Molecular characterization of hepatitis B virus (HBV) isolates, including identification of a novel recombinant, in patients with acute HBV infection attending an Irish Hospital

Journal of Medical Virology

Volumn 80, Issue 9, 2008, Pages 1554-1564

  Laoi, Bairbre Ni ^a,b   Crowley, Brendan ^a,c  

^a ST JAMES S HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Acute hepatitis B infection; Genetic heterogeneity; Genotyping; Novel recombinant; Phylogenetic analysis

Indexed keywords

ALANINE DERIVATIVE; ASPARAGINE; GLUTAMINE DERIVATIVE; GLYCINE DERIVATIVE; HEPATITIS B ANTIBODY; HEPATITIS B CORE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; SERINE DERIVATIVE;

ADULT; AFRICA; AGED; AMPLICON; ANTIBODY TITER; ARTICLE; DISEASE SEVERITY; FEMALE; GENE DELETION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; IRELAND; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PHYLOGENY; STOP CODON; STRUCTURAL GENE; VIRUS IDENTIFICATION; VIRUS ISOLATION;

AMINO ACID SUBSTITUTION; CODON, NONSENSE; DNA, VIRAL; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HOSPITALS; HUMANS; IRELAND; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PHYLOGENY; POINT MUTATION; POLYMORPHISM, GENETIC; RECOMBINATION, GENETIC; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; SEQUENCE HOMOLOGY; VIRAL ENVELOPE PROTEINS;

HEPATITIS B VIRUS;

EID: 48249131565     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21273     Document Type: Article

References (40)

