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Volumn 26, Issue 5, 2008, Pages 620-631

Mitochondria as the target for mildronate's protective effects in azidothymidine (AZT)-induced toxicity of isolated rat liver mitochondria

Author keywords

AZT; Mildronate; Mitochondria; Rat liver; Respiratory complex I

Indexed keywords

MILDRONATE; ZIDOVUDINE;

EID: 48249102367     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1486     Document Type: Article
Times cited : (28)

References (42)
  • 1
    • 33750523442 scopus 로고    scopus 로고
    • Mitochondrial calcium signalling and cell death: Approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis
    • Hajnoczky G, Csordas G, Das S, et al. Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis. Cell Calcium 2006; 40: 553-560.
    • (2006) Cell Calcium , vol.40 , pp. 553-560
    • Hajnoczky, G.1    Csordas, G.2    Das, S.3
  • 2
    • 12344305124 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and type 2 diabetes
    • Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science 2005; 307: 384-387.
    • (2005) Science , vol.307 , pp. 384-387
    • Lowell, B.B.1    Shulman, G.I.2
  • 3
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Michael TL, Beal MR Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006; 443: 787-795.
    • (2006) Nature , vol.443 , pp. 787-795
    • Michael, T.L.1    Beal, M.R.2
  • 4
    • 33646859687 scopus 로고    scopus 로고
    • Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia
    • Longley MJ, Clark S, Yu Wai Man C, et al. Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia. Am J Hum Genet 2006; 78: 1026-1034.
    • (2006) Am J Hum Genet , vol.78 , pp. 1026-1034
    • Longley, M.J.1    Clark, S.2    Yu3    Wai Man, C.4
  • 5
    • 33750216506 scopus 로고    scopus 로고
    • Mitochondrial myopathies
    • DiMauro S. Mitochondrial myopathies. Curr Opin Rheumatol 2006; 18: 636-641.
    • (2006) Curr Opin Rheumatol , vol.18 , pp. 636-641
    • DiMauro, S.1
  • 6
    • 2342477730 scopus 로고    scopus 로고
    • Erralpha and Gabpa/ b specify PGC-1 alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
    • Mootha VK, Handschin C, Arlow D, et al. Erralpha and Gabpa/ b specify PGC-1 alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci USA 2004; 101: 6570-6575.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6570-6575
    • Mootha, V.K.1    Handschin, C.2    Arlow, D.3
  • 7
    • 33749999530 scopus 로고    scopus 로고
    • Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    • St-Pierre J, Drori S, Uldry M, et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006; 127: 397-408.
    • (2006) Cell , vol.127 , pp. 397-408
    • St-Pierre, J.1    Drori, S.2    Uldry, M.3
  • 8
    • 34250676955 scopus 로고    scopus 로고
    • Mitochondrial diseases: Therapeutic approaches
    • DiMauro S, Mancuso M. Mitochondrial diseases: therapeutic approaches. Biosci Rep 2007; 27: 125-137.
    • (2007) Biosci Rep , vol.27 , pp. 125-137
    • DiMauro, S.1    Mancuso, M.2
  • 9
    • 0029001125 scopus 로고
    • Enhancment of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and gamma-butyrobetaine hydroxylase inhibitor
    • Tsoko M, Beauseigneur F, Gresti J, et al. Enhancment of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and gamma-butyrobetaine hydroxylase inhibitor. Biochem Pharmacol 1995; 49: 1403-1410.
    • (1995) Biochem Pharmacol , vol.49 , pp. 1403-1410
    • Tsoko, M.1    Beauseigneur, F.2    Gresti, J.3
  • 10
    • 33750075751 scopus 로고    scopus 로고
    • Protection of azidothymidine-induced cardiopathology in mice by mildronate, a mitochondria-targeted drug
    • Klusa V, Pupure J, Isajevs S, et al. Protection of azidothymidine-induced cardiopathology in mice by mildronate, a mitochondria-targeted drug. Basic Clin Pharmacol Toxicol 2006; 99: 323-328.
