10.1080/026404199366091. PMID:10362386.
44. Shirreffs, S.M., Watson, P., and Maughan, R.J. 2007. Milk as an effective post-exercise rehydration drink. Br. J. Nutr. 98: 173-180. doi:10.1017/S0007114507695543. PMID:17459189.
45. Sorichter, S., Mair, J., Koller, A., Calzolari, C., Huonker, M., Pau, B., and Puschendorf, B. 2001. Release of muscle proteins after downhill running in male and female subjects. Scand. J. Med. Sci. Sports, 11: 28-32. doi:10.1034/j.1600-0838.2001.011001028.x. PMID:11169232.
46. Sugita, M., Ohtani, M., Ishii, N., Maruyama, K., and Kobayashi, K. 2003. Effect of a selected amino acid mixture on the recovery from muscle fatigue during and after eccentric contraction exercise training. Biosci. Biotechnol. Biochem. 67: 372-375. doi:10.1271/bbb.67.372. PMID:12729001.
47. Tipton, K.D., and Wolfe, R.R. 2001. Exercise, protein metabolism, and muscle growth. Int. J. Sport Nutr. 11: 109-132.
48. Tipton, K.D., Rasmussen, B.B., Miller, S.L., Wolf, S.E., Owens-Stovall, S.K., Petrini, B.E., and Wolfe, R.R. 2001. Timing of amino acid - carbohydrate ingestion alters anabolic response of muscle to resistance exercise. Am. J. Physiol. 281: E197-E206.
49. Twist, C., and Eston, R. 2005. The effects of exercise-induced muscle damage on maximal intensity intermittent exercise performance. Eur. J. Appl. Physiol. 94: 652-658. doi:10.1007/s00421-005-1357-9. PMID:15887020.
50. Warren, G.L., Ingalls, C.P., Lowe, D.A., and Armstrong, R.B. 2001. Excitation-contraction uncoupling: major role in contraction-induced muscle injury. Exerc. Sport Sci. Rev. 29: 82-87. doi:10.1097/00003677-200104000- 00008. PMID:11337828.
51. Wojcik, J.R., Walberg-Ranking, J., Smith, L.L., and Gwazdauskas, F.C. 2001. Comparison of a carbohydrate and milk-based beverages on muscle damage and glycogen following exercise. Int. J. Sport Nutr. 11: 406-419.
52. Wolfe, R.R. 2001. Effects of amino acid intake on anabolic processes. Can. J. Appl. Physiol. 26(Suppl.): S220-S227. PMID:11897897.