Mechanisms of synaptic vesicle exocytosis

Annual Review of Cell and Developmental Biology

Volumn 16, Issue , 2000, Pages 19-49

  Lin, R C ^a   Scheller, R H ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Membrane fusion; SNARE; Syntaxin; VAMP; Vesicle trafficking

Indexed keywords

SNARE PROTEIN; SYNAPTOTAGMIN; SYNTAXIN;

CALCIUM BINDING; CELL COMMUNICATION; EXOCYTOSIS; LEARNING; MEMBRANE FUSION; MEMBRANE VESICLE; MEMORY; NERVE CELL PLASTICITY; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION;

ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; EXOCYTOSIS; HUMANS; MEMBRANE FUSION; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MUNC18 PROTEINS; NERVE TISSUE PROTEINS; PHOSPHORYLATION; RAB3A GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SNARE PROTEINS; SYNAPTIC VESICLES; SYNAPTOTAGMINS; VESICULAR TRANSPORT PROTEINS;

EID: 0034523701     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.16.1.19     Document Type: Review

References (131)

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2. Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse
3. 2+-activated exocytosis
4. 2+-dependent exocytosis
5. Hrs-2 is an ATPase implicated in calcium-regulated secretion
6. Syntaxin: A synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones
7. Casein kinase II phosphorylates the synaptic vesicle protein p65
8. The molecular machinery for secretion is conserved from yeast to neurons
9. A temperature-sensitive step in exocytosis
10. Kinetic analysis of secretion from permeabilized adrenal chromaffin cells reveals distinct components
11. Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis
12. Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosis
13. Interactions of three domains distinguishing the Ras-related GTP-binding proteins Ypt1 and Sec4
14. Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission
15. Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRAI)
16. Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly
17. Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking
18. Assembly of a ternary complex by the predicted minimal coiled-coil-forming domains of syntaxin, SNAP-25, and synaptobrevin. A circular dichroism study
19. Piccolo, a novel 420 kDa protein associated with the presynaptic cytomatrix
20. 2+ regulates the interaction between synaptotagmin and syntaxin 1
21. 2+ and drives membrane fusion
22. SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast
23. Mammalian phosphatidylinositol transfer proteins: Emerging roles in signal transduction and vesicular traffic
24. 2+ sensitivity
25. Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily
26. Phosphorylation of synaptotagmin I by casein kinase II
27. Synaptic transmission persists in synaptotagmin mutants of Drosophila
28. A conformational switch in syntaxin during exocytosis: Role of munc18
29. Interaction of a Golgi-associated kinesin-like protein with Rab6
30. Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties
31. A structural change occurs upon binding of syntaxin to SNAP-25
32. Identification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly
33. Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs
34. Spontaneous subthreshold activity at motor nerve endings
35. Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A
36. Folding intermediates of SNARE complex assembly
37. Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: Its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin
38. Tomosyn: A syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process
39. Identification of a novel alternatively spliced septin
40. Depolarization of cerebellar granule cells increases phosphorylation of rabphilin-3A
41. A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants
42. 2+ sensor for transmitter release at a central synapse
43. The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion
44. RAB3 and synaptotagmin: The yin and yang of synaptic membrane fusion
45. Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells
46. The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis
47. Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy
48. SED5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex
49. Mutations in the Drosophila Rop gene suggest a function in general secretion and synaptic transmission
50. 2+-activated secretion
51. Resolution of regulated secretion into sequential MgATP-dependent and calcium-dependent stages mediated by distinct cytosolic proteins
52. SNAREs and NSF in targeted membrane fusion
53. Synaptic vesicle membrane fusion complex: Action of clostridial neurotoxins on assembly
54. The Sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains
55. MgATP-independent and MgATP-dependent exocytosis. Evidence that MgATP primes adrenal chromaffin cells to undergo exocytosis
56. Targeting vesicles to specific sites on the plasma membrane: The role of the Sec6/8 complex
57. Subunit composition, protein interactions, and structures of the mammalian brain Sec6/8 complex and septin filaments
58. A post-docking role for synaptobrevin in synaptic vesicle fusion
59. Physical and functional interaction of rabphilin-3A with alpha-actinin
60. Localization of synaptotagmin-binding domains on syntaxin
61. Essential role of myosin light chain kinase in the mechanism for MgATP-dependent priming of exocytosis in adrenal chromaffin cells
