Mechanism of metal-mediated DNA damage and apoptosis induced by 6-hydroxydopamine in neuroblastoma SH-SY5Y cells

Free Radical Research

Volumn 42, Issue 7, 2008, Pages 651-660

  Kobayashi, Hatasu ^a   Oikawa, Shinji ^a   Umemura, So ^a   Hirosawa, Iwao ^b   Kawanishi, Shosuke ^c  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KANSAI UNIVERSITY OF WELFARE SCIENCES   (Japan)

^c SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

6 hydroxydopamine; Apoptosis; Copper; DNA damage; Iron; Parkinson's disease

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; COPPER; DNA; EDETIC ACID; HYDROGEN PEROXIDE; IRON; IRON CHELATING AGENT; METAL; OXIDOPAMINE; PHOSPHORUS 32; QUINONE DERIVATIVE; SCOPOLETIN;

APOPTOSIS; ARTICLE; AUTOOXIDATION; CONTROLLED STUDY; DISEASE MODEL; DNA DAMAGE; HUMAN; HUMAN CELL; INHIBITION KINETICS; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROTOXICITY; OXIDATIVE STRESS; PARKINSON DISEASE; SPECTROPHOTOMETRY;

APOPTOSIS; BENZOQUINONES; BIOLOGICAL MARKERS; CELL LINE, TUMOR; CHELATING AGENTS; COPPER; DEOXYGUANOSINE; DNA DAMAGE; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; HUMANS; HYDROGEN PEROXIDE; IRON; IRON CHELATING AGENTS; NEUROBLASTOMA; NEURONS; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXIDOPAMINE; TIME FACTORS;

ANIMALIA;

EID: 48449092397     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760802270334     Document Type: Article

References (49)