    • (2006) Basic Clin Pharmacol Toxicol , vol.99 , pp. 323-328
    • Klusa, V.1    Pupure, J.2    Isajevs, S.3
  • 11
    • 0034600294 scopus 로고    scopus 로고
    • Beneficial effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor in rats with heart failure following myocardial infarction
    • Hayashi Y, Kiromoto T, Asaka N, et al. Beneficial effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor in rats with heart failure following myocardial infarction. Eur J Pharmacol 2000; 395: 217-224.
    • (2000) Eur J Pharmacol , vol.395 , pp. 217-224
    • Hayashi, Y.1    Kiromoto, T.2    Asaka, N.3
  • 12
    • 0031978533 scopus 로고    scopus 로고
    • Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts
    • Asaka N, Muranaka Y, Kirimoto T, Miyake H. Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts. Fundam Clin Pharmacol 1998; 12: 158-163.
    • (1998) Fundam Clin Pharmacol , vol.12 , pp. 158-163
    • Asaka, N.1    Muranaka, Y.2    Kirimoto, T.3    Miyake, H.4
  • 13
    • 0034836831 scopus 로고    scopus 로고
    • Development and characterization of an animal model of carnitine deficiency
    • Spaniol M, Brooks H, Auer L, et al. Development and characterization of an animal model of carnitine deficiency. Eur J Biochem 2001; 268: 1876-1887.
    • (2001) Eur J Biochem , vol.268 , pp. 1876-1887
    • Spaniol, M.1    Brooks, H.2    Auer, L.3
  • 14
    • 33644949217 scopus 로고    scopus 로고
    • Mildronate: Cardioprotective action through carnitine-lowering effect
    • Dambrova M, Liepinsh E, Kalvinsh I. Mildronate: cardioprotective action through carnitine-lowering effect. Trends Cardiovasc Med 2002; 9: 155-159.
    • (2002) Trends Cardiovasc Med , vol.9 , pp. 155-159
    • Dambrova, M.1    Liepinsh, E.2    Kalvinsh, I.3
  • 15
    • 33744915313 scopus 로고    scopus 로고
    • 3′-Azido-3′-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria
    • Lynx MD, McKee EE. 3′-Azido-3′-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria. Biochem Pharmacol 2006; 72: 239-243.
    • (2006) Biochem Pharmacol , vol.72 , pp. 239-243
    • Lynx, M.D.1    McKee, E.E.2
  • 17
    • 0030002975 scopus 로고    scopus 로고
    • Hepatic morphological alterations induced by zidovudine (ZDV) in an experimental model
    • Corcuera T, Alonso MJ, Picazo A, et al. Hepatic morphological alterations induced by zidovudine (ZDV) in an experimental model. Pathol Res Pract 1996; 192: 182-187.
    • (1996) Pathol Res Pract , vol.192 , pp. 182-187
    • Corcuera, T.1    Alonso, M.J.2    Picazo, A.3
  • 18
    • 0037721374 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: Experimental clarifications and persistent clinical questions
    • Lewis W. Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: experimental clarifications and persistent clinical questions. Antiviral Res 2003; 58: 189-197.
    • (2003) Antiviral Res , vol.58 , pp. 189-197
    • Lewis, W.1
  • 19
    • 33645124958 scopus 로고    scopus 로고
    • 3′-Azido-3′-deoxythimidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: A possible mechanism of AZT hepatotoxicity
    • Lynx MD, Bentley AT, McKee EE. 3′-Azido-3′-deoxythimidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity. Biochem Pharmacol 2006; 71: 1342-1348.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1342-1348
    • Lynx, M.D.1    Bentley, A.T.2    McKee, E.E.3
  • 21
    • 0002897142 scopus 로고
    • Laboratory manual on transport and bioenergetics
    • Carafoli E, Semenza G eds, Springer: New York
    • Gazotti P, Malmstron K, Crompton MA. Laboratory manual on transport and bioenergetics. In Membrane Biochemistry, Carafoli E, Semenza G (eds). Springer: New York, 1979; 62-69.
    • (1979) Membrane Biochemistry , pp. 62-69
    • Gazotti, P.1    Malmstron, K.2    Crompton, M.A.3
  • 22
    • 29744466425 scopus 로고
    • Determination of serum proteins by means of the biuret reaction
