Effect of the type of lubricant on the characteristics of orally disintegrating tablets manufactured using the phase transition of sugar alcohol

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 69, Issue 3, 2008, Pages 986-992

  Kuno, Yoshio ^a   Kojima, Masazumi ^a   Nakagami, Hiroaki ^a   Yonemochi, Etsuo ^b   Terada, Katsuhide ^b  

^a Formulation Technology Research Laboratories   (Japan)

^b TOHO UNIVERSITY   (Japan)

Author keywords

Lubricant; Orally disintegrating tablets; Phase transition; Saccharide; Sugar alcohol; Talc

Indexed keywords

AEROSIL; CROSPOVIDONE; DISINTEGRATING AGENT; GLIDING AGENT; LACTOSE; LUBRICATING AGENT; MAGNESIUM STEARATE; STEARYL FUMARATE SODIUM; SUGAR ALCOHOL; TALC; UNCLASSIFIED DRUG; XYLITOL;

ARTICLE; DRUG SOLUBILITY; ENERGY; HEATING; MEASUREMENT; PHASE TRANSITION; SURFACE PROPERTY; TABLET COMPRESSION; TABLET HARDNESS; TABLET MANUFACTURE; WATER ABSORPTION;

ABSORPTION; ADMINISTRATION, ORAL; CHEMISTRY, PHYSICAL; EXCIPIENTS; FUMARATES; HARDNESS; LACTOSE; LUBRICANTS; POROSITY; SOLUBILITY; STEARIC ACIDS; SUGAR ALCOHOLS; SURFACE PROPERTIES; TABLETS; TALC; WATER; XYLITOL;

EID: 48149087078     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.02.016     Document Type: Article

References (19)

1. Watanabe A., Hanada T., and Sugihara M. New oral dosage form for the elderly - rapid dissolving tablet in mouth without addition of water. Yakuzaigaku 54 (1998) 103-110
2. Sunada H., and Bi Y. Preparation, evaluation and optimization of rapidly disintegrating tablets. Powder Technol. 122 (2002) 188-198
3. Fukami J., Yonemochi E., Yoshihashi Y., and Terada K. Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose. Int. J. Pharm. 310 (2006) 101-109
4. Katou S., Kearney P., and Yarwood R.J. The zydis fast dissolving oral dosage form. Pharm. Tech. Jpn. 9 (1993) 713-719
5. Tsushima Y. Tablets that are easily to be taken - dosage form developed for elderly patients. Farumashia 33 (1997) 1119-1123
6. Mizumoto T., Masuda Y., Yamamoto T., Yonemochi E., and Terada K. Formulation design of a novel fast-disintegrating tablet. Int. J. Pharm. 306 (2005) 83-90
7. Sugimoto M., Narisawa S., Matsubara K., Yoshino H., Nakano M., and Handa T. Development of manufacturing method for rapidly disintegrating oral tablets using the crystalline transition of amorphous sucrose. Int. J. Pharm. 320 (2006) 71-78
8. Sugimoto M., Maejima T., Narisawa S., Matshubara K., and Yoshino H. Factors affecting the characteristics of rapidly disintegrating tablets in the mouth prepared by the crystalline transition of amorphous sucrose. Int. J. Pharm. 296 (2005) 64-72
9. Kuno Y., Kojima M., Ando S., and Nakagami H. Evaluation of rapidly disintegrating tablets manufactured by phase transition of sugar alcohols. J. Control. Release 105 (2005) 16-22
10. Bolhuis G.K., Lerk C.F., Zijlstra H.T., and De Boer A.H. Film formulation by magnesium stearate during mixing and its effect on tabletting. Pharm. Weekblad 100 (1975) 317-325
11. Fassihi R.A., McPhillips A.M., Uraizee S.A., and Sakr A.M. Potential use of magnesium stearate and talc as dissolution retardants in the development of controlled drug delivery systems. Pharm. Ind. 56 (1994) 579-583
12. Nogami H., Nagai T., Fukuoka E., and Sonobe T. Disintegration of the aspirin tablets containing potato starch and microcrystalline cellulose in various concentrations. Chem. Pharm. Bull. 17 (1969) 1450-1455
13. Terada K., and Yonemochi E. Physicochemical properties and surface free energy of ground talc. Solid State Ionics 172 (2004) 459-462
14. Chowhan Z.T., and Chi L.-H. Drug-excipient interactions resulting from powder mixing IV: role of lubricants and their effect on in vitro dissolution. J. Pharm. Sci. 75 (1986) 542-545
15. Charnay C., Lagerge S., and Partyka S. Determination of surface heterogeneity of talc materials. Prog. Colloid Polym. Sci. 115 (2000) 66-71
16. Anne M.J. Relation between breaking force and pore structure of lactose, glucose and mannitol tablets. Int. J. Pharm. 127 (1996) 95-102
17. Mattsson S., and Nystrom C. The use of mercury porosimetry in assessing the effect of different binders on the pore structure and bonding properties of tablets. Eur. J. Pharm. Biopharm. 52 (2001) 237-247
18. Nystrom C., and Karehill P.G. Studies on direct compression of tablets XVI. The use of surface area measurements for the evaluation of bonding surface area in compressed powders. Powder Technol. 47 (1986) 201-209
19. Nystrom C., Alderborn G., Duberg M., and Karehill P.G. Bonding surface area and bonding mechanism - two important factors for the understanding of powder compactability. Drug Dev. Ind. Pharm. 19 (1993) 2143-2196