A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype

Molecular Biology of the Cell

Volumn 17, Issue 4, 2006, Pages 1880-1887

  Liu, Miaoliang ^a   Horowitz, Arie ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; PDZ PROTEIN; PROTEIN SYX1; PROTEIN ZO1; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MYOSIN HEAVY CHAIN; MYOSIN VI; NEUROPEPTIDE; RGS19IP1 PROTEIN, MOUSE; SYX PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TUMOR; CARCINOGENICITY; CELL MEMBRANE; CELL MIGRATION; CELL TYPE; CONTROLLED STUDY; ENDOTHELIUM CELL; FLUORESCENCE RESONANCE ENERGY TRANSFER; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN TARGETING; TRANSCRIPTION REGULATION; ALTERNATIVE RNA SPLICING; ANIMAL; CELL MOTION; CHEMISTRY; CYTOPLASM; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PHYSIOLOGY;

ALTERNATIVE SPLICING; AMINO ACID MOTIFS; ANIMALS; BRAIN NEOPLASMS; CARRIER PROTEINS; CELL MOVEMENT; CYTOPLASM; ENDOTHELIAL CELLS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MAP KINASE KINASE 4; MICE; MYOSIN HEAVY CHAINS; NEUROPEPTIDES; RHOA GTP-BINDING PROTEIN; TRANSCRIPTION, GENETIC;

EID: 33745403621     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E06-01-0002     Document Type: Article

References (33)

1. Aschenbrenner, L., Lee, T., and Hasson, T. (2003). Myo6 facilitates the translocation of endocytic vesicles from cell peripheries. Mol. Biol. Cell 14, 2728-2743.
2. Blobe, G. C., Liu, X., Fang, S. J., How, T., and Lodish, H. F. (2001). A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. J. Biol. Chem. 276, 39608-39617.
3. Dance, A. L., Miller, M., Seragaki, S., Aryal, P., White, B., Aschenbrenner, L., and Hasson, T. (2004). Regulation of myosin-VI targeting to endocytic compartments. Traffic 5, 798-813.
4. Davis, R. J. (2000). Signal transduction by the JNK group of MAP kinases. Cell 103, 239-252.
5. De Toledo, M., Coulon, V., Schmidt, S., Fort, P., and Blangy, A. (2001). The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3. Oncogene 20, 7307-7317.
6. Derijard, B., Hibi, M., Wu, I. H., Barrett, T., Su, B., Deng, T., Karin, M., and Davis, R. J. (1994). JNK1, a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037.
7. Erickson, J. W., and Cerione, R. A. (2004). Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes. Biochemistry 43, 837-842.
8. Favre-Bonvin, A., Reynaud, C., Kretz-Remy, C., and Jalinot, P. (2005). Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasome. J. Virol. 79, 4229-4237.
9. Fukata, M., Nakagawa, M., and Kaibuchi, K. (2003). Roles of Rho-family GTPases in cell polarisation and directional migration. Curr. Opin. Cell Biol. 15, 590-597.
10. Gao, Y., Li, M., Chen, W., and Simons, M. (2000). Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration. J. Cell Physiol. 184, 373-379.
11. Hasson, T. (2003). Myosin VI: two distinct roles in endocytosis. J. Cell Sci. 116, 3453-3461.
12. Hasson, T., and Mooseker, M. S. (1994). Porcine myosin-VI: characterization of a new mammalian unconventional myosin. J. Cell Biol. 127, 425-440.
13. Horowitz, A., Tkachenko, E., and Simons, M. (2002). Fibroblast growth factor-specific modulation of cellular response by syndecan-4. J. Cell Biol. 157, 715-725.
14. Kikuno, R., Nagase, T., Waki, M., and Ohara, O. (2002). HUGE: a database for human large proteins identified in the Kazusa cDNA sequencing project. Nucleic Acids Res. 30, 166-168.
15. ΔΔCT Method. Methods 25, 402-408.
16. Lou, X., Yano, H., Lee, F., Chao, M. V., and Farquhar, M. G. (2001). GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. Mol. Biol. Cell 12, 615-627.
17. Marinissen, M. J., Chiariello, M., Tanos, T., Bernard, O., Narumiya, S., and Gutkind, J. S. (2004). The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. Mol. Cell 14, 29-41.
18. Marx, R., Henderson, J., Wang, J., and Baraban, J. M. (2005). Tech: a RhoA GEF selectively expressed in hippocampal and cortical neurons. J. Neurochem. 92, 850-858.
19. Park, E., Na, M., Choi, J., Kim, S., Lee, J. R., Yoon, J., Park, D., Sheng, M., and Kim, E. (2003). The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the βPIX guanine nucleotide exchange factor for Rac1 and Cdc42. J. Biol. Chem. 278, 19220-19229.
20. Partovian, C., Zhuang, Z., Moodie, K., Lin, M., Ouchi, N., Sessa, W. C., Walsh, K., and Simons, M. (2005). Protein kinase Cα activates eNOS and increases arterial blood flow in vivo. Circ. Res. 97, 482-487.
21. Penzes, P., Johnson, R. C., Sattler, R., Zhang, X., Huganir, R. L., Kambampati, V., Mains, R. E., and Eipper, B. A. (2001). The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Neuron 29, 229-242.
22. Qin, H., Carr, H. S., Wu, X., Muallem, D., Tran, N. H., and Frost, J. A. (2005). Characterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1. J. Biol. Chem. 280, 7603-7613.
23. Reed, B. C., Cefalu, C., Bellaire, B., Cardelli, J. A., Louis, T., Salamon, J., Bloecher, M. A., and Bunn, R. C. (2005). GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and Myosin VI: evidence supporting an adapter function for GLUT1CBP. Mol. Biol. Cell 16, 4183-4201.
24. Ron, D., Graziani, G., Aaronson, S. A., and Eva, A. (1989). The N-terminal region of proto-dbl down regulates its transforming activity. Oncogene 4, 1067-1072.
25. Rossman, K. L., Der, C. J., and Sondek, J. (2005). GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell. Biol. 6, 167-180.
26. Sheng, M. (2001). Molecular organization of the postsynaptic specialization. Proc. Natl. Acad. Sci. USA 98, 7058-7061.
27. Snyder, J. T., Worthylake, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J., and Sondek, J. (2002). Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat. Struct. Biol. 9, 468-475.
28. Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M., and Cantley, L. C. (1997). Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275, 73-77.
29. Stark, A. M., Nabavi, A., Mehdorn, H. M., and Blomer, U. (2005). Glioblastoma multiforme-report of 267 cases treated at a single institution. Surg. Neurol. 63, 162-169; discussion 169.
30. van Nieuw Amerongen, G. P., Koolwijk, P., Versteilen, A., and van Hinsbergh, V. W. (2003). Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro. Arterioscler. Thromb. Vasc. Biol. 23, 211-217.
31. Wells, A. L., Lin, A. W., Chen, L. Q., Safer, D., Cain, S. M., Hasson, T., Carragher, B. O., Milligan, R. A., and Sweeney, H. L. (1999). Myosin VI is an actin-based motor that moves backwards. Nature 403, 505-508.
32. Yoshizaki, H., Ohba, Y., Kurokawa, K., Itoh, R. E., Nakamura, T., Mochizuki, N., Nagashima, K., and Matsuda, M. (2003). Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J. Cell Biol. 162, 223-232.
33. Zhang, Y., Chittenden, T., and Simons, M. (2004). Characterization of synectin expression and promoter activity. Gene 342, 29-34.