    • Gornall AG, Bardawill CJ, David MM. Determination of serum proteins by means of the biuret reaction. J BiolChem 1949; 177: 751-766.
    • (1949) J BiolChem , vol.177 , pp. 751-766
    • Gornall, A.G.1    Bardawill, C.J.2    David, M.M.3
  • 23
    • 78651031094 scopus 로고
    • The respiratory chain and oxidative phosphorylation
    • Chance B, Williams GR. The respiratory chain and oxidative phosphorylation. Adv Enzymol 1956; 17: 65-134.
    • (1956) Adv Enzymol , vol.17 , pp. 65-134
    • Chance, B.1    Williams, G.R.2
  • 24
    • 0018665167 scopus 로고
    • Membrane potential of mitochondria measured with an electrode sensitive to tetraphenylphosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state
    • Kamo N, Muratsugu M, Hongoh R, Kobatake N. Membrane potential of mitochondria measured with an electrode sensitive to tetraphenylphosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state. J Membr Biol 1979; 49: 105-121.
    • (1979) J Membr Biol , vol.49 , pp. 105-121
    • Kamo, N.1    Muratsugu, M.2    Hongoh, R.3    Kobatake, N.4
  • 25
    • 0029863399 scopus 로고    scopus 로고
    • Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites
    • Costantini P, Chernyak BV, Petronilli V, Bernardi P. Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites. J Biol Chem 1996; 271: 6746-6751.
    • (1996) J Biol Chem , vol.271 , pp. 6746-6751
    • Costantini, P.1    Chernyak, B.V.2    Petronilli, V.3    Bernardi, P.4
  • 26
    • 0036328867 scopus 로고    scopus 로고
    • 2 generation in isolated mitochondria
    • 2 generation in isolated mitochondria. J Bioenerg Biomembr 2002; 34: 227-233.
    • (2002) J Bioenerg Biomembr , vol.34 , pp. 227-233
    • Barja, G.1
  • 27
    • 0024360271 scopus 로고
    • Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria
    • Broekemeier KM, Dempsey ME, Pfeiffer DR. Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria. J Biol Chem 1989; 264: 7826-7830.
    • (1989) J Biol Chem , vol.264 , pp. 7826-7830
    • Broekemeier, K.M.1    Dempsey, M.E.2    Pfeiffer, D.R.3
  • 28
    • 0028719493 scopus 로고
    • Histochemical and ultrastructural changes induced by zidovudine in mitochondria of rat cardiac muscle
    • Corcuera Pindado MT, Lopez Bravo A, Martinez-Rodriguez R, et al. Histochemical and ultrastructural changes induced by zidovudine in mitochondria of rat cardiac muscle. Eur J Histochem 1994; 38: 311-318.
    • (1994) Eur J Histochem , vol.38 , pp. 311-318
    • Corcuera Pindado, M.T.1    Lopez Bravo, A.2    Martinez-Rodriguez, R.3
  • 29
    • 0032192305 scopus 로고    scopus 로고
    • AZT decreases rat myocardial cytochrome oxidase activity and increases beta-myosin heavy chain content
    • McCurdy DT, Kennedy JM. AZT decreases rat myocardial cytochrome oxidase activity and increases beta-myosin heavy chain content. J Mol Cell Cardiol 1998; 18: 1979-1989.
    • (1998) J Mol Cell Cardiol , vol.18 , pp. 1979-1989
    • McCurdy, D.T.1    Kennedy, J.M.2
  • 31
    • 0030753860 scopus 로고    scopus 로고
    • Effect of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on myocardial derangements induced by hydrogen peroxide in the isolated perfused rat heart
    • Akahira M, Hara A, Abiko Y. Effect of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on myocardial derangements induced by hydrogen peroxide in the isolated perfused rat heart. Fundam Clin Pharmacol 1997; 11: 356-364.
    • (1997) Fundam Clin Pharmacol , vol.11 , pp. 356-364
    • Akahira, M.1    Hara, A.2    Abiko, Y.3
  • 32
    • 33750006534 scopus 로고    scopus 로고
    • The role of the mitochondrial permeability transition in cell death
    • Armstrong JS. The role of the mitochondrial permeability transition in cell death. Mitochondrion 2006; 5: 225-234.
    • (2006) Mitochondrion , vol.5 , pp. 225-234