62. 2+-dependent and -independent activities of neural and nonneural synaptotagmins
63. Ypt1p implicated in v-SNARE activation
64. Structural organization of the synaptic exocytosis core complex
65. Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants
66. Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse
67. Region-specific phosphorylation of rabphilin in mossy fiber nerve terminals of the hippocampus
68. Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis
69. Evidence for synaptotagmin as an inhibitory clamp on synaptic vesicle release in Aplysia neurons
70. Stages of regulated exocytosis
71. Docking of yeast vacuoles is catalyzed by the Ras-like GTPase Ypt7p after symmetric priming by Sec18p (NSF)
72. Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles
73. Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13
74. Complexins: Cytosolic proteins that regulate SNAP receptor function
75. Role of the C2A domain of synaptotagmin in transmitter release as determined by specific antibody injection into the squid giant synapse preterminal
76. Three-dimensional structure of the neuronal-Sec1/syntaxin complex
77. Myosin II is involved in transmitter release at synapses formed between rat sympathetic neurons in culture
78. Synaptic vesicles retain their identity through the endocytic cycle
79. Homotypic vacuolar fusion mediated by t- and v-SNAREs
80. Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs
81. Phosphorylation of VAMP/synaptobrevin in synaptic vesicles by endogenous protein kinases
82. Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin
83. Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants
84. Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles
85. Order of events in the yeast secretory pathway
86. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway
87. The diversity of Rab proteins in vesicle transport
88. Disruption of syntaxin-mediated protein inter-actions blocks neurotransmitter secretion
89. Structural basis of Rab effector specificity: Crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A
90. The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations
91. Rapid and efficient fusion of phospholipid vesicles by the α-helical core of a SNARE complex in the absence of an N-terminal regulatory domain
92. Tetanus and botulinum neurotoxins: Mechanism of action and therapeutic uses
93. Specificity and regulation of a synaptic vesicle docking complex
94. Transport vesicle docking: SNAREs and associates
95. Protease resistance of syntaxin-SNAP-25-VAMP complexes: Implications for assembly and structure
96. The synaptic SNARE complex is a parallel four-stranded helical bundle
97. Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae
98. 2+-induced insulin exocytosis
99. Differential phosphorylation of syntaxin and synaptosome-associated protein of 25 kDa (SNAP-25) isoforms
100. Inhibitors of myosin light chain kinase block synaptic vesicle pool mobilization during action potential firing
101. Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses
102. Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release
103. Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission
104. Rop, a Drosophila homolog of yeast Sec1 and vertebrate nSec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo
105. 2 domains of synaptotagmin and protein kinase C
106. 2+-dependent electrostatic switch
107. Phosphorylation of 25-kDa synaptosome-associated protein. Possible involvement in protein kinase C-mediated regulation of neurotransmitter release
108. Coiled coils in both intracellular vesicle and viral membrane fusion
109. Arab protein is required for the assembly of SNARE complexes in the docking of transport vesicles
110. A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
111. SNAP receptors implicated in vesicle targeting and fusion
112. 2+/phospholipid-binding fold
113. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
114. The phosphatidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle-mediated vacuolar protein sorting
115. Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae
116. Insights into the molecular mechanisms of synàptic vesicle docking and fusion
117. Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals
118. Septins: A highly conserved family of membrane-associated GT-Pases with functions in cell division and beyond
119. VAMP-1: A synaptic vesicle-associated integral membrane protein
120. Defining the functions of trans-SNARE pairs
121. Changes of synaptotagmin interaction with t-SNARE proteins in vitro after calcium/calmodulin-dependent phosphorylation
122. The t-SNAREs syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling
123. Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin
124. Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion
125. SNARE-pins: Minimal machinery for membrane fusion
126. Chromaffin granule-associated phosphatidylinositol 4-kinase activity is required for stimulated secretion
127. ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage dependent manner
128. SNARE interactions are not selective
129. nSec1 binds a closed conformation of syntaxin1 A
130. An α-helical minimal binding domain within the H3 domain of syntaxin is required for SNAP-25 binding
131. SNAP-25 is phosphorylated by glucose and GLP-1 in RIN 1046-38 cells