-
1
-
-
0033009998
-
Is the role of the small intestine in řst-pass metabolism overemphasized? Pharmacol
-
Lin, J. H., Chiba, M. and Baillie, T. A.: Is the role of the small intestine in řst-pass metabolism overemphasized? Pharmacol. Revs., 51: 135-157 (1999).
-
(1999)
Revs.
, vol.51
, pp. 135-157
-
-
Lin, J.H.1
Chiba, M.2
Baillie, T.A.3
-
2
-
-
0033972441
-
Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
-
Dresser, G. K., Spence, D. and Bailey, D. G.: Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin. Pharmacokinet., 38: 41-57 (2000).
-
(2000)
Clin. Pharmacokinet.
, vol.38
, pp. 41-57
-
-
Dresser, G.K.1
Spence, D.2
Bailey, D.G.3
-
3
-
-
0036093847
-
The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism? Clin.
-
Doherty, M. M. and Charman, W. N.: The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism? Clin. Pharmacokinet., 41: 235-253 (2002).
-
(2002)
Pharmacokinet.
, vol.41
, pp. 235-253
-
-
Doherty, M.M.1
Charman, W.N.2
-
4
-
-
0026099498
-
Interaction of citrus juices with felodipine and nifedipine.
-
Bailey, D. G., Spence, J. D., Munoz, C. and Arnold, J. M. O.: Interaction of citrus juices with felodipine and nifedipine. Lancet, 337: 268-269 (1991).
-
(1991)
Lancet
, vol.337
, pp. 268-269
-
-
Bailey, D.G.1
Spence, J.D.2
Munoz, C.3
Arnold, J.M.O.4
-
5
-
-
0028153858
-
Grapefruit juice and drugs: how signîcant is the interaction?.
-
Bailey, D. G., Arnold, J. M. O. and Spence, J. D.: Grapefruit juice and drugs: how signîcant is the interaction?. Clin. Pharmacokinet., 26: 91-98 (1994).
-
(1994)
Clin. Pharmacokinet.
, vol.26
, pp. 91-98
-
-
Bailey, D.G.1
Arnold, J.M.O.2
Spence, J.D.3
-
6
-
-
0029070369
-
Factors aŝecting the absolute bioavailability of nifedipine. Br
-
Rashid, T. J., Martin, U., Clarke, H., Waller, D. G., Renwick, A. G. and George, C. F.: Factors aŝecting the absolute bioavailability of nifedipine. Br. J. Clin. Pharmacol., 40: 51-58 (1995).
-
(1995)
J. Clin. Pharmacol
, vol.40
, pp. 51-58
-
-
Rashid, T.J.1
Martin, U.2
Clarke, H.3
Waller, D.G.4
Renwick, A.G.5
George, C.F.6
-
7
-
-
0028054999
-
Extrahepatic metabolism of drugs in humans
-
Krishna, R. D. and Klotz, U.: Extrahepatic metabolism of drugs in humans. Clin. Pharmacokinet., 26: 144-160 (1994).
-
(1994)
Clin. Pharmacokinet.
, vol.26
, pp. 144-160
-
-
Krishna, R.D.1
Klotz, U.2
-
8
-
-
0031445547
-
Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism
-
Paine, M. F., Khalighi, M., Fisher, J. M., Shen, D. D., Kunze, K. L., Marsh, C. L., Perkins, J. D. and Thummel, K. E.: Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. J. Pharmacol. Exp. Ther., 283: 1552-1562 (1997).
-
(1997)
J. Pharmacol. Exp. Ther
, vol.283
, pp. 1552-1562
-
-
Paine, M.F.1
Khalighi, M.2
Fisher, J.M.3
Shen, D.D.4
Kunze, K.L.5
Marsh, C.L.6
Perkins, J.D.7
Thummel, K.E.8
-
9
-
-
0033022765
-
Characterization of human small intestinal cytochromes P-450. Drug Metab
-
Zhang, Q. Y., Dunber, D., Ostrowska, A., Zeisloft, S., Yang, J. and Kaminsky, L. S.: Characterization of human small intestinal cytochromes P-450. Drug Metab. Dispos., 27: 804-809 (1999).
