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Volumn 17, Issue 6, 2002, Pages 546-553

Metabolic Extraction of Nifedipine during Absorption from the Rat Small Intestine

Author keywords

absorption; CYP3A; metabolism; nifedipine; rat; small intestine

Indexed keywords


EID: 4844220358     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.17.546     Document Type: Article
Times cited : (25)

References (36)
  • 1
    • 0033009998 scopus 로고    scopus 로고
    • Is the role of the small intestine in řst-pass metabolism overemphasized? Pharmacol
    • Lin, J. H., Chiba, M. and Baillie, T. A.: Is the role of the small intestine in řst-pass metabolism overemphasized? Pharmacol. Revs., 51: 135-157 (1999).
    • (1999) Revs. , vol.51 , pp. 135-157
    • Lin, J.H.1    Chiba, M.2    Baillie, T.A.3
  • 2
    • 0033972441 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
    • Dresser, G. K., Spence, D. and Bailey, D. G.: Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin. Pharmacokinet., 38: 41-57 (2000).
    • (2000) Clin. Pharmacokinet. , vol.38 , pp. 41-57
    • Dresser, G.K.1    Spence, D.2    Bailey, D.G.3
  • 3
    • 0036093847 scopus 로고    scopus 로고
    • The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism? Clin.
    • Doherty, M. M. and Charman, W. N.: The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism? Clin. Pharmacokinet., 41: 235-253 (2002).
    • (2002) Pharmacokinet. , vol.41 , pp. 235-253
    • Doherty, M.M.1    Charman, W.N.2
  • 4
    • 0026099498 scopus 로고
    • Interaction of citrus juices with felodipine and nifedipine.
    • Bailey, D. G., Spence, J. D., Munoz, C. and Arnold, J. M. O.: Interaction of citrus juices with felodipine and nifedipine. Lancet, 337: 268-269 (1991).
    • (1991) Lancet , vol.337 , pp. 268-269
    • Bailey, D.G.1    Spence, J.D.2    Munoz, C.3    Arnold, J.M.O.4
  • 5
    • 0028153858 scopus 로고
    • Grapefruit juice and drugs: how signîcant is the interaction?.
    • Bailey, D. G., Arnold, J. M. O. and Spence, J. D.: Grapefruit juice and drugs: how signîcant is the interaction?. Clin. Pharmacokinet., 26: 91-98 (1994).
    • (1994) Clin. Pharmacokinet. , vol.26 , pp. 91-98
    • Bailey, D.G.1    Arnold, J.M.O.2    Spence, J.D.3
  • 7
    • 0028054999 scopus 로고
    • Extrahepatic metabolism of drugs in humans
    • Krishna, R. D. and Klotz, U.: Extrahepatic metabolism of drugs in humans. Clin. Pharmacokinet., 26: 144-160 (1994).
    • (1994) Clin. Pharmacokinet. , vol.26 , pp. 144-160
    • Krishna, R.D.1    Klotz, U.2
  • 9
    • 0033022765 scopus 로고    scopus 로고
    • Characterization of human small intestinal cytochromes P-450. Drug Metab
    • Zhang, Q. Y., Dunber, D., Ostrowska, A., Zeisloft, S., Yang, J. and Kaminsky, L. S.: Characterization of human small intestinal cytochromes P-450. Drug Metab. Dispos., 27: 804-809 (1999).
    • (1999) Dispos. , vol.27 , pp. 804-809
    • Zhang, Q.Y.1    Dunber, D.2    Ostrowska, A.3    Zeisloft, S.4    Yang, J.5    Kaminsky, L.S.6
  • 10
    • 0032956839 scopus 로고    scopus 로고
    • Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression
    • Gibbs, M. A., Thummel, K. E., Shen, D. D. and Kunze, K. L.: Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression. Drug Metab. Dispos., 27: 180-187 (1999).
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 180-187
    • Gibbs, M.A.1    Thummel, K.E.2    Shen, D.D.3    Kunze, K.L.4
  • 11
    • 0035118551 scopus 로고    scopus 로고
    • Metabolic characterization of the major human small intestinal cytochromes P-450s
    • Obach, R. S., Zhang, Q. Y., Dunber, D. and Kaminsky, L. S.: Metabolic characterization of the major human small intestinal cytochromes P-450s. Drug Metab. Dispos., 29: 347-352 (2001).
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 347-352
    • Obach, R.S.1    Zhang, Q.Y.2    Dunber, D.3    Kaminsky, L.S.4
  • 13
    • 0026581559 scopus 로고
    • Clinical pharmacokinetics of calcium antagonists: an update
    • Kelly, J. G. and O‚Malley, K.: Clinical pharmacokinetics of calcium antagonists: an update. Clin. Pharmacokinet., 22: 416-433 (1992).
    • (1992) Clin. Pharmacokinet. , vol.22 , pp. 416-433
    • Kelly, J.G.1    O‚Malley, K.2
  • 14
    • 0023629955 scopus 로고
