Targeted delivery of a designed sTRAIL mutant results in superior apoptotic activity towards EGFR-positive tumor cells

Journal of Molecular Medicine

Volumn 86, Issue 8, 2008, Pages 909-924

  Bremer, Edwin ^a   De Bruyn, Marco ^a   Samplonius, Douwe F ^a   Bijma, Theo ^a   Ten Cate, Bram ^a   De Leij, Lou F M H ^a   Helfrich, Wijnand ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

EGFR; Mutant; Selective; Targeting; TRAIL; TRAIL receptor

Indexed keywords

CASPASE 8; CISPLATIN; DEATH RECEPTOR 4; DEATH RECEPTOR 5; EPIDERMAL GROWTH FACTOR RECEPTOR; HISTONE DEACETYLASE INHIBITOR; HYBRID PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VALPROIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE FUSION; GENE SEQUENCE; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR BINDING; TUMOR CELL;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; CELL LINE, TUMOR; GENE TRANSFER TECHNIQUES; HUMANS; JURKAT CELLS; LIGANDS; MUTATION; NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 48149103900     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-008-0348-9     Document Type: Article

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