1. Bove, J., Prou, D., Perier, C. and Przedborski, S. (2005) Toxin-induced models of Parkinson's disease. 2, pp. 484-494.
2. Schober, A. (2004) Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. 318, pp. 215-224.
3. Deumens, R., Blokland, A. and Prickaerts, J. (2002) Modeling Parkinson's disease in rats: An evaluation of 6-OHDA lesions of the nigrostriatal pathway. 175, pp. 303-317.
4. Double, KL, Riederer, PF and Gerlach, M. (1999) Role of iron in 6-hydroxydopamine neurotoxicity. 80, pp. 287-296.
5. Shachar, DB, Kahana, N., Kampel, V., Warshawsky, A. and Youdim, MB. (2004) Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats. 46, pp. 254-263.
6. Zheng, H., Youdim, MB, Weiner, LM and Fridkin, M. (2005) Synthesis and evaluation of peptidic metal chelators for neuroprotection in neurodegenerative diseases. 66, pp. 190-203.
7. Asanuma, M., Miyazaki, I., Higashi, Y., Tanaka, K., Haque, ME, Fujita, N. and Ogawa, N. (2002) Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain. 327, pp. 61-65.
8. Hidalgo, J., Aschner, M., Zatta, P. and Vasak, M. (2001) Roles of the metallothionein family of proteins in the central nervous system. 55, pp. 133-145.
9. Egli, D., Domenech, J., Selvaraj, A., Balamurugan, K., Hua, H., Capdevila, M., Georgiev, O., Schaffner, W. and Atrian, S. (2006) The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification. 11, pp. 647-658.
10. Culmsee, C. and Mattson, MP. (2005) p53 in neuronal apoptosis. 331, pp. 761-777.
11. Morrison, RS, Kinoshita, Y., Johnson, MD, Guo, W. and Garden, GA. (2003) p53-dependent cell death signaling in neurons. 28, pp. 15-27.
12. Ferger, B., Rose, S., Jenner, A., Halliwell, B. and Jenner, P. (2001) 6-hydroxydopamine increases hydroxyl free radical production and DNA damage in rat striatum. 12, pp. 1155-1159.
13. Yasuhara, T., Hara, K., Sethi, KD, Morgan, JC and Borlongan, CV. (2007) Increased 8-OHdG levels in the urine, serum, and substantia nigra of hemiparkinsonian rats. 1133, pp. 49-52.
14. Bruchelt, G., Schraufstatter, IU, Niethammer, D. and Cochrane, CG. (1991) Ascorbic acid enhances the effects of 6-hydroxydopamine and H2O2 on iron-dependent DNA strand breaks and related processes in the neuroblastoma cell line SK-N-SH. 51, pp. 6066-6072.
15. Oikawa, S., Hirosawa, I., Tada-Oikawa, S., Furukawa, A., Nishiura, K. and Kawanishi, S. (2006) Mechanism for manganese enhancement of dopamine-induced oxidative DNA damage and neuronal cell death. 41, pp. 748-756.
16. Kobayashi, H., Oikawa, S. and Kawanishi, S. (2006) Mechanism of DNA damage and apoptosis induced by tetrahydropapaveroline, a metabolite of dopamine. 31, pp. 523-532.
17. Starkebaum, G. and Harlan, JM. (1986) Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. 77, pp. 1370-1376.
18. Kasai, H., Crain, PF, Kuchino, Y., Nishimura, S., Ootsuyama, A. and Tanooka, H. (1986) Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. 7, pp. 1849-1851.
19. Ito, K., Inoue, S., Yamamoto, K. and Kawanishi, S. (1993) 8-Hydroxydeoxyguanosine formation at the 5' site of 5'-GG-3' sequences in double-stranded DNA by UV radiation with riboflavin. 268, pp. 13221-13227.
20. Serrano, M., Hannon, GJ and Beach, D. (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. 366, pp. 704-707.
21. Oikawa, S., Murakami, K. and Kawanishi, S. (2003) Oxidative damage to cellular and isolated DNA by homocysteine: Implications for carcinogenesis. 22, pp. 3530-3538.
22. Yamashita, N., Murata, M., Inoue, S., Hiraku, Y., Yoshinaga, T. and Kawanishi, S. (1998) Superoxide formation and DNA damage induced by a fragrant furanone in the presence of copper(II). 397, pp. 191-201.
23. Yamamoto, K. and Kawanishi, S. (1991) Site-specific DNA damage induced by hydrazine in the presence of manganese and copper ions. The role of hydroxyl radical and hydrogen atom. 266, pp. 1509-1515.
24. Kawanishi, S. and Yamamoto, K. (1991) Mechanism of site-specific DNA damage induced by methylhydrazines in the presence of copper(II) or manganese(III). 30, pp. 3069-3075.
25. Capon, DJ, Chen, EY, Levinson, AD, Seeburg, PH and Goeddel, DV. (1983) Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. 302, pp. 33-37.
26. Maxam, AM and Gilbert, W. (1980) Sequencing end-labeled DNA with base-specific chemical cleavages. 65, pp. 499-560.
