The gene expression signature of relapse in paediatric acute lymphoblastic leukaemia: Implications for mechanisms of therapy failure

British Journal of Haematology

Volumn 131, Issue 4, 2005, Pages 447-456

  Beesley, Alex H ^a   Cummings, Aaron J ^a   Freitas, Joseph R ^a   Hoffmann, Katrin ^a   Firth, Martin J ^a   Ford, Jette ^a   De Klerk, Nicolas H ^a   Kees, Ursula R ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Acute leukaemia; Drug resistance; Gene expression; Metastasis; Paediatric haematology

Indexed keywords

RNA; BSG PROTEIN, HUMAN; CD147 ANTIGEN; TUMOR PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; B CELL LEUKEMIA; BONE MARROW; CANCER DIAGNOSIS; CARCINOGENESIS; CELL DIFFERENTIATION; CELL GROWTH; CELL LINEAGE; CELL PROLIFERATION; CHILD; CHILDHOOD CANCER; CHROMOSOME 19P; CHROMOSOME ABERRATION; CHROMOSOME IDENTIFICATION; COMPREHENSION; CONTROLLED STUDY; CRYOPRESERVATION; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE LOCUS; GENE OVEREXPRESSION; GENETIC LINKAGE; HUMAN; HUMAN TISSUE; METASTASIS; MICROENVIRONMENT; MOLECULAR MECHANICS; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; RECURRENT CANCER; RNA EXTRACTION; RNA TRANSCRIPTION; T CELL LEUKEMIA; TISSUE SECTION; TREATMENT FAILURE; TREATMENT OUTCOME; ACUTE LYMPHOCYTIC LEUKEMIA; CELL DIVISION; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; INFANT; METABOLISM; PRESCHOOL CHILD; PROGNOSIS; RECURRENT DISEASE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL;

ADOLESCENT; ANTIGENS, CD147; CELL DIVISION; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INFANT; LEUKEMIA, B-CELL, ACUTE; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; LEUKEMIA, T-CELL, ACUTE; NEOPLASM PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; RECURRENCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL ANALYSIS; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 33644803035     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05785.x     Document Type: Article

References (31)

