Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: Chromosomal segregation, crossing over, and the construction of a genetic map

Genome Biology

Volumn 9, Issue 6, 2008, Pages

  Cooper, Anneli ^a   Tait, Andy ^a   Sweeney, Lindsay ^a   Tweedie, Alison ^a   Morrison, Liam ^a   Turner, C Michael R ^a   MacLeod, Annette ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME SEGREGATION; CROSSING OVER; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CONSERVATION; GENETIC LINKAGE; GENETIC RECOMBINATION; GENETIC STRAIN; GENETIC TRAIT; HETEROZYGOSITY; MICROSATELLITE MARKER; MUTATION RATE; NONHUMAN; PARASITE VIRULENCE; PHENOTYPE; PROTOZOAL GENETICS; SEQUENCE ANALYSIS; SPECIES DIFFERENCE; SYNTENY; TRYPANOSOMA; ANIMAL; CHROMOSOME MAP; GENE; GENETICS;

ANIMALIA; PROTOZOA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMA BRUCEI RHODESIENSE;

MICROSATELLITE DNA;

ANIMALS; CHROMOSOME MAPPING; CHROMOSOME SEGREGATION; CROSSING OVER, GENETIC; GENES, PROTOZOAN; MICROSATELLITE REPEATS; RECOMBINATION, GENETIC; TRYPANOSOMA BRUCEI GAMBIENSE;

EID: 48249106249     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2008-9-6-r103     Document Type: Article

References (58)