-
(1999)
Dispos.
, vol.27
, pp. 804-809
-
-
Zhang, Q.Y.1
Dunber, D.2
Ostrowska, A.3
Zeisloft, S.4
Yang, J.5
Kaminsky, L.S.6
-
10
-
-
0032956839
-
Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression
-
Gibbs, M. A., Thummel, K. E., Shen, D. D. and Kunze, K. L.: Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression. Drug Metab. Dispos., 27: 180-187 (1999).
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 180-187
-
-
Gibbs, M.A.1
Thummel, K.E.2
Shen, D.D.3
Kunze, K.L.4
-
11
-
-
0035118551
-
Metabolic characterization of the major human small intestinal cytochromes P-450s
-
Obach, R. S., Zhang, Q. Y., Dunber, D. and Kaminsky, L. S.: Metabolic characterization of the major human small intestinal cytochromes P-450s. Drug Metab. Dispos., 29: 347-352 (2001).
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 347-352
-
-
Obach, R.S.1
Zhang, Q.Y.2
Dunber, D.3
Kaminsky, L.S.4
-
12
-
-
0021237346
-
Nifedipine: kinetics and dynamics in healthy subjects
-
Kleinbloesem, C. H., van Brummelen, P., van de Linde, J. A., Voogd, P. J. and Breimer, D. D.: Nifedipine: kinetics and dynamics in healthy subjects. Clin. Pharmacol. Ther., 35: 742-749 (1984).
-
(1984)
Clin. Pharmacol. Ther.
, vol.35
, pp. 742-749
-
-
Kleinbloesem, C.H.1
van Brummelen, P.2
van de Linde, J.A.3
Voogd, P.J.4
Breimer, D.D.5
-
13
-
-
0026581559
-
Clinical pharmacokinetics of calcium antagonists: an update
-
Kelly, J. G. and O‚Malley, K.: Clinical pharmacokinetics of calcium antagonists: an update. Clin. Pharmacokinet., 22: 416-433 (1992).
-
(1992)
Clin. Pharmacokinet.
, vol.22
, pp. 416-433
-
-
Kelly, J.G.1
O‚Malley, K.2
-
14
-
-
0023629955
-
Moment analysis of intravenous, intraduodenal, buccal, rectal and percutaneous nifedipine in rats
-
Kondo, S. and Sugimoto, I.: Moment analysis of intravenous, intraduodenal, buccal, rectal and percutaneous nifedipine in rats. J. Pharmacobio-Dyn., 10: 462- 469 (1987).
-
(1987)
J. Pharmacobio-Dyn
, vol.10
, pp. 462-469
-
-
Kondo, S.1
Sugimoto, I.2
-
15
-
-
0030853841
-
Extrahepatiĉrst-pass metabolism of nifedipine in the rat
-
Grundy, J. S., Eliot, L. A. and Foster, R. T.: Extrahepatiĉrst-pass metabolism of nifedipine in the rat. Biopharm. Drug Dispos., 18: 509-522 (1997).
-
(1997)
Biopharm. Drug Dispos.
, vol.18
, pp. 509-522
-
-
Grundy, J.S.1
Eliot, L.A.2
Foster, R.T.3
-
16
-
-
0031949165
-
Grapefruit juice and orange juice eŝect on the bioavailability of nifedipine in the rat
-
Grundy, J. S., Eliot, L. A., Kulmatycki, K. M. and Foster, R. T.: Grapefruit juice and orange juice eŝect on the bioavailability of nifedipine in the rat. Biopharm. Drug Dispos., 19: 175-183 (1998).
-
(1998)
Biopharm. Drug Dispos.