1. Achuthan R. Bell S.M. Roberts P. Leek J.P. Horgan K. Markham A.F. MacLennan K.A. Speirs V. ( 2001) Genetic events during the transformation of a tamoxifen-sensitive human breast cancer cell line into a drug-resistant clone. Cancer Genetics and Cytogenetics, 130, 166 172.
2. Carter T.L. Reaman G.H. Kees U.R. ( 2001) INK4A/ARF deletions are acquired at relapse in childhood acute lymphoblastic leukaemia: a paired study on 25 patients using real-time polymerase chain reaction. British Journal of Haematology, 113, 323 328.
3. Flores-Diaz M. Higuita J.C. Florin I. Okada T. Pollesello P. Bergman T. Thelestam M. Mori K. Alape-Giron A. ( 2004) A cellular UDP-glucose deficiency causes overexpression of glucose/oxygen-regulated proteins independent of the endoplasmic reticulum stress elements. Journal of Biological Chemistry, 279, 21724 21731.
4. Gabison E.E. Hoang-Xuan T. Mauviel A. Menashi S. ( 2005) EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair. Biochimie, 87, 361 368.
5. Goker E. Waltham M. Kheradpour A. Trippett T. Mazumdar M. Elisseyeff Y. Schnieders B. Steinherz P. Tan C. Berman E. Bertino J.R. ( 1995) Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations. Blood, 86, 677 684.
6. Gustafsson B. Axelsson B. Christensson B. Winiarski J. ( 2001) MDM2 and p53 in childhood acute lymphoblastic leukemia: higher expression in childhood leukemias with poor prognosis compared to long-term survivors. Pediatric Hematology and Oncology, 18, 497 508.
7. Hazlehurst L.A. Landowski T.H. Dalton W.S. ( 2003) Role of the tumor microenvironment in mediating de novo resistance to drugs and physiological mediators of cell death. Oncogene, 22, 7396 7402.
8. Hicks G.G. Singh N. Nashabi A. Mai S. Bozek G. Klewes L. Arapovic D. White E.K. Koury M.J. Oltz E.M. Van Kaer L. Ruley H.E. ( 2000) Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Nature Genetics, 24, 175 179.
9. Hoffmann K. Firth M.J. Freitas J.R. de Klerk N.H. Kees U.R. ( 2005) Gene expression levels in small specimens from patients detected using oligonucleotide arrays. Molecular Biotechnology, 29, 31 38.
10. Ihaka R.A. Gentleman R. ( 1996) R: a language for data analysis and graphics. Journal of Computer Graphical Statistics, 5, 299 314
11. Irizarry R.A. Bolstad B.M. Collin F. Cope L.M. Hobbs B. Speed T.P. ( 2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Research, 31, e15.
12. Khalidi H.S. O'Donnell M.R. Slovak M.L. Arber D.A. ( 1999) Adult precursor-B acute lymphoblastic leukemia with translocations involving chromosome band 19p13 is associated with poor prognosis. Cancer Genetics and Cytogenetics, 109, 58 65.
13. Lugthart S. Cheok M.H. den Boer M.L. Yang W. Holleman A. Cheng C. Pui C.H. Relling M.V. Janka-Schaub G.E. Pieters R. Evans W.E. ( 2005) Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia. Cancer Cell, 7, 375 386.
14. Ma Y. Hendershot L.M. ( 2004) The role of the unfolded protein response in tumour development: friend or foe? Nature Reviews. Cancer, 4, 966 977.
15. Maloney K.W. McGavran L. Odom L.F. Hunger S.P. ( 1999) Acquisition of p16(INK4A) and p15(INK4B) gene abnormalities between initial diagnosis and relapse in children with acute lymphoblastic leukemia. Blood, 93, 2380 2385.
16. Marieb E.A. Zoltan-Jones A. Li R. Misra S. Ghatak S. Cao J. Zucker S. Toole B.P. ( 2004) Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production. Cancer Research, 64, 1229 1232.
17. Misra S. Ghatak S. Zoltan-Jones A. Toole B.P. ( 2003) Regulation of multidrug resistance in cancer cells by hyaluronan. Journal of Biological Chemistry, 278, 25285 25288.
18. Oue N. Hamai Y. Mitani Y. Matsumura S. Oshimo Y. Aung P.P. Kuraoka K. Nakayama H. Yasui W. ( 2004) Gene expression profile of gastric carcinoma: identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression. Cancer Research, 64, 2397 2405.
19. Perrotti D. Bonatti S. Trotta R. Martinez R. Skorski T. Salomoni P. Grassilli E. Lozzo R.V. Cooper D.R. Calabretta B. ( 1998) TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis. EMBO Journal, 17, 4442 4455.
20. Rahman L. Voeller D. Rahman M. Lipkowitz S. Allegra C. Barrett J.C. Kaye F.J. Zajac-Kaye M. ( 2004) Thymidylate synthase as an oncogene; a novel role for an essential DNA synthesis enzyme. Cancer Cell, 5, 341 351.
21. Sawada R. Lowe J.B. Fukuda M. ( 1993) E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels. Journal of Biological Chemistry, 268, 12675 12681.
22. Shikano T. Ishikawa Y. Ohkawa M. Hatayama Y. Nakadate H. Hatae Y. Takeda T. ( 1990) Karyotypic changes from initial diagnosis to relapse in childhood acute leukemia. Leukemia, 4, 419 422.
23. Staal F.J. van der Burg M. Wessels L.F. Barendregt B.H. Baert M.R. van den Burg C.M. van Huffel C. Langerak A.W. van der Velden V.H. Reinders M.J. van Dongen J.J. ( 2003) DNA microarrays for comparison of gene expression profiles between diagnosis and relapse in precursor-B acute lymphoblastic leukemia: choice of technique and purification influence the identification of potential diagnostic markers. Leukemia, 17, 1324 1332.
24. Tsai T. Davalath S. Rankin C. Radich J.P. Head D. Appelbaum F.R. Boldt D.H. ( 1996) Tumor suppressor gene alteration in adult acute lymphoblastic leukemia (ALL). Analysis of retinoblastoma (Rb) and p53 gene expression in lymphoblasts of patients with de novo, relapsed, or refractory ALL treated in Southwest Oncology Group studies. Leukemia, 10, 1901 1910.
25. Yan L. Zucker S. Toole B.P. ( 2005) Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression. Thrombosis and Haemostasis, 93, 199 204.
26. Yanaihara N. Okamoto A. Matsufuji S. ( 2003) A commonly deleted region in ovarian cancer on chromosome 19p13.3, not including the OAZ1 gene. International Journal of Oncology, 23, 567 575.
27. Yeoh E.J. Ross M.E. Shurtleff S.A. Williams W.K. Patel D. Mahfouz R. Behm F.G. Raimondi S.C. Relling M.V. Patel A. Cheng C. Campana D. Wilkins D. Zhou X. Li J. Liu H. Pui C.H. Evans W.E. Naeve C. Wong L. Downing J.R. ( 2002) Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell, 1, 133 143.
28. Zhang H. Yu C.Y. Singer B. Xiong M. ( 2001) Recursive partitioning for tumor classification with gene expression microarray data. Proceedings of the National Academy of Sciences of the United States of America, 98, 6730 6735.
29. Zhu Y.M. Foroni L. McQuaker I.G. Papaioannou M. Haynes A. Russell H.H. ( 1999) Mechanisms of relapse in acute leukaemia: involvement of p53 mutated subclones in disease progression in acute lymphoblastic leukaemia. British Journal of Cancer, 79, 1151 1157.
30. Zucker S. Hymowitz M. Rollo E.E. Mann R. Conner C.E. Cao J. Foda H.D. Tompkins D.C. Toole B.P. ( 2001) Tumorigenic potential of extracellular matrix metalloproteinase inducer. American Journal of Pathology, 158, 1921 1928.
31. Zuna J. Ford A.M. Peham M. Patel N. Saha V. Eckert C. Kochling J. Panzer-Grumayer R. Trka J. Greaves M. ( 2004) TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia. Clinical Cancer Research, 10, 5355 5360.