1. Su X Ferdig MT Huang Y Huynh CQ Liu A You J Wootton JC Wellems TE A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum. Science 1999, 286:1351-1353. 10558988
2. Martinelli A Hunt P Fawcett R Cravo PV Walliker D Carter R An AFLP-based genetic linkage map of Plasmodium chabaudi chabaudi. Malar J 2005, 4:11. 550669 15707493
3. Khan A Taylor S Su C Mackey AJ Boyle J Cole R Glover D Tang K Paulsen IT Berriman M Boothroyd JC Pfefferkorn ER Dubey JP Ajioka JW Roos DS Wootton JC Sibley LD Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii. Nucleic Acids Res 2005, 33:2980-2992. 1137028 15911631
4. Shirley MW Harvey DA A genetic linkage map of the apicomplexan protozoan parasite Eimeria tenella. Genome Res 2000, 10:1587-1593. 310971 11042156
5. Su X Kirkman LA Fujioka H Wellems TE Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa. Cell 1997, 91:593-603. 9393853
6. Ferdig MT Cooper RA Mu J Deng B Joy DA Su XZ Wellems TE Dissecting the loci of low-level quinine resistance in malaria parasites. Mol Microbiol 2004, 52:985-997. 15130119
7. Su C Howe DK Dubey JP Ajioka JW Sibley LD Identification of quantitative trait loci controlling acute virulence in Toxoplasma gondii. Proc Natl Acad Sci USA 2002, 99:10753-10758. 125035 12149482
8. Taylor S Barragan A Su C Fux B Fentress SJ Tang K Beatty WL Hajj HE Jerome M Behnke MS White M Wootton JC Sibley LD A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii. Science 2006, 314:1776-1780. 17170305
9. Saeij JP Boyle JP Coller S Taylor S Sibley LD Brooke-Powell ET Ajioka JW Boothroyd JC Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science 2006, 314:1780-1783. 17170306
10. Saeij JP Coller S Boyle JP Jerome ME White MW Boothroyd JC Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature 2007, 445:324-327. 17183270
11. Martinelli A Cheesman S Hunt P Culleton R Raza A Mackinnon M Carter R A genetic approach to the de novo identification of targets of strain-specific immunity in malaria parasites. Proc Natl Acad Sci USA 2005, 102:814-819. 545519 15640359
12. Sibley LD LeBlanc AJ Pfefferkorn ER Boothroyd JC Generation of a restriction fragment length polymorphism linkage map for Toxoplasma gondii. Genetics 1992, 132:1003-1015. 1205223 1360931
13. National Centre for Biotechnology Information http://www.ncbi.nlm.nih.gov/projects/Malaria/Mapsmarkers/ tabphysdistvsgmu.html
14. Jenni L Marti S Schweizer J Betschart B Le Page RW Wells JM Tait A Paindavoine P Pays E Steinert M Hybrid formation between African trypanosomes during cyclical transmission. Nature 1986, 322:173-175. 3724860
15. Gibson W Stevens J Genetic exchange in the trypanosomatidae. Adv Parasitol 1999, 43:1-46. 10214689
16. Turner CM Sternberg J Buchanan N Smith E Hide G Tait A Evidence that the mechanism of gene exchange in Trypanosoma brucei involves meiosis and syngamy. Parasitology 1990, 101(Pt 3):377-386. 1982633
17. MacLeod A Tweedie A McLellan S Hope M Taylor S Cooper A Sweeney L Turner CM Tait A Allelic segregation and independent assortment in T. brucei crosses: Proof that the genetic system is Mendelian and involves meiosis. Mol Biochem Parasitol 2005, 143:12-19. 2093985 15941603
18. Tait A Masiga D Ouma J MacLeod A Sasse J Melville S Lindegard G McIntosh A Turner M Genetic analysis of phenotype in Trypanosoma brucei: A classical approach to potentially complex traits. Philos Trans R Soc Lond B Biol Sci 2002, 357:89-99. 1692923 11839186
19. Ploeg Van der LH Cornelissen AW Barry JD Borst P Chromosomes of kinetoplastida. Embo J 1984, 3:3109-3115. 557825 6526012
20. Melville SE Leech V Gerrard CS Tait A Blackwell JM The molecular karyotype of the megabase chromosomes of Trypanosoma brucei and the assignment of chromosome markers. Mol Biochem Parasitol 1998, 94:155-173. 9747967
21. Gottesdiener K Garcia-Anoveros J Lee MG Ploeg Van der LH Chromosome organization of the protozoan Trypanosoma brucei. Mol Cell Biol 1990, 10:6079-6083. 361410 2233733
22. Ploeg Van der LH Cornelissen AW Michels PA Borst P Chromosome rearrangements in Trypanosoma brucei. Cell 1984, 39:213-221. 6488319
23. Weiden M Osheim YN Beyer AL Ploeg Van der LH Chromosome structure: DNA nucleotide sequence elements of a subset of the minichromosomes of the protozoan Trypanosoma brucei. Mol Cell Biol 1991, 11:3823-3834. 361163 2072894
24. Williams RO Young JR Majiwa PA Genomic environment of T. brucei VSG genes: Presence of a minichromosome. Nature 1982, 299:417-421. 7121578
25. Berriman M Ghedin E Hertz-Fowler C Blandin G Renauld H Bartholomeu DC Lennard NJ Caler E Hamlin NE Haas B Bohme U Hannick L Aslett MA Shallom J Marcello L Hou L Wickstead B Alsmark UC Arrowsmith C Atkin RJ Barron AJ Bringaud F Brooks K Carrington M Cherevach I Chillingworth TJ Churcher C Clark LN Corton CH Cronin A et al.: The genome of the African trypanosome Trypanosoma brucei. Science 2005, 309:416-422. 16020726
26. MacLeod A Tweedie A McLellan S Taylor S Hall N Berriman M El-Sayed NM Hope M Turner CM Tait A The genetic map and comparative analysis with the physical map of Trypanosoma brucei. Nucleic Acids Res 2005, 33:6688-6693. 1297707 16314301
27. WHO Human African trypanosomiasis (sleeping sickness): Epidemiological update. Wkly Epidemiol Rec 2006, 81:71-80. 16673459
28. Simarro PP Jannin J Cattand P Eliminating human African trypanosomiasis: where do we stand and what comes next? PLoS Med 2008, 5:e55. 2253612 18303943
29. Gibson WC Will the real Trypanosoma b. gambiense please stand up. Parasitol Today 1986, 2:255-257. 15462856
30. Hide G Cattand P LeRay D Barry JD Tait A The identification of Trypanosoma brucei subspecies using repetitive DNA sequences. Mol Biochem Parasitol 1990, 39:213-225. 1969612