, vol.19
, pp. 175-183
-
-
Grundy, J.S.1
Eliot, L.A.2
Kulmatycki, K.M.3
Foster, R.T.4
-
17
-
-
0034029572
-
Eŝects of long-term grapefruit juice ingestion on nifedipine pharmacokinetics: induction of rat hepatic P-450 by grapefruit juice
-
Mohri, K., Uesawa, Y. and Sagawa, K.: Eŝects of long-term grapefruit juice ingestion on nifedipine pharmacokinetics: induction of rat hepatic P-450 by grapefruit juice. Drug Metab. Dispos., 28: 482-486 (2000).
-
(2000)
Drug Metab. Dispos.
, vol.28
, pp. 482-486
-
-
Mohri, K.1
Uesawa, Y.2
Sagawa, K.3
-
18
-
-
0034948448
-
Eŝects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats
-
Mohri, K. and Uesawa, Y.: Eŝects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats. Pharm. Res., 18: 177-182 (2001).
-
(2001)
Pharm. Res.
, vol.18
, pp. 177-182
-
-
Mohri, K.1
Uesawa, Y.2
-
19
-
-
0034802152
-
Intestinal řst-pass metabolism of eperisone in the rat
-
Mihara, K., Matsumura, M., Yoshioka, E., Hanada, K., Nakasa, H., Ohmori, S., Kitada, M. and Ogata, H.: Intestinal řst-pass metabolism of eperisone in the rat. Pharm. Res., 18: 1131-1137 (2001).
-
(2001)
Pharm. Res.
, vol.18
, pp. 1131-1137
-
-
Mihara, K.1
Matsumura, M.2
Yoshioka, E.3
Hanada, K.4
Nakasa, H.5
Ohmori, S.6
Kitada, M.7
Ogata, H.8
-
20
-
-
0022517959
-
Determination of kinetic parameters of a carrier-mediated transport in the perfused intestine by two-dimensional laminar flow model: eŝect of the unstirred water layer
-
Yuasa, H., Miyamoto, Y., Iga, T. and Hanano, M.: Determination of kinetic parameters of a carrier-mediated transport in the perfused intestine by two-dimensional laminar flow model: eŝect of the unstirred water layer. Biochim. Biophys. Acta, 856: 219-230 (1986).
-
(1986)
Biochim. Biophys. Acta
, vol.856
, pp. 219-230
-
-
Yuasa, H.1
Miyamoto, Y.2
Iga, T.3
Hanano, M.4
-
21
-
-
0030588993
-
Sensitive high-performance liquid chromatographic determination of nifedipine in dog plasma using an automated sample preparation system with laboratory robot
-
Horvath, V., Andrea, H. P., Niegreisz, Z., Kocsi, E., Horvai, G., Godorhazy, L., Tolokan, A., Klebovich, I. and Katalin, B. N.: Sensitive high-performance liquid chromatographic determination of nifedipine in dog plasma using an automated sample preparation system with laboratory robot. J. Chromatogr. B., 686: 211-219 (1996).
-
(1996)
J. Chromatogr. B
, vol.686
, pp. 211-219
-
-
Horvath, V.1
Andrea, H.P.2
Niegreisz, Z.3
Kocsi, E.4
Horvai, G.5
Godorhazy, L.6
Tolokan, A.7
Klebovich, I.8
Katalin, B.N.9
-
22
-
-
0024290936
-
Comparative assessment of the resistance of the unstirred water layer to solute transport between two diŝerent intestinal perfusion systems
-
Yuasa, H., Iga, T., Hanano, M. and Watanabe, J.: Comparative assessment of the resistance of the unstirred water layer to solute transport between two diŝerent intestinal perfusion systems. Biochim. Biophys. Acta, 938: 189-198 (1988).
-
(1988)
Biochim. Biophys. Acta
, vol.938
, pp. 189-198
-
-
Yuasa, H.1
Iga, T.2
Hanano, M.3
Watanabe, J.4
-
23
-
-
0027231109
-
Influence of anesthetic regimens on intestinal absorption in rats
-
Yuasa, H., Matsuda, K. and Watanabe, J.: Influence of anesthetic regimens on intestinal absorption in rats. Pharm. Res., 10: 884-888 (1993).