    • Armstrong, J.S.1
  • 33
    • 0033806242 scopus 로고    scopus 로고
    • Oxidative stress and regulation of glutathione in lung inflammation
    • Rahman I, MacNee W. Oxidative stress and regulation of glutathione in lung inflammation. Eur Resp J 2000; 16: 534-554.
    • (2000) Eur Resp J , vol.16 , pp. 534-554
    • Rahman, I.1    MacNee, W.2
  • 35
    • 9244222256 scopus 로고    scopus 로고
    • Direct effects of nucleoside reverse transcriptase inhibitors on rat cardiac mitochondrial bioenergetics
    • Lund KC, Wallace KB. Direct effects of nucleoside reverse transcriptase inhibitors on rat cardiac mitochondrial bioenergetics. Mitochondrion 2004; 4: 193-202.
    • (2004) Mitochondrion , vol.4 , pp. 193-202
    • Lund, K.C.1    Wallace, K.B.2
  • 36
    • 1842577842 scopus 로고    scopus 로고
    • Azidothymidine promotes free radical generation by activated macrophages and hydrogen peroxide-iron-mediated oxidation in a cell-free system
    • Komarov AM, Hall JM, Weglicki WB. Azidothymidine promotes free radical generation by activated macrophages and hydrogen peroxide-iron-mediated oxidation in a cell-free system. Biochim Biophys Acta 2004; 1688: 257-264.
    • (2004) Biochim Biophys Acta , vol.1688 , pp. 257-264
    • Komarov, A.M.1    Hall, J.M.2    Weglicki, W.B.3
  • 37
    • 1842570096 scopus 로고    scopus 로고
    • AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria
    • De la Asunción JG, Del Olmo ML, Sastre J, et al. AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. J Clin Invest 1998; 102: 4-9.
    • (1998) J Clin Invest , vol.102 , pp. 4-9
    • De la Asunción, J.G.1    Del Olmo, M.L.2    Sastre, J.3
  • 38
    • 0026356201 scopus 로고
    • Abnormal skeletal and cardiac muscle mitochondria induced by zidovudine (AZT) in human muscle in vitro and in an animal model
    • Lamperth L, Dalakas MC, Dagani F, Anderson J, Ferrari R. Abnormal skeletal and cardiac muscle mitochondria induced by zidovudine (AZT) in human muscle in vitro and in an animal model. Lab Invest 1991; 65: 742-751.
    • (1991) Lab Invest , vol.65 , pp. 742-751
    • Lamperth, L.1    Dalakas, M.C.2    Dagani, F.3    Anderson, J.4    Ferrari, R.5
  • 39
    • 0027170504 scopus 로고
    • AZT causes tissue-specific inhibition of mitochondrial bioenergetic function
    • Modica-Napolitano JS. AZT causes tissue-specific inhibition of mitochondrial bioenergetic function. Biochem Biophys Res Commun 1993; 194: 170-177.
    • (1993) Biochem Biophys Res Commun , vol.194 , pp. 170-177
    • Modica-Napolitano, J.S.1
  • 40
    • 36849090632 scopus 로고    scopus 로고
    • Adenosine 3′,5′-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitors
    • Lund KC, Wallace KB. Adenosine 3′,5′-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitors. Toxicol Appl Pharmacol 2008; 226: 94-106.
    • (2008) Toxicol Appl Pharmacol , vol.226 , pp. 94-106
    • Lund, K.C.1    Wallace, K.B.2
  • 41
    • 0029195917 scopus 로고
    • The toxicity of azidothymidine (AZT) on human and animal cells in culture at concentrations used for antiviral therapy
    • Chiu DT, Duesberg PH. The toxicity of azidothymidine (AZT) on human and animal cells in culture at concentrations used for antiviral therapy. Genetica 1995; 95: 103-109.
    • (1995) Genetica , vol.95 , pp. 103-109
    • Chiu, D.T.1    Duesberg, P.H.2
  • 42
    • 48249126823 scopus 로고    scopus 로고
    • Mildronate improves peripheral circulation in patients with chronic heart failure: Results of a clinical trial
    • Dzerve V, Matisone D, Kukulis I, et al. Mildronate improves peripheral circulation in patients with chronic heart failure: results of a clinical trial. Sem Cardiol 2005; 11: 1648-7966.
    • (2005) Sem Cardiol , vol.11 , pp. 1648-7966
    • Dzerve, V.1    Matisone, D.2    Kukulis, I.3


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