31. Paindavoine P Zampetti-Bosseler F Coquelet H Pays E Steinert M Different allele frequencies in Trypanosoma brucei brucei and Trypanosoma brucei gambiense populations. Mol Biochem Parasitol 1989, 32:61-71. 2563145
32. Turner CM McLellan S Lindergard LA Bisoni L Tait A MacLeod A Human infectivity trait in Trypanosoma brucei: Stability, heritability and relationship to sra expression. Parasitology 2004, 129:445-454. 15521633
33. Benson G Tandem repeats finder: A program to analyze DNA sequences. Nucleic Acids Res 1999, 27:573-580. 148217 9862982
34. Manly KF Cudmore RH Jr Meer JM Map Manager QTX, cross-platform software for genetic mapping. Mamm Genome 2001, 12:930-932. 11707780
35. Petes TD Meiotic recombination hot spots and cold spots. Nat Rev Genet 2001, 2:360-369. 11331902
36. El-Sayed NM Ghedin E Song J MacLeod A Bringaud F Larkin C Wanless D Peterson J Hou L Taylor S Tweedie A Biteau N Khalak HG Lin X Mason T Hannick L Caler E Blandin G Bartholomeu D Simpson AJ Kaul S Zhao H Pai G Van Aken S Utterback T Haas B Koo HL Umayam L Suh B Gerrard C The sequence and analysis of Trypanosoma brucei chromosome II. Nucleic Acids Res 2003, 31:4856-4863. 169936 12907728
37. Hall N Berriman M Lennard NJ Harris BR Hertz-Fowler C Bart-Delabesse EN Gerrard CS Atkin RJ Barron AJ Bowman S Bray-Allen SP Bringaud F Clark LN Corton CH Cronin A Davies R Doggett J Fraser A Gruter E Hall S Harper AD Kay MP Leech V Mayes R Price C Quail MA Rabbinowitsch E Reitter C Rutherford K Sasse J et al.: The DNA sequence of chromosome I of an African trypanosome: Gene content, chromosome organisation, recombination and polymorphism. Nucleic Acids Res 2003, 31:4864-4873. 169939 12907729
38. Tait A Buchanan N Hide G Turner CM Self-fertilisation in Trypanosoma brucei. Mol Biochem Parasitol 1996, 76:31-42. 8919993
39. Janse CJ Chromosome size polymorphism and DNA rearrangements in plasmodium. Parasitol Today 1993, 9:19-22. 15463659
40. Lanzer M de Bruin D Wertheimer SP Ravetch JV Organization of chromosomes in Plasmodium falciparum: A model for generating karyotypic diversity. Parasitol Today 1994, 10:114-117. 15275494
41. Lanzer M de Bruin D Ravetch JV Transcriptional differences in polymorphic and conserved domains of a complete cloned P. falciparum chromosome. Nature 1993, 361:654-657. 8437626
42. Ravel C Wincker P Blaineau C Britto C Bastien P Pages M Medium-range restriction maps of five chromosomes of Leishmania infantum and localization of size-variable regions. Genomics 1996, 35:509-516. 8812485
43. Wincker P Ravel C Blaineau C Pages M Jauffret Y Dedet JP Bastien P The Leishmania genome comprises 36 chromosomes conserved across widely divergent human pathogenic species. Nucleic Acids Res 1996, 24:1688-1694. 145848 8649987
44. Blaineau C Bastien P Rioux JA Roizes G Pages M Long-range restriction maps of size-variable homologous chromosomes in Leishmania infantum. Mol Biochem Parasitol 1991, 46:292-302. 1922200
45. Henriksson J Porcel B Rydaker M Ruiz A Sabaj V Galanti N Cazzulo JJ Frasch AC Pettersson U Chromosome specific markers reveal conserved linkage groups in spite of extensive chromosomal size variation in Trypanosoma cruzi. Mol Biochem Parasitol 1995, 73:63-74. 8577348
46. Melville SE Leech V Navarro M Cross GA The molecular karyotype of the megabase chromosomes of Trypanosoma brucei stock 427. Mol Biochem Parasitol 2000, 111:261-273. 11163435
47. El-Sayed NM Myler PJ Blandin G Berriman M Crabtree J Aggarwal G Caler E Renauld H Worthey EA Hertz-Fowler C Ghedin E Peacock C Bartholomeu DC Haas BJ Tran AN Wortman JR Alsmark UC Angiuoli S Anupama A Badger J Bringaud F Cadag E Carlton JM Cerqueira GC Creasy T Delcher AL Djikeng A Embley TM Hauser C Ivens AC et al.: Comparative genomics of trypanosomatid parasitic protozoa. Science 2005, 309:404-409. 16020724
48. Callejas S Leech V Reitter C Melville S Hemizygous subtelomeres of an African trypanosome chromosome may account for over 75% of chromosome length. Genome Res 2006, 16:1109-1118. 1557766 16899654
49. Baker BS Carpenter AT Esposito MS Esposito RE Sandler L The genetic control of meiosis. Annu Rev Genet 1976, 10:53-134. 797314
50. Anderson TJ Haubold B Williams JT Estrada-Franco JG Richardson L Mollinedo R Bockarie M Mokili J Mharakurwa S French N Whitworth J Velez ID Brockman AH Nosten F Ferreira MU Day KP Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Mol Biol Evol 2000, 17:1467-1482. 11018154
51. Venter JC Adams MD Myers EW Li PW Mural RJ Sutton GG Smith HO Yandell M Evans CA Holt RA Gocayne JD Amanatides P Ballew RM Huson DH Wortman JR Zhang Q Kodira CD Zheng XH Chen L Skupski M Subramanian G Thomas PD Zhang J Gabor Miklos GL Nelson C Broder S Clark AG Nadeau J McKusick VA Zinder N et al.: The sequence of the human genome. Science 2001. 291:1304-1351. 11181995
52. Wellems TE Walker-Jonah A Panton LJ Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7. Proc Natl Acad Sci USA 1991, 88:3382-3386. 51451 1673031
53. Sasse J The development of genetic markers for the T. brucei genome. University of Cambridge 1998.
54. MacLeod A Turner CM Tait A A high level of mixed Trypanosoma brucei infections in tsetse flies detected by three hypervariable minisatellites. Mol Biochem Parasitol 1999, 102:237-248. 10498180
55. Trypanosoma brucei GeneDB http://www.genedb.org/genedb/tryp/index.jsp
56. Tandem Repeats Finder http://tandem.bu.edu/trf/trf.submit.options.html
57. PRIDE http://www.dkfz-heidelberg.de/tbi_old/services/Pride/search_primer
58. Trypanosome Genetic Mapping Database http://www.gla.ac.uk/centres/wcmp/ research/macleod/trypanosomegeneticmappingdatabase