1. Abbas Z, Muzaffar R, Siddiqui A, Naqvi SA, Rizvi SA. 2006. Genetic variability in the precore and core promoter regions of hepatitis B virus strains in Karachi. BMC Gastroenterol 6:20.
2. Bartholomeusz A, Schaefer S. 2004. Hepatitis B virus genotypes: Comparison of genotyping methods. Rev Med Virol 14:3-16.
3. Bekondi C, Olinger CM, Boua N, Talarmin A, Muller CP, Le Faou A, Venard V. 2007. Central African Republic is part of the West-African hepatitis B virus genotype E crescent. J Clin Virol 40:31-37.
4. Bozkaya H, Ayola B, Lok AS. 1996. High rate of mutations in the hepatitis B core gene during the immune clearance phase of chronic hepatitis B virus infection. Hepatology 24:32-37.
5. Bracho MA, Gosalbes MJ, Gonzalez F, Moya A, Gonzalez-Candelas F. 2006. Molecular epidemiology and evolution in an outbreak of fulminant hepatitis B virus. J Clin Microbiol 44:1288-1294.
6. Chen CH, Lee CM, Lu SN, Changchien CS, Eng HL, Huang CM, Wang JH, Hung CH, Hu TH. 2005. Clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations affecting HBV e antigen expression in Taiwan. J Clin Microbiol 43:6000-6006.
7. Chu CJ, Lok AS. 2002. Clinical significance of hepatitis B virus genotypes. Hepatology 35:1274-1276.
8. Hallett RL, Ngui SL, Meigh RE, Mutton KJ, Boxall EH, Teo CG. 2004. Widespread dissemination in England of a stable and persistent hepatitis B virus variant. Clin Infect Dis 39:945-952.
9. Hou J, Wang Z, Cheng J, Lin Y, Lau GK, Sun J, Zhou F, Waters J, Karayiannis P, Luo K. 2001. Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers. Hepatology 34:1027-1034.
10. Kao JH, Chen DS. 2005. Changing disease burden of hepatocellular carcinoma in the Far East and Southeast Asia. Liver Int 25:696-703.
11. Kao JH, Chen PJ, Lai MY, Chen DS. 2000. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 118:554-559.
12. Kao JH, Chen PJ, Lai MY, Chen DS. 2003. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 124:327-334.
13. Kurbanov F, Tanaka Y, Fujiwara K, Sugauchi F, Mbanya D, Zekeng L, Ndembi N, Ngansop C, Kaptue L, Miura T, Ido E, Hayami M, Ichimura H, Mizokami M. 2005. A new subtype (subgenotype) Ac (A3) of hepatitis B virus and recombination between genotypes A and E in Cameroon. J Gen Virol 86:2047-2056.
14. Liu CJ, Kao JH, Lai MY, Chen PJ, Chen DS. 2004. Precore/core promoter mutations and genotypes of hepatitis B virus in chronic hepatitis B patients with fulminant or subfulminant hepatitis. J Med Virol 72:545-550.
15. Lole KS, Bollinger RC, Paranjape RS, Gadkari D, Kulkarni SS, Novak NG, Ingersoll R, Sheppard HW, Ray SC. 1999. Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol 73:152-160.
16. Mathet VL, Cuestas ML, Ruiz V, Minassian ML, Rivero C, Trinks J, Daleoso G, Leon LM, Sala A, Libellara B, Corach D, Oubina JR. 2006. Detection of hepatitis B virus (HBV) genotype E carried - Even in the presence of high titers of anti-HBs antibodies - By an Argentinean patient of African descent who had received vaccination against HBV. J Clin Microbiol 44:3435-3439.
17. McIntosh ED, Givney R, Zhang SS, Courouce AM, Burgess M, Cossart YE. 1998. Molecular epidemiology and variation of hepatitis B in recent immigrant families to Australia. J Med Virol 56:10-17.
18. Norder H, Hammas B, Lee SD, Bile K, Courouce AM, Mushahwar IK, Magnius LO. 1993. Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen. J Gen Virol 74:1341-1348.
19. Norder H, Courouce AM, Magnius LO. 1994. Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology 198:489-503.
20. Norder H, Courouce AM, Coursaget P, Echevarria JM, Lee SD, Mushahwar IK, Robertson BH, Locarnini S, Magnius LO. 2004. Genetic diversity of hepatitis B virus strains derived worldwide: Genotypes, subgenotypes, and HBsAg subtypes. Intervirology 47:289-309.
21. Omata M, Ehata T, Yokosuka O, Hosoda K, Ohto M. 1991. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 324:1699-1704.
22. Oon C-J, Chen Wei N, Koh S, Lim Gek K. 1999. Identification of hepatitis B surface antigen variants with alterations outside the "a" determinant in immunized Singapore infants. Jpn J Infect Dis 179:259.
23. Osiowy C, Giles E, Tanaka Y, Mizokami M, Minuk GY. 2006. Molecular evolution of hepatitis B virus over 25 years. J Virol 80:10307-10314.
24. Parekh S, Zoulim F, Ahn SH, Tsai A, Li J, Kawai S, Khan N, Trepo C, Wands J, Tong S. 2003. Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants. J Virol 77:6601-6612.
25. Pollicino T, Zanetti AR, Cacciola I, Petit MA, Smedile A, Campo S, Sagliocca L, Pasquali M, Tanzi E, Longo G, Raimondo G. 1997. PreS2 defective hepatitis B virus infection in patients with fulminant hepatitis. Hepatology 26:495-499.
26. Posada D, Crandall KA. 1998. MODELTEST: Testingthe model of DNA substitution. Bioinformatics 14:817-818.
27. Sainokami S, Abe K, Sato A, Endo R, Takikawa Y, Suzuki K, Okamoto H. 2007. Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection. J Gastroenterol 42:241-249.
28. Sato S, Suzuki K, Akahane Y, Akamatsu K, Akiyama K, Yunomura K, Tsuda F, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M. 1995. Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis. Ann Intern Med 122:241-248.
29. Simmonds P, Midgley S. 2005. Recombination in the genesis and evolution of hepatitis B virus genotypes. J Virol 79:15467-15476.
30. Song BC, Kim SH, Kim H, Ying YH, Kim HJ, Kim YJ, Yoon JH, Lee HS, Cha CY, Kook YH, Kim BJ. 2005. Prevalence of naturally occurring surface antigen variants of hepatitis B virus in Korean patients infected chronically. J Med Virol 76:194-202.
31. Stuyver L, De Gendt S, Van Geyt C, Zoulim F, Fried M, Schinazi RF, Rossau R. 2000. A new genotype of hepatitis B virus: Complete genome and phylogenetic relatedness. J Gen Virol 81:67-74.
32. Sugauchi F, Mizokami M, Orito E, Ohno T, Hayashi K, Kato T, Tanaka Y, Kato H, Ueda R. 2000. Molecular evolutionary analysis of the complete nucleotide sequence of hepatitis B virus (HBV) in a case of HBV infection acquired through a needlestick accident. Clin Infect Dis 31:1195-1201.
33. Sugauchi F, Orito E, Ichida T, Kato H, Sakugawa H, Kakumu S, Ishida T, Chutaputti A, Lai CL, Ueda R, Miyakawa Y, Mizokami M. 2002. Hepatitis B virus of genotype B with or without recombination with genotype C over the precore region plus the core gene. J Virol 76:5985-5992.
34. Sugiyama M, Tanaka Y, Kurbanov F, Nakayama N, Mochida S, Mizokami M. 2007. Influences on hepatitis B virus replication by a naturally occurring mutation in the core gene. Virology 365:285-291.
35. Swofford DL. 2002. PAUP*. Phylogenetic prolysis using parsimony (* and other methods). 4. 0b10. Sunderland, MA: Sinaur Associates Inc.
36. Tacke F, Amini-Bavil-Olyaee S, Heim A, Luedde T, Manns MP, Trautwein C. 2007. Acute hepatitis B virus infection by genotype F despite successful vaccination in an immune-competent German patient. J Clin Virol 38:353-357.
37. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. 1997. The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 25:4876-4882.
38. Wang Z, Liu Z, Zeng G, Wen S, Qi Y, Ma S, Naoumov NV, Hou J. 2005. A new intertype recombinant between genotypes C and D of hepatitis B virus identified in China. J Gen Virol 86:985-990.
39. Wu W, Chen Y, Ruan B, Li LJ. 2005. Gene heterogeneity of hepatitis B virus isolates from patients with severe hepatitis B. Hepatobiliary Pancreat Dis Int 4:530-534.
40. Yang J, Xing K, Deng R, Wang J, Wang X. 2006. Identification of Hepatitis B virus putative intergenotype recombinants by using fragment typing. J Gen Virol 87:2203-2215.