    • Moment analysis of intravenous, intraduodenal, buccal, rectal and percutaneous nifedipine in rats
    • Kondo, S. and Sugimoto, I.: Moment analysis of intravenous, intraduodenal, buccal, rectal and percutaneous nifedipine in rats. J. Pharmacobio-Dyn., 10: 462- 469 (1987).
    • (1987) J. Pharmacobio-Dyn , vol.10 , pp. 462-469
    • Kondo, S.1    Sugimoto, I.2
  • 15
    • 0030853841 scopus 로고    scopus 로고
    • Extrahepatiĉrst-pass metabolism of nifedipine in the rat
    • Grundy, J. S., Eliot, L. A. and Foster, R. T.: Extrahepatiĉrst-pass metabolism of nifedipine in the rat. Biopharm. Drug Dispos., 18: 509-522 (1997).
    • (1997) Biopharm. Drug Dispos. , vol.18 , pp. 509-522
    • Grundy, J.S.1    Eliot, L.A.2    Foster, R.T.3
  • 16
    • 0031949165 scopus 로고    scopus 로고
    • Grapefruit juice and orange juice eŝect on the bioavailability of nifedipine in the rat
    • Grundy, J. S., Eliot, L. A., Kulmatycki, K. M. and Foster, R. T.: Grapefruit juice and orange juice eŝect on the bioavailability of nifedipine in the rat. Biopharm. Drug Dispos., 19: 175-183 (1998).
    • (1998) Biopharm. Drug Dispos. , vol.19 , pp. 175-183
    • Grundy, J.S.1    Eliot, L.A.2    Kulmatycki, K.M.3    Foster, R.T.4
  • 17
    • 0034029572 scopus 로고    scopus 로고
    • Eŝects of long-term grapefruit juice ingestion on nifedipine pharmacokinetics: induction of rat hepatic P-450 by grapefruit juice
    • Mohri, K., Uesawa, Y. and Sagawa, K.: Eŝects of long-term grapefruit juice ingestion on nifedipine pharmacokinetics: induction of rat hepatic P-450 by grapefruit juice. Drug Metab. Dispos., 28: 482-486 (2000).
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 482-486
    • Mohri, K.1    Uesawa, Y.2    Sagawa, K.3
  • 18
    • 0034948448 scopus 로고    scopus 로고
    • Eŝects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats
    • Mohri, K. and Uesawa, Y.: Eŝects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats. Pharm. Res., 18: 177-182 (2001).
    • (2001) Pharm. Res. , vol.18 , pp. 177-182
    • Mohri, K.1    Uesawa, Y.2
  • 20
    • 0022517959 scopus 로고
    • Determination of kinetic parameters of a carrier-mediated transport in the perfused intestine by two-dimensional laminar flow model: eŝect of the unstirred water layer
    • Yuasa, H., Miyamoto, Y., Iga, T. and Hanano, M.: Determination of kinetic parameters of a carrier-mediated transport in the perfused intestine by two-dimensional laminar flow model: eŝect of the unstirred water layer. Biochim. Biophys. Acta, 856: 219-230 (1986).
    • (1986) Biochim. Biophys. Acta , vol.856 , pp. 219-230
    • Yuasa, H.1    Miyamoto, Y.2    Iga, T.3    Hanano, M.4
  • 21
    • 0030588993 scopus 로고    scopus 로고
    • Sensitive high-performance liquid chromatographic determination of nifedipine in dog plasma using an automated sample preparation system with laboratory robot
    • Horvath, V., Andrea, H. P., Niegreisz, Z., Kocsi, E., Horvai, G., Godorhazy, L., Tolokan, A., Klebovich, I. and Katalin, B. N.: Sensitive high-performance liquid chromatographic determination of nifedipine in dog plasma using an automated sample preparation system with laboratory robot. J. Chromatogr. B., 686: 211-219 (1996).
    • (1996) J. Chromatogr. B , vol.686 , pp. 211-219
    • Horvath, V.1    Andrea, H.P.2    Niegreisz, Z.3    Kocsi, E.4    Horvai, G.5    Godorhazy, L.6    Tolokan, A.7    Klebovich, I.8    Katalin, B.N.9
  • 22
    • 0024290936 scopus 로고
    • Comparative assessment of the resistance of the unstirred water layer to solute transport between two diŝerent intestinal perfusion systems
    • Yuasa, H., Iga, T., Hanano, M. and Watanabe, J.: Comparative assessment of the resistance of the unstirred water layer to solute transport between two diŝerent intestinal perfusion systems. Biochim. Biophys. Acta, 938: 189-198 (1988).
    • (1988) Biochim. Biophys. Acta , vol.938 , pp. 189-198
    • Yuasa, H.1    Iga, T.2    Hanano, M.3    Watanabe, J.4
  • 23
    • 0027231109 scopus 로고
    • Influence of anesthetic regimens on intestinal absorption in rats
    • Yuasa, H., Matsuda, K. and Watanabe, J.: Influence of anesthetic regimens on intestinal absorption in rats. Pharm. Res., 10: 884-888 (1993).