-
(1993)
Pharm. Res.
, vol.10
, pp. 884-888
-
-
Yuasa, H.1
Matsuda, K.2
Watanabe, J.3
-
24
-
-
0029037039
-
Influence of anesthetic regimens on the intestinal absorption of 5-fluorouracil in rats
-
Yuasa, H., Matsuda, K. and Watanabe, J.: Influence of anesthetic regimens on the intestinal absorption of 5-fluorouracil in rats. Biol. Pharm. Bull., 18: 747-752 (1995).
-
(1995)
Biol. Pharm. Bull.
, vol.18
, pp. 747-752
-
-
Yuasa, H.1
Matsuda, K.2
Watanabe, J.3
-
25
-
-
0345262775
-
Physicochemical properties of drugs that control absorption rate after subcutaneous implantation
-
Ballard, B. E. and Nelson, E.: Physicochemical properties of drugs that control absorption rate after subcutaneous implantation. J. Pharmacol. Exp. Ther., 135: 120-127 (1962).
-
(1962)
J. Pharmacol. Exp. Ther
, vol.135
, pp. 120-127
-
-
Ballard, B.E.1
Nelson, E.2
-
26
-
-
0029827089
-
Dose-dependent gastrointestinal absorption of 5-fluorouracil in rats in vivo
-
Yuasa, H., Matsuda, K., Gu, J., Suzuki, E., Yokouchi, I. and Watanabe, J.: Dose-dependent gastrointestinal absorption of 5-fluorouracil in rats in vivo. Biol. Pharm. Bull., 19: 1494-1498 (1996).
-
(1996)
Biol. Pharm. Bull.
, vol.19
, pp. 1494-1498
-
-
Yuasa, H.1
Matsuda, K.2
Gu, J.3
Suzuki, E.4
Yokouchi, I.5
Watanabe, J.6
-
27
-
-
0023715382
-
Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds
-
Amidon, G. L., Sinko, P. J. and Fleisher, D.: Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds. Pharm. Res., 5: 651-654 (1988).
-
(1988)
Pharm. Res.
, vol.5
, pp. 651-654
-
-
Amidon, G.L.1
Sinko, P.J.2
Fleisher, D.3
-
28
-
-
0029028792
-
Overlapping substrate specîcities and tissue distribution of cytochrome P450 and P-glycoprotein: implications drug delivery activity in cancer chemotherapy
-
Wachar, V. J., Wu, C.-Y. and Benet, L. Z.: Overlapping substrate specîcities and tissue distribution of cytochrome P450 and P-glycoprotein: implications and drug delivery and activity in cancer chemotherapy. Mol. Carcinog., 13: 129-134 (1995).
-
(1995)
Mol. Carcinog.
, vol.13
, pp. 129-134
-
-
Wachar, V.J.1
Wu, C.-Y.2
Benet, L.Z.3
-
29
-
-
0032907322
-
Interrelationship between substrates and inhibitors of human CYP3A and Pglycoprotein
-
Kim, R. B., Wandel, C., Leake, B., Cvetkovic, M., Fromm, M. F., Dempsey, P. J., Roden, M. M., Belas, F., Chaudhary, A. K., Roden, D. M., Wood, A. J. J. and Wilkinson, G. R.: Interrelationship between substrates and inhibitors of human CYP3A and Pglycoprotein. Pharm. Res., 16: 408-414 (1999).
-
(1999)
Pharm. Res.
, vol.16
, pp. 408-414
-
-
Kim, R.B.1
Wandel, C.2
Leake, B.3
Cvetkovic, M.4
Fromm, M.F.5
Dempsey, P.J.6
Roden, M.M.7
Belas, F.8
Chaudhary, A.K.9
Roden, D.M.10
Wood, A.J.J.11
Wilkinson, G.R.12
-
30
-
-
0028858960
-
Cytochrome P450 inhibitors: evaluation of specîcities in the in vitro metabolism therapeutic agents by human liver microsomes
-
Newton, D. J., Wang, R. W. and Lu, A. Y. H.: Cytochrome P450 inhibitors: evaluation of specîcities in the in vitro metabolism therapeutic agents by human liver microsomes. Drug Metab. Dispos., 23: 154-158 (1995).
