The neuronal RhoA GEF, Tech, interacts with the synaptic multi-PDZ-domain-containing protein, MUPP1

Journal of Neurochemistry

Volumn 106, Issue 3, 2008, Pages 1287-1297

  Estévez, Marcel A ^a   Henderson, Jennifer A ^a   Ahn, David ^a   Zhu, Xin Ran ^b   Poschmann, Gereon ^b   Lübbert, Hermann ^b   Marx, Ruth ^a   Baraban, Jay M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Guanine nucleotide exchange factor; Hippocampus; PDZ domain; RhoA; Synapse

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; PDZ PROTEIN; PROTEIN MUPP1; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TWO HYBRID SYSTEM;

ANIMALS; CARRIER PROTEINS; CELL LINE; CELLS, CULTURED; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; NERVE TISSUE PROTEINS; NEURONS; PDZ DOMAINS; RATS; RHOA GTP-BINDING PROTEIN; SYNAPSES;

RATTUS;

EID: 48249131234     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05472.x     Document Type: Article

References (37)

1. Ahnert-Hilger G., Höltje M., Grosse G., Pickert G., Mucke C., Nixdorf-Bergweiler B., Boquet P., Hofmann F. Just I. (2004) Differential effects of Rho GTPases on axonal and dendritic development in hippocampal neurones. J. Neurochem. 90, 9 18.
2. B receptor association with the PDZ scaffold Mupp1 alters receptor stability and function. J. Biol. Chem. 282, 4162 4171.
3. Becamel C., Figge A., Poliak S., Dumuis A., Peles E., Bockaert J., Lübbert H. Ullmer C. (2001) Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. J. Biol. Chem. 276, 12974 12982.
4. Benarroch E. E. (2007) Rho GTPases: role in dendrite and axonal growth, mental retardation, and axonal regeneration. Neurology 68, 1315 1318.
5. Chen H. J., Rojas-Soto M., Oguni A. Kennedy M. B. (1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron. 20, 895 904.
6. Doyle D. A., Lee A., Lewis J., Kim E., Sheng M. MacKinnon R. (1996) Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 85, 1067 1076.
7. Etienne-Manneville S. Hall A. (2002) RhoGTPases in cell biology. Nature 420, 629 635.
8. Garcia-Mata R. Burridge K. (2007) Catching a GEF by its tail. Trends Cell Biol. 17, 36 43.
9. Garner C. C., Kindler S. Gundelfinger E. D. (2000) Molecular determinants of presynaptic active zones. Curr. Opin. Neurobiol. 10, 321 327.
10. Govek E. E., Newey S. E., Akerman C. J., Cross J. R., Van der Veken L. Van Aelst L. (2004) The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis. Nat. Neurosci. 7, 364 372.
11. Iida J., Ishizaki H., Okamoto-Tanaka M. et al. (2007) S-SCAMα is a scaffold to mediate NMDA receptor-dependent RhoA activation in dendrites. Mol. Cell. Biol. 27, 4388 4405.
12. Kaneko T., Maeda A., Takefuji M., Aoyama H., Nakayama M., Kawabata S., Kawano Y., Iwamatsu A., Amano M. Kaibuchi K. (2005) Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho-kinase. Genes Cells 10, 973 987.
13. Kim E. Sheng M. (2004) PDZ domain proteins of synapses. Nat. Rev. Neurosci. 5, 771 781.
14. Kim J. H., Liao D., Lau L. F. Huganir R. L. (1998) SynGAP: a synaptic RasGAP that associates with the PSD95/SAP90 protein family. Neuron. 20, 683 691.
15. Kimber W. A., Trinkle-Mulcahy L., Cheung P. C. et al. (2002) Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. Biochem. J. 361, 525 536.
16. Krapivinsky G., Medina I., Krapivinsky L., Gapon S. Clapham D. E. (2004) SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron 43, 563 574.
17. Kuner R., Swiercz J. M., Zywietz A., Tappe A. Offermanns S. (2002) Characterization of the expression of PDZ-RhoGEF, LARG and G(alpha)12/G(alpha)13 proteins in the murine nervous system. Eur. J. Neurosci. 16, 2333 2341.
18. Lee S. S., Glaunsinger B., Mantovani F., Banks L. Javier R. T. (2000) Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. J. Virol. 74, 9680 9693.