27. European Standards Committee on Oxidative DNA Damage (2002) Comparative analysis of baseline 8-oxo-7,8-dihydroguanine in mammalian cell DNA, by different methods in different laboratories: An approach to consensus. 23, pp. 2129-2133.
28. Sachs, C., Jonsson, G., Heikkila, R. and Cohen, G. (1975) Control of the neurotoxicity of 6-hydroxydopamine by intraneuronal noradrenaline in rat iris. 93, pp. 345-351.
29. Kasai, H. (1997) Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. 387, pp. 147-163.
30. Pilger, A. and Rudiger, HW. (2006) 8-Hydroxy-2'-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures. 80, pp. 1-15.
31. Levay, G., Ye, Q. and Bodell, WJ. (1997) Formation of DNA adducts and oxidative base damage by copper mediated oxidation of dopamine and 6-hydroxydopamine. 146, pp. 570-574.
32. Mizutani, H., Tada-Oikawa, S., Hiraku, Y., Kojima, M. and Kawanishi, S. (2005) Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide. 76, pp. 1439-1453.
33. Tada-Oikawa, S., Oikawa, S. and Kawanishi, S. (2000) Determination of DNA damage, peroxide generation, mitochondrial membrane potential, and caspase-3 activity during ultraviolet A-induced apoptosis. 319, pp. 331-342.
34. Hertzberg, RP and Dervan, PB. (1984) Cleavage of DNA with methidiumpropyl-EDTA-iron(II): Reaction conditions and product analyses. 23, pp. 3934-3945.
35. Kawanishi, S., Inoue, S. and Sano, S. (1986) Mechanism of DNA cleavage induced by sodium chromate(VI) in the presence of hydrogen peroxide. 261, pp. 5952-5958.
36. Celander, DW and Cech, TR. (1990) Iron(II)-ethylenediaminetetraacetic acid catalyzed cleavage of RNA and DNA oligonucleotides: Similar reactivity toward single- and double-stranded forms. 29, pp. 1355-1361.
37. Rao, PS, Luber Jr, JM, Milinowicz, J., Lalezari, P. and Mueller, HS. (1988) Specificity of oxygen radical scavengers and assessment of free radical scavenger efficiency using luminol enhanced chemiluminescence. 150, pp. 39-44.
38. Frelon, S., Douki, T., Favier, A. and Cadet, J. (2003) Hydroxyl radical is not the main reactive species involved in the degradation of DNA bases by copper in the presence of hydrogen peroxide. 16, pp. 191-197.
39. Soto-Otero, R., Mendez-Alvarez, E., Hermida-Ameijeiras, A., Munoz-Patino, AM and Labandeira-Garcia, JL. (2000) Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. 74, pp. 1605-1612.
40. Saito, Y., Nishio, K., Ogawa, Y., Kinumi, T., Yoshida, Y., Masuo, Y. and Niki, E. (2007) Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: Involvement of hydrogen peroxide-dependent and -independent action. 42, pp. 675-685.
41. Oikawa, S. and Kawanishi, S. (1998) Distinct mechanisms of site-specific DNA damage induced by endogenous reductants in the presence of iron(III) and copper(II). 1399, pp. 19-30.
42. Wang, J., Jiang, H. and Xie, JX. (2004) Time dependent effects of 6-OHDA lesions on iron level and neuronal loss in rat nigrostriatal system. 29, pp. 2239-2243.
43. Tarohda, T., Ishida, Y., Kawai, K., Yamamoto, M. and Amano, R. (2005) Regional distributions of manganese, iron, copper, and zinc in the brains of 6-hydroxydopamine-induced parkinsonian rats. 383, pp. 224-234.
44. He, Y., Lee, T. and Leong, SK. (1999) Time course of dopaminergic cell death and changes in iron, ferritin and transferrin levels in the rat substantia nigra after 6-hydroxydopamine (6-OHDA) lesioning. 31, pp. 103-112.
45. Gaeta, A. and Hider, RC. (2005) The crucial role of metal ions in neurodegeneration: The basis for a promising therapeutic strategy. 146, pp. 1041-1059.
46. Sayre, LM, Moreira, PI, Smith, MA and Perry, G. (2005) Metal ions and oxidative protein modification in neurological disease. 41, pp. 143-164.
47. Leveugle, B., Faucheux, BA, Bouras, C., Nillesse, N., Spik, G., Hirsch, EC, Agid, Y. and Hof, PR. (1996) Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases. 91, pp. 566-572.
48. Ke, Y. and Ming Qian, Z. (2003) Iron misregulation in the brain: A primary cause of neurodegenerative disorders. 2, pp. 246-253.
49. Zecca, L., Stroppolo, A., Gatti, A., Tampellini, D., Toscani, M., Gallorini, M., Giaveri, G., Arosio, P., Santambrogio, P., Fariello, RG, Karatekin, E., Kleinman, MH, Turro, N., Hornykiewicz, O. and Zucca, FA. (2004) The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. 101, pp. 9843-9848.