Leukotriene B4-loaded microspheres: A new therapeutic strategy to modulate cell activation

BMC Immunology

Volumn 9, Issue , 2008, Pages

  Nicolete, Roberto ^a   Rius, Cristina ^b   Piqueras, Laura ^b   Jose, Peter J ^b   Sorgi, Carlos A ^a   Soares, Edson G ^a   Sanz, Maria J ^b,c   Faccioli, Lúcia H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF VALENCIA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOTRIENE B4; MICROSPHERE; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; NITRITE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DELIVERY SYSTEM; DRUG MECHANISM; ENCAPSULATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; INNATE IMMUNITY; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; LEUKOCYTE ROLLING; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN EXPRESSION; UMBILICAL ARTERY; UMBILICAL VEIN; ANIMAL; BIOSYNTHESIS; CELL ADHESION; CELL MOTION; IMMUNOLOGY; LEUKOCYTE; LUNG; METABOLISM;

ANIMALS; CELL ADHESION; CELL MOVEMENT; CHEMOKINE CCL2; ENDOTHELIAL CELLS; HUMANS; LEUKOCYTE ROLLING; LEUKOCYTES; LEUKOTRIENE B4; LUNG; MACROPHAGES, PERITONEAL; MICE; MICROSPHERES; NITRIC OXIDE; NITRITES; PPAR ALPHA;

EID: 48449105512     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-9-36     Document Type: Article

References (39)