    • (1993) Pharm. Res. , vol.10 , pp. 884-888
    • Yuasa, H.1    Matsuda, K.2    Watanabe, J.3
  • 24
    • 0029037039 scopus 로고
    • Influence of anesthetic regimens on the intestinal absorption of 5-fluorouracil in rats
    • Yuasa, H., Matsuda, K. and Watanabe, J.: Influence of anesthetic regimens on the intestinal absorption of 5-fluorouracil in rats. Biol. Pharm. Bull., 18: 747-752 (1995).
    • (1995) Biol. Pharm. Bull. , vol.18 , pp. 747-752
    • Yuasa, H.1    Matsuda, K.2    Watanabe, J.3
  • 25
    • 0345262775 scopus 로고
    • Physicochemical properties of drugs that control absorption rate after subcutaneous implantation
    • Ballard, B. E. and Nelson, E.: Physicochemical properties of drugs that control absorption rate after subcutaneous implantation. J. Pharmacol. Exp. Ther., 135: 120-127 (1962).
    • (1962) J. Pharmacol. Exp. Ther , vol.135 , pp. 120-127
    • Ballard, B.E.1    Nelson, E.2
  • 26
    • 0029827089 scopus 로고    scopus 로고
    • Dose-dependent gastrointestinal absorption of 5-fluorouracil in rats in vivo
    • Yuasa, H., Matsuda, K., Gu, J., Suzuki, E., Yokouchi, I. and Watanabe, J.: Dose-dependent gastrointestinal absorption of 5-fluorouracil in rats in vivo. Biol. Pharm. Bull., 19: 1494-1498 (1996).
    • (1996) Biol. Pharm. Bull. , vol.19 , pp. 1494-1498
    • Yuasa, H.1    Matsuda, K.2    Gu, J.3    Suzuki, E.4    Yokouchi, I.5    Watanabe, J.6
  • 27
    • 0023715382 scopus 로고
    • Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds
    • Amidon, G. L., Sinko, P. J. and Fleisher, D.: Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds. Pharm. Res., 5: 651-654 (1988).
    • (1988) Pharm. Res. , vol.5 , pp. 651-654
    • Amidon, G.L.1    Sinko, P.J.2    Fleisher, D.3
  • 28
    • 0029028792 scopus 로고
    • Overlapping substrate specîcities and tissue distribution of cytochrome P450 and P-glycoprotein: implications drug delivery activity in cancer chemotherapy
    • Wachar, V. J., Wu, C.-Y. and Benet, L. Z.: Overlapping substrate specîcities and tissue distribution of cytochrome P450 and P-glycoprotein: implications and drug delivery and activity in cancer chemotherapy. Mol. Carcinog., 13: 129-134 (1995).
    • (1995) Mol. Carcinog. , vol.13 , pp. 129-134
    • Wachar, V.J.1    Wu, C.-Y.2    Benet, L.Z.3
  • 30
    • 0028858960 scopus 로고
    • Cytochrome P450 inhibitors: evaluation of specîcities in the in vitro metabolism therapeutic agents by human liver microsomes
    • Newton, D. J., Wang, R. W. and Lu, A. Y. H.: Cytochrome P450 inhibitors: evaluation of specîcities in the in vitro metabolism therapeutic agents by human liver microsomes. Drug Metab. Dispos., 23: 154-158 (1995).
    • (1995) Drug Metab. Dispos. , vol.23 , pp. 154-158
    • Newton, D.J.1    Wang, R.W.2    Lu, A.Y.H.3
  • 33
    • 0036266176 scopus 로고    scopus 로고
    • In vitro biotransformation of sildenâl (Viagra) in the male rat: the role of CYP2C11.
    • Warrington, J. S., Moltke, L. L. V., Shader, R. I. and Greenblatt, D. J.: In vitro biotransformation of sildenâl (Viagra) in the male rat: the role of CYP2C11. Drug Metab. Dispos., 30: 655-657 (2002).
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 655-657
    • Warrington, J.S.1    Moltke, L.L.V.2    Shader, R.I.3    Greenblatt, D.J.4
  • 34
    • 0022998708 scopus 로고
    • Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
    • Guengerich, F. P., Martin, M. V., Beaune, P. H., Kremers, P., Wolŝ, T. and Waxman, D. J.: Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. J. Biol. Chem 261: 5051-5060, (1986).
    • (1986) J. Biol. Chem , vol.261 , pp. 5051-5060
    • Guengerich, F.P.1    Martin, M.V.2    Beaune, P.H.3    Kremers, P.4    Wolŝ, T.5    Waxman, D.J.6
  • 35
    • 9044236908 scopus 로고    scopus 로고
    • Characterization of rat small intestinal cytochrome P-450 composition and inducibility
    • Zhang, Q. Y., Wikoŝ, J., Dunber, D., Ostrowska, A.and Kaminsky, L. S.: Characterization of rat small intestinal cytochrome P-450 composition and inducibility. Drug Metab. Dispos., 24: 322-328 (1996).
    • (1996) Drug Metab. Dispos. , vol.24 , pp. 322-328
    • Zhang, Q.Y.1    Wikoŝ, J.2    Dunber, D.3    Ostrowska, A.4    Kaminsky, L.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.