19. Liu M. Horowitz A. (2006) A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Mol. Biol. Cell 17, 1880 1887.
20. Luo L. (2000) Rho GTPases in neuronal morphogenesis. Nat. Rev. Neurosci. 1, 173 180.
21. Marx R., Henderson J., Wang J. Baraban J. M. (2005) Tech: a RhoA GEF selectively expressed in hippocampal and cortical neurons. J. Neurochem. 92, 850 858.
22. Maystadt I., Rezsohazy R., Barkats M. et al. (2007) The nuclear factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive lower motor neuron disease with childhood onset. Am. J. Hum. Genet. 81, 67 76.
23. Morais Cabral J. H., Petosa C., Sutcliffe M. J., Raza S., Byron O., Poy F., Marfatia S. M., Chishti A. H. Liddington R. C. (1996) Crystal structure of a PDZ domain. Nature 382, 649 652.
24. Naccache S. N., Hasson T. Horowitz A. (2006) Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles. Proc. Natl Acad. Sci. USA 103, 12735 12740.
25. Nakazawa T., Watabe A. M., Tezuka T., Yoshida Y., Yokoyama H., Umemori H., Inoue A., Okabe S., Manabe T. Yamamoto T. (2003) p250, a novel brain-enriched GTPase-activating protein for Rho family GTPases is involved in the N-methyl D-aspartate receptor signaling. Mol. Biol. Cell 14, 2921 2934.
26. Neumann H., Schweigreiter R., Yamashita T., Rosenkranz K., Wekerle H. Barde Y. A. (2002) Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a Rho-dependent mechanism. J. Neurosci. 22, 854 862.
27. Parker L. L., Backstrom J. R., Sanders-Bush E. Shieh B. H. (2003) Agonist-induced phosphorylation of the serotonin 5-HT2C receptor regulates its interaction with multiple PDZ protein 1. J. Biol. Chem. 278, 21576 21583.
28. Penzes P., Johnson R. C., Sattler R., Zhang X., Huganir R. L., Kambampati V., Mains R. E. Eipper B. A. (2001) The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Neuron 29, 229 242.
29. Ryan X. P., Alldritt J., Svenningsson P., Allen P. B., Wu G. Y., Nairn A. C. Greengard P. (2005) The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Neuron 47, 85 100.
30. Schubert V., Da Silva J. S. Dotti C. G. (2006) Localized recruitment and activation of RhoA underlies dendritic spine morphology in a glutamate receptor-dependent manner. J. Cell Biol. 172, 453 467.
31. Semenova M. M., Maki-Hokkonen A. M. J., Cao J., Komarovski V., Forsberg K. M., Koistinaho M., Coffey E. T. Courtney M. J. (2007) Rho mediates calcium-dependent activation of p38α and subsequent excitotoxic cell death. Nat. Neurosci. 10, 436 443.
32. Sitek B., Poschmann G., Schmidtke K., Ullmer C., Maskri L., Andriske M., Stichel C. C., Zhu X. R. Luebbert H. (2003) Expression of MUPP1 protein in mouse brain. Brain Res. 970, 178 187.
33. Songyang Z., Fanning A. S., Fu C., Xu J., Marfatia S. M., Chishti A. H., Crompton A., Chan A. C., Anderson J. M. Cantley L. C. (1997) Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275, 73 77.
34. Tabuchi A., Estévez M., Henderson J. A., Marx R., Shiota J., Nakano H. Baraban J. M. (2005) Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling. J. Neurochem. 94, 169 180.
35. Ullmer C., Schmuck K., Figge A. Lübbert H. (1998) Cloning and characterization of MUPP1, a novel PDZ domain protein. FEBS Lett. 424, 63 68.
36. Varsano T., Dong M. Q., Niesman I., Gacula H., Lou X., Ma T., Testa J. R., Yates J. R. III Farquhar M. G. (2006) GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling. Mol. Cell. Biol. 26, 8942 8952.
37. Yi Z., Petralia R. S., Fu Z., Swanwick C. C., Wang Y. X., Prybylowski K., Sans N., Vicini S. Wenthold R. J. (2007) The role of the PDZ protein GIPC in regulating NMDA receptor trafficking. J. Neurosci. 27, 11663 11675.