-
(1995)
Drug Metab. Dispos.
, vol.23
, pp. 154-158
-
-
Newton, D.J.1
Wang, R.W.2
Lu, A.Y.H.3
-
31
-
-
0029971798
-
Multiple forms of human P450 expressed in Saccharomyces cerevisiae
-
Imaoka, S., Yamada, T., Hiroi, T., Hayashi, K., Sakai, T., Yabusaki, Y. and Funae, Y.: Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Biochem. Pharmacol., 51: 1041-1050 (1996).
-
(1996)
Biochem. Pharmacol.
, vol.51
, pp. 1041-1050
-
-
Imaoka, S.1
Yamada, T.2
Hiroi, T.3
Hayashi, K.4
Sakai, T.5
Yabusaki, Y.6
Funae, Y.7
-
32
-
-
0034961288
-
Drug interaction between simvastatin and itraconazole in male and female rats.
-
Ishigaki, M., Kawabata, K., Takasaki, W., Ikeda, T., Komai, T., Ito, K. and Sugiyama, Y.: Drug interaction between simvastatin and itraconazole in male and female rats. Drug Metab. Dispos., 29: 1068-1072 (2001).
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 1068-1072
-
-
Ishigaki, M.1
Kawabata, K.2
Takasaki, W.3
Ikeda, T.4
Komai, T.5
Ito, K.6
Sugiyama, Y.7
-
33
-
-
0036266176
-
In vitro biotransformation of sildenâl (Viagra) in the male rat: the role of CYP2C11.
-
Warrington, J. S., Moltke, L. L. V., Shader, R. I. and Greenblatt, D. J.: In vitro biotransformation of sildenâl (Viagra) in the male rat: the role of CYP2C11. Drug Metab. Dispos., 30: 655-657 (2002).
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 655-657
-
-
Warrington, J.S.1
Moltke, L.L.V.2
Shader, R.I.3
Greenblatt, D.J.4
-
34
-
-
0022998708
-
Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
-
Guengerich, F. P., Martin, M. V., Beaune, P. H., Kremers, P., Wolŝ, T. and Waxman, D. J.: Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. J. Biol. Chem 261: 5051-5060, (1986).
-
(1986)
J. Biol. Chem
, vol.261
, pp. 5051-5060
-
-
Guengerich, F.P.1
Martin, M.V.2
Beaune, P.H.3
Kremers, P.4
Wolŝ, T.5
Waxman, D.J.6
-
35
-
-
9044236908
-
Characterization of rat small intestinal cytochrome P-450 composition and inducibility
-
Zhang, Q. Y., Wikoŝ, J., Dunber, D., Ostrowska, A.and Kaminsky, L. S.: Characterization of rat small intestinal cytochrome P-450 composition and inducibility. Drug Metab. Dispos., 24: 322-328 (1996).
-
(1996)
Drug Metab. Dispos.
, vol.24
, pp. 322-328
-
-
Zhang, Q.Y.1
Wikoŝ, J.2
Dunber, D.3
Ostrowska, A.4
Kaminsky, L.S.5
-
36
-
-
0033574047
-
A novel cytochrome P450 3A isoenzyme in rat intestinal microsomes
-
Gushchin, G. V., Gushchin, M. I., Gerber, N. and Boyd, R. T.: A novel cytochrome P450 3A isoenzyme in rat intestinal microsomes. Biochem. Biophys. Res. Commun., 255: 394-398 (1999).
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.255
, pp. 394-398
-
-
Gushchin, G.V.1
Gushchin, M.I.2
Gerber, N.3
Boyd, R.T.4
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