Reduction of myocardial infarct size by inhibition of inducible nitric oxide synthase

American Journal of Hypertension

Volumn 12, Issue 2 I, 1999, Pages 174-182

  Wang, D ^a   Yang, X P ^a   Liu, Y H ^a   Carretero, O A ^a   LaPointe, M C ^a  

^a HENRY FORD HOSPITAL   (United States)

Author keywords

Aminoguanidine; Cytokines; Hypoxia; Myocardial infarction; Nitric oxide; S methylisothiourea sulfate

Indexed keywords

AMINOGUANIDINE; CYTOKINE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; S METHYLISOTHIOUREA SULFATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LOCALIZATION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HYPOXIA; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NEUTROPHIL; NEWBORN; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT;

EID: 0033030552     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(98)00235-0     Document Type: Article

References (36)

1. S Moncada R.M.J Palmer D.A Higgs Nitric oxide physiology, pathophysiology and pharmacology Pharmacol Rev 43 1991 109 142
2. R Kelly J.-L Balligand T.W Smith Nitric oxide and cardiac function Circ Res 79 1996 363 380
3. H Hayakawa L Raij The link among nitric oxide synthase activity, endothelial function, and aortic and ventricular hypertrophy in hypertension Hypertension 29 1997 235 241
4. D Ungureanu-Longrois J.-L Balligand R.A Kelly T.W Smith Myocardial contractile dysfunction in the systemic inflammatory response syndrome role of a cytokine-inducible nitric oxide synthase in cardiac myocytes J Mol Cell Cardiol 127 1995 155 167
5. 2+-independent nitric oxide synthase in the myocardium Br J Pharmacol 105 1992 575 580
6. R.R Dudek S Wildhirt V Pinto Dexamethasone inhibits the expression of an inducible nitric oxide synthase in infarcted rabbit myocardium Biochem Biophys Res Commun 202 1994 1120 1126
7. X Yang N Chowdhury B Cai Induction of myocardial nitric oxide synthase by cardiac allograft rejection J Clin Invest 94 1994 714 721
8. N.K Worrall W.D Lazenby T.P Misko Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase J Exp Med 181 1995 63 70
9. G.A Haywood P.S Tsao H.E von der Leyen Expression of inducible nitric oxide synthase in human heart failure Circulation 93 1996 1087 1094
10. P Harding O.A Carretero M.C.L LaPointe Effects of interleukin-1β and nitric oxide on cardiac myocytes Hypertension 25 1995 421 430
11. J.-L Balligand D Ungureanu-Longrois W.W Simmons Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro J Biol Chem 269 1994 27580 27588
12. S.M Wildhirt R.R Dudek H Suzuki R.J Bing Involvement of inducible nitric oxide synthase in the inflammatory process of myocardial infarction Int J Cardiol 50 1995 253 261
13. S.M Wildhirt H Suzuki W.-P Wolf S -methylisothiourea inhibits inducible nitric oxide synthase and improves left ventricular performance after acute myocardial infarction Biochem Biophys Res Commun 227 1996 328 333
14. V.C Patel D.M Yellon K.J Singh Inhibition of nitric oxide limits infarct size in the in situ rabbit heart Biochem Biophys Res Commun 194 1993 234 238
15. X.-P Yang H Sabbah Y.-H Liu Ventriculographic evaluation in three rat models of cardiac dysfunction Am J Physiol 265 1993 H1946 H1952
16. S.M Wildhirt H Suzuki R.R Dudek Continuous inhibition of inducible nitric oxide synthase by aminoguanidine reduces infarct size and improves left ventricular performance after ischemia/reperfusion (abst) Circulation 94 1996 I-589
17. X.-P Yang Y.-H Liu E Peterson O.A Carretero Effect of neutral endopeptidase 24.11 inhibition on myocardial ischemia/reperfusion injury the role of kinins J Cardiovasc Pharmacol 29 1997 250 256
18. C.R Lyons G.J Orloff J.M Cunningham Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line J Biol Chem 267 1992 6370 6374
19. M.C LaPointe J.R Sitkins Mechanisms of interleukin-1β regulation of nitric oxide synthase in cardiac myocytes Hypertension 27 1996 709 714
20. S.M Wildhirt H Suzuki D Horstman Selective modulation of inducible nitric oxide synthase isozyme in myocardial infarction Circulation 96 1997 1616 1623
21. S Szabó G.J Southan C Thiemermann Beneficial effects and improved survival in rodent models of septic shock with S -methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase Proc Natl Acad Sci USA 91 1994 12472 12476
22. H Suzuki W.-P Wolf K Akiyama Effect of inhibitors of inducible form of nitric oxide synthase in infarcted heart muscle Proc Assoc Am Physicians 108 1996 173 178
23. G.L Wang G.L Semenza Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia J Biol Chem 268 1993 21513 21518
24. E.R Werner G Werner-Felmayer H Wachter B Mayer Biosynthesis of nitric oxide dependence on pteridine metabolism Rev Physiol Biochem Pharmacol 127 1995 97 135
25. C.V Oddis M.S Finkel NF-κB and GTP cyclohydrolase regulate cytokine-induced nitric oxide production by cardiac myocytes Am J Physiol 270 1996 H1864 H1868
26. W.W Simmons D Ungureanu-Longrois G.K Smith Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and l -arginine transport J Biol Chem 271 1996 23928 23937
27. A Herskowitz S Choi A Ansari S Wesselingh Cytokine mRNA expression in postischemic/reperfused myocardium Am J Pathol 146 1995 419 428
28. K Ono A Matsumori T Shioi Cytokine gene expression after myocardial infarction in rat hearts possible implication in left ventricular remodeling Circulation 98 1998 149 156
29. D.J Pinsky B Cai X Yang The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor β J Clin Invest 95 1995 677 685
30. J Kajstura W Cheng K Reiss Apoptotic and necrotic myocyte cell death are independent contributing variables of infarct size in rats Lab Invest 74 1996 86 107
31. R.A Gottlieb K.O Burleson R.A Kloner Reperfusion injury induces apoptosis in rabbit cardiomyocytes J Clin Invest 94 1994 1621 1628
32. V.G Sharov H.N Sabbah H Shimoyama Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure Am J Pathol 148 1996 141 149
33. J Narula N Haider R Virmani Apoptosis in myocytes in end-stage heart failure N Engl J Med 335 1996 1182 1189
34. E Teiger T.-V Dam L Richard Apoptosis in pressure overload-induced heart hypertrophy in the rat J Clin Invest 97 1996 2891 2897
35. H.H.H.W Schmidt U Walter NO at work Cell 78 1994 919 925
36. S.M Morris Jr T.R Billiar New insights into the regulation of inducible nitric oxide synthesis Am J Physiol 266 1994 E829 E839