1. Ford-Hutchinson A.W. Bray M.A. Doig M.V. Shipley M.E. Smith M.J. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes Nature 1980, 286:264-265. 10.1038/ 286264a0 6250050
2. Faccioli LH Nourshargh S Moqbel R Williams FM Sehmi R Kay AB Williams TJ The accumulation of 111In-eosinophils induced by inflammatory mediators, in vivo Immunology 1991, 73(2):222-227. 1649126 1384469
3. Goodarzi KM Goodarzi AM Tager AD Luster von Andrian UH Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues Nat Immunol 2003, 4:965-973. 10.1038/ni972 12949533
4. Medeiros AI SÁ-Nunes A Soares EG Peres CM Silva CL Faccioli LH Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis Infect Immun 2004, 72:1637-1644. 355884 14977971 10.1128/ IAI.72.3.1637-1644.2004
5. Machado ER Ueta MT Lourenço EV Anibal FF Sorgi CA Soares EG Roque-Barreira MC Medeiros AI Faccioli LH Leukotrienes play a role in the control of parasite burden in murine strongyloidiasis J Immunol 2005. 175:3892-3899. 16148135
6. Mancuso P Nana-Sinkam P Peters-Golden M Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumoniae Infect Immun 2001, 69:2011. 98124 11254552 10.1128/IAI.69.4.2011-2016.2001
7. Serezani CH Aronoff DM Jancar S Mancuso P Peters-Golden M Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase Blood 2005, 106:1067-1075. 1895163 15718414 10.1182/blood-2004-08-3323
8. Peres CM Aronoff DM Serezani CH Flamand N Faccioli LH Peters-Golden M Specific leukotriene receptors couple to distinct g proteins to effect stimulation of alveolar macrophage host defense functions J Immunol 2007, 179:5454-5461. 17911632
9. Malaviya R Abraham SN Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis J Leukoc Biol 2000, 67(6):841-6. 10857857
10. Yokomizo T Izumi T Chang K Takuwa Y Shimizu T A G-protein coupled receptor for leukotriene B4 that mediates chemotaxis Nature 1997, 387:620-624. 10.1038/42506 9177352
11. Tager AM Bromley SK Medoff BD Islam SA Bercury SD Friedrich EB Carafone AD Gerszten RE Luster AD Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment Nat Immunol 2003, 4:982-990. 10.1038/ni970 12949531
12. Devchand PR Keller H Peters JM Vazquez M Gonzalez FJ Wahli W The PPARα-leukotriene B4 pathway to inflammation control Nature 1996, 384;39-43. 10.1038/384039a0 8900274
13. Springer TA Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm Cell 1994, 76:301-314. 10.1016/ 0092-8674(94)90337-9 7507411
14. Gerszten RE Garcia-Zepeda EA Lim YC Yoshida M Ding HA Gimbrone MA Jr Luster AD Luscinskas FW Rosenzweig A MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions Nature 1999, 398:718-723. 10.1038/19546 10227295
15. Vaddi K Newton RC Regulation of monocyte integrin expression by β-family chemokines J Immunol 1994, 153:4721-4732. 7525713
16. Showell HJ Conklyn MJ Alpert R Hingorani GP Wright KF Smith MA Stam E Griffiths RJ The preclinical pharmacological profile of the potent and selective leukotriene B4 antagonist CP-195543 J Pharmacol Exp Ther 1998, 285:946-954. 9618393
17. Patrícia MK Kim JA Harper CM Shih PT Berliner JA Natarajan R Nadler JL Hedrick CC Lipoxygenase products increase monocyte adhesion to human aortic endothelial cells Arterioscler Thromb Vasc Biol 1999, 19:2615-2622. 10559003
18. Palmblad J Lerner R Larsson SH Signal transduction mechanisms for leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils J Immunol 1994, 152:262-269. 8254196
19. Hoover RL Karnovsky MJ Austen KF Corey EJ Lewis RA Leukotriene B4 action on endothelium mediates augmented neutrophil/endothelial adhesion Proc Natl Acad Sci USA 1984, 81:2191-2193. 345463 6326110 10.1073/ pnas.81.7.2191
20. Hong Q Anne-Sofie J Mattias S Min W Oliver S Jan P Jesper ZH Differential induction of BLT receptor expression on human endothelial cells by lipopolysacharide, cytokines, and leukotriene B4 Proc Natl Acad Sci USA 2006, 103:6913-6918. 1440767 16624877 10.1073/pnas.0602208103
21. Back M Bu DX Branstrom R Sheikin Y Yan ZQ Hansson GK Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia Proc Natl Acad Sci USA 2005, 102:17501-17506. 1297663 16293697 10.1073/pnas.0505845102
22. Palmblad JE Lerner R Leukotriene B4-induced hyperadhesiveness of endothelial cells for neutrophils: Relation to CD54 Clin Exp Immunol 1992, 90:300-304. 1554610 1358491
23. Palmblad J Lerner R Larsson SH Signal transduction mechanisms for leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils J Immunol 1994, 152:262-269. 8254196
24. Wedmore CV Williams TJ Control of vascular permeability by polymorphonuclear leukocytes in inflammation Nature 1981, 289:646-650. 10.1038/289646a0 7464931
25. Ulbrich H Eriksson EE Lindbom L Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease Trends Pharmacol Sci 2003, 24:640-647. 10.1016/ j.tips.2003.10.004 14654305
26. Lima KM Santos SA Lima VM Coelho-Castelo AA Rodrigues JMJR Silva CL Single dose of a vaccine based on DNA encoding mycobacterial hsp65 protein plus TDM-loaded PLGA microspheres protects mice against a virulent strain of Mycobacterium tuberculosis Gene Ther 2003, 10:678-685. 10.1038/sj.gt.3301908 12692596
27. Nicolete R Lima KM Rodrigues Júnior JM Baruffi MD Medeiros AI Bentley MVLB Silva CL Faccioli LH In vitro and in vivo activities of leukotriene B4-loaded biodegradable microspheres Prostaglandins & other Lipid Mediators 2007, 83:121-129. 10.1016/ j.prostaglandins.2006.10.007 17259078
28. Eldridge JH Staas JK Meulbroek JA Tice TR Gilley RM Biodegradable and biocompatible poly (DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies Infect Immun 1991, 59:2978-2986. 258122 1879922
29. Lima KM Rodrigues JM JR Poly-dl-lactide-co-glycolide microspheres as a controlled release antigen delivery system Braz J Med Biol Res 1999, 32:171-180. 10347752
30. Sanz MJ Hickey MJ Johnston B McCafferty DM Raharjo E Huang PL Kubes P Neuronal nitric oxide synthase (NOS) regulates leukocyte-endothelial cell interactions in endothelial NOS deficient mice Br J Pharmacol 2001, 134:305-312. 1572945 11564648 10.1038/sj.bjp.0704234
31. House SD Lipowsky HH Leukocyte-endothelium adhesion: Microhemodynamics in mesentery of the cat Microvasc Res 1987, 34;363-379. 10.1016/ 0026-2862(87)90068-9 3431483
32. Andonegui G Goyert SM Kubes P Lipopolysaccharide-induced leukocyte-endothelial cell interactions: A role for CD14 versus toll-like receptor 4 within microvessels J Immunol 2002, 169(4):2111-2119. 12165539
33. Jaffe EA Nachman RL Becker CG Minick CR Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria J Clin Invest 1973, 52:2745-2756. 302542 4355998 10.1172/JCI107470
34. NIH Image website http://rsb.info.nih.gov
35. Lerner R Changes of cytosolic calcium ion concentrations in human endothelial cells in response to thrombin, platelet-activating factor, and leukotriene B4 J Lab Clin Med 1994, 124:723-729. 7964131
36. Nohgawa M Sasada M Maeda A Asagoe K Harakawa N Takano K Yamamoto K Okuma M Leukotriene B4-activated human endothelial cells promote transendothelial neutrophil migration J Leukocyte Biol 1997, 62:203-209. 9261334
37. Lee H Shi W Tontonoz P Wang S Subbanagounder G Hedrick CC Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells Circ Res 2000, 87:516-521. 10988245
38. Goya K Sumitani S Xu X Kitamura T Yamamoto H Kurebayashi S Saito H Kouhara H Kasayama S Kawase I Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells Arterioscler Thromb Vasc Biol 2004, 24:658-663. 10.1161/01.ATV.0000118682.58708.78 14751809
39. Tontonoz P Nagy L Alvarez JG Thomazy VA Evans RM PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL Cell 1998, 93:241-252. 10.1016/S0092-8674(00)81575-5 9568716